UniProtKB - Q99523 (SORT_HUMAN)
Sortilin
SORT1
Functioni
GO - Molecular functioni
- enzyme binding Source: BHF-UCL
- nerve growth factor binding Source: BHF-UCL
- nerve growth factor receptor activity Source: BHF-UCL
- neurotensin receptor activity, non-G protein-coupled Source: BHF-UCL
- retromer complex binding Source: UniProtKB
GO - Biological processi
- endocytosis Source: UniProtKB
- endosome to lysosome transport Source: BHF-UCL
- endosome transport via multivesicular body sorting pathway Source: BHF-UCL
- extrinsic apoptotic signaling pathway via death domain receptors Source: BHF-UCL
- glucose import Source: BHF-UCL
- Golgi to endosome transport Source: BHF-UCL
- G protein-coupled receptor signaling pathway Source: BHF-UCL
- multicellular organism development Source: UniProtKB-KW
- myotube differentiation Source: BHF-UCL
- negative regulation of fat cell differentiation Source: Ensembl
- negative regulation of lipoprotein lipase activity Source: BHF-UCL
- neuropeptide signaling pathway Source: BHF-UCL
- neurotrophin TRK receptor signaling pathway Source: BHF-UCL
- ossification Source: UniProtKB-KW
- plasma membrane to endosome transport Source: BHF-UCL
- positive regulation of epithelial cell apoptotic process Source: Ensembl
- post-Golgi vesicle-mediated transport Source: GO_Central
- protein targeting to lysosome Source: Ensembl
- regulation of gene expression Source: BHF-UCL
- response to insulin Source: BHF-UCL
- vesicle organization Source: BHF-UCL
Keywordsi
Molecular function | Developmental protein, Receptor |
Biological process | Differentiation, Endocytosis, Osteogenesis, Transport |
Enzyme and pathway databases
PathwayCommonsi | Q99523 |
Reactomei | R-HSA-432722, Golgi Associated Vesicle Biogenesis |
Protein family/group databases
TCDBi | 9.A.63.1.3, the retromer-dependent vacuolar protein sorting (r-vps) family |
Names & Taxonomyi
Protein namesi | Recommended name: SortilinAlternative name(s): 100 kDa NT receptor Glycoprotein 95 Short name: Gp95 Neurotensin receptor 3 Short name: NT3 Short name: NTR3 |
Gene namesi | Name:SORT1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11186, SORT1 |
MIMi | 602458, gene |
neXtProti | NX_Q99523 |
VEuPathDBi | HostDB:ENSG00000134243.11 |
Subcellular locationi
Golgi apparatus
- Golgi stack membrane 1 Publication; Single-pass type I membrane protein Curated
Plasma membrane
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Single-pass type I membrane protein Curated
Endosome
- Endosome membrane 1 Publication; Single-pass type I membrane protein Curated
Lysosome
- Lysosome membrane Curated; Single-pass type I membrane protein Curated
Nucleus
- Nucleus membrane Curated; Single-pass type I membrane protein Curated
Note: Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin.
