UniProtKB - Q99490 (AGAP2_HUMAN)
Protein
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Gene
AGAP2
Organism
Homo sapiens (Human)
Status
Functioni
GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion.4 Publications
Activity regulationi
GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 413 – 420 | GTPSequence analysis | 8 | |
Nucleotide bindingi | 457 – 461 | GTPSequence analysis | 5 | |
Nucleotide bindingi | 515 – 518 | GTPSequence analysis | 4 | |
Zinc fingeri | 946 – 969 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
GO - Molecular functioni
- ATP binding Source: MGI
- GTPase activator activity Source: MGI
- GTPase activity Source: MGI
- GTP binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- phosphatidylinositol 3-kinase regulator activity Source: MGI
- protein kinase activator activity Source: MGI
- protein kinase binding Source: MGI
GO - Biological processi
- actin cytoskeleton organization Source: MGI
- endosomal transport Source: MGI
- negative regulation of neuron apoptotic process Source: MGI
- negative regulation of protein catabolic process Source: MGI
- positive regulation of 1-phosphatidylinositol-3-kinase activity Source: ARUK-UCL
- positive regulation of protein kinase activity Source: MGI
- protein transport Source: UniProtKB-KW
Keywordsi
Molecular function | GTPase activation |
Biological process | Protein transport, Transport |
Ligand | GTP-binding, Metal-binding, Nucleotide-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | Q99490 |
Reactomei | R-HSA-373752, Netrin-1 signaling |
SignaLinki | Q99490 |
SIGNORi | Q99490 |
Names & Taxonomyi
Protein namesi | Recommended name: Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2Short name: AGAP-2 Alternative name(s): Centaurin-gamma-1 Short name: Cnt-g1 GTP-binding and GTPase-activating protein 2 Short name: GGAP2 Phosphatidylinositol 3-kinase enhancer Short name: PIKE |
Gene namesi | Name:AGAP2 Synonyms:CENTG1, KIAA0167 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16921, AGAP2 |
MIMi | 605476, gene |
neXtProti | NX_Q99490 |
VEuPathDBi | HostDB:ENSG00000135439.11 |
Subcellular locationi
Other locations
Cytosol
- cytosol Source: HPA
Endosome
- endosome Source: MGI
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: MGI
Other locations
- cytoplasm Source: MGI
- Flemming body Source: HPA
- membrane Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Keywords - Diseasei
Tumor suppressorOrganism-specific databases
DisGeNETi | 116986 |
OpenTargetsi | ENSG00000135439 |
PharmGKBi | PA26411 |
Miscellaneous databases
Pharosi | Q99490, Tbio |
Genetic variation databases
BioMutai | AGAP2 |
DMDMi | 97535883 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074217 | 1 – 1192 | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2Add BLAST | 1192 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Modified residuei | 113 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 128 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 149 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 638 | PhosphoserineCombined sources | 1 | ||
Modified residuei | 750 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 752 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 808 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 927 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 985 | PhosphoserineBy similarity | 1 | ||
Modified residuei | 1178 | PhosphoserineBy similarity | 1 | ||
Isoform 2 (identifier: Q99490-2) | |||||
Modified residuei | 682 | Phosphotyrosine1 Publication | 1 | ||
Modified residuei | 774 | Phosphotyrosine1 Publication | 1 |
Post-translational modificationi
Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | Q99490 |
MassIVEi | Q99490 |
MaxQBi | Q99490 |
PaxDbi | Q99490 |
PeptideAtlasi | Q99490 |
PRIDEi | Q99490 |
ProteomicsDBi | 78295 [Q99490-1] 78296 [Q99490-2] |
PTM databases
iPTMneti | Q99490 |
PhosphoSitePlusi | Q99490 |
Expressioni
Tissue specificityi
Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart.5 Publications
Gene expression databases
Bgeei | ENSG00000135439, Expressed in right hemisphere of cerebellum and 195 other tissues |
ExpressionAtlasi | Q99490, baseline and differential |
Genevisiblei | Q99490, HS |
Organism-specific databases
HPAi | ENSG00000135439, Group enriched (brain, lymphoid tissue) |
Interactioni
Subunit structurei
Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity).
Isoform 2 interacts with activated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex.
