UniProtKB - Q99558 (M3K14_HUMAN)

BLAST

>sp|Q99558|M3K14_HUMAN Mitogen-activated protein kinase kinase kinase 14 OS=Homo sapiens OX=9606 GN=MAP3K14 PE=1 SV=2
MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILND
VITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNN
VAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQE
DESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVW
KLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPH
LSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTW
AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK
QTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQL
VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC
LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF
RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG
LKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPE
PPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLN
SLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSS
SWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFS
LVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP

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History
Entry version 185 (12 Sep 2018)
Sequence version 2 (04 Apr 2006)
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Protein

Mitogen-activated protein kinase kinase kinase 14

Gene

MAP3K14

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-selective manner.1 Publication

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	429	ATPPROSITE-ProRule annotation		1
Active siteⁱ	515	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	406 – 414	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
kinase activity Source: Reactome
MAP kinase kinase kinase activity Source: UniProtKB-EC
NF-kappaB-inducing kinase activity Source: UniProtKB
protein kinase activity
Source: MGI
Inferred from direct assayⁱ
- 15001576
protein serine/threonine kinase activity
Source: Reactome
Inferred from experimentⁱ
- 9520446

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of protein kinase activity Source: GO_Central
cellular response to mechanical stimulus
Source: UniProtKB
Inferred from expression patternⁱ
- 19593445
defense response to virus
Source: UniProtKB
Inferred from direct assayⁱ
- 21478870
I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
immune response Source: UniProtKB
NIK/NF-kappaB signaling Source: Reactome
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 10094049
regulation of apoptotic process Source: GO_Central
regulation of mitotic cell cycle Source: GO_Central
signal transduction by protein phosphorylation Source: GO_Central
stress-activated protein kinase signaling cascade Source: GO_Central
tumor necrosis factor-mediated signaling pathway Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-389357 CD28 dependent PI3K/Akt signaling R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5668541 TNFR2 non-canonical NF-kB pathway R-HSA-5676590 NIK-->noncanonical NF-kB signaling R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
SignaLinkⁱ	Q99558
SIGNORⁱ	Q99558

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Mitogen-activated protein kinase kinase kinase 14 (EC:2.7.11.25) Alternative name(s): NF-kappa-beta-inducing kinase Short name: HsNIK Serine/threonine-protein kinase NIK
Gene namesⁱ	Name:MAP3K14 Synonyms:NIK
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000006062.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6853 MAP3K14
MIMⁱ	604655 gene
neXtProtⁱ	NX_Q99558

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	429 – 430	KK → AA: Loss of autophosphorylation and 'Lys-63'-linked ubiquitination. 2 Publications		2
Mutagenesisⁱ	559	T → A: Abolishes 'Lys-63'-linked ubiquitination. 1 Publication		1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	9020
MalaCards human disease database More...MalaCardsⁱ	MAP3K14
Open Targets More...OpenTargetsⁱ	ENSG00000006062
PharmGKBⁱ	PA30597

Chemistry databases

ChEMBLⁱ	CHEMBL5888
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	2074

Polymorphism and mutation databases

BioMutaⁱ	MAP3K14
DMDMⁱ	92090612

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086266	1 – 947	Mitogen-activated protein kinase kinase kinase 14Add BLAST		947

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	559	Phosphothreonine1 Publication		1

Post-translational modificationⁱ

Autophosphorylated. Phosphorylation at Thr-559 is required to activates its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization.2 Publications

Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it.

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

PeptideAtlas More...PeptideAtlasⁱ	Q99558
PRIDEⁱ	Q99558
ProteomicsDBⁱ	78326

PTM databases

iPTMnetⁱ	Q99558
PhosphoSitePlusⁱ	Q99558

Expressionⁱ

Tissue specificityⁱ

Weakly expressed in testis, small intestine, spleen, thymus, peripheral blood leukocytes, prostate, ovary and colon.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000006062 Expressed in 141 organ(s), highest expression level in esophagogastric junction muscularis propria
CleanExⁱ	HS_MAP3K14
ExpressionAtlasⁱ	Q99558 baseline and differential
Genevisibleⁱ	Q99558 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA027269 HPA027270

