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Protein

SH3 and cysteine-rich domain-containing protein

Gene

STAC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 159Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST53

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandMetal-binding, Zinc

Protein family/group databases

TCDBi8.A.34.1.2 the endophilin (endophilin) family

Names & Taxonomyi

Protein namesi
Recommended name:
SH3 and cysteine-rich domain-containing protein
Alternative name(s):
Src homology 3 and cysteine-rich domain-containing protein
Gene namesi
Name:STAC
Synonyms:STAC11 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000144681.10
HGNCiHGNC:11353 STAC
MIMi602317 gene
neXtProtiNX_Q99469

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6769
OpenTargetsiENSG00000144681
PharmGKBiPA36175

Polymorphism and mutation databases

BioMutaiSTAC
DMDMi12229989

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000722351 – 402SH3 and cysteine-rich domain-containing proteinAdd BLAST402

Proteomic databases

PaxDbiQ99469
PeptideAtlasiQ99469
PRIDEiQ99469
ProteomicsDBi78285

PTM databases

iPTMnetiQ99469
PhosphoSitePlusiQ99469

Expressioni

Gene expression databases

BgeeiENSG00000144681 Expressed in 138 organ(s), highest expression level in dorsal root ganglion
CleanExiHS_STAC
ExpressionAtlasiQ99469 baseline and differential
GenevisibleiQ99469 HS

Organism-specific databases

HPAiHPA035143

Interactioni

Subunit structurei

Interacts (via SH3 domains) with CACNA1S (PubMed:29078335). Interacts with CACNA1H. Interacts with CACNA1C (By similarity).By similarity1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112646, 18 interactors
IntActiQ99469, 18 interactors
MINTiQ99469
STRINGi9606.ENSP00000273183

Structurei

Secondary structure

1402
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99469
SMRiQ99469
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99469

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini285 – 344SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini347 – 402SH3 2PROSITE-ProRule annotationAdd BLAST56

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 159Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Repeat, SH3 domain, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IF5B Eukaryota
ENOG410XQKX LUCA
GeneTreeiENSGT00390000008822
HOGENOMiHOG000230980
HOVERGENiHBG017859
InParanoidiQ99469
OMAiPKGFRRY
OrthoDBiEOG091G085P
PhylomeDBiQ99469
TreeFamiTF332878

Family and domain databases

CDDicd00029 C1, 1 hit
InterProiView protein in InterPro
IPR002219 PE/DAG-bd
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035508 STAC1
PANTHERiPTHR15135:SF3 PTHR15135:SF3, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 2 hits
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99469-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK
60 70 80 90 100
SLRSKSADNF FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG
110 120 130 140 150
LHPGGKAHAF QEYIFKKPTF CDVCNHMIVG TNAKHGLRCK ACKMSIHHKC
160 170 180 190 200
TDGLAPQRCM GKLPKGFRRY YSSPLLIHEQ FGCIKEVMPI ACGNKVDPVY
210 220 230 240 250
ETLRFGTSLA QRTKKGSSGS GSDSPHRTST SDLVEVPEEA NGPGGGYDLR
260 270 280 290 300
KRSNSVFTYP ENGTDDFRDP AKNINHQGSL SKDPLQMNTY VALYKFVPQE
310 320 330 340 350
NEDLEMRPGD IITLLEDSNE DWWKGKIQDR IGFFPANFVQ RLQQNEKIFR
360 370 380 390 400
CVRTFIGCKE QGQITLKENQ ICVSSEEEQD GFIRVLSGKK KGLIPLDVLE

NI
Length:402
Mass (Da):44,554
Last modified:May 1, 1997 - v1
Checksum:i211688D178E4F905
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PEA7E9PEA7_HUMAN
SH3 and cysteine-rich domain-contai...
STAC
341Annotation score:
C9J3Z9C9J3Z9_HUMAN
SH3 and cysteine-rich domain-contai...
STAC
252Annotation score:
F8WB25F8WB25_HUMAN
SH3 and cysteine-rich domain-contai...
STAC
51Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034505262N → S. Corresponds to variant dbSNP:rs7634545Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86640 mRNA Translation: BAA13152.1
AK313493 mRNA Translation: BAG36275.1
CH471055 Genomic DNA Translation: EAW64474.1
CCDSiCCDS2662.1
PIRiJC5270
RefSeqiNP_003140.1, NM_003149.2
UniGeneiHs.56045

Genome annotation databases

EnsembliENST00000273183; ENSP00000273183; ENSG00000144681
GeneIDi6769
KEGGihsa:6769
UCSCiuc003cgh.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86640 mRNA Translation: BAA13152.1
AK313493 mRNA Translation: BAG36275.1
CH471055 Genomic DNA Translation: EAW64474.1
CCDSiCCDS2662.1
PIRiJC5270
RefSeqiNP_003140.1, NM_003149.2
UniGeneiHs.56045

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DL4NMR-A288-342[»]
6B25X-ray2.39A288-402[»]
ProteinModelPortaliQ99469
SMRiQ99469
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112646, 18 interactors
IntActiQ99469, 18 interactors
MINTiQ99469
STRINGi9606.ENSP00000273183

Protein family/group databases

TCDBi8.A.34.1.2 the endophilin (endophilin) family

PTM databases

iPTMnetiQ99469
PhosphoSitePlusiQ99469

Polymorphism and mutation databases

BioMutaiSTAC
DMDMi12229989

Proteomic databases

PaxDbiQ99469
PeptideAtlasiQ99469
PRIDEiQ99469
ProteomicsDBi78285

Protocols and materials databases

DNASUi6769
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273183; ENSP00000273183; ENSG00000144681
GeneIDi6769
KEGGihsa:6769
UCSCiuc003cgh.2 human

Organism-specific databases

CTDi6769
DisGeNETi6769
EuPathDBiHostDB:ENSG00000144681.10
GeneCardsiSTAC
H-InvDBiHIX0119145
HGNCiHGNC:11353 STAC
HPAiHPA035143
MIMi602317 gene
neXtProtiNX_Q99469
OpenTargetsiENSG00000144681
PharmGKBiPA36175
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF5B Eukaryota
ENOG410XQKX LUCA
GeneTreeiENSGT00390000008822
HOGENOMiHOG000230980
HOVERGENiHBG017859
InParanoidiQ99469
OMAiPKGFRRY
OrthoDBiEOG091G085P
PhylomeDBiQ99469
TreeFamiTF332878

Miscellaneous databases

EvolutionaryTraceiQ99469
GenomeRNAii6769
PROiPR:Q99469
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000144681 Expressed in 138 organ(s), highest expression level in dorsal root ganglion
CleanExiHS_STAC
ExpressionAtlasiQ99469 baseline and differential
GenevisibleiQ99469 HS

Family and domain databases

CDDicd00029 C1, 1 hit
InterProiView protein in InterPro
IPR002219 PE/DAG-bd
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035508 STAC1
PANTHERiPTHR15135:SF3 PTHR15135:SF3, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 2 hits
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTAC_HUMAN
AccessioniPrimary (citable) accession number: Q99469
Secondary accession number(s): B2R8S8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: September 12, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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