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Protein

Sphingosine 1-phosphate receptor 3

Gene

S1PR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis.1 Publication

GO - Molecular functioni

  • G protein-coupled receptor activity Source: ProtInc
  • integrin binding Source: UniProtKB
  • lipid binding Source: ProtInc
  • sphingosine-1-phosphate receptor activity Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors
SIGNORiQ99500

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine 1-phosphate receptor 3
Short name:
S1P receptor 3
Short name:
S1P3
Alternative name(s):
Endothelial differentiation G-protein coupled receptor 3
Sphingosine 1-phosphate receptor Edg-3
Short name:
S1P receptor Edg-3
Gene namesi
Name:S1PR3
Synonyms:EDG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000213694.3
HGNCiHGNC:3167 S1PR3
MIMi601965 gene
neXtProtiNX_Q99500

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularBy similarityAdd BLAST40
Transmembranei41 – 65Helical; Name=1By similarityAdd BLAST25
Topological domaini66 – 72CytoplasmicBy similarity7
Transmembranei73 – 101Helical; Name=2By similarityAdd BLAST29
Topological domaini102 – 115ExtracellularBy similarityAdd BLAST14
Transmembranei116 – 134Helical; Name=3By similarityAdd BLAST19
Topological domaini135 – 153CytoplasmicBy similarityAdd BLAST19
Transmembranei154 – 179Helical; Name=4By similarityAdd BLAST26
Topological domaini180 – 195ExtracellularBy similarityAdd BLAST16
Transmembranei196 – 216Helical; Name=5By similarityAdd BLAST21
Topological domaini217 – 243CytoplasmicBy similarityAdd BLAST27
Transmembranei244 – 265Helical; Name=6By similarityAdd BLAST22
Topological domaini266 – 281ExtracellularBy similarityAdd BLAST16
Transmembranei282 – 302Helical; Name=7By similarityAdd BLAST21
Topological domaini303 – 378CytoplasmicBy similarityAdd BLAST76

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1903
OpenTargetsiENSG00000213694
PharmGKBiPA162402362

Chemistry databases

ChEMBLiCHEMBL3892
GuidetoPHARMACOLOGYi277

Polymorphism and mutation databases

BioMutaiS1PR3
DMDMi42560554

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000694211 – 378Sphingosine 1-phosphate receptor 3Add BLAST378

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi15N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei326PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ99500
PaxDbiQ99500
PeptideAtlasiQ99500
PRIDEiQ99500
ProteomicsDBi78299

PTM databases

iPTMnetiQ99500
PhosphoSitePlusiQ99500

Expressioni

Tissue specificityi

Expressed in all tissues, but most abundantly in heart, placenta, kidney, and liver.

Gene expression databases

BgeeiENSG00000213694 Expressed in 187 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_S1PR3
GenevisibleiQ99500 HS

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ITGB4P161443EBI-10634734,EBI-948678

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108227, 3 interactors
CORUMiQ99500
IntActiQ99500, 6 interactors
MINTiQ99500
STRINGi9606.ENSP00000350878

Chemistry databases

BindingDBiQ99500

Structurei

3D structure databases

ProteinModelPortaliQ99500
SMRiQ99500
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIA7 Eukaryota
ENOG410XQD3 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiQ99500
KOiK04290
OMAiHYNYVGK
OrthoDBiEOG091G0DD4
PhylomeDBiQ99500
TreeFamiTF330052