HPAⁱ

HPA027269
HPA027270

Interactionⁱ

Subunit structureⁱ

Interacts with TRAF2, TRAF5, TRAF6, IKKA and NFKB2/P100 (By similarity). Interacts with TRAF3 and PELI3. Interacts with NIBP; the interaction is direct. Interacts with ARRB1 and ARRB2. Interacts with GRB10. Interacts with ZFP91.By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
ALPL	P05186	4	EBI-358011,EBI-1054354
CDC37	Q16543	2	EBI-358011,EBI-295634
CHUK	O15111	6	EBI-358011,EBI-81249
Chuk	Q60680-2	3	EBI-358011,EBI-646264	From a different organism.
HSP90AB1	P08238	2	EBI-358011,EBI-352572
IKBKB	O14920	3	EBI-358011,EBI-81266
TRAF2	Q12933	7	EBI-358011,EBI-355744
TRAF6	Q9Y4K3	2	EBI-358011,EBI-359276

Protein-protein interaction databases

BioGridⁱ	114487, 35 interactors
CORUMⁱ	Q99558
Database of interacting proteins More...DIPⁱ	DIP-27522N
IntActⁱ	Q99558, 30 interactors
Molecular INTeraction database More...MINTⁱ	Q99558

Chemistry databases

BindingDBⁱ

Q99558

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	335 – 341	Combined sources	7
Beta strandⁱ	345 – 347	Combined sources	3
Helixⁱ	350 – 363	Combined sources	14
Beta strandⁱ	364 – 366	Combined sources	3
Beta strandⁱ	377 – 381	Combined sources	5
Turnⁱ	395 – 397	Combined sources	3
Beta strandⁱ	398 – 408	Combined sources	11
Beta strandⁱ	410 – 419	Combined sources	10
Turnⁱ	420 – 422	Combined sources	3
Beta strandⁱ	425 – 432	Combined sources	8
Helixⁱ	433 – 435	Combined sources	3
Helixⁱ	439 – 442	Combined sources	4
Turnⁱ	443 – 446	Combined sources	4
Beta strandⁱ	455 – 461	Combined sources	7
Beta strandⁱ	464 – 469	Combined sources	6
Helixⁱ	477 – 484	Combined sources	8
Helixⁱ	489 – 507	Combined sources	19
Turnⁱ	508 – 510	Combined sources	3
Helixⁱ	518 – 520	Combined sources	3
Beta strandⁱ	521 – 523	Combined sources	3
Beta strandⁱ	530 – 532	Combined sources	3
Helixⁱ	535 – 537	Combined sources	3
Beta strandⁱ	543 – 547	Combined sources	5
Turnⁱ	550 – 553	Combined sources	4
Helixⁱ	560 – 562	Combined sources	3
Helixⁱ	565 – 568	Combined sources	4
Helixⁱ	576 – 591	Combined sources	16
Turnⁱ	595 – 599	Combined sources	5
Helixⁱ	605 – 610	Combined sources	6
Helixⁱ	614 – 617	Combined sources	4
Helixⁱ	624 – 633	Combined sources	10
Turnⁱ	638 – 640	Combined sources	3
Helixⁱ	644 – 658	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	Q99558
SMRⁱ	Q99558
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	400 – 655	Protein kinasePROSITE-ProRule annotationAdd BLAST		256

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	401 – 653	Interaction with ZFP911 PublicationAdd BLAST		253

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00800000124036
HOGENOMⁱ	HOG000113436
HOVERGENⁱ	HBG052384
InParanoidⁱ	Q99558
KEGG Orthology (KO) More...KOⁱ	K04466
OMAⁱ	YDMEVPD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G018K
PhylomeDBⁱ	Q99558

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR017425 MAPKKK14 IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
PANTHERⁱ	PTHR24361:SF226 PTHR24361:SF226, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
PIRSFⁱ	PIRSF038175 MAPKKK14, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