By similarity3 PublicationsBinary interactionsi
Hide detailsQ99490
With | #Exp. | IntAct |
---|---|---|
INSR [P06213] | 2 | EBI-2361824,EBI-475899 |
Isoform 2 [Q99490-2]
With | #Exp. | IntAct |
---|---|---|
STAT5A [P42229] | 3 | EBI-7737644,EBI-749537 |
Prlr [Q08501] from Mus musculus. | 2 | EBI-7737644,EBI-7737664 |
Stat5a [P42230] from Mus musculus. | 2 | EBI-7737644,EBI-617434 |
GO - Molecular functioni
- protein kinase binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 125549, 18 interactors |
IntActi | Q99490, 9 interactors |
MINTi | Q99490 |
STRINGi | 9606.ENSP00000449241 |
Miscellaneous databases
RNActi | Q99490, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q99490 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q99490 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 676 – 910 | PHPROSITE-ProRule annotationAdd BLAST | 235 | |
Domaini | 931 – 1051 | Arf-GAPPROSITE-ProRule annotationAdd BLAST | 121 | |
Repeati | 1090 – 1119 | ANK 1Add BLAST | 30 | |
Repeati | 1123 – 1152 | ANK 2Add BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | Interaction with EPB41L1By similarityAdd BLAST | 23 | |
Regioni | 180 – 225 | Interactions with HOMER1 and NF2By similarityAdd BLAST | 46 | |
Regioni | 267 – 390 | Interaction with PLCG1By similarityAdd BLAST | 124 | |
Regioni | 405 – 572 | G domainAdd BLAST | 168 |
Domaini
G domain binds GTP and has GTPase activity.
Arf-GAP domain interacts with G domain and may regulate its GTPase activity.
Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the cytosol. PH domain of isoform 2 is required for binding to AP-1.
Sequence similaritiesi
Belongs to the centaurin gamma-like family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 946 – 969 | C4-typePROSITE-ProRule annotationAdd BLAST | 24 |
Keywords - Domaini
ANK repeat, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG0705, Eukaryota |
GeneTreei | ENSGT00940000158956 |
HOGENOMi | CLU_007326_1_0_1 |
InParanoidi | Q99490 |
PhylomeDBi | Q99490 |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 2.30.29.30, 2 hits 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF01412, ArfGap, 1 hit PF00071, Ras, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF52540, SSF52540, 1 hit SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 1 hit PS51419, RAB, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q99490-1) [UniParc]FASTAAdd to basket
Also known as: PIKE-L
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRGAGALQR RTTTYLISLT LVKLESVPPP PPSPSAAAVG APGARGSEPR
60 70 80 90 100
DPGSPRGAEE PGKKRHERLF HRQDALWIST SSAGAGGAEP PALSPAPASP
110 120 130 140 150
ARPVSPAPGR RLSLWAAPPG PPLSGGLSPD SKPGGAPSSS RRPLLSSPSW
160 170 180 190 200
GGPEPEGRTG GGVPGSSSPH PGTGSRRLKV APPPPAPKPC KTVTTSGAKA
210 220 230 240 250
GGGKGAGSRL SWPESEGKPR VKGSKSSAGT GASVSAAATA AAAGGGGSTA
260 270 280 290 300
STSGGVGAGA GARGKLSPRK GKSKTLDNSD LHPGPPAGSP PPLTLPPTPS
310 320 330 340 350
PATAVTAASA QPPGPAPPIT LEPPAPGLKR GREGGRASTR DRKMLKFISG
360 370 380 390 400
IFTKSTGGPP GSGPLPGPPS LSSGSGSREL LGAELRASPK AVINSQEWTL
410 420 430 440 450
SRSIPELRLG VLGDARSGKS SLIHRFLTGS YQVLEKTESE QYKKEMLVDG
460 470 480 490 500
QTHLVLIREE AGAPDAKFSG WADAVIFVFS LEDENSFQAV SRLHGQLSSL
510 520 530 540 550
RGEGRGGLAL ALVGTQDRIS ASSPRVVGDA RARALCADMK RCSYYETCAT
560 570 580 590 600
YGLNVDRVFQ EVAQKVVTLR KQQQLLAACK SLPSSPSHSA ASTPVAGQAS
610 620 630 640 650
NGGHTSDYSS SLPSSPNVGH RELRAEAAAV AGLSTPGSLH RAAKRRTSLF
660 670 680 690 700
ANRRGSDSEK RSLDSRGETT GSGRAIPIKQ SFLLKRSGNS LNKEWKKKYV
710 720 730 740 750
TLSSNGFLLY HPSINDYIHS THGKEMDLLR TTVKVPGKRP PRAISAFGPS
760 770 780 790 800
