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Protein

Transcription termination factor 1, mitochondrial

Gene

MTERF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription termination factor. Binds to a 28 bp region within the tRNA(Leu(uur)) gene at a position immediately adjacent to and downstream of the 16S rRNA gene; this region comprises a tridecamer sequence critical for directing accurate termination. Binds DNA along the major grove and promotes DNA bending and partial unwinding. Promotes base flipping. Transcription termination activity appears to be polarized with highest specificity for transcripts initiated on the light strand.1 Publication

GO - Molecular functioni

  • double-stranded DNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation, Transcription termination

Enzyme and pathway databases

ReactomeiR-HSA-163316 Mitochondrial transcription termination
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor 1, mitochondrial
Alternative name(s):
Mitochondrial transcription termination factor 1
Short name:
mTERF
Short name:
mTERF1
Gene namesi
Name:MTERF1
Synonyms:MTERF
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000127989.13
HGNCiHGNC:21463 MTERF1
MIMi602318 gene
neXtProtiNX_Q99551

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi162R → A: Reduces affinity for cognate DNA; when associated with A-243 and A-288. 1 Publication1
Mutagenesisi169R → A: Strongly reduces affinity for DNA. Strongly reduces transcription termination. 1 Publication1
Mutagenesisi202R → A: Strongly reduces affinity for DNA. Strongly reduces transcription termination. 1 Publication1
Mutagenesisi243F → A: Reduces affinity for cognate DNA; when associated with A-162 and A-288. 1 Publication1
Mutagenesisi251R → A: Strongly reduces transcription termination. 1 Publication1
Mutagenesisi288Y → A: Reduces affinity for cognate DNA; when associated with A-162 and A-243. 1 Publication1
Mutagenesisi350R → A: Reduces transcription termination. 1 Publication1
Mutagenesisi387R → A: Strongly reduces affinity for cognate DNA. Strongly reduces transcription termination. 1 Publication1

Organism-specific databases

DisGeNETi7978
OpenTargetsiENSG00000127989
PharmGKBiPA142671308

Polymorphism and mutation databases

BioMutaiMTERF
DMDMi12644536

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 57MitochondrionSequence analysisAdd BLAST57
ChainiPRO_000002177958 – 399Transcription termination factor 1, mitochondrialAdd BLAST342

Post-translational modificationi

Phosphoprotein with mostly four phosphate groups. While the DNA-binding activity is unaffected by the phosphorylation state, only the phosphorylated form of the protein is active for termination activity. Functioning seems to be regulated by phosphorylation.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99551
MaxQBiQ99551
PaxDbiQ99551
PeptideAtlasiQ99551
PRIDEiQ99551
ProteomicsDBi78325

PTM databases

iPTMnetiQ99551
PhosphoSitePlusiQ99551

Expressioni

Gene expression databases

BgeeiENSG00000127989 Expressed in 94 organ(s), highest expression level in corpus callosum
CleanExiHS_MTERF
ExpressionAtlasiQ99551 baseline and differential

Organism-specific databases

HPAiHPA044894
HPA069560

Interactioni

Subunit structurei

Monomer.2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei162Interaction with DNA1
Sitei202Interaction with DNA1
Sitei243Interaction with DNA1
Sitei288Interaction with DNA1
Sitei350Interaction with DNA1

Binary interactionsi

WithEntry#Exp.IntActNotes
DNAJC21Q5F1R62EBI-2690033,EBI-2654581

Protein-protein interaction databases

BioGridi113691, 11 interactors
IntActiQ99551, 14 interactors
MINTiQ99551
STRINGi9606.ENSP00000248643

Structurei

Secondary structure

1399
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99551
SMRiQ99551
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99551

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni169 – 170Interaction with DNA2
Regioni247 – 251Interaction with DNA5
Regioni324 – 331Interaction with DNA8
Regioni355 – 358Interaction with DNA4
Regioni384 – 391Interaction with DNA8

Domaini

Contains nine structural repeats of about 35 residues, where each repeat contains three helices. The repeats form a left-handed superhelical assembly with a solenoid structure that wraps itself around DNA.2 Publications

Sequence similaritiesi

Belongs to the mTERF family.Curated

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG1267 Eukaryota
ENOG410XT49 LUCA
GeneTreeiENSGT00530000063817
HOGENOMiHOG000252957
HOVERGENiHBG052524
InParanoidiQ99551
KOiK15031
OMAiFGSRCWM
OrthoDBiEOG091G0AQ5
PhylomeDBiQ99551
TreeFamiTF330821

Family and domain databases

Gene3Di1.25.70.10, 2 hits
InterProiView protein in InterPro
IPR003690 MTERF
IPR038538 MTERF_sf
PfamiView protein in Pfam
PF02536 mTERF, 1 hit
SMARTiView protein in SMART
SM00733 Mterf, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.iShow all