Q99558-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAVMEMACPG APGSAVGQQK ELPKAKEKTP PLGKKQSSVY KLEAVEKSPV 
        60         70         80         90        100
FCGKWEILND VITKGTAKEG SEAGPAAISI IAQAECENSQ EFSPTFSERI 
       110        120        130        140        150
FIAGSKQYSQ SESLDQIPNN VAHATEGKMA RVCWKGKRRS KARKKRKKKS 
       160        170        180        190        200
SKSLAHAGVA LAKPLPRTPE QESCTIPVQE DESPLGAPYV RNTPQFTKPL 
       210        220        230        240        250
KEPGLGQLCF KQLGEGLRPA LPRSELHKLI SPLQCLNHVW KLHHPQDGGP 
       260        270        280        290        300
LPLPTHPFPY SRLPHPFPFH PLQPWKPHPL ESFLGKLACV DSQKPLPDPH 
       310        320        330        340        350
LSKLACVDSP KPLPGPHLEP SCLSRGAHEK FSVEEYLVHA LQGSVSSGQA 
       360        370        380        390        400
HSLTSLAKTW AARGSRSREP SPKTEDNEGV LLTEKLKPVD YEYREEVHWA 
       410        420        430        440        450
THQLRLGRGS FGEVHRMEDK QTGFQCAVKK VRLEVFRAEE LMACAGLTSP 
       460        470        480        490        500
RIVPLYGAVR EGPWVNIFME LLEGGSLGQL VKEQGCLPED RALYYLGQAL 
       510        520        530        540        550
EGLEYLHSRR ILHGDVKADN VLLSSDGSHA ALCDFGHAVC LQPDGLGKSL 
       560        570        580        590        600
LTGDYIPGTE THMAPEVVLG RSCDAKVDVW SSCCMMLHML NGCHPWTQFF 
       610        620        630        640        650
RGPLCLKIAS EPPPVREIPP SCAPLTAQAI QEGLRKEPIH RVSAAELGGK 
       660        670        680        690        700
VNRALQQVGG LKSPWRGEYK EPRHPPPNQA NYHQTLHAQP RELSPRAPGP 
       710        720        730        740        750
RPAEETTGRA PKLQPPLPPE PPEPNKSPPL TLSKEESGMW EPLPLSSLEP 
       760        770        780        790        800
APARNPSSPE RKATVPEQEL QQLEIELFLN SLSQPFSLEE QEQILSCLSI 
       810        820        830        840        850
DSLSLSDDSE KNPSKASQSS RDTLSSGVHS WSSQAEARSS SWNMVLARGR 
       860        870        880        890        900
PTDTPSYFNG VKVQIQSLNG EHLHIREFHR VKVGDIATGI SSQIPAAAFS 
       910        920        930        940 
LVTKDGQPVR YDMEVPDSGI DLQCTLAPDG SFAWSWRVKH GQLENRP

Length:947

Mass (Da):104,042

Last modified:April 4, 2006 - v2

Checksum:ⁱC9D10F67FF7F48AC

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A087WXF1	A0A087WXF1_HUMAN		Mitogen-activated protein kinase ki... Mitogen-activated protein kinase kinase kinase 14	MAP3K14	157	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	25	A → P in CAA71306 (PubMed:9020361).Curated	1
Sequence conflictⁱ	348	G → S in CAA71306 (PubMed:9020361).Curated	1
Sequence conflictⁱ	880	R → G in BAF82892 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_040711	140	S → N1 PublicationCorresponds to variant dbSNP:rs11574819EnsemblClinVar.	1
Natural variantⁱVAR_051641	255	T → M. Corresponds to variant dbSNP:rs11574820EnsemblClinVar.	1
Natural variantⁱVAR_040712	514	G → K in a lung neuroendocrine carcinoma sample; somatic mutation; requires 2 nucleotide substitutions. 1 Publication	1
Natural variantⁱVAR_051642	674	H → Y. Corresponds to variant dbSNP:rs11867907EnsemblClinVar.	1
Natural variantⁱVAR_040713	764	T → A1 PublicationCorresponds to variant dbSNP:rs56302559EnsemblClinVar.	1
Natural variantⁱVAR_040714	852	T → I in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication	1
Natural variantⁱVAR_040715	928	P → H1 PublicationCorresponds to variant dbSNP:rs56036201Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10256 mRNA Translation: CAA71306.1 AK290203 mRNA Translation: BAF82892.1 DQ314874 Genomic DNA Translation: ABC40733.1 CH471178 Genomic DNA Translation: EAW51529.1 CH471178 Genomic DNA Translation: EAW51530.1 BC035576 mRNA Translation: AAH35576.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS74079.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003945.2, NM_003954.4 XP_011523743.1, XM_011525441.2
UniGeneⁱ	Hs.404183 Hs.668927 Hs.735695

Genome annotation databases

Ensemblⁱ	ENST00000344686; ENSP00000478552; ENSG00000006062 ENST00000376926; ENSP00000482657; ENSG00000006062
GeneIDⁱ	9020
KEGGⁱ	hsa:9020
UCSC genome browser More...UCSCⁱ	uc032fjy.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99558	Uncharacterized protein		CALJA		951	UniRef90_Q99558
Mitogen-activated protein kinase kinase kinase 14		SAIBB		949
Mitogen-activated protein kinase kinase kinase 14		PTEAL		949
Uncharacterized protein		Cebus capucinus imitator		948
Mitogen-activated protein kinase kinase kinase 14		OTOGA		948
+25

