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Entry version 190 (29 Sep 2021)
Sequence version 1 (01 May 1997)
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Protein

G-protein coupled estrogen receptor 1

Gene

GPER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.

14 Publications

Miscellaneous

Does not bind estradiol according to PubMed:18566127 and PubMed:16645038.

Caution

Data is conflicting regarding whether it fulfills the criteria of a membrane-bound estrogen receptor (PubMed:15705806, PubMed:17379646). Other reports suggest that it is not (PubMed:16645038, PubMed:18566127).4 Publications
Data is conflicting regarding whether it is localized either at the cell membrane (PM) (PubMed:15539556, PubMed:21427217, PubMed:21540189, PubMed:21354433, PubMed:21149639 and PubMed:23674134). Other reports suggest that it localizes at the endoplasmic reticulum (ER) (PubMed:15705806, PubMed:18566127).8 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Binds 17-beta-estradiol (E2) in plasma membranes with high affinity (Kd is 3.3 nM) and displays rapid kinetics of association and dissociation.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processApoptosis, Cell cycle, Differentiation, Immunity, Inflammatory response, Innate immunity, Neurogenesis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q99527

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276, Peptide ligand-binding receptors
R-HSA-418594, G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q99527

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.13.19, the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
G-protein coupled estrogen receptor 1Curated
Alternative name(s):
Chemoattractant receptor-like 2
Flow-induced endothelial G-protein coupled receptor 1
Short name:
FEG-1
G protein-coupled estrogen receptor 1
G-protein coupled receptor 302 Publications
GPCR-Br
IL8-related receptor DRY12
Lymphocyte-derived G-protein coupled receptor
Short name:
LYGPR
Membrane estrogen receptor
Short name:
mER
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GPER1Imported
Synonyms:CEPR, CMKRL2, DRY12, GPER, GPR302 Publications
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:4485, GPER1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601805, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99527

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000164850

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 62ExtracellularSequence analysisAdd BLAST62
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei63 – 84Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini85 – 96CytoplasmicSequence analysisAdd BLAST12
Transmembranei97 – 120Helical; Name=2Sequence analysisAdd BLAST24
Topological domaini121 – 132ExtracellularSequence analysisAdd BLAST12
Transmembranei133 – 153Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini154 – 175CytoplasmicSequence analysisAdd BLAST22
Transmembranei176 – 194Helical; Name=4Sequence analysisAdd BLAST19
Topological domaini195 – 220ExtracellularSequence analysisAdd BLAST26
Transmembranei221 – 236Helical; Name=5Sequence analysisAdd BLAST16
Topological domaini237 – 259CytoplasmicSequence analysisAdd BLAST23
Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini281 – 306ExtracellularSequence analysisAdd BLAST26
Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini328 – 375CytoplasmicSequence analysisAdd BLAST48

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Mitochondrion, Nucleus, Postsynaptic cell membrane, Synapse

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
2852

Open Targets

More...
OpenTargetsi
ENSG00000164850

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA28873

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q99527, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5872

Drug and drug target database

More...
DrugBanki
DB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB01645, Genistein
DB05939, MK-0354

DrugCentral

More...
DrugCentrali
Q99527

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
221

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GPER1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
3023539

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000693101 – 375G-protein coupled estrogen receptor 1Add BLAST375

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi130 ↔ 207PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; ubiquitination occurs at the plasma membrane and leads to proteasome-mediated degradation.1 Publication
Glycosylated.1 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q99527

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99527

PeptideAtlas

More...
PeptideAtlasi
Q99527

PRoteomics IDEntifications database

More...
PRIDEi
Q99527

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78311

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q99527, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99527

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99527

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in placenta, endothelial and epithelial cells, non laboring and laboring term myometrium, fibroblasts and cancer-associated fibroblasts (CAF), prostate cancer cells and invasive adenocarcinoma (at protein level). Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen.6 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by EGF and TGF-alpha in endometrial, ovarian and breast tumor cells. Up-regulated by progestin and by phorbol 12-myristate 13-acetate (PMA) in breast cancer cell lines.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000164850, Expressed in fundus of stomach and 172 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99527, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99527, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000164850, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (Probable). Heterodimer; heterodimerizes with other G-protein-coupled receptor (GPCRs) like CRHR1, HTR1A and PAQR8.

Interacts (via C-terminus tail motif) with DLG4 (via N-terminus tandem pair of PDZ domains); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner (By similarity).

Interacts with RAMP3.

Interacts with KRT7 and KRT8.

Interacts with EGFR; the interaction increases after agonist-induced stimulation in cancer-associated fibroblasts (CAF).

Interacts with EGFR and ESR1.

By similarityCurated4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
109110, 3 interactors

Protein interaction database and analysis system

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IntActi
Q99527, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000380281

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q99527

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99527, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG502QU56, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000154307

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_009579_8_3_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99527

Identification of Orthologs from Complete Genome Data

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OMAi
VHLQHTE

Database of Orthologous Groups

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OrthoDBi
736624at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99527

TreeFam database of animal gene trees

More...
TreeFami
TF333506

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001, 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00237, GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99527-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVTSQARGV GLEMYPGTAQ PAAPNTTSPE LNLSHPLLGT ALANGTGELS
60 70 80 90 100
EHQQYVIGLF LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN
110 120 130 140 150
LAVADLILVA DSLIEVFNLH ERYYDIAVLC TFMSLFLQVN MYSSVFFLTW
160 170 180 190 200
MSFDRYIALA RAMRCSLFRT KHHARLSCGL IWMASVSATL VPFTAVHLQH
210 220 230 240 250
TDEACFCFAD VREVQWLEVT LGFIVPFAII GLCYSLIVRV LVRAHRHRGL
260 270 280 290 300
RPRRQKALRM ILAVVLVFFV CWLPENVFIS VHLLQRTQPG AAPCKQSFRH
310 320 330 340 350
AHPLTGHIVN LAAFSNSCLN PLIYSFLGET FRDKLRLYIE QKTNLPALNR
360 370
FCHAALKAVI PDSTEQSDVR FSSAV
Length:375
Mass (Da):42,248
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A54EED8A698F075
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WVN0A0A087WVN0_HUMAN
G-protein-coupled estrogen receptor...
GPER1
408Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3W2C9J3W2_HUMAN
G-protein-coupled estrogen receptor...
GPER1
73Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A087X0Z4A0A087X0Z4_HUMAN
G-protein-coupled estrogen receptor...
GPER1
176Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20 – 21QP → HA in AAC52027 (PubMed:9479505).Curated2
Sequence conflicti32 – 49Missing in AAB02736 (Ref. 7) CuratedAdd BLAST18
Sequence conflicti104A → G in AAB02736 (Ref. 7) Curated1
Sequence conflicti140 – 146NMYSSVF → QHVQAASS in AAB02736 (Ref. 7) Curated7
Sequence conflicti179G → A in AAB02736 (Ref. 7) Curated1
Sequence conflicti184A → S in AAB02736 (Ref. 7) Curated1
Sequence conflicti312A → T in AAC51173 (PubMed:9070864).Curated1
Sequence conflicti320N → T in AAB02736 (Ref. 7) Curated1
Sequence conflicti355A → V in AAB02736 (Ref. 7) Curated1
Sequence conflicti358A → V in AAB02736 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03331916P → L2 PublicationsCorresponds to variant dbSNP:rs11544331Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
Y08162 mRNA Translation: CAA69354.1
U77827 Genomic DNA Translation: AAC51173.1
AF015257 mRNA Translation: AAC51904.1
X98510 mRNA Translation: CAA67133.1
U63917 mRNA Translation: AAB88017.1
AF027956 Genomic DNA Translation: AAC52027.1
U58828 mRNA Translation: AAB02736.1
CR541741 mRNA Translation: CAG46541.1
AK291590 mRNA Translation: BAF84279.1
AB451427 mRNA Translation: BAG70241.1
CH236953 Genomic DNA Translation: EAL23938.1
CH471144 Genomic DNA Translation: EAW87194.1
BC011634 mRNA Translation: AAH11634.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5322.1

Protein sequence database of the Protein Information Resource

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PIRi
G02670
JC5069

NCBI Reference Sequences

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RefSeqi
NP_001035055.1, NM_001039966.1
NP_001091671.1, NM_001098201.1
NP_001496.1, NM_001505.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000297469; ENSP00000297469; ENSG00000164850
ENST00000397088; ENSP00000380277; ENSG00000164850
ENST00000397092; ENSP00000380281; ENSG00000164850
ENST00000401670; ENSP00000385151; ENSG00000164850

Database of genes from NCBI RefSeq genomes

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GeneIDi
2852

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:2852

UCSC genome browser

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UCSCi
uc003sjz.1, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08162 mRNA Translation: CAA69354.1
U77827 Genomic DNA Translation: AAC51173.1
AF015257 mRNA Translation: AAC51904.1
X98510 mRNA Translation: CAA67133.1
U63917 mRNA Translation: AAB88017.1
AF027956 Genomic DNA Translation: AAC52027.1
U58828 mRNA Translation: AAB02736.1
CR541741 mRNA Translation: CAG46541.1
AK291590 mRNA Translation: BAF84279.1
AB451427 mRNA Translation: BAG70241.1
CH236953 Genomic DNA Translation: EAL23938.1
CH471144 Genomic DNA Translation: EAW87194.1
BC011634 mRNA Translation: AAH11634.1
CCDSiCCDS5322.1
PIRiG02670
JC5069
RefSeqiNP_001035055.1, NM_001039966.1
NP_001091671.1, NM_001098201.1
NP_001496.1, NM_001505.2

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi109110, 3 interactors
IntActiQ99527, 1 interactor
STRINGi9606.ENSP00000380281

Chemistry databases

BindingDBiQ99527
ChEMBLiCHEMBL5872
DrugBankiDB00783, Estradiol
DB13952, Estradiol acetate
DB13953, Estradiol benzoate
DB13954, Estradiol cypionate
DB13955, Estradiol dienanthate
DB13956, Estradiol valerate
DB01645, Genistein
DB05939, MK-0354
DrugCentraliQ99527
GuidetoPHARMACOLOGYi221

Protein family/group databases

TCDBi9.A.14.13.19, the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
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PTM databases

GlyGeniQ99527, 3 sites
iPTMnetiQ99527
PhosphoSitePlusiQ99527

Genetic variation databases

BioMutaiGPER1
DMDMi3023539

Proteomic databases

MassIVEiQ99527
PaxDbiQ99527
PeptideAtlasiQ99527
PRIDEiQ99527
ProteomicsDBi78311

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
10887, 429 antibodies

The DNASU plasmid repository

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DNASUi
2852

Genome annotation databases

EnsembliENST00000297469; ENSP00000297469; ENSG00000164850
ENST00000397088; ENSP00000380277; ENSG00000164850
ENST00000397092; ENSP00000380281; ENSG00000164850
ENST00000401670; ENSP00000385151; ENSG00000164850
GeneIDi2852
KEGGihsa:2852
UCSCiuc003sjz.1, human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
2852
DisGeNETi2852

GeneCards: human genes, protein and diseases

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GeneCardsi
GPER1
HGNCiHGNC:4485, GPER1
HPAiENSG00000164850, Low tissue specificity
MIMi601805, gene
neXtProtiNX_Q99527
OpenTargetsiENSG00000164850
PharmGKBiPA28873
VEuPathDBiHostDB:ENSG00000164850

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG502QU56, Eukaryota
GeneTreeiENSGT00940000154307
HOGENOMiCLU_009579_8_3_1
InParanoidiQ99527
OMAiVHLQHTE
OrthoDBi736624at2759
PhylomeDBiQ99527
TreeFamiTF333506

Enzyme and pathway databases

PathwayCommonsiQ99527
ReactomeiR-HSA-375276, Peptide ligand-binding receptors
R-HSA-418594, G alpha (i) signalling events
SIGNORiQ99527

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
2852, 7 hits in 997 CRISPR screens

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
GPR30

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
2852
PharosiQ99527, Tchem

Protein Ontology

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PROi
PR:Q99527
RNActiQ99527, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000164850, Expressed in fundus of stomach and 172 other tissues
ExpressionAtlasiQ99527, baseline and differential
GenevisibleiQ99527, HS

Family and domain databases

InterProiView protein in InterPro
IPR000276, GPCR_Rhodpsn
IPR017452, GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001, 7tm_1, 1 hit
PRINTSiPR00237, GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237, G_PROTEIN_RECEP_F1_1, 1 hit
PS50262, G_PROTEIN_RECEP_F1_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPER1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99527
Secondary accession number(s): A8K6C5
, B5BUJ1, O00143, O43494, Q13631, Q6FHL1, Q96F42, Q99981
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 1, 1997
Last modified: September 29, 2021
This is version 190 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families
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