Cytosol
- cytosol Source: HPA
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Endosome
- early endosome Source: BHF-UCL
- endosome membrane Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi cisterna membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
- lysosome Source: UniProtKB
Nucleus
- nuclear membrane Source: UniProtKB-SubCell
Plasma Membrane
- clathrin-coated pit Source: BHF-UCL
- plasma membrane Source: BHF-UCL
Other locations
- cell surface Source: BHF-UCL
- clathrin-coated vesicle Source: BHF-UCL
- cytoplasmic vesicle Source: BHF-UCL
- cytoplasmic vesicle membrane Source: Ensembl
- dendrite Source: Ensembl
- integral component of membrane Source: BHF-UCL
- neuronal cell body Source: Ensembl
- perinuclear region of cytoplasm Source: BHF-UCL
- trans-Golgi network transport vesicle Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 78 – 755 | ExtracellularSequence analysisAdd BLAST | 678 | |
Transmembranei | 756 – 778 | HelicalSequence analysisAdd BLAST | 23 | |
Topological domaini | 779 – 831 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell membrane, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 74 – 77 | RWRR → GWRA: Abrogates propeptide cleavage. 1 Publication | 4 | |
Mutagenesisi | 76 – 77 | RR → GG: Abrogates propeptide cleavage. 1 Publication | 2 | |
Mutagenesisi | 783 | C → S: Loss of palmitoylation. Decreased recycling from endosomes to the Golgi apparatus. Increased lysosomal degradation. 1 Publication | 1 | |
Mutagenesisi | 792 | Y → A: Reduces endocytosis and Golgi to endosome sorting; when associated with A-795. 1 Publication | 1 | |
Mutagenesisi | 795 | L → A: Reduces endocytosis and Golgi to endosome sorting; when associated with A-792. 1 Publication | 1 | |
Mutagenesisi | 823 – 824 | DD → NN: Reduces interaction with GGA1. 1 Publication | 2 | |
Mutagenesisi | 825 | S → A: Reduces interaction with GGA1. 1 Publication | 1 | |
Mutagenesisi | 826 – 828 | DED → NQN: Abrogates interaction with GGA1 and impairs localization to the Golgi. 1 Publication | 3 | |
Mutagenesisi | 829 – 830 | LL → AA: Abrogates interaction with GGA1 and impairs localization to the Golgi. 2 Publications | 2 | |
Mutagenesisi | 829 – 830 | Missing : Abrogates interaction with GGA2. Reduces endocytosis and Golgi to endosome sorting; when associated with A-792 and A-795. 2 Publications | 2 |
Organism-specific databases
DisGeNETi | 6272 |
MalaCardsi | SORT1 |
MIMi | 613589, phenotype |
OpenTargetsi | ENSG00000134243 |
PharmGKBi | PA36023 |
Miscellaneous databases
Pharosi | Q99523, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3091 |
Genetic variation databases
BioMutai | SORT1 |
DMDMi | 84028263 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 33 | By similarityAdd BLAST | 33 | |
PropeptideiPRO_0000033162 | 34 – 77 | Removed in mature form1 PublicationAdd BLAST | 44 | |
ChainiPRO_0000033163 | 78 – 831 | SortilinAdd BLAST | 754 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 86 ↔ 556 | |||
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineCurated | 1 | |
Glycosylationi | 162 | N-linked (GlcNAc...) asparagine2 Publications | 1 | |
Disulfide bondi | 257 ↔ 277 | |||
Glycosylationi | 274 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 406 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 448 ↔ 458 | |||
Glycosylationi | 582 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Disulfide bondi | 612 ↔ 651 | |||
Disulfide bondi | 634 ↔ 666 | |||
Disulfide bondi | 668 ↔ 723 | |||
Disulfide bondi | 675 ↔ 688 | |||
Glycosylationi | 684 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 702 ↔ 740 | |||
Lipidationi | 783 | S-palmitoyl cysteine1 Publication | 1 | |
Modified residuei | 814 | PhosphoserineCombined sources | 1 | |
Modified residuei | 819 | PhosphoserineCombined sources | 1 | |
Modified residuei | 825 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
EPDi | Q99523 |
jPOSTi | Q99523 |
MassIVEi | Q99523 |
MaxQBi | Q99523 |
PaxDbi | Q99523 |
PeptideAtlasi | Q99523 |
PRIDEi | Q99523 |
ProteomicsDBi | 5342 78309 [Q99523-1] |
PTM databases
GlyConnecti | 1765, 25 N-Linked glycans (4 sites) |
GlyGeni | Q99523, 9 sites, 3 N-linked glycans (2 sites) |
iPTMneti | Q99523 |
PhosphoSitePlusi | Q99523 |
SwissPalmi | Q99523 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000134243, Expressed in globus pallidus and 242 other tissues |
ExpressionAtlasi | Q99523, baseline and differential |
Genevisiblei | Q99523, HS |
Organism-specific databases
HPAi | ENSG00000134243, Tissue enhanced (brain, epididymis) |
Interactioni
Subunit structurei
Interacts with LPL and SLC2A4 (By similarity).
Interacts with the cytosolic adapter proteins GGA1 and GGA2 (PubMed:20015111).
Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP, GM2A and NTS.
Forms a complex with NGFR which binds specifically to the precursor forms of NGFB (proNGFB) and BDNF (proBDNF).
Interacts with the Trk receptors NTRK1, NTRK2 and NTRK3; may regulate their anterograde axonal transport and signaling.
Interacts with CLN5 (PubMed:22431521).
