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Protein

M-phase phosphoprotein 6

Gene

MPHOSPH6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D.2 Publications

GO - Molecular functioni

GO - Biological processi

  • maturation of 5.8S rRNA Source: UniProtKB
  • rRNA processing Source: Reactome

Keywordsi

Molecular functionRNA-binding
Biological processrRNA processing

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
M-phase phosphoprotein 6Curated
Gene namesi
Name:MPHOSPH6Imported
Synonyms:MPP61 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000135698.9
HGNCiHGNC:7214 MPHOSPH6
MIMi605500 gene
neXtProtiNX_Q99547

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10200
OpenTargetsiENSG00000135698
PharmGKBiPA30920

Polymorphism and mutation databases

BioMutaiMPHOSPH6
DMDMi296438296

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001224371 – 160M-phase phosphoprotein 6Add BLAST160

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki37Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki86Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei110PhosphoserineCombined sources1
Cross-linki127Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei147PhosphothreonineCombined sources1
Cross-linki150Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki153Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Post-translational modificationi

Phosphorylated in M (mitotic) phase.

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99547
MaxQBiQ99547
PaxDbiQ99547
PeptideAtlasiQ99547
PRIDEiQ99547
ProteomicsDBi78320

PTM databases

iPTMnetiQ99547
PhosphoSitePlusiQ99547
SwissPalmiQ99547

Expressioni

Gene expression databases

BgeeiENSG00000135698 Expressed in 226 organ(s), highest expression level in frontal cortex
CleanExiHS_MPHOSPH6
HS_MPP6
ExpressionAtlasiQ99547 baseline and differential
GenevisibleiQ99547 HS

Organism-specific databases

HPAiCAB003674
HPA026948

Interactioni

Subunit structurei

Associates with the RNA exosome complex, probably mediated by EXOSC10. Interacts with ARHGAP18, EXOSC10 and MTREX.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi115495, 56 interactors
DIPiDIP-31131N
IntActiQ99547, 29 interactors
MINTiQ99547
STRINGi9606.ENSP00000258169

Structurei

Secondary structure

1160
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99547
SMRiQ99547
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi116 – 133Nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 35Poly-Glu4

Sequence similaritiesi

Belongs to the MPP6 family.Curated

Phylogenomic databases

eggNOGiKOG4531 Eukaryota
ENOG4111K5Z LUCA
GeneTreeiENSGT00390000009212
HOGENOMiHOG000007728
HOVERGENiHBG031714
InParanoidiQ99547
KOiK12593
OMAiVLDMKFM
OrthoDBiEOG091G0T3X
PhylomeDBiQ99547
TreeFamiTF323810

Family and domain databases

InterProiView protein in InterPro
IPR019324 MPP6
PANTHERiPTHR13582 PTHR13582, 1 hit
PfamiView protein in Pfam
PF10175 MPP6, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q99547-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAERKTRLS KNLLRMKFMQ RGLDSETKKQ LEEEEKKIIS EEHWYLDLPE
60 70 80 90 100
LKEKESFIIE EQSFLLCEDL LYGRMSFRGF NPEVEKLMLQ MNAKHKAEEV
110 120 130 140 150
EDETVELDVS DEEMARRYET LVGTIGKKFA RKRDHANYEE DENGDITPIK
160
AKKMFLKPQD
Length:160
Mass (Da):19,024
Last modified:May 18, 2010 - v2
Checksum:i506D5274C839BD7E
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BSB3H3BSB3_HUMAN
M-phase phosphoprotein 6
MPHOSPH6
131Annotation score:
H3BNT4H3BNT4_HUMAN
M-phase phosphoprotein 6
MPHOSPH6
142Annotation score:
H3BNK8H3BNK8_HUMAN
M-phase phosphoprotein 6, isoform C...
MPHOSPH6 hCG_38475
55Annotation score:
H3BU96H3BU96_HUMAN
M-phase phosphoprotein 6
MPHOSPH6
97Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti8R → K in CAA66916 (PubMed:8885239).Curated1
Sequence conflicti8R → K in BAG36847 (PubMed:14702039).Curated1
Sequence conflicti8R → K in AAH05242 (PubMed:15489334).Curated1
Sequence conflicti8R → K in AAH11020 (PubMed:15489334).Curated1
Sequence conflicti8R → K in AAH31017 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05615058I → V. Corresponds to variant dbSNP:rs2303267Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98263 mRNA Translation: CAA66916.1
AK314163 mRNA Translation: BAG36847.1
AC138304 Genomic DNA No translation available.
BC005242 mRNA Translation: AAH05242.1
BC011020 mRNA Translation: AAH11020.1
BC031017 mRNA Translation: AAH31017.1
CCDSiCCDS10937.1
RefSeqiNP_005783.2, NM_005792.2
UniGeneiHs.344400

