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Entry version 174 (10 Apr 2019)
Sequence version 1 (01 May 1997)
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Protein

G-protein coupled estrogen receptor 1

Gene

GPER1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Stimulates cAMP production, calcium mobilization and tyrosine kinase Src inducing the release of heparin-bound epidermal growth factor (HB-EGF) and subsequent transactivation of the epidermal growth factor receptor (EGFR), activating downstream signaling pathways such as PI3K/Akt and ERK/MAPK. Mediates pleiotropic functions among others in the cardiovascular, endocrine, reproductive, immune and central nervous systems. Has a role in cardioprotection by reducing cardiac hypertrophy and perivascular fibrosis in a RAMP3-dependent manner. Regulates arterial blood pressure by stimulating vasodilation and reducing vascular smooth muscle and microvascular endothelial cell proliferation. Plays a role in blood glucose homeostasis contributing to the insulin secretion response by pancreatic beta cells. Triggers mitochondrial apoptosis during pachytene spermatocyte differentiation. Stimulates uterine epithelial cell proliferation. Enhances uterine contractility in response to oxytocin. Contributes to thymic atrophy by inducing apoptosis. Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. Promotes neuritogenesis in developing hippocampal neurons. Plays a role in acute neuroprotection against NMDA-induced excitotoxic neuronal death. Increases firing activity and intracellular calcium oscillations in luteinizing hormone-releasing hormone (LHRH) neurons. Inhibits early osteoblast proliferation at growth plate during skeletal development. Inhibits mature adipocyte differentiation and lipid accumulation. Involved in the recruitment of beta-arrestin 2 ARRB2 at the plasma membrane in epithelial cells. Functions also as a receptor for aldosterone mediating rapid regulation of vascular contractibility through the PI3K/ERK signaling pathway. Involved in cancer progression regulation. Stimulates cancer-associated fibroblast (CAF) proliferation by a rapid genomic response through the EGFR/ERK transduction pathway. Associated with EGFR, may act as a transcription factor activating growth regulatory genes (c-fos, cyclin D1). Promotes integrin alpha-5/beta-1 and fibronectin (FN) matrix assembly in breast cancer cells.14 Publications

Miscellaneous

Does not bind estradiol according to PubMed:18566127 and PubMed:16645038.

Caution

Data is conflicting regarding whether it fulfills the criteria of a membrane-bound estrogen receptor (PubMed:15705806, PubMed:17379646). Other reports suggest that it is not (PubMed:16645038, PubMed:18566127).4 Publications
Data is conflicting regarding whether it is localized either at the cell membrane (PM) (PubMed:15539556, PubMed:21427217, PubMed:21540189, PubMed:21354433, PubMed:21149639 and PubMed:23674134). Other reports suggest that it localizes at the endoplasmic reticulum (ER) (PubMed:15705806, PubMed:18566127).8 Publications

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Binds 17-beta-estradiol (E2) in plasma membranes with high affinity (Kd is 3.3 nM) and displays rapid kinetics of association and dissociation.3 Publications

      <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

      GO - Biological processi

      <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

      Molecular functionG-protein coupled receptor, Receptor, Transducer
      Biological processApoptosis, Cell cycle, Differentiation, Immunity, Inflammatory response, Innate immunity, Neurogenesis

      Enzyme and pathway databases

      Reactome - a knowledgebase of biological pathways and processes

      More...
      Reactomei
      R-HSA-375276 Peptide ligand-binding receptors
      R-HSA-418594 G alpha (i) signalling events

      SIGNOR Signaling Network Open Resource

      More...
      SIGNORi
      Q99527

      Protein family/group databases

      Transport Classification Database

      More...
      TCDBi
      9.A.14.13.19 the g-protein-coupled receptor (gpcr) family