ASINGLVKDM STVQMGEGLE ATTPMPSPSP SPSSLQPPPD QTSKHLLKPD
810 820 830 840 850
RNLARALSTD CTPSGDLSPL SREPPPSPMV KKQRRKKLTT PSKTEGSAGQ
860 870 880 890 900
AEAKRKMWKL KSFGSLRNIY KAEENFEFLI VSSTGQTWHF EAASFEERDA
910 920 930 940 950
WVQAIESQIL ASLQCCESSK VKLRTDSQSE AVAIQAIRNA KGNSICVDCG
960 970 980 990 1000
APNPTWASLN LGALICIECS GIHRNLGTHL SRVRSLDLDD WPRELTLVLT
1010 1020 1030 1040 1050
AIGNDTANRV WESDTRGRAK PSRDSSREER ESWIRAKYEQ LLFLAPLSTS
1060 1070 1080 1090 1100
EEPLGRQLWA AVQAQDVATV LLLLAHARHG PLDTSVEDPQ LRSPLHLAAE
1110 1120 1130 1140 1150
LAHVVITQLL LWYGADVAAR DAQGRTALFY ARQAGSQLCA DILLQHGCPG
1160 1170 1180 1190
EGGSAATTPS AATTPSITAT PSPRRRSSAA SVGRADAPVA LV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF8VVT9 | F8VVT9_HUMAN | Arf-GAP with GTPase, ANK repeat and... | AGAP2 | 1,192 | Annotation score: | ||
J3KNM6 | J3KNM6_HUMAN | Arf-GAP with GTPase, ANK repeat and... | AGAP2 | 1,036 | Annotation score: | ||
H0YHB1 | H0YHB1_HUMAN | Arf-GAP with GTPase, ANK repeat and... | AGAP2 | 169 | Annotation score: |
Sequence cautioni
The sequence BAA11484 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1137 | Q → H in AAC39522 (PubMed:9192850).Curated | 1 | |
Sequence conflicti | 1147 | G → A in AAC39522 (PubMed:9192850).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_036183 | 339 | T → A in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_026438 | 455 | V → A in a glioblastoma cell line. 1 Publication | 1 | |
Natural variantiVAR_022046 | 507 | G → S. Corresponds to variant dbSNP:rs2301553Ensembl. | 1 | |
Natural variantiVAR_026439 | 518 | R → G in a sarcoma cell line. 1 Publication | 1 | |
Natural variantiVAR_026440 | 568 | T → I in a neuroblastoma cell line. 1 Publication | 1 | |
Natural variantiVAR_026441 | 651 | A → V in a glioblastoma cell line. 1 Publication | 1 | |
Natural variantiVAR_026442 | 767 | E → V in a glioblastoma cell line. 1 Publication | 1 | |
Natural variantiVAR_036184 | 816 | D → Y in a breast cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_026443 | 939 | N → D in a glioblastoma cell line. 1 Publication | 1 | |
Natural variantiVAR_026444 | 947 | V → M in a sarcoma cell line. 1 Publication | 1 | |
Natural variantiVAR_026445 | 1022 | S → P in a glioblastoma cell line. 1 Publication | 1 | |
Natural variantiVAR_055532 | 1124 | G → V1 PublicationCorresponds to variant dbSNP:rs238521Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018531 | 1 – 336 | Missing in isoform 2. 5 PublicationsAdd BLAST | 336 | |
Alternative sequenceiVSP_018532 | 337 – 390 | ASTRD…RASPK → MHAQRQFVVAAVRAEVRRHE VAKQALNRLRKLAERVDDPE LQDSIQASLDSIRE in isoform 2. 5 PublicationsAdd BLAST | 54 | |
Alternative sequenceiVSP_018533 | 853 – 872 | Missing in isoform 2. 5 PublicationsAdd BLAST | 20 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U81031 Genomic DNA Translation: AAC39522.2 AF384128 mRNA Translation: AAO39848.1 AY128689 mRNA Translation: AAM97540.1 D79989 mRNA Translation: BAA11484.2 Different initiation. AF413077 mRNA Translation: AAL04171.1 AK292672 mRNA Translation: BAF85361.1 CH471054 Genomic DNA Translation: EAW97049.1 BC028020 mRNA Translation: AAH28020.1 |
CCDSi | CCDS44932.1 [Q99490-1] CCDS8951.1 [Q99490-2] |
RefSeqi | NP_001116244.1, NM_001122772.2 NP_055585.1, NM_014770.3 [Q99490-2] |
Genome annotation databases
Ensembli | ENST00000257897; ENSP00000257897; ENSG00000135439 [Q99490-2] |
GeneIDi | 116986 |
KEGGi | hsa:116986 |
UCSCi | uc001spr.4, human [Q99490-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U81031 Genomic DNA Translation: AAC39522.2 AF384128 mRNA Translation: AAO39848.1 AY128689 mRNA Translation: AAM97540.1 D79989 mRNA Translation: BAA11484.2 Different initiation. AF413077 mRNA Translation: AAL04171.1 AK292672 mRNA Translation: BAF85361.1 CH471054 Genomic DNA Translation: EAW97049.1 BC028020 mRNA Translation: AAH28020.1 |