Family and domain databases

CDDicd15345 7tmA_S1PR3_Edg3, 1 hit
InterProiView protein in InterPro
IPR004062 EDG3_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004061 S1P_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01524 EDG3RECEPTOR
PR00237 GPCRRHODOPSN
PR01523 S1PRECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q99500-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATALPPRLQ PVRGNETLRE HYQYVGKLAG RLKEASEGST LTTVLFLVIC
60 70 80 90 100
SFIVLENLMV LIAIWKNNKF HNRMYFFIGN LALCDLLAGI AYKVNILMSG
110 120 130 140 150
KKTFSLSPTV WFLREGSMFV ALGASTCSLL AIAIERHLTM IKMRPYDANK
160 170 180 190 200
RHRVFLLIGM CWLIAFTLGA LPILGWNCLH NLPDCSTILP LYSKKYIAFC
210 220 230 240 250
ISIFTAILVT IVILYARIYF LVKSSSRKVA NHNNSERSMA LLRTVVIVVS
260 270 280 290 300
VFIACWSPLF ILFLIDVACR VQACPILFKA QWFIVLAVLN SAMNPVIYTL
310 320 330 340 350
ASKEMRRAFF RLVCNCLVRG RGARASPIQP ALDPSRSKSS SSNNSSHSPK
360 370
VKEDLPHTAP SSCIMDKNAA LQNGIFCN
Length:378
Mass (Da):42,250
Last modified:February 16, 2004 - v2
Checksum:i79A00300968F439F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti359A → D in CAA58744 (PubMed:8878560).Curated1
Sequence conflicti359A → D in AAC51906 (PubMed:9409733).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033465243R → Q. Corresponds to variant dbSNP:rs34075341Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83864 Genomic DNA Translation: CAA58744.1
AF022139 mRNA Translation: AAC51906.1
AY322540 Genomic DNA Translation: AAP84353.1
AK312798 mRNA Translation: BAG35658.1
AL772202 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62758.1
BC060827 mRNA Translation: AAH60827.1
BC069579 mRNA Translation: AAH69579.1
CCDSiCCDS6680.1
PIRiJC5245
RefSeqiNP_005217.2, NM_005226.3
UniGeneiHs.585118

Genome annotation databases

EnsembliENST00000358157; ENSP00000350878; ENSG00000213694
ENST00000375846; ENSP00000365006; ENSG00000213694
GeneIDi1903
KEGGihsa:1903
UCSCiuc004aqe.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83864 Genomic DNA Translation: CAA58744.1
AF022139 mRNA Translation: AAC51906.1
AY322540 Genomic DNA Translation: AAP84353.1
AK312798 mRNA Translation: BAG35658.1
AL772202 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62758.1
BC060827 mRNA Translation: AAH60827.1
BC069579 mRNA Translation: AAH69579.1
CCDSiCCDS6680.1
PIRiJC5245
RefSeqiNP_005217.2, NM_005226.3
UniGeneiHs.585118

3D structure databases

ProteinModelPortaliQ99500
SMRiQ99500
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108227, 3 interactors
CORUMiQ99500
IntActiQ99500, 6 interactors
MINTiQ99500
STRINGi9606.ENSP00000350878

Chemistry databases

BindingDBiQ99500
ChEMBLiCHEMBL3892
GuidetoPHARMACOLOGYi277

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ99500
PhosphoSitePlusiQ99500

Polymorphism and mutation databases

BioMutaiS1PR3
DMDMi42560554

Proteomic databases

MaxQBiQ99500
PaxDbiQ99500
PeptideAtlasiQ99500
PRIDEiQ99500
ProteomicsDBi78299

Protocols and materials databases

DNASUi1903
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000358157; ENSP00000350878; ENSG00000213694
ENST00000375846; ENSP00000365006; ENSG00000213694
GeneIDi1903
KEGGihsa:1903
UCSCiuc004aqe.5 human

Organism-specific databases

CTDi1903
DisGeNETi1903
EuPathDBiHostDB:ENSG00000213694.3
GeneCardsiS1PR3
HGNCiHGNC:3167 S1PR3
MIMi601965 gene
neXtProtiNX_Q99500
OpenTargetsiENSG00000213694
PharmGKBiPA162402362
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IIA7 Eukaryota
ENOG410XQD3 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000233501
HOVERGENiHBG103071
InParanoidiQ99500
KOiK04290
OMAiHYNYVGK
OrthoDBiEOG091G0DD4
PhylomeDBiQ99500
TreeFamiTF330052

Enzyme and pathway databases

ReactomeiR-HSA-418594 G alpha (i) signalling events
R-HSA-419408 Lysosphingolipid and LPA receptors
SIGNORiQ99500

Miscellaneous databases

GeneWikiiS1PR3
GenomeRNAii1903
PROiPR:Q99500
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000213694 Expressed in 187 organ(s), highest expression level in layer of synovial tissue
CleanExiHS_S1PR3
GenevisibleiQ99500 HS

Family and domain databases

CDDicd15345 7tmA_S1PR3_Edg3, 1 hit
InterProiView protein in InterPro
IPR004062 EDG3_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR004061 S1P_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01524 EDG3RECEPTOR
PR00237 GPCRRHODOPSN
PR01523 S1PRECEPTOR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS1PR3_HUMAN
AccessioniPrimary (citable) accession number: Q99500
Secondary accession number(s): Q5SQD8, Q7Z5I2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 16, 2004
Last modified: November 7, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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