      <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
      Recommended name:
      G-protein coupled estrogen receptor 1
      Alternative name(s):
      Chemoattractant receptor-like 2
      Flow-induced endothelial G-protein coupled receptor 1
      Short name:
      FEG-1
      G protein-coupled estrogen receptor 1
      G-protein coupled receptor 30
      GPCR-Br
      IL8-related receptor DRY12
      Lymphocyte-derived G-protein coupled receptor
      Short name:
      LYGPR
      Membrane estrogen receptor
      Short name:
      mER
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
      Name:GPER1
      Synonyms:CEPR, CMKRL2, DRY12, GPER, GPR30
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
      <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
      • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

      Organism-specific databases

      Eukaryotic Pathogen Database Resources

      More...
      EuPathDBi
      HostDB:ENSG00000164850.14

      Human Gene Nomenclature Database

      More...
      HGNCi
      HGNC:4485 GPER1

      Online Mendelian Inheritance in Man (OMIM)

      More...
      MIMi
      601805 gene

      neXtProt; the human protein knowledge platform

      More...
      neXtProti
      NX_Q99527

      <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

      Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

      Topology

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 62ExtracellularSequence analysisAdd BLAST62
      <p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei63 – 84Helical; Name=1Sequence analysisAdd BLAST22
      Topological domaini85 – 96CytoplasmicSequence analysisAdd BLAST12
      Transmembranei97 – 120Helical; Name=2Sequence analysisAdd BLAST24
      Topological domaini121 – 132ExtracellularSequence analysisAdd BLAST12
      Transmembranei133 – 153Helical; Name=3Sequence analysisAdd BLAST21
      Topological domaini154 – 175CytoplasmicSequence analysisAdd BLAST22
      Transmembranei176 – 194Helical; Name=4Sequence analysisAdd BLAST19
      Topological domaini195 – 220ExtracellularSequence analysisAdd BLAST26
      Transmembranei221 – 236Helical; Name=5Sequence analysisAdd BLAST16
      Topological domaini237 – 259CytoplasmicSequence analysisAdd BLAST23
      Transmembranei260 – 280Helical; Name=6Sequence analysisAdd BLAST21
      Topological domaini281 – 306ExtracellularSequence analysisAdd BLAST26
      Transmembranei307 – 327Helical; Name=7Sequence analysisAdd BLAST21
      Topological domaini328 – 375CytoplasmicSequence analysisAdd BLAST48

      Keywords - Cellular componenti

      Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Mitochondrion, Nucleus, Postsynaptic cell membrane, Synapse

      <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

      Organism-specific databases

      DisGeNET

      More...
      DisGeNETi
      2852

      Open Targets

      More...
      OpenTargetsi
      ENSG00000164850

      The Pharmacogenetics and Pharmacogenomics Knowledge Base

      More...
      PharmGKBi
      PA28873

      Chemistry databases

      ChEMBL database of bioactive drug-like small molecules

      More...
      ChEMBLi
      CHEMBL5872

      IUPHAR/BPS Guide to PHARMACOLOGY

      More...
      GuidetoPHARMACOLOGYi
      221

      Polymorphism and mutation databases

      BioMuta curated single-nucleotide variation and disease association database

      More...
      BioMutai
      GPER1

      Domain mapping of disease mutations (DMDM)

      More...
      DMDMi
      3023539

      <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

      Molecule processing

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000693101 – 375G-protein coupled estrogen receptor 1Add BLAST375

      Amino acid modifications

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
      <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
      Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
      Glycosylationi44N-linked (GlcNAc...) asparagineSequence analysis1
      <p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi130 ↔ 207PROSITE-ProRule annotation

      <p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

      Ubiquitinated; ubiquitination occurs at the plasma membrane and leads to proteasome-mediated degradation.1 Publication
      Glycosylated.1 Publication