CCDSi | CCDS44932.1 [Q99490-1] CCDS8951.1 [Q99490-2] |
RefSeqi | NP_001116244.1, NM_001122772.2 NP_055585.1, NM_014770.3 [Q99490-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2BMJ | X-ray | 2.10 | A | 402-577 | [»] | |
2IWR | X-ray | 1.50 | A | 402-577 | [»] | |
2RLO | NMR | - | A | 674-914 | [»] | |
SMRi | Q99490 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 125549, 18 interactors |
IntActi | Q99490, 9 interactors |
MINTi | Q99490 |
STRINGi | 9606.ENSP00000449241 |
PTM databases
iPTMneti | Q99490 |
PhosphoSitePlusi | Q99490 |
Genetic variation databases
BioMutai | AGAP2 |
DMDMi | 97535883 |
Proteomic databases
jPOSTi | Q99490 |
MassIVEi | Q99490 |
MaxQBi | Q99490 |
PaxDbi | Q99490 |
PeptideAtlasi | Q99490 |
PRIDEi | Q99490 |
ProteomicsDBi | 78295 [Q99490-1] 78296 [Q99490-2] |
Protocols and materials databases
Antibodypediai | 16354, 284 antibodies |
Genome annotation databases
Ensembli | ENST00000257897; ENSP00000257897; ENSG00000135439 [Q99490-2] |
GeneIDi | 116986 |
KEGGi | hsa:116986 |
UCSCi | uc001spr.4, human [Q99490-1] |
Organism-specific databases
CTDi | 116986 |
DisGeNETi | 116986 |
GeneCardsi | AGAP2 |
HGNCi | HGNC:16921, AGAP2 |
HPAi | ENSG00000135439, Group enriched (brain, lymphoid tissue) |
MIMi | 605476, gene |
neXtProti | NX_Q99490 |
OpenTargetsi | ENSG00000135439 |
PharmGKBi | PA26411 |
VEuPathDBi | HostDB:ENSG00000135439.11 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0705, Eukaryota |
GeneTreei | ENSGT00940000158956 |
HOGENOMi | CLU_007326_1_0_1 |
InParanoidi | Q99490 |
PhylomeDBi | Q99490 |
Enzyme and pathway databases
PathwayCommonsi | Q99490 |
Reactomei | R-HSA-373752, Netrin-1 signaling |
SignaLinki | Q99490 |
SIGNORi | Q99490 |
Miscellaneous databases
BioGRID-ORCSi | 116986, 31 hits in 875 CRISPR screens |
ChiTaRSi | AGAP2, human |
EvolutionaryTracei | Q99490 |
GeneWikii | CENTG1 |
GenomeRNAii | 116986 |
Pharosi | Q99490, Tbio |
PROi | PR:Q99490 |
RNActi | Q99490, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000135439, Expressed in right hemisphere of cerebellum and 195 other tissues |
ExpressionAtlasi | Q99490, baseline and differential |
Genevisiblei | Q99490, HS |
Family and domain databases
Gene3Di | 1.25.40.20, 1 hit 2.30.29.30, 2 hits 3.30.40.160, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR037278, ARFGAP/RecO IPR001164, ArfGAP_dom IPR038508, ArfGAP_dom_sf IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR001806, Small_GTPase |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit PF01412, ArfGap, 1 hit PF00071, Ras, 1 hit |
PRINTSi | PR00405, REVINTRACTNG |
SMARTi | View protein in SMART SM00105, ArfGap, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF48403, SSF48403, 1 hit SSF52540, SSF52540, 1 hit SSF57863, SSF57863, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 1 hit PS50115, ARFGAP, 1 hit PS50003, PH_DOMAIN, 1 hit PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AGAP2_HUMAN | |
Accessioni | Q99490Primary (citable) accession number: Q99490 Secondary accession number(s): A8K9F7 Q8IWU3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | May 16, 2006 | |
Last modified: | February 10, 2021 | |
This is version 207 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 12
Human chromosome 12: entries, gene names and cross-references to MIM - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with genetic variants
List of human entries with genetic variants