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Protein

Perilipin-2

Gene

PLIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in development and maintenance of adipose tissue.By similarity

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
SIGNORiQ99541

Names & Taxonomyi

Protein namesi
Recommended name:
Perilipin-2
Alternative name(s):
Adipophilin
Adipose differentiation-related protein
Short name:
ADRP
Gene namesi
Name:PLIN2
Synonyms:ADFP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000147872.9
HGNCiHGNC:248 PLIN2
MIMi103195 gene
neXtProtiNX_Q99541

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lipid droplet, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi123
OpenTargetsiENSG00000147872
PharmGKBiPA24569

Polymorphism and mutation databases

BioMutaiPLIN2
DMDMi21264409

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000998882 – 437Perilipin-2Add BLAST436

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei215PhosphoserineCombined sources1

Post-translational modificationi

Acylated; primarily with C14, C16 and C18 fatty acids.

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein

Proteomic databases

EPDiQ99541
MaxQBiQ99541
PaxDbiQ99541
PeptideAtlasiQ99541
PRIDEiQ99541
ProteomicsDBi78314

PTM databases

iPTMnetiQ99541
PhosphoSitePlusiQ99541

Expressioni

Tissue specificityi

Milk lipid globules.

Gene expression databases

BgeeiENSG00000147872 Expressed in 222 organ(s), highest expression level in pericardium
CleanExiHS_ADFP
ExpressionAtlasiQ99541 baseline and differential
GenevisibleiQ99541 HS

Organism-specific databases

HPAiCAB037331
HPA016607

Interactioni

Protein-protein interaction databases

BioGridi106635, 3 interactors
IntActiQ99541, 7 interactors
STRINGi9606.ENSP00000276914

Structurei

3D structure databases

ProteinModelPortaliQ99541
SMRiQ99541
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the perilipin family.Curated

Phylogenomic databases

eggNOGiENOG410IJG1 Eukaryota
ENOG410XTQ5 LUCA
GeneTreeiENSGT00500000044795
HOGENOMiHOG000033816
HOVERGENiHBG002935
InParanoidiQ99541
KOiK17284
OMAiTSAMPII
OrthoDBiEOG091G0D6Q
PhylomeDBiQ99541
TreeFamiTF328397

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit
PIRSFiPIRSF036881 PAT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99541-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASVAVDPQP SVVTRVVNLP LVSSTYDLMS SAYLSTKDQY PYLKSVCEMA
60 70 80 90 100
ENGVKTITSV AMTSALPIIQ KLEPQIAVAN TYACKGLDRI EERLPILNQP
110 120 130 140 150
STQIVANAKG AVTGAKDAVT TTVTGAKDSV ASTITGVMDK TKGAVTGSVE
160 170 180 190 200
KTKSVVSGSI NTVLGSRMMQ LVSSGVENAL TKSELLVEQY LPLTEEELEK
210 220 230 240 250
EAKKVEGFDL VQKPSYYVRL GSLSTKLHSR AYQQALSRVK EAKQKSQQTI
260 270 280 290 300
SQLHSTVHLI EFARKNVYSA NQKIQDAQDK LYLSWVEWKR SIGYDDTDES
310 320 330 340 350
HCAEHIESRT LAIARNLTQQ LQTTCHTLLS NIQGVPQNIQ DQAKHMGVMA
360 370 380 390 400
GDIYSVFRNA ASFKEVSDSL LTSSKGQLQK MKESLDDVMD YLVNNTPLNW
410 420 430
LVGPFYPQLT ESQNAQDQGA EMDKSSQETQ RSEHKTH
Length:437
Mass (Da):48,075
Last modified:May 27, 2002 - v2
Checksum:i36411341619E53BF
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5SYF4Q5SYF4_HUMAN
Perilipin-2
PLIN2
126Annotation score:
Q5SYF3Q5SYF3_HUMAN
Perilipin-2
PLIN2
110Annotation score:
Q5SYF5Q5SYF5_HUMAN
Perilipin-2
PLIN2
125Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti305 – 306HI → QF in CAA65989 (PubMed:9003395).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061506251S → P. Corresponds to variant dbSNP:rs35568725Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97324 mRNA Translation: CAA65989.1
AF443203 mRNA Translation: AAL35614.1
BC005127 mRNA Translation: AAH05127.1
CCDSiCCDS6490.1
RefSeqiNP_001113.2, NM_001122.3
UniGeneiHs.3416

Genome annotation databases

EnsembliENST00000276914; ENSP00000276914; ENSG00000147872
GeneIDi123
KEGGihsa:123
UCSCiuc003zno.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97324 mRNA Translation: CAA65989.1
AF443203 mRNA Translation: AAL35614.1
BC005127 mRNA Translation: AAH05127.1
CCDSiCCDS6490.1
RefSeqiNP_001113.2, NM_001122.3
UniGeneiHs.3416

3D structure databases

ProteinModelPortaliQ99541
SMRiQ99541
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106635, 3 interactors
IntActiQ99541, 7 interactors
STRINGi9606.ENSP00000276914

PTM databases

iPTMnetiQ99541
PhosphoSitePlusiQ99541

Polymorphism and mutation databases

BioMutaiPLIN2
DMDMi21264409

Proteomic databases

EPDiQ99541
MaxQBiQ99541
PaxDbiQ99541
PeptideAtlasiQ99541
PRIDEiQ99541
ProteomicsDBi78314

Protocols and materials databases

DNASUi123
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276914; ENSP00000276914; ENSG00000147872
GeneIDi123
KEGGihsa:123
UCSCiuc003zno.4 human

Organism-specific databases

CTDi123
DisGeNETi123
EuPathDBiHostDB:ENSG00000147872.9
GeneCardsiPLIN2
HGNCiHGNC:248 PLIN2
HPAiCAB037331
HPA016607
MIMi103195 gene
neXtProtiNX_Q99541
OpenTargetsiENSG00000147872
PharmGKBiPA24569
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IJG1 Eukaryota
ENOG410XTQ5 LUCA
GeneTreeiENSGT00500000044795
HOGENOMiHOG000033816
HOVERGENiHBG002935
InParanoidiQ99541
KOiK17284
OMAiTSAMPII
OrthoDBiEOG091G0D6Q
PhylomeDBiQ99541
TreeFamiTF328397

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
SIGNORiQ99541

Miscellaneous databases

ChiTaRSiPLIN2 human
GeneWikiiAdipose_differentiation-related_protein
GenomeRNAii123
PROiPR:Q99541
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147872 Expressed in 222 organ(s), highest expression level in pericardium
CleanExiHS_ADFP
ExpressionAtlasiQ99541 baseline and differential
GenevisibleiQ99541 HS

Family and domain databases

InterProiView protein in InterPro
IPR004279 Perilipin
PfamiView protein in Pfam
PF03036 Perilipin, 1 hit
PIRSFiPIRSF036881 PAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLIN2_HUMAN
AccessioniPrimary (citable) accession number: Q99541
Secondary accession number(s): Q9BSC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 27, 2002
Last modified: September 12, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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