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Entry version 167 (18 Sep 2019)
Sequence version 1 (01 May 1997)
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Protein

D-aspartate oxidase

Gene

DDO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Selectively catalyzes the oxidative deamination of D-aspartate and its N-methylated derivative, N-methyl D-aspartate.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

FAD, 6-hydroxy-FAD

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei166FAD; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei183FADBy similarity1
Binding sitei223SubstrateBy similarity1
Binding sitei278SubstrateBy similarity1
Binding sitei312FADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi6 – 20FADBy similarityAdd BLAST15
Nucleotide bindingi36 – 37FADBy similarity2
Nucleotide bindingi43 – 44FADBy similarity2
Nucleotide bindingi48 – 50FADBy similarity3
Nucleotide bindingi307 – 311FADBy similarity5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-389661 Glyoxylate metabolism and glycine degradation
R-HSA-9033241 Peroxisomal protein import

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q99489

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
D-aspartate oxidase (EC:1.4.3.1)
Short name:
DASOX
Short name:
DDO
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DDO
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2727 DDO

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
124450 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99489

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
8528

Open Targets

More...
OpenTargetsi
ENSG00000203797

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27194

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5887

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
DDO

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2494037

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001627701 – 341D-aspartate oxidaseAdd BLAST341

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q99489

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99489

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99489

PeptideAtlas

More...
PeptideAtlasi
Q99489

PRoteomics IDEntifications database

More...
PRIDEi
Q99489

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78291 [Q99489-1]
78292 [Q99489-2]
78293 [Q99489-3]
78294 [Q99489-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99489

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99489

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000203797 Expressed in 164 organ(s), highest expression level in heart left ventricle

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99489 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99489 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA037525
HPA037526

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
114098, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q99489, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000357920

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
Q99489

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99489

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi339 – 341Microbody targeting signalSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DAMOX/DASOX family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3923 Eukaryota
COG0665 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000018635

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000046303

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99489

KEGG Orthology (KO)

More...
KOi
K00272

Identification of Orthologs from Complete Genome Data

More...
OMAi
AGIHFQK

Database of Orthologous Groups

More...
OrthoDBi
1363414at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99489

TreeFam database of animal gene trees

More...
TreeFami
TF313887

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR006181 D-amino_acid_oxidase_CS
IPR023209 DAO
IPR006076 FAD-dep_OxRdtase

The PANTHER Classification System

More...
PANTHERi
PTHR11530 PTHR11530, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01266 DAO, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000189 D-aa_oxidase, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00677 DAO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform DDO-1 (identifier: Q99489-1) [UniParc]FASTAAdd to basket
Also known as: A

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDTARIAVVG AGVVGLSTAV CISKLVPRCS VTIISDKFTP DTTSDVAAGM
60 70 80 90 100
LIPHTYPDTP IHTQKQWFRE TFNHLFAIAN SAEAGDAGVH LVSGWQIFQS
110 120 130 140 150
TPTEEVPFWA DVVLGFRKMT EAELKKFPQY VFGQAFTTLK CECPAYLPWL
160 170 180 190 200
EKRIKGSGGW TLTRRIEDLW ELHPSFDIVV NCSGLGSRQL AGDSKIFPVR
210 220 230 240 250
GQVLQVQAPW VEHFIRDGSG LTYIYPGTSH VTLGGTRQKG DWNLSPDAEN
260 270 280 290 300
SREILSRCCA LEPSLHGACN IREKVGLRPY RPGVRLQTEL LARDGQRLPV
310 320 330 340
VHHYGHGSGG ISVHWGTALE AARLVSECVH ALRTPIPKSN L
Length:341
Mass (Da):37,535
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8CAE7501FB7F215C
GO
Isoform DDO-2 (identifier: Q99489-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     95-153: Missing.

Show »
Length:282
Mass (Da):30,522
Checksum:iDBD01D57E5B72F7A
GO
Isoform 3 (identifier: Q99489-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRPARHWETRFGARDFGGFQDCFFRDRLM

Show »
Length:369
Mass (Da):40,993
Checksum:i4E4C372EE90DD7C5
GO
Isoform 4 (identifier: Q99489-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MRPARHWETRFGARDFGGFQDCFFRDRLM
     95-153: Missing.

Show »
Length:310
Mass (Da):33,980
Checksum:iE74BBF6D27BE5CB3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z2E0F2Z2E0_HUMAN
D-aspartate oxidase
DDO
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti278R → S in BAF85718 (PubMed:14702039).Curated1
Isoform 4 (identifier: Q99489-4)
Sequence conflicti9T → N in DN990727 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_036244136F → L in a breast cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_014939189Q → E. Corresponds to variant dbSNP:rs17622Ensembl.1
Natural variantiVAR_014940230H → Y. Corresponds to variant dbSNP:rs17621Ensembl.1
Natural variantiVAR_014941255L → R. Corresponds to variant dbSNP:rs17623Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0376641M → MRPARHWETRFGARDFGGFQ DCFFRDRLM in isoform 3 and isoform 4. 3 Publications1
Alternative sequenceiVSP_00126995 – 153Missing in isoform DDO-2 and isoform 4. 2 PublicationsAdd BLAST59

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D89858 mRNA Translation: BAA14031.1
AK293029 mRNA Translation: BAF85718.1
AL050350 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48316.1
CH471051 Genomic DNA Translation: EAW48317.1
BC032786 mRNA Translation: AAH32786.3
DN990727 mRNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS5082.1 [Q99489-3]
CCDS5083.1 [Q99489-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5438
JC5439

NCBI Reference Sequences

More...
RefSeqi
NP_003640.2, NM_003649.2 [Q99489-3]
NP_004023.2, NM_004032.2 [Q99489-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000368923; ENSP00000357919; ENSG00000203797 [Q99489-4]
ENST00000368924; ENSP00000357920; ENSG00000203797 [Q99489-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
8528

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:8528

UCSC genome browser

More...
UCSCi
uc003puc.4 human [Q99489-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89858 mRNA Translation: BAA14031.1
AK293029 mRNA Translation: BAF85718.1
AL050350 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48316.1
CH471051 Genomic DNA Translation: EAW48317.1
BC032786 mRNA Translation: AAH32786.3
DN990727 mRNA No translation available.
CCDSiCCDS5082.1 [Q99489-3]
CCDS5083.1 [Q99489-2]
PIRiJC5438
JC5439
RefSeqiNP_003640.2, NM_003649.2 [Q99489-3]
NP_004023.2, NM_004032.2 [Q99489-2]

3D structure databases

SMRiQ99489
ModBaseiSearch...

Protein-protein interaction databases

BioGridi114098, 3 interactors
IntActiQ99489, 1 interactor
STRINGi9606.ENSP00000357920

Chemistry databases

BindingDBiQ99489
ChEMBLiCHEMBL5887

PTM databases

iPTMnetiQ99489
PhosphoSitePlusiQ99489

Polymorphism and mutation databases

BioMutaiDDO
DMDMi2494037

Proteomic databases

MassIVEiQ99489
MaxQBiQ99489
PaxDbiQ99489
PeptideAtlasiQ99489
PRIDEiQ99489
ProteomicsDBi78291 [Q99489-1]
78292 [Q99489-2]
78293 [Q99489-3]
78294 [Q99489-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368923; ENSP00000357919; ENSG00000203797 [Q99489-4]
ENST00000368924; ENSP00000357920; ENSG00000203797 [Q99489-3]
GeneIDi8528
KEGGihsa:8528
UCSCiuc003puc.4 human [Q99489-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8528
DisGeNETi8528

GeneCards: human genes, protein and diseases

More...
GeneCardsi
DDO
HGNCiHGNC:2727 DDO
HPAiHPA037525
HPA037526
MIMi124450 gene
neXtProtiNX_Q99489
OpenTargetsiENSG00000203797
PharmGKBiPA27194

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3923 Eukaryota
COG0665 LUCA
GeneTreeiENSGT00390000018635
HOGENOMiHOG000046303
InParanoidiQ99489
KOiK00272
OMAiAGIHFQK
OrthoDBi1363414at2759
PhylomeDBiQ99489
TreeFamiTF313887

Enzyme and pathway databases

ReactomeiR-HSA-389661 Glyoxylate metabolism and glycine degradation
R-HSA-9033241 Peroxisomal protein import
SABIO-RKiQ99489

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
DDO human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
DDO_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
8528

Pharos

More...
Pharosi
Q99489

Protein Ontology

More...
PROi
PR:Q99489

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000203797 Expressed in 164 organ(s), highest expression level in heart left ventricle
ExpressionAtlasiQ99489 baseline and differential
GenevisibleiQ99489 HS

Family and domain databases

InterProiView protein in InterPro
IPR006181 D-amino_acid_oxidase_CS
IPR023209 DAO
IPR006076 FAD-dep_OxRdtase
PANTHERiPTHR11530 PTHR11530, 1 hit
PfamiView protein in Pfam
PF01266 DAO, 1 hit
PIRSFiPIRSF000189 D-aa_oxidase, 1 hit
PROSITEiView protein in PROSITE
PS00677 DAO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOXDD_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99489
Secondary accession number(s): A8KAG4
, Q5JXM4, Q5JXM5, Q5JXM6, Q8N552
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: September 18, 2019
This is version 167 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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