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Protein

Histone H4-like protein type G

Gene

HIST1H4G

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi17 – 21By similarity5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Histone H4-like protein type G
Gene namesi
Name:HIST1H4G
Synonyms:H4/L, H4FL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000275663.1
HGNCiHGNC:4792 HIST1H4G
MIMi602832 gene
neXtProtiNX_Q99525

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleosome core, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000275663
PharmGKBiPA29167

Polymorphism and mutation databases

BioMutaiHIST1H4G
DMDMi74752149

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003243921 – 98Histone H4-like protein type GAdd BLAST98

Proteomic databases

PaxDbiQ99525
PeptideAtlasiQ99525
PRIDEiQ99525
ProteomicsDBi78310

PTM databases

iPTMnetiQ99525
PhosphoSitePlusiQ99525

Expressioni

Gene expression databases

BgeeiENSG00000275663 Expressed in 19 organ(s), highest expression level in muscle tissue
CleanExiHS_HIST1H4G
GenevisibleiQ99525 HS

Organism-specific databases

HPAiHPA042201

Interactioni

Subunit structurei

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AGTRAPQ6RW133EBI-10294329,EBI-741181

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113965, 4 interactors
IntActiQ99525, 7 interactors
STRINGi9606.ENSP00000244537

Structurei

3D structure databases

ProteinModelPortaliQ99525
SMRiQ99525
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone H4 family.Curated

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00760000119019
HOGENOMiHOG000234654
HOVERGENiHBG051878
InParanoidiQ99525
KOiK11254
OMAiCHRKVLS
OrthoDBiEOG091G135V
PhylomeDBiQ99525

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR001951 Histone_H4
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

Q99525-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVRGKAGKG LGKGGAKCHR KVLSDNIQGI TKCTIRRLAR HGGVKRILGL
60 70 80 90
IYEETRRVFK VFLENVIWYA VTNTEHAKRK TVTAMAVVYV LKRQGRTL
Length:98
Mass (Da):11,009
Last modified:May 1, 1997 - v1
Checksum:iB76078AC96AE4DEB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z80788 Genomic DNA Translation: CAB02550.1
AY128660 Genomic DNA Translation: AAN01445.1
AL031777 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55550.1
BC126276 mRNA Translation: AAI26277.1
BC126278 mRNA Translation: AAI26279.1
CCDSiCCDS4599.1
RefSeqiNP_003538.1, NM_003547.2
UniGeneiHs.553507

Genome annotation databases

EnsembliENST00000611444; ENSP00000477870; ENSG00000275663
GeneIDi8369
KEGGihsa:8369
UCSCiuc003nhf.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z80788 Genomic DNA Translation: CAB02550.1
AY128660 Genomic DNA Translation: AAN01445.1
AL031777 Genomic DNA No translation available.
CH471087 Genomic DNA Translation: EAW55550.1
BC126276 mRNA Translation: AAI26277.1
BC126278 mRNA Translation: AAI26279.1
CCDSiCCDS4599.1
RefSeqiNP_003538.1, NM_003547.2
UniGeneiHs.553507

3D structure databases

ProteinModelPortaliQ99525
SMRiQ99525
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113965, 4 interactors
IntActiQ99525, 7 interactors
STRINGi9606.ENSP00000244537

PTM databases

iPTMnetiQ99525
PhosphoSitePlusiQ99525

Polymorphism and mutation databases

BioMutaiHIST1H4G
DMDMi74752149

Proteomic databases

PaxDbiQ99525
PeptideAtlasiQ99525
PRIDEiQ99525
ProteomicsDBi78310

Protocols and materials databases

DNASUi8369
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000611444; ENSP00000477870; ENSG00000275663
GeneIDi8369
KEGGihsa:8369
UCSCiuc003nhf.4 human

Organism-specific databases

CTDi8369
EuPathDBiHostDB:ENSG00000275663.1
GeneCardsiHIST1H4G
HGNCiHGNC:4792 HIST1H4G
HPAiHPA042201
MIMi602832 gene
neXtProtiNX_Q99525
OpenTargetsiENSG00000275663
PharmGKBiPA29167
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3467 Eukaryota
COG2036 LUCA
GeneTreeiENSGT00760000119019
HOGENOMiHOG000234654
HOVERGENiHBG051878
InParanoidiQ99525
KOiK11254
OMAiCHRKVLS
OrthoDBiEOG091G135V
PhylomeDBiQ99525

Miscellaneous databases

GeneWikiiHIST1H4G
GenomeRNAii8369
PROiPR:Q99525
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000275663 Expressed in 19 organ(s), highest expression level in muscle tissue
CleanExiHS_HIST1H4G
GenevisibleiQ99525 HS

Family and domain databases

Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR001951 Histone_H4
PRINTSiPR00623 HISTONEH4
SMARTiView protein in SMART
SM00417 H4, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiH4G_HUMAN
AccessioniPrimary (citable) accession number: Q99525
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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