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Protein

SH3 and cysteine-rich domain-containing protein

Gene

STAC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes expression of the ion channel CACNA1H at the cell membrane, and thereby contributes to the regulation of channel activity. Plays a minor and redundant role in promoting the expression of calcium channel CACNA1S at the cell membrane, and thereby contributes to increased channel activity. Slows down the inactivation rate of the calcium channel CACNA1C.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri107 – 159Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST53

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Protein family/group databases

Transport Classification Database

More...
TCDBi
8.A.34.1.2 the endophilin (endophilin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SH3 and cysteine-rich domain-containing protein
Alternative name(s):
Src homology 3 and cysteine-rich domain-containing protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:STAC
Synonyms:STAC11 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000144681.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11353 STAC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602317 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99469

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
6769

Open Targets

More...
OpenTargetsi
ENSG00000144681

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36175

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
STAC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12229989

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000722351 – 402SH3 and cysteine-rich domain-containing proteinAdd BLAST402

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99469

PeptideAtlas

More...
PeptideAtlasi
Q99469

PRoteomics IDEntifications database

More...
PRIDEi
Q99469

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78285

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99469

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99469

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000144681 Expressed in 138 organ(s), highest expression level in dorsal root ganglion

CleanEx database of gene expression profiles

More...
CleanExi
HS_STAC

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99469 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99469 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA035143

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via SH3 domains) with CACNA1S (PubMed:29078335). Interacts with CACNA1H. Interacts with CACNA1C (By similarity).By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112646, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q99469, 18 interactors

Molecular INTeraction database

More...
MINTi
Q99469

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000273183

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1402
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q99469

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99469

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q99469

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini285 – 344SH3 1PROSITE-ProRule annotationAdd BLAST60
Domaini347 – 402SH3 2PROSITE-ProRule annotationAdd BLAST56

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri107 – 159Phorbol-ester/DAG-typePROSITE-ProRule annotationAdd BLAST53

Keywords - Domaini

Repeat, SH3 domain, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IF5B Eukaryota
ENOG410XQKX LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154000

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230980

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG017859

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99469

Identification of Orthologs from Complete Genome Data

More...
OMAi
EMRPGDM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G085P

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99469

TreeFam database of animal gene trees

More...
TreeFami
TF332878

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00029 C1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002219 PE/DAG-bd
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035508 STAC1
IPR039688 STAC1/2/3

The PANTHER Classification System

More...
PANTHERi
PTHR15135 PTHR15135, 1 hit
PTHR15135:SF3 PTHR15135:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00130 C1_1, 1 hit
PF00018 SH3_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00452 SH3DOMAIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00109 C1, 1 hit
SM00326 SH3, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50044 SSF50044, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50002 SH3, 2 hits
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99469-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIPPSSPRED GVDGLPKEAV GAEQPPSPAS TSSQESKLQK LKRSLSFKTK
60 70 80 90 100
SLRSKSADNF FQRTNSEDMK LQAHMVAEIS PSSSPLPAPG SLTSTPARAG
110 120 130 140 150
LHPGGKAHAF QEYIFKKPTF CDVCNHMIVG TNAKHGLRCK ACKMSIHHKC
160 170 180 190 200
TDGLAPQRCM GKLPKGFRRY YSSPLLIHEQ FGCIKEVMPI ACGNKVDPVY
210 220 230 240 250
ETLRFGTSLA QRTKKGSSGS GSDSPHRTST SDLVEVPEEA NGPGGGYDLR
260 270 280 290 300
KRSNSVFTYP ENGTDDFRDP AKNINHQGSL SKDPLQMNTY VALYKFVPQE
310 320 330 340 350
NEDLEMRPGD IITLLEDSNE DWWKGKIQDR IGFFPANFVQ RLQQNEKIFR
360 370 380 390 400
CVRTFIGCKE QGQITLKENQ ICVSSEEEQD GFIRVLSGKK KGLIPLDVLE

NI
Length:402
Mass (Da):44,554
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i211688D178E4F905
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PEA7E9PEA7_HUMAN
SH3 and cysteine-rich domain-contai...
STAC
341Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J3Z9C9J3Z9_HUMAN
SH3 and cysteine-rich domain-contai...
STAC
252Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WB25F8WB25_HUMAN
SH3 and cysteine-rich domain-contai...
STAC
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_034505262N → S. Corresponds to variant dbSNP:rs7634545Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D86640 mRNA Translation: BAA13152.1
AK313493 mRNA Translation: BAG36275.1
CH471055 Genomic DNA Translation: EAW64474.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2662.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5270

NCBI Reference Sequences

More...
RefSeqi
NP_003140.1, NM_003149.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.56045

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000273183; ENSP00000273183; ENSG00000144681

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
6769

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:6769

UCSC genome browser

More...
UCSCi
uc003cgh.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86640 mRNA Translation: BAA13152.1
AK313493 mRNA Translation: BAG36275.1
CH471055 Genomic DNA Translation: EAW64474.1
CCDSiCCDS2662.1
PIRiJC5270
RefSeqiNP_003140.1, NM_003149.2
UniGeneiHs.56045

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DL4NMR-A288-342[»]
6B25X-ray2.39A288-402[»]
ProteinModelPortaliQ99469
SMRiQ99469
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112646, 19 interactors
IntActiQ99469, 18 interactors
MINTiQ99469
STRINGi9606.ENSP00000273183

Protein family/group databases

TCDBi8.A.34.1.2 the endophilin (endophilin) family

PTM databases

iPTMnetiQ99469
PhosphoSitePlusiQ99469

Polymorphism and mutation databases

BioMutaiSTAC
DMDMi12229989

Proteomic databases

PaxDbiQ99469
PeptideAtlasiQ99469
PRIDEiQ99469
ProteomicsDBi78285

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
6769
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000273183; ENSP00000273183; ENSG00000144681
GeneIDi6769
KEGGihsa:6769
UCSCiuc003cgh.2 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6769
DisGeNETi6769
EuPathDBiHostDB:ENSG00000144681.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
STAC

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0119145
HGNCiHGNC:11353 STAC
HPAiHPA035143
MIMi602317 gene
neXtProtiNX_Q99469
OpenTargetsiENSG00000144681
PharmGKBiPA36175

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF5B Eukaryota
ENOG410XQKX LUCA
GeneTreeiENSGT00940000154000
HOGENOMiHOG000230980
HOVERGENiHBG017859
InParanoidiQ99469
OMAiEMRPGDM
OrthoDBiEOG091G085P
PhylomeDBiQ99469
TreeFamiTF332878

Miscellaneous databases

EvolutionaryTraceiQ99469

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
6769

Protein Ontology

More...
PROi
PR:Q99469

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000144681 Expressed in 138 organ(s), highest expression level in dorsal root ganglion
CleanExiHS_STAC
ExpressionAtlasiQ99469 baseline and differential
GenevisibleiQ99469 HS

Family and domain databases

CDDicd00029 C1, 1 hit
InterProiView protein in InterPro
IPR002219 PE/DAG-bd
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR035508 STAC1
IPR039688 STAC1/2/3
PANTHERiPTHR15135 PTHR15135, 1 hit
PTHR15135:SF3 PTHR15135:SF3, 1 hit
PfamiView protein in Pfam
PF00130 C1_1, 1 hit
PF00018 SH3_1, 1 hit
PRINTSiPR00452 SH3DOMAIN
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50002 SH3, 2 hits
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSTAC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99469
Secondary accession number(s): B2R8S8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 1997
Last modified: December 5, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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