Interacts with PSAP (PubMed:22431521, PubMed:14657016).
Interacts with GRN; this interaction mediates endocytosis and lysosome delivery of progranulin; interaction occurs at the neuronal cell surface in a stressed nervous system (PubMed:21092856).
Interacts with the heterotrimeric retromer cargo-selective complex (CSC), also described as vacuolar protein sorting subcomplex (VPS), formed by VPS26 (VPS26A or VPS26B), VPS29 and VPS35; which is involved in retrograde trafficking of the receptor from endosomes to the Golgi apparatus (PubMed:18817523).
By similarity16 PublicationsBinary interactionsi
Hide detailsQ99523
Sortilin (PRO_0000033163)
With | #Exp. | IntAct |
---|---|---|
APP - isoform APP695 [P05067-4] | 4 | EBI-21467118,EBI-302641 |
GO - Molecular functioni
- enzyme binding Source: BHF-UCL
- nerve growth factor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112180, 147 interactors |
CORUMi | Q99523 |
DIPi | DIP-41798N |
ELMi | Q99523 |
IntActi | Q99523, 167 interactors |
MINTi | Q99523 |
STRINGi | 9606.ENSP00000256637 |
Chemistry databases
BindingDBi | Q99523 |
Miscellaneous databases
RNActi | Q99523, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q99523 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q99523 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 145 – 156 | BNR 1Add BLAST | 12 | |
Repeati | 198 – 209 | BNR 2Add BLAST | 12 | |
Repeati | 240 – 251 | BNR 3Add BLAST | 12 | |
Repeati | 287 – 298 | BNR 4Add BLAST | 12 | |
Repeati | 328 – 339 | BNR 5Add BLAST | 12 | |
Repeati | 377 – 388 | BNR 6Add BLAST | 12 | |
Repeati | 428 – 439 | BNR 7Add BLAST | 12 | |
Repeati | 506 – 517 | BNR 8Add BLAST | 12 | |
Repeati | 548 – 559 | BNR 9Add BLAST | 12 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 50 – 61 | Intrachain binding of the propeptide and the extracellular domainAdd BLAST | 12 | |
Regioni | 612 – 756 | Interactions with LRPAP1 and NGFBAdd BLAST | 145 | |
Regioni | 779 – 831 | Golgi to endosome transport and interactions with GGA1 and GGA2Add BLAST | 53 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 787 – 792 | Endocytosis signalCurated | 6 | |
Motifi | 826 – 830 | DXXLL motif involved in the interaction with GGA11 Publication | 5 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3511, Eukaryota |
GeneTreei | ENSGT00990000203671 |
HOGENOMi | CLU_013596_0_0_1 |
InParanoidi | Q99523 |
OMAi | FAPFYSV |
OrthoDBi | 1046610at2759 |
PhylomeDBi | Q99523 |
TreeFami | TF324918 |
Family and domain databases
DisProti | DP01551 |
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR031777, Sortilin_C IPR031778, Sortilin_N IPR006581, VPS10 IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF15902, Sortilin-Vps10, 1 hit PF15901, Sortilin_C, 1 hit |
SMARTi | View protein in SMART SM00602, VPS10, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MERPWGAADG LSRWPHGLGL LLLLQLLPPS TLSQDRLDAP PPPAAPLPRW
60 70 80 90 100
SGPIGVSWGL RAAAAGGAFP RGGRWRRSAP GEDEECGRVR DFVAKLANNT
110 120 130 140 150
HQHVFDDLRG SVSLSWVGDS TGVILVLTTF HVPLVIMTFG QSKLYRSEDY
160 170 180 190 200
GKNFKDITDL INNTFIRTEF GMAIGPENSG KVVLTAEVSG GSRGGRIFRS
210 220 230 240 250
SDFAKNFVQT DLPFHPLTQM MYSPQNSDYL LALSTENGLW VSKNFGGKWE
