UniProtKB - Q99572 (P2RX7_HUMAN)
Protein
P2X purinoceptor 7
Gene
P2RX7
Organism
Homo sapiens (Human)
Status
Functioni
Receptor for ATP that acts as a ligand-gated ion channel. Responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Could function in both fast synaptic transmission and the ATP-mediated lysis of antigen-presenting cells. In the absence of its natural ligand, ATP, functions as a scavenger receptor in the recognition and engulfment of apoptotic cells (PubMed:21821797, PubMed:23303206).3 Publications
GO - Molecular functioni
- ATP binding Source: BHF-UCL
- extracellularly ATP-gated cation channel activity Source: BHF-UCL
- identical protein binding Source: BHF-UCL
- lipopolysaccharide binding Source: BHF-UCL
- purinergic nucleotide receptor activity Source: BHF-UCL
- signaling receptor binding Source: BHF-UCL
GO - Biological processi
- activation of MAPK activity Source: Ensembl
- apoptotic signaling pathway Source: BHF-UCL
- bleb assembly Source: UniProtKB
- blood coagulation Source: Reactome
- calcium ion transmembrane transport Source: ARUK-UCL
- calcium-mediated signaling using extracellular calcium source Source: ARUK-UCL
- cell morphogenesis Source: Ensembl
- cell surface receptor signaling pathway Source: BHF-UCL
- cell surface receptor signaling pathway involved in cell-cell signaling Source: ARUK-UCL
- cellular response to ATP Source: ARUK-UCL
- cellular response to dsRNA Source: Ensembl
- cellular response to extracellular stimulus Source: Ensembl
- ceramide biosynthetic process Source: Ensembl
- collagen metabolic process Source: Ensembl
- defense response to Gram-positive bacterium Source: Ensembl
- extrinsic apoptotic signaling pathway Source: BHF-UCL
- homeostasis of number of cells within a tissue Source: Ensembl
- inflammatory response Source: Ensembl
- membrane depolarization Source: BHF-UCL
- membrane protein ectodomain proteolysis Source: Ensembl
- mitochondrion organization Source: Ensembl
- NAD transport Source: Ensembl
- negative regulation of bone resorption Source: BHF-UCL
- negative regulation of cell volume Source: UniProtKB
- negative regulation of MAPK cascade Source: BHF-UCL
- phagolysosome assembly Source: Ensembl
- phospholipid transfer to membrane Source: Ensembl
- plasma membrane phospholipid scrambling Source: UniProtKB
- pore complex assembly Source: BHF-UCL
- positive regulation of bleb assembly Source: UniProtKB
- positive regulation of bone mineralization Source: BHF-UCL
- positive regulation of calcium ion transport into cytosol Source: BHF-UCL
- positive regulation of cytokine secretion Source: Ensembl
- positive regulation of cytoskeleton organization Source: BHF-UCL
- positive regulation of gamma-aminobutyric acid secretion Source: Ensembl
- positive regulation of gene expression Source: CACAO
- positive regulation of glutamate secretion Source: Ensembl
- positive regulation of glycolytic process Source: CACAO
- positive regulation of interleukin-1 alpha production Source: Ensembl
- positive regulation of interleukin-1 beta production Source: BHF-UCL
- positive regulation of interleukin-6 production Source: Ensembl
- positive regulation of ion transmembrane transport Source: UniProtKB
- positive regulation of lymphocyte apoptotic process Source: Ensembl
- positive regulation of mitochondrial depolarization Source: Ensembl
- positive regulation of prostaglandin secretion Source: Ensembl
- positive regulation of T cell mediated cytotoxicity Source: Ensembl
- protein catabolic process Source: Ensembl
- protein phosphorylation Source: Ensembl
- protein processing Source: Ensembl
- purinergic nucleotide receptor signaling pathway Source: UniProtKB
- reactive oxygen species metabolic process Source: Ensembl
- regulation of killing of cells of other organism Source: BHF-UCL
- regulation of sodium ion transport Source: BHF-UCL
- release of sequestered calcium ion into cytosol Source: Ensembl
- response to ATP Source: BHF-UCL
- response to calcium ion Source: Ensembl
- response to drug Source: Ensembl
- response to electrical stimulus Source: Ensembl
- response to fluid shear stress Source: Ensembl
- response to ischemia Source: ARUK-UCL
- response to lipopolysaccharide Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- response to zinc ion Source: Ensembl
- sensory perception of pain Source: BHF-UCL
- skeletal system morphogenesis Source: Ensembl
- synaptic vesicle exocytosis Source: Ensembl
- T cell homeostasis Source: Ensembl
- T cell proliferation Source: Ensembl
- vesicle budding from membrane Source: Ensembl
Keywordsi
| Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
| Biological process | Ion transport, Transport |
Enzyme and pathway databases
| PathwayCommonsi | Q99572 |
| Reactomei | R-HSA-139853, Elevation of cytosolic Ca2+ levels R-HSA-418346, Platelet homeostasis R-HSA-844456, The NLRP3 inflammasome R-HSA-9660826, Purinergic signaling in leishmaniasis infection |
| SignaLinki | Q99572 |
| SIGNORi | Q99572 |
Protein family/group databases
| TCDBi | 1.A.7.1.3, the atp-gated p2x receptor cation channel (p2x receptor) family |
Names & Taxonomyi
| Protein namesi | Recommended name: P2X purinoceptor 7Short name: P2X7 Alternative name(s): ATP receptor P2Z receptor Purinergic receptor |
| Gene namesi | Name:P2RX7 |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | HostDB:ENSG00000089041.16 |
| HGNCi | HGNC:8537, P2RX7 |
| MIMi | 602566, gene |
| neXtProti | NX_Q99572 |
Subcellular locationi
Plasma membrane
- Cell membrane 3 Publications; Multi-pass membrane protein Sequence analysis
Nucleus
- integral component of nuclear inner membrane Source: GO_Central
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- integral component of plasma membrane Source: BHF-UCL
- plasma membrane Source: UniProtKB
Other locations
- bleb Source: BHF-UCL
- cell-cell junction Source: Ensembl
- cytoplasm Source: BHF-UCL
- membrane Source: BHF-UCL
- neuromuscular junction Source: Ensembl
- neuronal cell body Source: Ensembl
- postsynapse Source: GOC
- presynapse Source: GOC
Topology
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Topological domaini | 1 – 25 | CytoplasmicSequence analysisAdd BLAST | 25 | |
| Transmembranei | 26 – 46 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
| Topological domaini | 47 – 334 | ExtracellularSequence analysisAdd BLAST | 288 | |
| Transmembranei | 335 – 355 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
| Topological domaini | 356 – 595 | CytoplasmicSequence analysisAdd BLAST | 240 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Mutagenesisi | 187 | N → A: Alters cell surface expression. 1 Publication | 1 |
Organism-specific databases
| DisGeNETi | 5027 |
| MalaCardsi | P2RX7 |
| OpenTargetsi | ENSG00000089041 |
| Orphaneti | 67038, B-cell chronic lymphocytic leukemia |
| PharmGKBi | PA32866 |
Miscellaneous databases
| Pharosi | Q99572, Tchem |
Chemistry databases
| ChEMBLi | CHEMBL4805 |
| DrugBanki | DB01069, Promethazine |
| GuidetoPHARMACOLOGYi | 484 |
Polymorphism and mutation databases
| BioMutai | P2RX7 |
| DMDMi | 395398617 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| ChainiPRO_0000161560 | 1 – 595 | P2X purinoceptor 7Add BLAST | 595 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Disulfide bondi | 119 ↔ 168 | By similarity | ||
| Modified residuei | 125 | ADP-ribosylarginineBy similarity | 1 | |
| Disulfide bondi | 129 ↔ 152 | By similarity | ||
| Modified residuei | 133 | ADP-ribosylarginineBy similarity | 1 | |
| Disulfide bondi | 135 ↔ 162 | By similarity | ||
| Glycosylationi | 187 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Glycosylationi | 202 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Glycosylationi | 213 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Disulfide bondi | 216 ↔ 226 | By similarity | ||
| Glycosylationi | 241 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Disulfide bondi | 260 ↔ 269 | By similarity | ||
| Glycosylationi | 284 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
| Modified residuei | 343 | Phosphotyrosine1 Publication | 1 | |
| Modified residuei | 390 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylation results in its inactivation.1 Publication
ADP-ribosylation at Arg-125 is necessary and sufficient to activate P2RX7 and gate the channel.By similarity
Palmitoylation of several cysteines in the C-terminal cytoplasmic tail is required for efficient localization to cell surface.1 Publication
Keywords - PTMi
ADP-ribosylation, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
| CPTACi | CPTAC-2229 |
| jPOSTi | Q99572 |
| MassIVEi | Q99572 |
| PaxDbi | Q99572 |
| PeptideAtlasi | Q99572 |
| PRIDEi | Q99572 |
| ProteomicsDBi | 16961 27247 27466 30262 62309 78332 [Q99572-1] |
PTM databases
| GlyConnecti | 1591, 1 N-Linked glycan (1 site) |
| GlyGeni | Q99572, 5 sites |
| iPTMneti | Q99572 |
| PhosphoSitePlusi | Q99572 |
| SwissPalmi | Q99572 |
Expressioni
Tissue specificityi
Widely expressed with highest levels in brain and immune tissues.1 Publication
Gene expression databases
| Bgeei | ENSG00000089041, Expressed in corpus callosum and 194 other tissues |
| ExpressionAtlasi | Q99572, baseline and differential |
| Genevisiblei | Q99572, HS |
Organism-specific databases
| HPAi | ENSG00000089041, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Functional P2XRs are organized as homomeric and heteromeric trimers.
Interacts with LAMA3, ITGB2, ACTB, ACTN4, SVIL, MPP3, HSPA1, HSPCB, HSPA8, PIK230 and PTPRB.
Interacts (via C-terminus) with EMP2 (PubMed:12107182).
2 PublicationsBinary interactionsi
Hide detailsQ99572
GO - Molecular functioni
- identical protein binding Source: BHF-UCL
- signaling receptor binding Source: BHF-UCL
Protein-protein interaction databases
| BioGRIDi | 111066, 14 interactors |
| CORUMi | Q99572 |
| ELMi | Q99572 |
| IntActi | Q99572, 17 interactors |
| STRINGi | 9606.ENSP00000330696 |
Chemistry databases
| BindingDBi | Q99572 |
Miscellaneous databases
| RNActi | Q99572, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the P2X receptor family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
| eggNOGi | ENOG502QSBN, Eukaryota |
| GeneTreei | ENSGT01000000214439 |
| HOGENOMi | CLU_034469_7_0_1 |
| InParanoidi | Q99572 |
| KOi | K05220 |
| OMAi | CNLDSWF |
| OrthoDBi | 1128763at2759 |
| TreeFami | TF328633 |
Family and domain databases
| Gene3Di | 2.60.490.10, 1 hit |
| InterProi | View protein in InterPro IPR003050, P2X7_purinoceptor IPR027309, P2X_extracellular_dom_sf IPR001429, P2X_purnocptor |
| PANTHERi | PTHR10125:SF13, PTHR10125:SF13, 1 hit |
| PRINTSi | PR01314, P2X7RECEPTOR PR01307, P2XRECEPTOR |
| TIGRFAMsi | TIGR00863, P2X, 1 hit |
| PROSITEi | View protein in PROSITE PS01212, P2X_RECEPTOR, 1 hit |
Sequences (8+)i
Sequence statusi: Complete.
This entry describes 8 isoformsi produced by alternative splicing. AlignAdd to basketThis entry has 8 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform A (identifier: Q99572-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MPACCSCSDV FQYETNKVTR IQSMNYGTIK WFFHVIIFSY VCFALVSDKL
60 70 80 90 100
YQRKEPVISS VHTKVKGIAE VKEEIVENGV KKLVHSVFDT ADYTFPLQGN
110 120 130 140 150
SFFVMTNFLK TEGQEQRLCP EYPTRRTLCS SDRGCKKGWM DPQSKGIQTG
160 170 180 190 200
RCVVYEGNQK TCEVSAWCPI EAVEEAPRPA LLNSAENFTV LIKNNIDFPG
210 220 230 240 250
HNYTTRNILP GLNITCTFHK TQNPQCPIFR LGDIFRETGD NFSDVAIQGG
260 270 280 290 300
IMGIEIYWDC NLDRWFHHCR PKYSFRRLDD KTTNVSLYPG YNFRYAKYYK
310 320 330 340 350
ENNVEKRTLI KVFGIRFDIL VFGTGGKFDI IQLVVYIGST LSYFGLAAVF
360 370 380 390 400
IDFLIDTYSS NCCRSHIYPW CKCCQPCVVN EYYYRKKCES IVEPKPTLKY
410 420 430 440 450
VSFVDESHIR MVNQQLLGRS LQDVKGQEVP RPAMDFTDLS RLPLALHDTP
460 470 480 490 500
PIPGQPEEIQ LLRKEATPRS RDSPVWCQCG SCLPSQLPES HRCLEELCCR
510 520 530 540 550
KKPGACITTS ELFRKLVLSR HVLQFLLLYQ EPLLALDVDS TNSRLRHCAY
560 570 580 590
RCYATWRFGS QDMADFAILP SCCRWRIRKE FPKSEGQYSG FKSPY
Isoform B (identifier: Q99572-2) [UniParc]FASTAAdd to basket
Also known as: Delta-C, cytoplasmic tail deleted
The sequence of this isoform differs from the canonical sequence as follows:
347-364: AAVFIDFLIDTYSSNCCR → VRDSLFHALGKWFGEGSD
365-595: Missing.
Note: Predominant form in many tissues.Curated
Show »Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket| F5H2X6 | F5H2X6_HUMAN | P2X purinoceptor 7 | P2RX7 | 127 | Annotation score: | ||
| F5H8E7 | F5H8E7_HUMAN | P2X purinoceptor 7 | P2RX7 | 258 | Annotation score: | ||
| J3KN30 | J3KN30_HUMAN | P2X purinoceptor 7 | P2RX7 | 149 | Annotation score: | ||
| F5H237 | F5H237_HUMAN | P2X purinoceptor 7 | P2RX7 | 47 | Annotation score: |
Experimental Info
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sequence conflicti | 481 | S → R in CAA73360 (PubMed:9826911).Curated | 1 |
Natural variant
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Natural variantiVAR_036444 | 25 | N → S in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
| Natural variantiVAR_057665 | 76 | V → A2 PublicationsCorresponds to variant dbSNP:rs17525809Ensembl. | 1 | |
| Natural variantiVAR_079880 | 117 | R → W1 PublicationCorresponds to variant dbSNP:rs28360445Ensembl. | 1 | |
| Natural variantiVAR_079881 | 125 | R → L1 PublicationCorresponds to variant dbSNP:rs201668926Ensembl. | 1 | |
| Natural variantiVAR_079882 | 148 | Q → R1 PublicationCorresponds to variant dbSNP:rs150235326Ensembl. | 1 | |
| Natural variantiVAR_057666 | 150 | G → R Decreases cell surface expression; decreases phagocytosis activity. 2 PublicationsCorresponds to variant dbSNP:rs28360447Ensembl. | 1 | |
| Natural variantiVAR_019649 | 155 | Y → H6 PublicationsCorresponds to variant dbSNP:rs208294Ensembl. | 1 | |
| Natural variantiVAR_079883 | 205 | T → M Polymorphism; may influence susceptibility to multiple sclerosis in the presence of variant S-135 in P2RX4; decreases cell surface expression; decreases pore complex assembly; decreases phagocytosis activity. 1 PublicationCorresponds to variant dbSNP:rs140915863Ensembl. | 1 | |
| Natural variantiVAR_079884 | 264 | R → H1 PublicationCorresponds to variant dbSNP:rs149639375Ensembl. | 1 | |
| Natural variantiVAR_057667 | 270 | R → C. Corresponds to variant dbSNP:rs16950860EnsemblClinVar. | 1 | |
| Natural variantiVAR_019648 | 270 | R → H5 PublicationsCorresponds to variant dbSNP:rs7958311Ensembl. | 1 | |
| Natural variantiVAR_057668 | 276 | R → H2 PublicationsCorresponds to variant dbSNP:rs7958316Ensembl. | 1 | |
| Natural variantiVAR_079885 | 288 | Y → H1 PublicationCorresponds to variant dbSNP:rs146725537EnsemblClinVar. | 1 | |
| Natural variantiVAR_057669 | 307 | R → Q Polymorphism; results in a loss of function. 3 PublicationsCorresponds to variant dbSNP:rs28360457EnsemblClinVar. | 1 | |
| Natural variantiVAR_057670 | 348 | A → T3 PublicationsCorresponds to variant dbSNP:rs1718119Ensembl. | 1 | |
| Natural variantiVAR_019650 | 357 | T → S3 PublicationsCorresponds to variant dbSNP:rs2230911Ensembl. | 1 | |
| Natural variantiVAR_079886 | 361 | N → S Polymorphism; may influence susceptibility to multiple sclerosis in the presence of variant S-135 in P2RX4; no effect on cell surface expression; no effect on pore complex assembly. 1 PublicationCorresponds to variant dbSNP:rs201921967Ensembl. | 1 | |
| Natural variantiVAR_057671 | 430 | P → R. Corresponds to variant dbSNP:rs10160951Ensembl. | 1 | |
| Natural variantiVAR_057672 | 433 | A → V1 PublicationCorresponds to variant dbSNP:rs28360459Ensembl. | 1 | |
| Natural variantiVAR_019651 | 460 | Q → R2 PublicationsCorresponds to variant dbSNP:rs2230912Ensembl. | 1 | |
| Natural variantiVAR_019652 | 496 | E → A Polymorphism; results in a loss of function. 4 PublicationsCorresponds to variant dbSNP:rs3751143Ensembl. | 1 | |
| Natural variantiVAR_057673 | 521 | H → Q1 PublicationCorresponds to variant dbSNP:rs2230913Ensembl. | 1 | |
| Natural variantiVAR_057674 | 522 | V → I1 PublicationCorresponds to variant dbSNP:rs34219304EnsemblClinVar. | 1 | |
| Natural variantiVAR_079887 | 535 | A → V1 PublicationCorresponds to variant dbSNP:rs201256156Ensembl. | 1 | |
| Natural variantiVAR_079888 | 544 | R → Q1 PublicationCorresponds to variant dbSNP:rs34567077Ensembl. | 1 | |
| Natural variantiVAR_068011 | 568 | I → N Polymorphism; results in trafficking defect and around 50% loss of function. 4 PublicationsCorresponds to variant dbSNP:rs1653624Ensembl. | 1 | |
| Natural variantiVAR_036445 | 574 | R → L in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
| Natural variantiVAR_057675 | 578 | R → Q. Corresponds to variant dbSNP:rs28360460EnsemblClinVar. | 1 |
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Alternative sequenceiVSP_047776 | 1 – 98 | MPACC…TFPLQ → MTPGDHSW in isoform G and isoform H. 1 PublicationAdd BLAST | 98 | |
| Alternative sequenceiVSP_047777 | 1 – 7 | MPACCSC → MDGPAEQ in isoform D. 2 Publications | 7 | |
| Alternative sequenceiVSP_047778 | 1 – 3 | MPA → MWQ in isoform F. 1 Publication | 3 | |
| Alternative sequenceiVSP_047779 | 4 – 292 | Missing in isoform F. 1 PublicationAdd BLAST | 289 | |
| Alternative sequenceiVSP_047780 | 8 – 177 | Missing in isoform D. 2 PublicationsAdd BLAST | 170 | |
| Alternative sequenceiVSP_047781 | 122 – 128 | YPTRRTL → EFRPEGV in isoform C. 2 Publications | 7 | |
| Alternative sequenceiVSP_047782 | 129 – 595 | Missing in isoform C. 2 PublicationsAdd BLAST | 467 | |
| Alternative sequenceiVSP_047783 | 206 – 294 | Missing in isoform E. 1 PublicationAdd BLAST | 89 | |
| Alternative sequenceiVSP_047784 | 347 – 364 | AAVFI…SNCCR → VRDSLFHALGKWFGEGSD in isoform B, isoform E and isoform G. 1 PublicationAdd BLAST | 18 | |
| Alternative sequenceiVSP_047785 | 365 – 595 | Missing in isoform B, isoform E and isoform G. 1 PublicationAdd BLAST | 231 |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09561 mRNA Translation: CAA70755.1 Y12851 , Y12852, Y12853, Y12854, Y12855 Genomic DNA Translation: CAA73360.1 AY847298 mRNA Translation: AAX82087.1 AY847299 mRNA Translation: AAX82088.1 AY847300 mRNA Translation: AAX82089.1 AY847301 mRNA Translation: AAX82090.1 AY847302 mRNA Translation: AAX82091.1 AY847303 mRNA Translation: AAX82092.1 AY847304 mRNA Translation: AAX82093.1 AK290405 mRNA Translation: BAF83094.1 AK294126 mRNA Translation: BAH11678.1 AC069209 Genomic DNA No translation available. AC079602 Genomic DNA No translation available. Z98941 Genomic DNA No translation available. BC007679 mRNA Translation: AAH07679.1 BC011913 mRNA Translation: AAH11913.1 |
| CCDSi | CCDS9213.1 [Q99572-1] |
| RefSeqi | NP_002553.3, NM_002562.5 [Q99572-1] XP_011536722.1, XM_011538420.2 [Q99572-6] |
Genome annotation databases
| Ensembli | ENST00000328963; ENSP00000330696; ENSG00000089041 [Q99572-1] ENST00000535250; ENSP00000442572; ENSG00000089041 [Q99572-2] ENST00000535600; ENSP00000442470; ENSG00000089041 [Q99572-5] ENST00000541022; ENSP00000441230; ENSG00000089041 [Q99572-3] ENST00000541716; ENSP00000437729; ENSG00000089041 [Q99572-3] |
| GeneIDi | 5027 |
| KEGGi | hsa:5027 |
| UCSCi | uc001tzm.4, human [Q99572-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
| Atlas of Genetics and Cytogenetics in Oncology and Haematology |
| Wikipedia P2X receptor entry |
| Wikipedia P2RX7 entry |
Sequence databases
| Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09561 mRNA Translation: CAA70755.1 Y12851 , Y12852, Y12853, Y12854, Y12855 Genomic DNA Translation: CAA73360.1 AY847298 mRNA Translation: AAX82087.1 AY847299 mRNA Translation: AAX82088.1 AY847300 mRNA Translation: AAX82089.1 AY847301 mRNA Translation: AAX82090.1 AY847302 mRNA Translation: AAX82091.1 AY847303 mRNA Translation: AAX82092.1 AY847304 mRNA Translation: AAX82093.1 AK290405 mRNA Translation: BAF83094.1 AK294126 mRNA Translation: BAH11678.1 AC069209 Genomic DNA No translation available. AC079602 Genomic DNA No translation available. Z98941 Genomic DNA No translation available. BC007679 mRNA Translation: AAH07679.1 BC011913 mRNA Translation: AAH11913.1 |
| CCDSi | CCDS9213.1 [Q99572-1] |
| RefSeqi | NP_002553.3, NM_002562.5 [Q99572-1] XP_011536722.1, XM_011538420.2 [Q99572-6] |
3D structure databases
| SMRi | Q99572 |
| ModBasei | Search... |
Protein-protein interaction databases
| BioGRIDi | 111066, 14 interactors |
| CORUMi | Q99572 |
| ELMi | Q99572 |
| IntActi | Q99572, 17 interactors |
| STRINGi | 9606.ENSP00000330696 |
Chemistry databases
| BindingDBi | Q99572 |
| ChEMBLi | CHEMBL4805 |
| DrugBanki | DB01069, Promethazine |
| GuidetoPHARMACOLOGYi | 484 |
Protein family/group databases
| TCDBi | 1.A.7.1.3, the atp-gated p2x receptor cation channel (p2x receptor) family |
PTM databases
| GlyConnecti | 1591, 1 N-Linked glycan (1 site) |
| GlyGeni | Q99572, 5 sites |
| iPTMneti | Q99572 |
| PhosphoSitePlusi | Q99572 |
| SwissPalmi | Q99572 |
Polymorphism and mutation databases
| BioMutai | P2RX7 |
| DMDMi | 395398617 |
Proteomic databases
| CPTACi | CPTAC-2229 |
| jPOSTi | Q99572 |
| MassIVEi | Q99572 |
| PaxDbi | Q99572 |
| PeptideAtlasi | Q99572 |
| PRIDEi | Q99572 |
| ProteomicsDBi | 16961 27247 27466 30262 62309 78332 [Q99572-1] |
Protocols and materials databases
| Antibodypediai | 19042, 432 antibodies |
| DNASUi | 5027 |
Genome annotation databases
| Ensembli | ENST00000328963; ENSP00000330696; ENSG00000089041 [Q99572-1] ENST00000535250; ENSP00000442572; ENSG00000089041 [Q99572-2] ENST00000535600; ENSP00000442470; ENSG00000089041 [Q99572-5] ENST00000541022; ENSP00000441230; ENSG00000089041 [Q99572-3] ENST00000541716; ENSP00000437729; ENSG00000089041 [Q99572-3] |
| GeneIDi | 5027 |
| KEGGi | hsa:5027 |
| UCSCi | uc001tzm.4, human [Q99572-1] |
Organism-specific databases
| CTDi | 5027 |
| DisGeNETi | 5027 |
| EuPathDBi | HostDB:ENSG00000089041.16 |
| GeneCardsi | P2RX7 |
| HGNCi | HGNC:8537, P2RX7 |
| HPAi | ENSG00000089041, Tissue enhanced (brain) |
| MalaCardsi | P2RX7 |
| MIMi | 602566, gene |
| neXtProti | NX_Q99572 |
| OpenTargetsi | ENSG00000089041 |
| Orphaneti | 67038, B-cell chronic lymphocytic leukemia |
| PharmGKBi | PA32866 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | ENOG502QSBN, Eukaryota |
| GeneTreei | ENSGT01000000214439 |
| HOGENOMi | CLU_034469_7_0_1 |
| InParanoidi | Q99572 |
| KOi | K05220 |
| OMAi | CNLDSWF |
| OrthoDBi | 1128763at2759 |
| TreeFami | TF328633 |
Enzyme and pathway databases
| PathwayCommonsi | Q99572 |
| Reactomei | R-HSA-139853, Elevation of cytosolic Ca2+ levels R-HSA-418346, Platelet homeostasis R-HSA-844456, The NLRP3 inflammasome R-HSA-9660826, Purinergic signaling in leishmaniasis infection |
| SignaLinki | Q99572 |
| SIGNORi | Q99572 |
Miscellaneous databases
| BioGRID-ORCSi | 5027, 28 hits in 874 CRISPR screens |
| ChiTaRSi | P2RX7, human |
| GeneWikii | P2RX7 |
| GenomeRNAii | 5027 |
| Pharosi | Q99572, Tchem |
| PROi | PR:Q99572 |
| RNActi | Q99572, protein |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000089041, Expressed in corpus callosum and 194 other tissues |
| ExpressionAtlasi | Q99572, baseline and differential |
| Genevisiblei | Q99572, HS |
Family and domain databases
| Gene3Di | 2.60.490.10, 1 hit |
| InterProi | View protein in InterPro IPR003050, P2X7_purinoceptor IPR027309, P2X_extracellular_dom_sf IPR001429, P2X_purnocptor |
| PANTHERi | PTHR10125:SF13, PTHR10125:SF13, 1 hit |
| PRINTSi | PR01314, P2X7RECEPTOR PR01307, P2XRECEPTOR |
| TIGRFAMsi | TIGR00863, P2X, 1 hit |
| PROSITEi | View protein in PROSITE PS01212, P2X_RECEPTOR, 1 hit |
| ProtoNeti | Search... |
| MobiDBi | Search... |
Entry informationi
| Entry namei | P2RX7_HUMAN | |
| Accessioni | Q99572Primary (citable) accession number: Q99572 Secondary accession number(s): A8K2Z0 Q96EV7 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
| Last sequence update: | July 11, 2012 | |
| Last modified: | October 7, 2020 | |
| This is version 198 of the entry and version 4 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