Genome annotation databases

EnsembliENST00000258169; ENSP00000258169; ENSG00000135698
GeneIDi10200
KEGGihsa:10200
UCSCiuc002fgw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X98263 mRNA Translation: CAA66916.1
AK314163 mRNA Translation: BAG36847.1
AC138304 Genomic DNA No translation available.
BC005242 mRNA Translation: AAH05242.1
BC011020 mRNA Translation: AAH11020.1
BC031017 mRNA Translation: AAH31017.1
CCDSiCCDS10937.1
RefSeqiNP_005783.2, NM_005792.2
UniGeneiHs.344400

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6D6Qelectron microscopy3.45L1-160[»]
6D6Relectron microscopy3.45L1-160[»]
6H25electron microscopy3.80K1-160[»]
ProteinModelPortaliQ99547
SMRiQ99547
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115495, 56 interactors
DIPiDIP-31131N
IntActiQ99547, 29 interactors
MINTiQ99547
STRINGi9606.ENSP00000258169

PTM databases

iPTMnetiQ99547
PhosphoSitePlusiQ99547
SwissPalmiQ99547

Polymorphism and mutation databases

BioMutaiMPHOSPH6
DMDMi296438296

Proteomic databases

EPDiQ99547
MaxQBiQ99547
PaxDbiQ99547
PeptideAtlasiQ99547
PRIDEiQ99547
ProteomicsDBi78320

Protocols and materials databases

DNASUi10200
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258169; ENSP00000258169; ENSG00000135698
GeneIDi10200
KEGGihsa:10200
UCSCiuc002fgw.4 human

Organism-specific databases

CTDi10200
DisGeNETi10200
EuPathDBiHostDB:ENSG00000135698.9
GeneCardsiMPHOSPH6
H-InvDBiHIX0013281
HGNCiHGNC:7214 MPHOSPH6
HPAiCAB003674
HPA026948
MIMi605500 gene
neXtProtiNX_Q99547
OpenTargetsiENSG00000135698
PharmGKBiPA30920
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4531 Eukaryota
ENOG4111K5Z LUCA
GeneTreeiENSGT00390000009212
HOGENOMiHOG000007728
HOVERGENiHBG031714
InParanoidiQ99547
KOiK12593
OMAiVLDMKFM
OrthoDBiEOG091G0T3X
PhylomeDBiQ99547
TreeFamiTF323810

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Miscellaneous databases

ChiTaRSiMPHOSPH6 human
GeneWikiiMPHOSPH6
GenomeRNAii10200
PROiPR:Q99547
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135698 Expressed in 226 organ(s), highest expression level in frontal cortex
CleanExiHS_MPHOSPH6
HS_MPP6
ExpressionAtlasiQ99547 baseline and differential
GenevisibleiQ99547 HS

Family and domain databases

InterProiView protein in InterPro
IPR019324 MPP6
PANTHERiPTHR13582 PTHR13582, 1 hit
PfamiView protein in Pfam
PF10175 MPP6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMPH6_HUMAN
AccessioniPrimary (citable) accession number: Q99547
Secondary accession number(s): B2RAF0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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