260 270 280 290 300
EIHKAVCLAK WGSDNTIFFT TYANGSCKAD LGALELWRTS DLGKSFKTIG
310 320 330 340 350
VKIYSFGLGG RFLFASVMAD KDTTRRIHVS TDQGDTWSMA QLPSVGQEQF
360 370 380 390 400
YSILAANDDM VFMHVDEPGD TGFGTIFTSD DRGIVYSKSL DRHLYTTTGG
410 420 430 440 450
ETDFTNVTSL RGVYITSVLS EDNSIQTMIT FDQGGRWTHL RKPENSECDA
460 470 480 490 500
TAKNKNECSL HIHASYSISQ KLNVPMAPLS EPNAVGIVIA HGSVGDAISV
510 520 530 540 550
MVPDVYISDD GGYSWTKMLE GPHYYTILDS GGIIVAIEHS SRPINVIKFS
560 570 580 590 600
TDEGQCWQTY TFTRDPIYFT GLASEPGARS MNISIWGFTE SFLTSQWVSY
610 620 630 640 650
TIDFKDILER NCEEKDYTIW LAHSTDPEDY EDGCILGYKE QFLRLRKSSV
660 670 680 690 700
CQNGRDYVVT KQPSICLCSL EDFLCDFGYY RPENDSKCVE QPELKGHDLE
710 720 730 740 750
FCLYGREEHL TTNGYRKIPG DKCQGGVNPV REVKDLKKKC TSNFLSPEKQ
760 770 780 790 800
NSKSNSVPII LAIVGLMLVT VVAGVLIVKK YVCGGRFLVH RYSVLQQHAE
810 820 830
ANGVDGVDAL DTASHTNKSG YHDDSDEDLL E
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0J9YVU2 | A0A0J9YVU2_HUMAN | Sortilin | SORT1 | 104 | Annotation score: | ||
A0A0J9YY30 | A0A0J9YY30_HUMAN | Sortilin | SORT1 | 20 | Annotation score: | ||
A0A0J9YX61 | A0A0J9YX61_HUMAN | Sortilin | SORT1 | 118 | Annotation score: | ||
A0A0J9YVX1 | A0A0J9YVX1_HUMAN | Sortilin | SORT1 | 60 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 650 | V → M in CAA66904 (PubMed:9013611).Curated | 1 |
Polymorphismi
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_053681 | 358 | D → Y. Corresponds to variant dbSNP:rs2228605EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_046239 | 1 – 136 | Missing in isoform 2. 1 PublicationAdd BLAST | 136 | |
Alternative sequenceiVSP_046240 | 278 – 279 | KA → T in isoform 2. 1 Publication | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X98248 mRNA Translation: CAA66904.2 FJ525881 Genomic DNA Translation: ACN81319.1 AK301548 mRNA Translation: BAG63045.1 AL390252 Genomic DNA No translation available. BC023542 mRNA Translation: AAH23542.1 |
CCDSi | CCDS55618.1 [Q99523-2] CCDS798.1 [Q99523-1] |
RefSeqi | NP_001192157.1, NM_001205228.1 [Q99523-2] NP_002950.3, NM_002959.6 [Q99523-1] |
Genome annotation databases
Ensembli | ENST00000256637; ENSP00000256637; ENSG00000134243 [Q99523-1] ENST00000538502; ENSP00000438597; ENSG00000134243 [Q99523-2] |
GeneIDi | 6272 |
KEGGi | hsa:6272 |
UCSCi | uc001dxm.3, human [Q99523-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X98248 mRNA Translation: CAA66904.2 FJ525881 Genomic DNA Translation: ACN81319.1 AK301548 mRNA Translation: BAG63045.1 AL390252 Genomic DNA No translation available. BC023542 mRNA Translation: AAH23542.1 |
CCDSi | CCDS55618.1 [Q99523-2] CCDS798.1 [Q99523-1] |
RefSeqi | NP_001192157.1, NM_001205228.1 [Q99523-2] NP_002950.3, NM_002959.6 [Q99523-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3F6K | X-ray | 2.00 | A | 78-756 | [»] | |
3G2U | X-ray | 2.30 | C/D | 819-831 | [»] | |
3G2V | X-ray | 2.10 | C/D | 819-831 | [»] | |
4MSL | X-ray | 2.70 | A | 78-756 | [»] | |
4N7E | X-ray | 2.70 | A | 78-756 | [»] | |
4PO7 | X-ray | 2.66 | A | 78-756 | [»] | |
5MRH | X-ray | 2.50 | A | 78-756 | [»] | |
5MRI | X-ray | 2.00 | A | 78-756 | [»] | |
6EHO | X-ray | 3.50 | A | 34-756 | [»] | |
6X3L | X-ray | 2.70 | A | 1-756 | [»] | |
