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UniProtKB - Q99571 (P2RX4_HUMAN)

Protein

P2X purinoceptor 4

Gene

P2RX4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for ATP that acts as a ligand-gated ion channel. This receptor is insensitive to the antagonists PPADS and suramin.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ATP binding Source: BHF-UCL
  • ATP-gated ion channel activity Source: GO_Central
  • cadherin binding Source: BHF-UCL
  • copper ion binding Source: BHF-UCL
  • extracellularly ATP-gated cation channel activity Source: UniProtKB
  • ligand-gated calcium channel activity Source: BHF-UCL
  • protein homodimerization activity Source: BHF-UCL
  • purinergic nucleotide receptor activity Source: BHF-UCL
  • signaling receptor binding Source: BHF-UCL
  • zinc ion binding Source: BHF-UCL
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-418346 Platelet homeostasis

Protein family/group databases

Transport Classification Database

More...TCDBi		1.A.7.1.5 the atp-gated p2x receptor cation channel (p2x receptor) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
P2X purinoceptor 4
Short name:
P2X4
Alternative name(s):
ATP receptor
Purinergic receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P2RX4
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000135124.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:8535 P2RX4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600846 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99571

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 33CytoplasmicSequence analysisAdd BLAST33
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 54Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini55 – 338ExtracellularSequence analysisAdd BLAST284
Transmembranei339 – 359Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini360 – 388CytoplasmicSequence analysisAdd BLAST29

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi119I → V: Does not change ATP-induced inward current. Does not change affinity for ATP. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		5025

Open Targets

More...OpenTargetsi		ENSG00000135124

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA32864

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL2104

Drug and drug target database

More...DrugBanki		DB09119 Eslicarbazepine acetate

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		481

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		P2RX4

Domain mapping of disease mutations (DMDM)

More...DMDMi		116242696

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001615531 – 388P2X purinoceptor 4Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi75N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi116 ↔ 165By similarity
Disulfide bondi126 ↔ 149By similarity
Disulfide bondi132 ↔ 159By similarity
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi184N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi199N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi217 ↔ 227By similarity
Disulfide bondi261 ↔ 270By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99571

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99571

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99571

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99571

PeptideAtlas

More...PeptideAtlasi		Q99571

PRoteomics IDEntifications database

More...PRIDEi		Q99571

ProteomicsDB human proteome resource

More...ProteomicsDBi		78331

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		1590

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99571

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99571

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000135124 Expressed in 185 organ(s), highest expression level in colonic mucosa

CleanEx database of gene expression profiles

More...CleanExi		HS_P2RX4

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99571 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99571 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA039494

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		111064, 34 interactors

Protein interaction database and analysis system

More...IntActi		Q99571, 8 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000336607

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q99571

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q99571

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99571

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IFJF Eukaryota
ENOG410XR0C LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154114

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000232042

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG053086

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99571

KEGG Orthology (KO)

More...KOi		K05218

Identification of Orthologs from Complete Genome Data

More...OMAi		CDIVVLY

Database of Orthologous Groups

More...OrthoDBi		998086at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99571

TreeFam database of animal gene trees

More...TreeFami		TF328633

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.490.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003047 P2X4_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF005713 P2X_purinoceptor, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01311 P2X4RECEPTOR
PR01307 P2XRECEPTOR

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00863 P2X, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99571-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGCCAALAA FLFEYDTPRI VLIRSRKVGL MNRAVQLLIL AYVIGWVFVW 
        60         70         80         90        100
EKGYQETDSV VSSVTTKVKG VAVTNTSKLG FRIWDVADYV IPAQEENSLF 
       110        120        130        140        150
VMTNVILTMN QTQGLCPEIP DATTVCKSDA SCTAGSAGTH SNGVSTGRCV 
       160        170        180        190        200
AFNGSVKTCE VAAWCPVEDD THVPQPAFLK AAENFTLLVK NNIWYPKFNF 
       210        220        230        240        250
SKRNILPNIT TTYLKSCIYD AKTDPFCPIF RLGKIVENAG HSFQDMAVEG 
       260        270        280        290        300
GIMGIQVNWD CNLDRAASLC LPRYSFRRLD TRDVEHNVSP GYNFRFAKYY 
       310        320        330        340        350
RDLAGNEQRT LIKAYGIRFD IIVFGKAGKF DIIPTMINIG SGLALLGMAT 
       360        370        380 
VLCDIIVLYC MKKRLYYREK KYKYVEDYEQ GLASELDQ
Length:388
Mass (Da):43,369
Last modified:October 17, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA3BE7F30114C2A5
GO
Isoform 2 (identifier: Q99571-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-45: G → GCYHPHLAEVEMESPRR

Note: No experimental confirmation available.
Show »
Length:404
Mass (Da):45,305
Checksum:i0A8CB40D3D899F21
GO
Isoform 3 (identifier: Q99571-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     149-175: Missing.

Show »
Length:361
Mass (Da):40,481
Checksum:i9D09FA497870DDB1
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6SFZ6F6SFZ6_HUMAN
P2X purinoceptor 4
P2RX4
341Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GZQ9F5GZQ9_HUMAN
P2X purinoceptor 4
P2RX4
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YF70H0YF70_HUMAN
P2X purinoceptor 4
P2RX4
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H1M6F5H1M6_HUMAN
P2X purinoceptor 4
P2RX4
145Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H2S3F5H2S3_HUMAN
P2X purinoceptor 4
P2RX4
52Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti121D → S in AAB66834 (Ref. 8) Curated1
Sequence conflicti148R → W in AAB66834 (Ref. 8) Curated1
Sequence conflicti179L → F in AAB66834 (Ref. 8) Curated1
Sequence conflicti238N → I in AAB66834 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0798563G → C1 PublicationCorresponds to variant dbSNP:rs200492184Ensembl.1
Natural variantiVAR_0283076A → S Polymorphism; does not change ATP-induced inward current; does not change affinity for ATP. 4 PublicationsCorresponds to variant dbSNP:rs1044249Ensembl.1
Natural variantiVAR_079857135G → S Polymorphism; does not change protein expression; does not affect membrane subcellular location; increases ATP-induced inward current. 1 PublicationCorresponds to variant dbSNP:rs765866317Ensembl.1
Natural variantiVAR_014942242S → G Polymorphism; does not change ATP-induced inward current; does not change affinity for ATP. 3 PublicationsCorresponds to variant dbSNP:rs25644Ensembl.1
Natural variantiVAR_079858315Y → C Rare polymorphism; may influence susceptibility to multiple sclerosis in the presence of variants M-205 and S-361 in P2RX7; does not affect membrane subcellular location; reduces ATP-induced inward current; decreases affinity for ATP. 4 PublicationsCorresponds to variant dbSNP:rs28360472Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05381245G → GCYHPHLAEVEMESPRR in isoform 2. Curated1
Alternative sequenceiVSP_053813149 – 175Missing in isoform 3. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y07684 mRNA Translation: CAA68948.1
U87270
, U85971, U85972, U85973, U85974, U85975 Genomic DNA Translation: AAD00556.1
U83993 mRNA Translation: AAD00553.1
AF191093 Genomic DNA Translation: AAF06661.1
BT019738 mRNA Translation: AAV38543.1
BT019739 mRNA Translation: AAV38544.1
AC069209 Genomic DNA No translation available.
BC033826 mRNA Translation: AAH33826.1
AF000234 mRNA Translation: AAB58405.1
AF012903 mRNA Translation: AAB66834.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS58282.1 [Q99571-2]
CCDS9214.1 [Q99571-1]

NCBI Reference Sequences

More...RefSeqi		NP_001243725.1, NM_001256796.1 [Q99571-2]
NP_001248326.1, NM_001261397.1 [Q99571-3]
NP_002551.2, NM_002560.2 [Q99571-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.321709