Q99551-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSLSLGQTS ISKGLNYLTI MAPGNLWHMR NNFLFGSRCW MTRFSAENIF
60 70 80 90 100
KSVSFRLFGV KCHNTDSEPL KNEDLLKNLL TMGVDIDMAR KRQPGVFHRM
110 120 130 140 150
ITNEQDLKMF LLSKGASKEV IASIISRYPR AITRTPENLS KRWDLWRKIV
160 170 180 190 200
TSDLEIVNIL ERSPESFFRS NNNLNLENNI KFLYSVGLTR KCLCRLLTNA
210 220 230 240 250
PRTFSNSLDL NKQMVEFLQA AGLSLGHNDP ADFVRKIIFK NPFILIQSTK
260 270 280 290 300
RVKANIEFLR STFNLNSEEL LVLICGPGAE ILDLSNDYAR RSYANIKEKL
310 320 330 340 350
FSLGCTEEEV QKFVLSYPDV IFLAEKKFND KIDCLMEENI SISQIIENPR
360 370 380 390
VLDSSISTLK SRIKELVNAG CNLSTLNITL LSWSKKRYEA KLKKLSRFA
Length:399
Mass (Da):45,778
Last modified:May 1, 1997 - v1
Checksum:iA0C6CE4A8498526E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DPR9B4DPR9_HUMAN
Transcription termination factor 1,...
MTERF1
379Annotation score:
C9JE25C9JE25_HUMAN
Transcription termination factor 1,...
MTERF1
158Annotation score:
C9JNM8C9JNM8_HUMAN
Transcription termination factor 1,...
MTERF1
139Annotation score:
C9JU79C9JU79_HUMAN
Transcription termination factor 1,...
MTERF1
26Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_053785231A → T1 PublicationCorresponds to variant dbSNP:rs17856025Ensembl.1
Natural variantiVAR_024237294A → T1 PublicationCorresponds to variant dbSNP:rs10266424Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09615 mRNA Translation: CAA70830.1
AK222730 mRNA Translation: BAD96450.1
AC003086 Genomic DNA Translation: AAB83941.1
CH236949 Genomic DNA Translation: EAL24159.1
CH471091 Genomic DNA Translation: EAW76869.1
BC000965 mRNA Translation: AAH00965.1
BC108648 mRNA Translation: AAI08649.1
BC130389 mRNA Translation: AAI30390.1
BC130391 mRNA Translation: AAI30392.1
CCDSiCCDS5621.1
RefSeqiNP_001288063.1, NM_001301134.1
NP_001288064.1, NM_001301135.1
NP_008911.1, NM_006980.4
XP_005250650.1, XM_005250593.3
XP_006716189.1, XM_006716126.3
UniGeneiHs.532216

Genome annotation databases

EnsembliENST00000351870; ENSP00000248643; ENSG00000127989
GeneIDi7978
KEGGihsa:7978
UCSCiuc003ulc.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09615 mRNA Translation: CAA70830.1
AK222730 mRNA Translation: BAD96450.1
AC003086 Genomic DNA Translation: AAB83941.1
CH236949 Genomic DNA Translation: EAL24159.1
CH471091 Genomic DNA Translation: EAW76869.1
BC000965 mRNA Translation: AAH00965.1
BC108648 mRNA Translation: AAI08649.1
BC130389 mRNA Translation: AAI30390.1
BC130391 mRNA Translation: AAI30392.1
CCDSiCCDS5621.1
RefSeqiNP_001288063.1, NM_001301134.1
NP_001288064.1, NM_001301135.1
NP_008911.1, NM_006980.4
XP_005250650.1, XM_005250593.3
XP_006716189.1, XM_006716126.3
UniGeneiHs.532216

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MVAX-ray2.20O57-396[»]
3MVBX-ray2.79O57-396[»]
3N6SX-ray3.10A56-399[»]
3N7QX-ray2.40A99-399[»]
5CKYX-ray2.62O73-396[»]
5CO0X-ray2.65O73-396[»]
5CRJX-ray2.59O73-396[»]
5CRKX-ray2.48O73-396[»]
ProteinModelPortaliQ99551
SMRiQ99551
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113691, 11 interactors
IntActiQ99551, 14 interactors
MINTiQ99551
STRINGi9606.ENSP00000248643

PTM databases

iPTMnetiQ99551
PhosphoSitePlusiQ99551

Polymorphism and mutation databases

BioMutaiMTERF
DMDMi12644536

Proteomic databases

EPDiQ99551
MaxQBiQ99551
PaxDbiQ99551
PeptideAtlasiQ99551
PRIDEiQ99551
ProteomicsDBi78325

Protocols and materials databases

DNASUi7978
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000351870; ENSP00000248643; ENSG00000127989
GeneIDi7978
KEGGihsa:7978
UCSCiuc003ulc.2 human

Organism-specific databases

CTDi7978
DisGeNETi7978
EuPathDBiHostDB:ENSG00000127989.13
GeneCardsiMTERF1
HGNCiHGNC:21463 MTERF1
HPAiHPA044894
HPA069560
MIMi602318 gene
neXtProtiNX_Q99551
OpenTargetsiENSG00000127989
PharmGKBiPA142671308
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1267 Eukaryota
ENOG410XT49 LUCA
GeneTreeiENSGT00530000063817
HOGENOMiHOG000252957
HOVERGENiHBG052524
InParanoidiQ99551
KOiK15031
OMAiFGSRCWM
OrthoDBiEOG091G0AQ5
PhylomeDBiQ99551
TreeFamiTF330821

Enzyme and pathway databases

ReactomeiR-HSA-163316 Mitochondrial transcription termination
R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis

Miscellaneous databases

ChiTaRSiMTERF1 human
EvolutionaryTraceiQ99551
GeneWikiiMTERF
GenomeRNAii7978
PROiPR:Q99551
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000127989 Expressed in 94 organ(s), highest expression level in corpus callosum
CleanExiHS_MTERF
ExpressionAtlasiQ99551 baseline and differential

Family and domain databases

Gene3Di1.25.70.10, 2 hits
InterProiView protein in InterPro
IPR003690 MTERF
IPR038538 MTERF_sf
PfamiView protein in Pfam
PF02536 mTERF, 1 hit
SMARTiView protein in SMART
SM00733 Mterf, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMTEF1_HUMAN
AccessioniPrimary (citable) accession number: Q99551
Secondary accession number(s): A4D1E3
, Q32NF8, Q53H51, Q9BVR7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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