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Entry version 185 (10 Feb 2021)
Sequence version 2 (11 Jan 2001)
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Protein

Prefoldin subunit 5

Gene

PFDN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. Represses the transcriptional activity of MYC.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

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PathwayCommonsi
Q99471

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Prefoldin subunit 5
Alternative name(s):
Myc modulator 1
c-Myc-binding protein Mm-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PFDN5
Synonyms:MM1, PFD5
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Human Gene Nomenclature Database

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HGNCi
HGNC:8869, PFDN5

Online Mendelian Inheritance in Man (OMIM)

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MIMi
604899, gene

neXtProt; the human protein knowledge platform

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neXtProti
NX_Q99471

Eukaryotic Pathogen, Vector and Host Database Resources

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VEuPathDBi
HostDB:ENSG00000123349.13

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

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DisGeNETi
5204

Open Targets

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OpenTargetsi
ENSG00000123349

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA33210

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

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Pharosi
Q99471, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PFDN5

Domain mapping of disease mutations (DMDM)

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DMDMi
12231038

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001536612 – 154Prefoldin subunit 5Add BLAST153

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
Modified residuei42N6-acetyllysineCombined sources1
Modified residuei56PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q99471

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q99471

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q99471

MaxQB - The MaxQuant DataBase

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MaxQBi
Q99471

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q99471

PeptideAtlas

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PeptideAtlasi
Q99471

PRoteomics IDEntifications database

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PRIDEi
Q99471

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
78287 [Q99471-1]
78288 [Q99471-2]
78289 [Q99471-3]

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q99471-1 [Q99471-1]
Q99471-3 [Q99471-3]

2D gel databases

USC-OGP 2-DE database

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OGPi
Q99471

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q99471

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q99471

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99471

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in pancreas and skeletal muscle and moderately in other tissues.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000123349, Expressed in testis and 113 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99471, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99471, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000123349, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to MYC; interacts with its N-terminal domain.