6X48 | X-ray | 2.90 | A | 86-748 | [»] | |
6X4H | X-ray | 2.90 | A | 86-748 | [»] | |
SMRi | Q99523 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112180, 147 interactors |
CORUMi | Q99523 |
DIPi | DIP-41798N |
ELMi | Q99523 |
IntActi | Q99523, 167 interactors |
MINTi | Q99523 |
STRINGi | 9606.ENSP00000256637 |
Chemistry databases
BindingDBi | Q99523 |
ChEMBLi | CHEMBL3091 |
Protein family/group databases
TCDBi | 9.A.63.1.3, the retromer-dependent vacuolar protein sorting (r-vps) family |
PTM databases
GlyConnecti | 1765, 25 N-Linked glycans (4 sites) |
GlyGeni | Q99523, 9 sites, 3 N-linked glycans (2 sites) |
iPTMneti | Q99523 |
PhosphoSitePlusi | Q99523 |
SwissPalmi | Q99523 |
Genetic variation databases
BioMutai | SORT1 |
DMDMi | 84028263 |
Proteomic databases
EPDi | Q99523 |
jPOSTi | Q99523 |
MassIVEi | Q99523 |
MaxQBi | Q99523 |
PaxDbi | Q99523 |
PeptideAtlasi | Q99523 |
PRIDEi | Q99523 |
ProteomicsDBi | 5342 78309 [Q99523-1] |
Protocols and materials databases
Antibodypediai | 1533, 259 antibodies |
DNASUi | 6272 |
Genome annotation databases
Ensembli | ENST00000256637; ENSP00000256637; ENSG00000134243 [Q99523-1] ENST00000538502; ENSP00000438597; ENSG00000134243 [Q99523-2] |
GeneIDi | 6272 |
KEGGi | hsa:6272 |
UCSCi | uc001dxm.3, human [Q99523-1] |
Organism-specific databases
CTDi | 6272 |
DisGeNETi | 6272 |
GeneCardsi | SORT1 |
HGNCi | HGNC:11186, SORT1 |
HPAi | ENSG00000134243, Tissue enhanced (brain, epididymis) |
MalaCardsi | SORT1 |
MIMi | 602458, gene 613589, phenotype |
neXtProti | NX_Q99523 |
OpenTargetsi | ENSG00000134243 |
PharmGKBi | PA36023 |
VEuPathDBi | HostDB:ENSG00000134243.11 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3511, Eukaryota |
GeneTreei | ENSGT00990000203671 |
HOGENOMi | CLU_013596_0_0_1 |
InParanoidi | Q99523 |
OMAi | FAPFYSV |
OrthoDBi | 1046610at2759 |
PhylomeDBi | Q99523 |
TreeFami | TF324918 |
Enzyme and pathway databases
PathwayCommonsi | Q99523 |
Reactomei | R-HSA-432722, Golgi Associated Vesicle Biogenesis |
Miscellaneous databases
BioGRID-ORCSi | 6272, 7 hits in 875 CRISPR screens |
ChiTaRSi | SORT1, human |
EvolutionaryTracei | Q99523 |
GeneWikii | Sortilin_1 |
GenomeRNAii | 6272 |
Pharosi | Q99523, Tchem |
PROi | PR:Q99523 |
RNActi | Q99523, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134243, Expressed in globus pallidus and 242 other tissues |
ExpressionAtlasi | Q99523, baseline and differential |
Genevisiblei | Q99523, HS |
Family and domain databases
DisProti | DP01551 |
Gene3Di | 2.130.10.10, 2 hits |
InterProi | View protein in InterPro IPR031777, Sortilin_C IPR031778, Sortilin_N IPR006581, VPS10 IPR015943, WD40/YVTN_repeat-like_dom_sf |
Pfami | View protein in Pfam PF15902, Sortilin-Vps10, 1 hit PF15901, Sortilin_C, 1 hit |
SMARTi | View protein in SMART SM00602, VPS10, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SORT_HUMAN | |
Accessioni | Q99523Primary (citable) accession number: Q99523 Secondary accession number(s): B4DWI3, C0JYZ0, Q8IZ49 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 20, 2005 | |
Last modified: | February 10, 2021 | |
This is version 202 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants