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Protein

Synaptic vesicle membrane protein VAT-1 homolog

Gene

VAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).By similarity3 Publications

GO - Molecular functioni

GO - Biological processi

  • negative regulation of mitochondrial fusion Source: UniProtKB
  • neutrophil degranulation Source: Reactome

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptic vesicle membrane protein VAT-1 homolog (EC:1.-.-.-)
Gene namesi
Name:VAT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000108828.15
HGNCiHGNC:16919 VAT1
MIMi604631 gene
neXtProtiNX_Q99536

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi10493
OpenTargetsiENSG00000108828
PharmGKBiPA38422

Polymorphism and mutation databases

BioMutaiVAT1
DMDMi52788294

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001609182 – 393Synaptic vesicle membrane protein VAT-1 homologAdd BLAST392

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1 Publication1
Modified residuei2PhosphoserineBy similarity1
Modified residuei18PhosphoserineCombined sources1
Modified residuei27PhosphoserineCombined sources1
Modified residuei35PhosphoserineCombined sources1
Modified residuei44PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99536
MaxQBiQ99536
PaxDbiQ99536
PeptideAtlasiQ99536
PRIDEiQ99536
ProteomicsDBi78312
TopDownProteomicsiQ99536-1 [Q99536-1]

PTM databases

iPTMnetiQ99536
PhosphoSitePlusiQ99536
SwissPalmiQ99536

Expressioni

Tissue specificityi

Expressed in brain. Also expressed in glioblastoma cells.1 Publication

Inductioni

Increased expression in glioblastomas and on wounding, in basal keratinocytes. This expression is calcium ion-dependent.1 Publication

Gene expression databases

BgeeiENSG00000108828 Expressed in 237 organ(s), highest expression level in right adrenal gland cortex
CleanExiHS_VAT1
ExpressionAtlasiQ99536 baseline and differential
GenevisibleiQ99536 HS

Organism-specific databases

HPAiHPA045170

Interactioni

Protein-protein interaction databases

BioGridi115756, 25 interactors
IntActiQ99536, 15 interactors
MINTiQ99536
STRINGi9606.ENSP00000347872

Structurei

3D structure databases

ProteinModelPortaliQ99536
SMRiQ99536
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1198 Eukaryota
COG0604 LUCA
GeneTreeiENSGT00550000074483
HOGENOMiHOG000294681
HOVERGENiHBG002466
InParanoidiQ99536
OMAiTLRVRAC
OrthoDBiEOG091G0EEJ
PhylomeDBiQ99536
TreeFamiTF314255

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01162 QOR_ZETA_CRYSTAL, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99536-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSDEREVAEA ATGEDASSPP PKTEAASDPQ HPAASEGAAA AAASPPLLRC
60 70 80 90 100
LVLTGFGGYD KVKLQSRPAA PPAPGPGQLT LRLRACGLNF ADLMARQGLY
110 120 130 140 150
DRLPPLPVTP GMEGAGVVIA VGEGVSDRKA GDRVMVLNRS GMWQEEVTVP
160 170 180 190 200
SVQTFLIPEA MTFEEAAALL VNYITAYMVL FDFGNLQPGH SVLVHMAAGG
210 220 230 240 250
VGMAAVQLCR TVENVTVFGT ASASKHEALK ENGVTHPIDY HTTDYVDEIK
260 270 280 290 300
KISPKGVDIV MDPLGGSDTA KGYNLLKPMG KVVTYGMANL LTGPKRNLMA
310 320 330 340 350
LARTWWNQFS VTALQLLQAN RAVCGFHLGY LDGEVELVSG VVARLLALYN
360 370 380 390
QGHIKPHIDS VWPFEKVADA MKQMQEKKNV GKVLLVPGPE KEN
Length:393
Mass (Da):41,920
Last modified:September 27, 2004 - v2
Checksum:i25933347742C2FE6
GO
Isoform 2 (identifier: Q99536-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Note: No experimental confirmation available.
Show »
Length:259
Mass (Da):28,341
Checksum:iF18FE952D93B9481
GO
Isoform 3 (identifier: Q99536-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     61-128: Missing.

Note: No experimental confirmation available.
Show »
Length:325
Mass (Da):34,890
Checksum:iE7343C6107A69186
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7ENX2K7ENX2_HUMAN
Synaptic vesicle membrane protein V...
VAT1
151Annotation score:
K7EM19K7EM19_HUMAN
Synaptic vesicle membrane protein V...
VAT1
154Annotation score:
K7ER81K7ER81_HUMAN
Synaptic vesicle membrane protein V...
VAT1
92Annotation score:
K7ERT7K7ERT7_HUMAN
Synaptic vesicle membrane protein V...
VAT1
146Annotation score:
K7ESA3K7ESA3_HUMAN
Synaptic vesicle membrane protein V...
VAT1
125Annotation score:
K7EJM4K7EJM4_HUMAN
Synaptic vesicle membrane protein V...
VAT1
30Annotation score:

Sequence cautioni

The sequence AAC37596 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti71P → A in AAC37596 (PubMed:8938427).Curated1
Sequence conflicti82 – 86RLRAC → NSARG in AAA95990 (PubMed:7774926).Curated5
Sequence conflicti207 – 208QL → HV in AAA95990 (PubMed:7774926).Curated2
Sequence conflicti392E → Q in AAC37596 (PubMed:8938427).Curated1
Sequence conflicti393N → S in AAA95990 (PubMed:7774926).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0557941 – 134Missing in isoform 2. 1 PublicationAdd BLAST134
Alternative sequenceiVSP_05579561 – 128Missing in isoform 3. 1 PublicationAdd BLAST68

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L78833 Genomic DNA Translation: AAC37596.1 Different initiation.
BT007369 mRNA Translation: AAP36033.1
AK298536 mRNA Translation: BAG60736.1
AK290460 mRNA Translation: BAF83149.1
AK315838 mRNA Translation: BAF98729.1
AC055866 Genomic DNA No translation available.
AC135721 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60917.1
BC001913 mRNA Translation: AAH01913.2
BC008725 mRNA Translation: AAH08725.2
BC014279 mRNA Translation: AAH14279.1
BC015041 mRNA Translation: AAH15041.1
BC090858 mRNA Translation: AAH90858.1
U18009 mRNA Translation: AAA95990.1
CCDSiCCDS11451.1 [Q99536-1]
RefSeqiNP_006364.2, NM_006373.3 [Q99536-1]
UniGeneiHs.514199

Genome annotation databases

EnsembliENST00000355653; ENSP00000347872; ENSG00000108828 [Q99536-1]
ENST00000420567; ENSP00000408553; ENSG00000108828 [Q99536-2]
ENST00000587173; ENSP00000465946; ENSG00000108828 [Q99536-3]
GeneIDi10493
KEGGihsa:10493
UCSCiuc002icm.2 human [Q99536-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L78833 Genomic DNA Translation: AAC37596.1 Different initiation.
BT007369 mRNA Translation: AAP36033.1
AK298536 mRNA Translation: BAG60736.1
AK290460 mRNA Translation: BAF83149.1
AK315838 mRNA Translation: BAF98729.1
AC055866 Genomic DNA No translation available.
AC135721 Genomic DNA No translation available.
CH471152 Genomic DNA Translation: EAW60917.1
BC001913 mRNA Translation: AAH01913.2
BC008725 mRNA Translation: AAH08725.2
BC014279 mRNA Translation: AAH14279.1
BC015041 mRNA Translation: AAH15041.1
BC090858 mRNA Translation: AAH90858.1
U18009 mRNA Translation: AAA95990.1
CCDSiCCDS11451.1 [Q99536-1]
RefSeqiNP_006364.2, NM_006373.3 [Q99536-1]
UniGeneiHs.514199

3D structure databases

ProteinModelPortaliQ99536
SMRiQ99536
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115756, 25 interactors
IntActiQ99536, 15 interactors
MINTiQ99536
STRINGi9606.ENSP00000347872

PTM databases

iPTMnetiQ99536
PhosphoSitePlusiQ99536
SwissPalmiQ99536

Polymorphism and mutation databases

BioMutaiVAT1
DMDMi52788294

Proteomic databases

EPDiQ99536
MaxQBiQ99536
PaxDbiQ99536
PeptideAtlasiQ99536
PRIDEiQ99536
ProteomicsDBi78312
TopDownProteomicsiQ99536-1 [Q99536-1]

Protocols and materials databases

DNASUi10493
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355653; ENSP00000347872; ENSG00000108828 [Q99536-1]
ENST00000420567; ENSP00000408553; ENSG00000108828 [Q99536-2]
ENST00000587173; ENSP00000465946; ENSG00000108828 [Q99536-3]
GeneIDi10493
KEGGihsa:10493
UCSCiuc002icm.2 human [Q99536-1]

Organism-specific databases

CTDi10493
DisGeNETi10493
EuPathDBiHostDB:ENSG00000108828.15
GeneCardsiVAT1
HGNCiHGNC:16919 VAT1
HPAiHPA045170
MIMi604631 gene
neXtProtiNX_Q99536
OpenTargetsiENSG00000108828
PharmGKBiPA38422
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1198 Eukaryota
COG0604 LUCA
GeneTreeiENSGT00550000074483
HOGENOMiHOG000294681
HOVERGENiHBG002466
InParanoidiQ99536
OMAiTLRVRAC
OrthoDBiEOG091G0EEJ
PhylomeDBiQ99536
TreeFamiTF314255

Enzyme and pathway databases

ReactomeiR-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiVAT1 human
GeneWikiiVAT1
GenomeRNAii10493
PROiPR:Q99536
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000108828 Expressed in 237 organ(s), highest expression level in right adrenal gland cortex
CleanExiHS_VAT1
ExpressionAtlasiQ99536 baseline and differential
GenevisibleiQ99536 HS

Family and domain databases

InterProiView protein in InterPro
IPR013149 ADH_C
IPR013154 ADH_N
IPR011032 GroES-like_sf
IPR036291 NAD(P)-bd_dom_sf
IPR020843 PKS_ER
IPR002364 Quin_OxRdtase/zeta-crystal_CS
PfamiView protein in Pfam
PF08240 ADH_N, 1 hit
PF00107 ADH_zinc_N, 1 hit
SMARTiView protein in SMART
SM00829 PKS_ER, 1 hit
SUPFAMiSSF50129 SSF50129, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS01162 QOR_ZETA_CRYSTAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVAT1_HUMAN
AccessioniPrimary (citable) accession number: Q99536
Secondary accession number(s): A8K345
, B0AZP7, B4DPX4, Q13035, Q5BKZ7, Q96A39, Q9BUT8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: September 27, 2004
Last modified: September 12, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
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