      Keywords - PTMi

      Acetylation, Disulfide bond, Glycoprotein, Ubl conjugation

      Proteomic databases

      PaxDb, a database of protein abundance averages across all three domains of life

      More...
      PaxDbi
      Q99527

      PeptideAtlas

      More...
      PeptideAtlasi
      Q99527

      PRoteomics IDEntifications database

      More...
      PRIDEi
      Q99527

      ProteomicsDB human proteome resource

      More...
      ProteomicsDBi
      78311

      PTM databases

      iPTMnet integrated resource for PTMs in systems biology context

      More...
      iPTMneti
      Q99527

      Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

      More...
      PhosphoSitePlusi
      Q99527

      <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

      <p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

      Expressed in placenta, endothelial and epithelial cells, non laboring and laboring term myometrium, fibroblasts and cancer-associated fibroblasts (CAF), prostate cancer cells and invasive adenocarcinoma (at protein level). Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen.6 Publications

      <p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

      Up-regulated by EGF and TGF-alpha in endometrial, ovarian and breast tumor cells. Up-regulated by progestin and by phorbol 12-myristate 13-acetate (PMA) in breast cancer cell lines.2 Publications

      Gene expression databases

      Bgee dataBase for Gene Expression Evolution

      More...
      Bgeei
      ENSG00000164850 Expressed in 154 organ(s), highest expression level in fundus of stomach

      ExpressionAtlas, Differential and Baseline Expression

      More...
      ExpressionAtlasi
      Q99527 baseline and differential

      Genevisible search portal to normalized and curated expression data from Genevestigator

      More...
      Genevisiblei
      Q99527 HS

      Organism-specific databases

      Human Protein Atlas

      More...
      HPAi
      HPA027052

      <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

      <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

      Homodimer (Probable). Heterodimer; heterodimerizes with other G-protein-coupled receptor (GPCRs) like CRHR1, HTR1A and PAQR8. Interacts (via C-terminus tail motif) with DLG4 (via N-terminus tandem pair of PDZ domains); the interaction is direct and induces the increase of GPER1 protein levels residing at the plasma membrane surface in a estradiol-independent manner (By similarity). Interacts with RAMP3. Interacts with KRT7 and KRT8. Interacts with EGFR; the interaction increases after agonist-induced stimulation in cancer-associated fibroblasts (CAF). Interacts with EGFR and ESR1.By similarityCurated4 Publications

      Protein-protein interaction databases

      The Biological General Repository for Interaction Datasets (BioGrid)

      More...
      BioGridi
      109110, 2 interactors

      Protein interaction database and analysis system

      More...
      IntActi
      Q99527, 1 interactor

      STRING: functional protein association networks

      More...
      STRINGi
      9606.ENSP00000380281

      Chemistry databases

      BindingDB database of measured binding affinities

      More...
      BindingDBi
      Q99527

      <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

      3D structure databases

      Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

      More...
      ProteinModelPortali
      Q99527

      Database of comparative protein structure models

      More...
      ModBasei
      Search...

      MobiDB: a database of protein disorder and mobility annotations

      More...
      MobiDBi
      Search...

      <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

      <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

      Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

      Keywords - Domaini

      Transmembrane, Transmembrane helix

      Phylogenomic databases

      evolutionary genealogy of genes: Non-supervised Orthologous Groups

      More...
      eggNOGi
      ENOG410IEGB Eukaryota
      ENOG4111653 LUCA

      Ensembl GeneTree

      More...
      GeneTreei
      ENSGT00940000154307

      The HOVERGEN Database of Homologous Vertebrate Genes

      More...
      HOVERGENi
      HBG005351

      InParanoid: Eukaryotic Ortholog Groups

      More...
      InParanoidi
      Q99527

      KEGG Orthology (KO)

      More...
      KOi
      K04246

      Identification of Orthologs from Complete Genome Data

      More...
      OMAi
      QHARLSC

      Database of Orthologous Groups

      More...
      OrthoDBi
      646662at2759

      Database for complete collections of gene phylogenies

      More...
      PhylomeDBi
      Q99527

      TreeFam database of animal gene trees

      More...
      TreeFami
      TF333506

      Family and domain databases

      Integrated resource of protein families, domains and functional sites

      More...
      InterProi
      View protein in InterPro
      IPR000276 GPCR_Rhodpsn
      IPR017452 GPCR_Rhodpsn_7TM

      Pfam protein domain database

      More...
      Pfami
      View protein in Pfam
      PF00001 7tm_1, 1 hit

      Protein Motif fingerprint database; a protein domain database

      More...
      PRINTSi
      PR00237 GPCRRHODOPSN

      PROSITE; a protein domain and family database

      More...
      PROSITEi
      View protein in PROSITE
      PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
      PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

      <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

      <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

      This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

      Q99527-1 [UniParc]FASTAAdd to basket
      « Hide
              10         20         30         40         50
      MDVTSQARGV GLEMYPGTAQ PAAPNTTSPE LNLSHPLLGT ALANGTGELS
      60 70 80 90 100
      EHQQYVIGLF LSCLYTIFLF PIGFVGNILI LVVNISFREK MTIPDLYFIN
      110 120 130 140 150
      LAVADLILVA DSLIEVFNLH ERYYDIAVLC TFMSLFLQVN MYSSVFFLTW
      160 170 180 190 200
      MSFDRYIALA RAMRCSLFRT KHHARLSCGL IWMASVSATL VPFTAVHLQH
      210 220 230 240 250
      TDEACFCFAD VREVQWLEVT LGFIVPFAII GLCYSLIVRV LVRAHRHRGL
      260 270 280 290 300
      RPRRQKALRM ILAVVLVFFV CWLPENVFIS VHLLQRTQPG AAPCKQSFRH
      310 320 330 340 350
      AHPLTGHIVN LAAFSNSCLN PLIYSFLGET FRDKLRLYIE QKTNLPALNR
      360 370
      FCHAALKAVI PDSTEQSDVR FSSAV
      Length:375
      Mass (Da):42,248
      Last modified:May 1, 1997 - v1
      <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A54EED8A698F075
      GO

      <p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

      There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
      EntryEntry nameProtein names
      Gene namesLengthAnnotation
      A0A087WVN0A0A087WVN0_HUMAN
      G-protein-coupled estrogen receptor...
      GPER1
      408Annotation score:

      Annotation score:1 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
      C9J3W2C9J3W2_HUMAN
      G-protein-coupled estrogen receptor...
      GPER1
      73Annotation score:

      Annotation score:1 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
      A0A087X0Z4A0A087X0Z4_HUMAN
      G-protein-coupled estrogen receptor...
      GPER1
      176Annotation score:

      Annotation score:1 out of 5

      <p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

      Experimental Info

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20 – 21QP → HA in AAC52027 (PubMed:9479505).Curated2
      Sequence conflicti32 – 49Missing in AAB02736 (Ref. 7) CuratedAdd BLAST18
      Sequence conflicti104A → G in AAB02736 (Ref. 7) Curated1
      Sequence conflicti140 – 146NMYSSVF → QHVQAASS in AAB02736 (Ref. 7) Curated7
      Sequence conflicti179G → A in AAB02736 (Ref. 7) Curated1
      Sequence conflicti184A → S in AAB02736 (Ref. 7) Curated1
      Sequence conflicti312A → T in AAC51173 (PubMed:9070864).Curated1
      Sequence conflicti320N → T in AAB02736 (Ref. 7) Curated1
      Sequence conflicti355A → V in AAB02736 (Ref. 7) Curated1
      Sequence conflicti358A → V in AAB02736 (Ref. 7) Curated1

      Natural variant

      Feature keyPosition(s)DescriptionActionsGraphical viewLength
      <p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03331916P → L2 PublicationsCorresponds to variant dbSNP:rs11544331Ensembl.1

      Sequence databases

      Select the link destinations:

      EMBL nucleotide sequence database

      More...
      EMBLi

      GenBank nucleotide sequence database

      More...
      GenBanki

      DNA Data Bank of Japan; a nucleotide sequence database

      More...
      DDBJi
      Links Updated
      Y08162 mRNA Translation: CAA69354.1
      U77827 Genomic DNA Translation: AAC51173.1
      AF015257 mRNA Translation: AAC51904.1
      X98510 mRNA Translation: CAA67133.1
      U63917 mRNA Translation: AAB88017.1
      AF027956 Genomic DNA Translation: AAC52027.1
      U58828 mRNA Translation: AAB02736.1
      CR541741 mRNA Translation: CAG46541.1
      AK291590 mRNA Translation: BAF84279.1
      AB451427 mRNA Translation: BAG70241.1
      CH236953 Genomic DNA Translation: EAL23938.1
      CH471144 Genomic DNA Translation: EAW87194.1
      BC011634 mRNA Translation: AAH11634.1

      The Consensus CDS (CCDS) project

      More...
      CCDSi
      CCDS5322.1

      Protein sequence database of the Protein Information Resource

      More...
      PIRi
      G02670
      JC5069

      NCBI Reference Sequences

      More...
      RefSeqi
      NP_001035055.1, NM_001039966.1
      NP_001091671.1, NM_001098201.1
      NP_001496.1, NM_001505.2

      UniGene gene-oriented nucleotide sequence clusters

      More...
      UniGenei
      Hs.20961

      Genome annotation databases

      Ensembl eukaryotic genome annotation project

      More...
      Ensembli
      ENST00000297469; ENSP00000297469; ENSG00000164850
      ENST00000397088; ENSP00000380277; ENSG00000164850
      ENST00000397092; ENSP00000380281; ENSG00000164850
      ENST00000401670; ENSP00000385151; ENSG00000164850

      Database of genes from NCBI RefSeq genomes

      More...
      GeneIDi
      2852

      KEGG: Kyoto Encyclopedia of Genes and Genomes

      More...
      KEGGi
      hsa:2852

      UCSC genome browser

      More...
      UCSCi
      uc003sjz.1 human

      Keywords - Coding sequence diversityi

      Polymorphism

      <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

      <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

      <p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

      Atlas of Genetics and Cytogenetics in Oncology and Haematology

      Sequence databases

      Select the link destinations:
      EMBLi
      GenBanki
      DDBJi
      Links Updated
      Y08162 mRNA Translation: CAA69354.1
      U77827 Genomic DNA Translation: AAC51173.1
      AF015257 mRNA Translation: AAC51904.1
      X98510 mRNA Translation: CAA67133.1
      U63917 mRNA Translation: AAB88017.1
      AF027956 Genomic DNA Translation: AAC52027.1
      U58828 mRNA Translation: AAB02736.1
      CR541741 mRNA Translation: CAG46541.1
      AK291590 mRNA Translation: BAF84279.1
      AB451427 mRNA Translation: BAG70241.1
      CH236953 Genomic DNA Translation: EAL23938.1
      CH471144 Genomic DNA Translation: EAW87194.1
      BC011634 mRNA Translation: AAH11634.1
      CCDSiCCDS5322.1
      PIRiG02670
      JC5069
      RefSeqiNP_001035055.1, NM_001039966.1
      NP_001091671.1, NM_001098201.1
      NP_001496.1, NM_001505.2
      UniGeneiHs.20961

      3D structure databases

      ProteinModelPortaliQ99527
      ModBaseiSearch...
      MobiDBiSearch...

      Protein-protein interaction databases

      BioGridi109110, 2 interactors
      IntActiQ99527, 1 interactor
      STRINGi9606.ENSP00000380281

      Chemistry databases

      BindingDBiQ99527
      ChEMBLiCHEMBL5872
      GuidetoPHARMACOLOGYi221

      Protein family/group databases

      TCDBi9.A.14.13.19 the g-protein-coupled receptor (gpcr) family

      Information system for G protein-coupled receptors (GPCRs)

      More...
      GPCRDBi
      Search...

      PTM databases

      iPTMnetiQ99527
      PhosphoSitePlusiQ99527

      Polymorphism and mutation databases

      BioMutaiGPER1
      DMDMi3023539

      Proteomic databases

      PaxDbiQ99527
      PeptideAtlasiQ99527
      PRIDEiQ99527
      ProteomicsDBi78311

      Protocols and materials databases

      The DNASU plasmid repository

      More...
      DNASUi
      2852
      Structural Biology KnowledgebaseSearch...

      Genome annotation databases

      EnsembliENST00000297469; ENSP00000297469; ENSG00000164850
      ENST00000397088; ENSP00000380277; ENSG00000164850
      ENST00000397092; ENSP00000380281; ENSG00000164850
      ENST00000401670; ENSP00000385151; ENSG00000164850
      GeneIDi2852
      KEGGihsa:2852
      UCSCiuc003sjz.1 human

      Organism-specific databases

      Comparative Toxicogenomics Database

      More...
      CTDi
      2852
      DisGeNETi2852
      EuPathDBiHostDB:ENSG00000164850.14

      GeneCards: human genes, protein and diseases

      More...
      GeneCardsi
      GPER1

      H-Invitational Database, human transcriptome db

      More...
      H-InvDBi
      HIX0167652
      HGNCiHGNC:4485 GPER1
      HPAiHPA027052
      MIMi601805 gene
      neXtProtiNX_Q99527
      OpenTargetsiENSG00000164850
      PharmGKBiPA28873

      GenAtlas: human gene database

      More...
      GenAtlasi
      Search...

      Phylogenomic databases

      eggNOGiENOG410IEGB Eukaryota
      ENOG4111653 LUCA
      GeneTreeiENSGT00940000154307
      HOVERGENiHBG005351
      InParanoidiQ99527
      KOiK04246
      OMAiQHARLSC
      OrthoDBi646662at2759
      PhylomeDBiQ99527
      TreeFamiTF333506

      Enzyme and pathway databases

      ReactomeiR-HSA-375276 Peptide ligand-binding receptors
      R-HSA-418594 G alpha (i) signalling events
      SIGNORiQ99527

      Miscellaneous databases

      The Gene Wiki collection of pages on human genes and proteins

      More...
      GeneWikii
      GPR30

      Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

      More...
      GenomeRNAii
      2852

      Protein Ontology

      More...
      PROi
      PR:Q99527

      The Stanford Online Universal Resource for Clones and ESTs

      More...
      SOURCEi
      Search...

      Gene expression databases

      BgeeiENSG00000164850 Expressed in 154 organ(s), highest expression level in fundus of stomach
      ExpressionAtlasiQ99527 baseline and differential
      GenevisibleiQ99527 HS

      Family and domain databases

      InterProiView protein in InterPro
      IPR000276 GPCR_Rhodpsn
      IPR017452 GPCR_Rhodpsn_7TM
      PfamiView protein in Pfam
      PF00001 7tm_1, 1 hit
      PRINTSiPR00237 GPCRRHODOPSN
      PROSITEiView protein in PROSITE
      PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
      PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

      ProtoNet; Automatic hierarchical classification of proteins

      More...
      ProtoNeti
      Search...

      <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

      <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGPER1_HUMAN
      <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99527
      Secondary accession number(s): A8K6C5
      , B5BUJ1, O00143, O43494, Q13631, Q6FHL1, Q96F42, Q99981
      <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
      Last sequence update: May 1, 1997
      Last modified: April 10, 2019
      This is version 174 of the entry and version 1 of the sequence. See complete history.
      <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
      Annotation programChordata Protein Annotation Program
      DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

      <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

      Keywords - Technical termi

      Complete proteome, Reference proteome

      Documents

      1. SIMILARITY comments
        Index of protein domains and families
      2. Human chromosome 7
        Human chromosome 7: entries, gene names and cross-references to MIM
      3. 7-transmembrane G-linked receptors
        List of 7-transmembrane G-linked receptor entries
      4. Human polymorphisms and disease mutations
        Index of human polymorphisms and disease mutations
      5. MIM cross-references
        Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
      6. Human entries with polymorphisms or disease mutations
        List of human entries with polymorphisms or disease mutations
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