Protein	Similar proteins		Species	Score	Length	Source
Q99558	Mitogen-activated protein kinase kinase kinase 14	)	MOUSE		942	UniRef50_Q99558
Uncharacterized protein		CALJA		951
Mitogen-activated protein kinase kinase kinase 14		PTEAL		949
Mitogen-activated protein kinase kinase kinase 14		SAIBB		949
Uncharacterized protein		Cebus capucinus imitator		948
+250

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y10256 mRNA Translation: CAA71306.1 AK290203 mRNA Translation: BAF82892.1 DQ314874 Genomic DNA Translation: ABC40733.1 CH471178 Genomic DNA Translation: EAW51529.1 CH471178 Genomic DNA Translation: EAW51530.1 BC035576 mRNA Translation: AAH35576.1
CCDSⁱ	CCDS74079.1
RefSeqⁱ	NP_003945.2, NM_003954.4 XP_011523743.1, XM_011525441.2
UniGeneⁱ	Hs.404183 Hs.668927 Hs.735695

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4DN5	X-ray	2.50	A/B	330-680	[»]
	4G3D	X-ray	2.90	A/B/D/E	308-673	[»]
	4IDT	X-ray	2.40	A/B	330-680	[»]
	4IDV	X-ray	2.90	A/B/C/D	330-680	[»]
ProteinModelPortalⁱ	Q99558
SMRⁱ	Q99558
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	114487, 35 interactors
CORUMⁱ	Q99558
DIPⁱ	DIP-27522N
IntActⁱ	Q99558, 30 interactors
MINTⁱ	Q99558

Chemistry databases

BindingDBⁱ	Q99558
ChEMBLⁱ	CHEMBL5888
GuidetoPHARMACOLOGYⁱ	2074

PTM databases

iPTMnetⁱ	Q99558
PhosphoSitePlusⁱ	Q99558

Polymorphism and mutation databases

BioMutaⁱ	MAP3K14
DMDMⁱ	92090612

Proteomic databases

PeptideAtlasⁱ	Q99558
PRIDEⁱ	Q99558
ProteomicsDBⁱ	78326

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	9020
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000344686; ENSP00000478552; ENSG00000006062 ENST00000376926; ENSP00000482657; ENSG00000006062
GeneIDⁱ	9020
KEGGⁱ	hsa:9020
UCSCⁱ	uc032fjy.2 human

Organism-specific databases

CTDⁱ	9020
DisGeNETⁱ	9020
EuPathDBⁱ	HostDB:ENSG00000006062.13
GeneCardsⁱ	MAP3K14
HGNCⁱ	HGNC:6853 MAP3K14
HPAⁱ	HPA027269 HPA027270
MalaCardsⁱ	MAP3K14
MIMⁱ	604655 gene
neXtProtⁱ	NX_Q99558
OpenTargetsⁱ	ENSG00000006062
PharmGKBⁱ	PA30597
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00800000124036
HOGENOMⁱ	HOG000113436
HOVERGENⁱ	HBG052384
InParanoidⁱ	Q99558
KOⁱ	K04466
OMAⁱ	YDMEVPD
OrthoDBⁱ	EOG091G018K
PhylomeDBⁱ	Q99558

Enzyme and pathway databases

Reactomeⁱ	R-HSA-389357 CD28 dependent PI3K/Akt signaling R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling R-HSA-5668541 TNFR2 non-canonical NF-kB pathway R-HSA-5676590 NIK-->noncanonical NF-kB signaling R-HSA-5676594 TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
SignaLinkⁱ	Q99558
SIGNORⁱ	Q99558

Miscellaneous databases

ChiTaRSⁱ	MAP3K14 human
GeneWikiⁱ	MAP3K14
GenomeRNAiⁱ	9020
Protein Ontology More...PROⁱ	PR:Q99558
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000006062 Expressed in 141 organ(s), highest expression level in esophagogastric junction muscularis propria
CleanExⁱ	HS_MAP3K14
ExpressionAtlasⁱ	Q99558 baseline and differential
Genevisibleⁱ	Q99558 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR017425 MAPKKK14 IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
PANTHERⁱ	PTHR24361:SF226 PTHR24361:SF226, 1 hit
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
PIRSFⁱ	PIRSF038175 MAPKKK14, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	M3K14_HUMAN
Accessionⁱ	Q99558Primary (citable) accession number: Q99558 Secondary accession number(s): A8K2D8, D3DX67, Q8IYN1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 1, 2001
	Last sequence update:	April 4, 2006
	Last modified:	September 12, 2018
	This is version 185 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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Supporting data

UniProtKB - Q99558 (M3K14_HUMAN)

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Mitogen-activated protein kinase kinase kinase 14

MAP3K14

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