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q99471
With#Exp.IntAct
ABI2 - isoform 2 [Q9NYB9-2]3EBI-357275,EBI-11096309
ANKRD55 [Q3KP44]3EBI-357275,EBI-14493093
BCAS2 [O75934]3EBI-357275,EBI-1050106
BCL6 [P41182]3EBI-357275,EBI-765407
BHLHE40 [O14503]3EBI-357275,EBI-711810
C10orf55 [Q5SWW7]3EBI-357275,EBI-12809220
C10orf62 [Q5T681]3EBI-357275,EBI-744052
C20orf85 [Q9H1P6]3EBI-357275,EBI-12155483
C22orf39 [Q6P5X5]3EBI-357275,EBI-7317823
C4orf45 [Q96LM5]3EBI-357275,EBI-12020542
C7orf31 [Q8N865]3EBI-357275,EBI-10174456
CALCOCO2 [Q13137]4EBI-357275,EBI-739580
CCDC198 [E9PSE9]3EBI-357275,EBI-11748295
CSPP1 - isoform 1 [Q1MSJ5-1]3EBI-357275,EBI-10239122
DMRT3 [Q9NQL9]3EBI-357275,EBI-9679045
DOK4 [Q8TEW6]3EBI-357275,EBI-6918542
DOK5 - isoform 2 [Q9P104-2]3EBI-357275,EBI-10692909
ELK3 [P41970]3EBI-357275,EBI-1758534
ESPNL [Q6ZVH7]3EBI-357275,EBI-12831272
FAAP20 - isoform 4 [Q6NZ36-4]3EBI-357275,EBI-12013806
FAM102A - isoform 3 [Q5T9C2-3]3EBI-357275,EBI-11980989
FAM110A [Q9BQ89]3EBI-357275,EBI-1752811
FAM214B [Q7L5A3]3EBI-357275,EBI-745689
FAM221A [A4D161]3EBI-357275,EBI-11960181
FAM222B [Q8WU58]3EBI-357275,EBI-2807642
FAM90A1 [Q86YD7]3EBI-357275,EBI-6658203
GLRX3 [O76003]3EBI-357275,EBI-374781
GLYCTK [Q8IVS8]3EBI-357275,EBI-748515
GPANK1 [O95872]3EBI-357275,EBI-751540
GSTO2 [Q9H4Y5]3EBI-357275,EBI-10194609
GUCD1 - isoform 2 [Q96NT3-2]3EBI-357275,EBI-11978177
HAPLN2 [Q9GZV7]3EBI-357275,EBI-11956675
HHEX [Q03014]3EBI-357275,EBI-747421
HOXB9 [P17482]3EBI-357275,EBI-745290
HOXC8 [P31273]3EBI-357275,EBI-1752118
HTT [P42858]3EBI-357275,EBI-466029
IKZF3 [Q9UKT9]7EBI-357275,EBI-747204
IL16 - isoform 2 [Q14005-2]3EBI-357275,EBI-17178971
INCA1 [Q0VD86]3EBI-357275,EBI-6509505
IRX2 [Q9BZI1]3EBI-357275,EBI-12166369
IRX6 [P78412]3EBI-357275,EBI-12100506
KCTD9 [Q7L273]3EBI-357275,EBI-4397613
KDM1A [O60341]3EBI-357275,EBI-710124
KLF11 [O14901]3EBI-357275,EBI-948266
KLHL38 [Q2WGJ6]3EBI-357275,EBI-6426443
KLHL42 [Q9P2K6]3EBI-357275,EBI-739890
LARP4 [Q6P4E2]3EBI-357275,EBI-12079790
LNX1 [Q8TBB1]3EBI-357275,EBI-739832
MAP2K5 [Q13163]3EBI-357275,EBI-307294
METTL21A [Q8WXB1]3EBI-357275,EBI-8652459
MISP [Q8IVT2]3EBI-357275,EBI-2555085
MRPL45 [Q9BRJ2]3EBI-357275,EBI-2514313
MYOT [Q9UBF9]3EBI-357275,EBI-296701
MYOZ1 [Q9NP98]3EBI-357275,EBI-744402
NEUROG2 [Q9H2A3]3EBI-357275,EBI-7969348
NOXA1 - isoform 2 [Q86UR1-2]3EBI-357275,EBI-12025760
NTAQ1 [Q96HA8]3EBI-357275,EBI-741158
PATZ1 - isoform 4 [Q9HBE1-4]3EBI-357275,EBI-11022007
PAX9 [P55771]3EBI-357275,EBI-12111000
PEX26 [Q7Z412]3EBI-357275,EBI-752057
PFDN2 [Q9UHV9]5EBI-357275,EBI-359873
PHF1 [O43189]3EBI-357275,EBI-530034
PHF24 [Q9UPV7]3EBI-357275,EBI-17717171
PILRA [C9JJ79]3EBI-357275,EBI-12117156
PITX1 [P78337]3EBI-357275,EBI-748265
PITX2 - isoform PTX2C [Q99697-2]3EBI-357275,EBI-12138495
POGZ [Q7Z3K3]3EBI-357275,EBI-1389308
PPP1R32 - isoform 2 [Q7Z5V6-2]3EBI-357275,EBI-12000762
PRKAB2 [O43741]3EBI-357275,EBI-1053424
PRPF18 [Q99633]3EBI-357275,EBI-2798416
PRR35 [P0CG20]3EBI-357275,EBI-11986293
PSMB4 [P28070]3EBI-357275,EBI-603350
PSMB8 - isoform 2 [P28062-2]3EBI-357275,EBI-372312
PSME3 [P61289]6EBI-357275,EBI-355546
RIBC1 [Q8N443]3EBI-357275,EBI-10265323
RIPPLY1 [Q0D2K3]3EBI-357275,EBI-10226430
RSRC2 [Q7L4I2]3EBI-357275,EBI-953753
RUSC1 [Q9BVN2]3EBI-357275,EBI-6257312
SAXO1 [Q8IYX7]3EBI-357275,EBI-3957636
SCNM1 [Q9BWG6]3EBI-357275,EBI-748391
SDCBP [O00560]3EBI-357275,EBI-727004
SHISA6 [Q6ZSJ9]3EBI-357275,EBI-12037847
SLAIN1 [Q8ND83]3EBI-357275,EBI-10269374
SMAP1 - isoform 2 [Q8IYB5-2]3EBI-357275,EBI-12061577
SMG9 [Q9H0W8]3EBI-357275,EBI-2872322
SNAI1 [O95863]3EBI-357275,EBI-1045459
SNRNP25 [Q9BV90]3EBI-357275,EBI-9675976
SNRPB - isoform SM-B [P14678-2]3EBI-357275,EBI-372475
SOHLH1 [Q5JUK2]3EBI-357275,EBI-12288855
SPAG8 - isoform 2 [Q99932-2]3EBI-357275,EBI-11959123
SPG21 [Q9NZD8]3EBI-357275,EBI-742688
STK19 [B7ZLI8]3EBI-357275,EBI-10176124
SYT17 [Q9BSW7]3EBI-357275,EBI-745392
TAF6L [Q9Y6J9]3EBI-357275,EBI-743984
TBX3 [O15119]3EBI-357275,EBI-3452216
TCF19 [Q9Y242]3EBI-357275,EBI-7413767
TFG [Q92734]3EBI-357275,EBI-357061
TLE5 - isoform 2 [Q08117-2]3EBI-357275,EBI-11741437
TRAPPC6A - isoform 2 [O75865-2]3EBI-357275,EBI-8451480
VAX2 [Q9UIW0]3EBI-357275,EBI-12090999
VBP1 [P61758]7EBI-357275,EBI-357430
VEZF1 [Q14119]3EBI-357275,EBI-11980193
VGLL1 [Q99990]3EBI-357275,EBI-11983165
WDR25 - isoform 2 [Q64LD2-2]3EBI-357275,EBI-12032042
YPEL5 [P62699]3EBI-357275,EBI-11721624
ZC2HC1C - isoform 2 [Q53FD0-2]3EBI-357275,EBI-14104088
ZNF148 - isoform 2 [Q9UQR1-2]3EBI-357275,EBI-11742222
vIRF-3 [Q9DUN1] from Human herpesvirus 8.8EBI-357275,EBI-1647907

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
111226, 200 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-6149, Prefoldin co-chaperone complex

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q99471

Database of interacting proteins

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DIPi
DIP-28155N

Protein interaction database and analysis system

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IntActi
Q99471, 155 interactors

Molecular INTeraction database

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MINTi
Q99471

STRING: functional protein association networks

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STRINGi
9606.ENSP00000447942

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99471, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99471

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the prefoldin subunit alpha family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3048, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00390000008783

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
CLU_091867_0_1_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99471

Identification of Orthologs from Complete Genome Data

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OMAi
VPGKLCD

Database of Orthologous Groups

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OrthoDBi
1449403at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99471

TreeFam database of animal gene trees

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TreeFami
TF106509

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.287.370, 1 hit

HAMAP database of protein families

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HAMAPi
MF_00308, PfdA, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR011599, PFD_alpha_archaea
IPR009053, Prefoldin
IPR004127, Prefoldin_subunit_alpha

Pfam protein domain database

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Pfami
View protein in Pfam
PF02996, Prefoldin, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00293, TIGR00293, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99471-1) [UniParc]FASTAAdd to basket
Also known as: MM1-alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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        10         20         30         40         50
MAQSINITEL NLPQLEMLKN QLDQEVEFLS TSIAQLKVVQ TKYVEAKDCL
60 70 80 90 100
NVLNKSNEGK ELLVPLTSSM YVPGKLHDVE HVLIDVGTGY YVEKTAEDAK
110 120 130 140 150
DFFKRKIDFL TKQMEKIQPA LQEKHAMKQA VMEMMSQKIQ QLTALGAAQA

TAKA
Length:154
Mass (Da):17,328
Last modified:January 11, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0DA1F3644548CB14
GO
Isoform 2 (identifier: Q99471-2) [UniParc]FASTAAdd to basket
Also known as: MM1-beta

The sequence of this isoform differs from the canonical sequence as follows:
     59-154: GKELLVPLTS...LGAAQATAKA → DVCPWEAA

Note: Does not repress transcription activity of MYC.Curated
Show »
Length:66
Mass (Da):7,481
Checksum:iC07E3472E5BD2A76
GO
Isoform 3 (identifier: Q99471-3) [UniParc]FASTAAdd to basket
Also known as: MM1-gamma

The sequence of this isoform differs from the canonical sequence as follows:
     25-69: Missing.

Show »
Length:109
Mass (Da):12,379
Checksum:i899AFF472DCC00D7
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BPF6H3BPF6_HUMAN
Prefoldin subunit 5
PFDN5
152Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BMQ1H3BMQ1_HUMAN
Prefoldin subunit 5
PFDN5
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VQZ2F8VQZ2_HUMAN
Prefoldin subunit 5
PFDN5
37Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VNW6F8VNW6_HUMAN
Prefoldin subunit 5
PFDN5
29Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA14006 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04310325 – 69Missing in isoform 3. 1 PublicationAdd BLAST45
Alternative sequenceiVSP_04310459 – 154GKELL…ATAKA → DVCPWEAA in isoform 2. 1 PublicationAdd BLAST96

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D89667 mRNA Translation: BAA14006.1 Different initiation.
AB055802 Genomic DNA Translation: BAB32643.1
AB055803 mRNA Translation: BAB32644.1
AB055804 mRNA Translation: BAB32645.1
AB055805 mRNA Translation: BAB32646.1
BT007195 mRNA Translation: AAP35859.1
AK292623 mRNA Translation: BAF85312.1
AC073611 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96683.1
CH471054 Genomic DNA Translation: EAW96685.1
BC003373 mRNA No translation available.
BC062671 mRNA Translation: AAH62671.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8853.1 [Q99471-1]
CCDS8854.1 [Q99471-3]

NCBI Reference Sequences

More...
RefSeqi
NP_002615.2, NM_002624.3 [Q99471-1]
NP_665904.1, NM_145897.2 [Q99471-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000243040; ENSP00000243040; ENSG00000123349 [Q99471-2]
ENST00000334478; ENSP00000334188; ENSG00000123349 [Q99471-1]
ENST00000351500; ENSP00000266964; ENSG00000123349 [Q99471-3]
ENST00000551018; ENSP00000447942; ENSG00000123349 [Q99471-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
5204

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:5204

UCSC genome browser

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UCSCi
uc001scl.5, human [Q99471-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89667 mRNA Translation: BAA14006.1 Different initiation.
AB055802 Genomic DNA Translation: BAB32643.1
AB055803 mRNA Translation: BAB32644.1
AB055804 mRNA Translation: BAB32645.1
AB055805 mRNA Translation: BAB32646.1
BT007195 mRNA Translation: AAP35859.1
AK292623 mRNA Translation: BAF85312.1
AC073611 Genomic DNA No translation available.
CH471054 Genomic DNA Translation: EAW96683.1
CH471054 Genomic DNA Translation: EAW96685.1
BC003373 mRNA No translation available.
BC062671 mRNA Translation: AAH62671.1
CCDSiCCDS8853.1 [Q99471-1]
CCDS8854.1 [Q99471-3]
RefSeqiNP_002615.2, NM_002624.3 [Q99471-1]
NP_665904.1, NM_145897.2 [Q99471-3]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6NR8electron microscopy7.80511-137[»]
6NR9electron microscopy8.50511-137[»]
6NRBelectron microscopy8.70511-137[»]
6NRCelectron microscopy8.30511-137[»]
6NRDelectron microscopy8.20511-137[»]
SMRiQ99471
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi111226, 200 interactors
ComplexPortaliCPX-6149, Prefoldin co-chaperone complex
CORUMiQ99471
DIPiDIP-28155N
IntActiQ99471, 155 interactors
MINTiQ99471
STRINGi9606.ENSP00000447942

PTM databases

iPTMnetiQ99471
PhosphoSitePlusiQ99471
SwissPalmiQ99471

Genetic variation databases

BioMutaiPFDN5
DMDMi12231038

2D gel databases

OGPiQ99471

Proteomic databases

EPDiQ99471
jPOSTiQ99471
MassIVEiQ99471
MaxQBiQ99471
PaxDbiQ99471
PeptideAtlasiQ99471
PRIDEiQ99471
ProteomicsDBi78287 [Q99471-1]
78288 [Q99471-2]
78289 [Q99471-3]
TopDownProteomicsiQ99471-1 [Q99471-1]
Q99471-3 [Q99471-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1782, 243 antibodies

The DNASU plasmid repository

More...
DNASUi
5204

Genome annotation databases

EnsembliENST00000243040; ENSP00000243040; ENSG00000123349 [Q99471-2]
ENST00000334478; ENSP00000334188; ENSG00000123349 [Q99471-1]
ENST00000351500; ENSP00000266964; ENSG00000123349 [Q99471-3]
ENST00000551018; ENSP00000447942; ENSG00000123349 [Q99471-1]
GeneIDi5204
KEGGihsa:5204
UCSCiuc001scl.5, human [Q99471-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5204
DisGeNETi5204

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PFDN5
HGNCiHGNC:8869, PFDN5
HPAiENSG00000123349, Low tissue specificity
MIMi604899, gene
neXtProtiNX_Q99471
OpenTargetsiENSG00000123349
PharmGKBiPA33210
VEuPathDBiHostDB:ENSG00000123349.13

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3048, Eukaryota
GeneTreeiENSGT00390000008783
HOGENOMiCLU_091867_0_1_1
InParanoidiQ99471
OMAiVPGKLCD
OrthoDBi1449403at2759
PhylomeDBiQ99471
TreeFamiTF106509

Enzyme and pathway databases

PathwayCommonsiQ99471
ReactomeiR-HSA-389957, Prefoldin mediated transfer of substrate to CCT/TriC

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
5204, 427 hits in 883 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PFDN5, human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
PFDN5

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5204
PharosiQ99471, Tbio

Protein Ontology

More...
PROi
PR:Q99471
RNActiQ99471, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000123349, Expressed in testis and 113 other tissues
ExpressionAtlasiQ99471, baseline and differential
GenevisibleiQ99471, HS

Family and domain databases

Gene3Di1.10.287.370, 1 hit
HAMAPiMF_00308, PfdA, 1 hit
InterProiView protein in InterPro
IPR011599, PFD_alpha_archaea
IPR009053, Prefoldin
IPR004127, Prefoldin_subunit_alpha
PfamiView protein in Pfam
PF02996, Prefoldin, 1 hit
TIGRFAMsiTIGR00293, TIGR00293, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPFD5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99471
Secondary accession number(s): A8K9A8
, Q54AA8, Q9C083, Q9C084
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2001
Last modified: February 10, 2021
This is version 185 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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