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000337233; ENSP00000336607; ENSG00000135124 [Q99571-1]
ENST00000359949; ENSP00000353032; ENSG00000135124 [Q99571-2]
ENST00000542067; ENSP00000438329; ENSG00000135124 [Q99571-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		5025

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:5025

UCSC genome browser

More...UCSCi		uc001tzr.4 human [Q99571-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

P2X receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07684 mRNA Translation: CAA68948.1
U87270
, U85971, U85972, U85973, U85974, U85975 Genomic DNA Translation: AAD00556.1
U83993 mRNA Translation: AAD00553.1
AF191093 Genomic DNA Translation: AAF06661.1
BT019738 mRNA Translation: AAV38543.1
BT019739 mRNA Translation: AAV38544.1
AC069209 Genomic DNA No translation available.
BC033826 mRNA Translation: AAH33826.1
AF000234 mRNA Translation: AAB58405.1
AF012903 mRNA Translation: AAB66834.1
CCDSiCCDS58282.1 [Q99571-2]
CCDS9214.1 [Q99571-1]
RefSeqiNP_001243725.1, NM_001256796.1 [Q99571-2]
NP_001248326.1, NM_001261397.1 [Q99571-3]
NP_002551.2, NM_002560.2 [Q99571-1]
UniGeneiHs.321709

3D structure databases

ProteinModelPortaliQ99571
SMRiQ99571
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111064, 34 interactors
IntActiQ99571, 8 interactors
STRINGi9606.ENSP00000336607

Chemistry databases

BindingDBiQ99571
ChEMBLiCHEMBL2104
DrugBankiDB09119 Eslicarbazepine acetate
GuidetoPHARMACOLOGYi481

Protein family/group databases

TCDBi1.A.7.1.5 the atp-gated p2x receptor cation channel (p2x receptor) family

PTM databases

GlyConnecti1590
iPTMnetiQ99571
PhosphoSitePlusiQ99571

Polymorphism and mutation databases

BioMutaiP2RX4
DMDMi116242696

Proteomic databases

EPDiQ99571
jPOSTiQ99571
MaxQBiQ99571
PaxDbiQ99571
PeptideAtlasiQ99571
PRIDEiQ99571
ProteomicsDBi78331

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		5025
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337233; ENSP00000336607; ENSG00000135124 [Q99571-1]
ENST00000359949; ENSP00000353032; ENSG00000135124 [Q99571-2]
ENST00000542067; ENSP00000438329; ENSG00000135124 [Q99571-3]
GeneIDi5025
KEGGihsa:5025
UCSCiuc001tzr.4 human [Q99571-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		5025
DisGeNETi5025
EuPathDBiHostDB:ENSG00000135124.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		P2RX4
HGNCiHGNC:8535 P2RX4
HPAiHPA039494
MIMi600846 gene
neXtProtiNX_Q99571
OpenTargetsiENSG00000135124
PharmGKBiPA32864

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00940000154114
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiQ99571
KOiK05218
OMAiCDIVVLY
OrthoDBi998086at2759
PhylomeDBiQ99571
TreeFamiTF328633

Enzyme and pathway databases

ReactomeiR-HSA-139853 Elevation of cytosolic Ca2+ levels
R-HSA-418346 Platelet homeostasis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		P2RX4 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		P2RX4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		5025

Protein Ontology

More...PROi		PR:Q99571

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000135124 Expressed in 185 organ(s), highest expression level in colonic mucosa
CleanExiHS_P2RX4
ExpressionAtlasiQ99571 baseline and differential
GenevisibleiQ99571 HS

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003047 P2X4_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01311 P2X4RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2RX4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99571
Secondary accession number(s): E7EPF7
, F6RU17, O00450, O14722, Q5U089, Q5U090, Q8N4N1, Q9UBG9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 17, 2006
Last modified: January 16, 2019
This is version 175 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
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