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UniProtKB - Q99467 (CD180_HUMAN)

Entry version 174 (25 May 2022)
Sequence version 2 (18 May 2010)
Previous versions | rss
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Protein

CD180 antigen

Gene

CD180

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q99467

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-166016, Toll Like Receptor 4 (TLR4) Cascade

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q99467

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD180 antigen
Alternative name(s):
Lymphocyte antigen 64
Radioprotective 105 kDa protein
CD_antigen: CD180
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD180
Synonyms:LY64, RP105
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:6726, CD180

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602226, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99467

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000134061

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini24 – 626ExtracellularSequence analysisAdd BLAST603
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei627 – 650HelicalSequence analysisAdd BLAST24
Topological domaini651 – 661CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		4064

Open Targets

More...OpenTargetsi		ENSG00000134061

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA30490

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99467, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CD180

Domain mapping of disease mutations (DMDM)

More...DMDMi		296434437

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 231 PublicationAdd BLAST23
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000003474124 – 661CD180 antigenAdd BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi451N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi573N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99467

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99467

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99467

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99467

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99467

PeptideAtlas

More...PeptideAtlasi		Q99467

PRoteomics IDEntifications database

More...PRIDEi		Q99467

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78284

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q99467, 11 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99467

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99467

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000134061, Expressed in blood and 136 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99467, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000134061, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

M-shaped tetramer of two CD180-LY86 heterodimers.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		110242, 1 interactor

Database of interacting proteins

More...DIPi		DIP-59104N

Protein interaction database and analysis system

More...IntActi		Q99467, 1 interactor

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000256447

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99467, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1661
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q99467

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99467

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 53LRRNTAdd BLAST21
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati54 – 75LRR 1Add BLAST22
Repeati78 – 99LRR 2Add BLAST22
Repeati102 – 123LRR 3Add BLAST22
Repeati126 – 147LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati201 – 221LRR 7Add BLAST21
Repeati275 – 296LRR 8Add BLAST22
Repeati299 – 320LRR 9Add BLAST22
Repeati322 – 343LRR 10Add BLAST22
Repeati346 – 366LRR 11Add BLAST21
Repeati371 – 391LRR 12Add BLAST21
Repeati397 – 418LRR 13Add BLAST22
Repeati421 – 442LRR 14Add BLAST22
Repeati446 – 466LRR 15Add BLAST21
Repeati470 – 493LRR 16Add BLAST24
Repeati497 – 518LRR 17Add BLAST22
Repeati521 – 544LRR 18Add BLAST24
Repeati546 – 564LRR 19Add BLAST19
Domaini577 – 627LRRCTAdd BLAST51

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4641, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161183

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_006000_5_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99467

Identification of Orthologs from Complete Genome Data

More...OMAi		MCTEKEA

Database of Orthologous Groups

More...OrthoDBi		826997at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99467

TreeFam database of animal gene trees

More...TreeFami		TF351113

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR041281, LRR_11
IPR032675, LRR_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00560, LRR_1, 1 hit
PF18831, LRR_11, 1 hit
PF13855, LRR_8, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00369, LRR_TYP, 8 hits
SM00082, LRRCT, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51450, LRR, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q99467-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFDVSCFFW VVLFSAGCKV ITSWDQMCIE KEANKTYNCE NLGLSEIPDT 
        60         70         80         90        100
LPNTTEFLEF SFNFLPTIHN RTFSRLMNLT FLDLTRCQIN WIHEDTFQSH 
       110        120        130        140        150
HQLSTLVLTG NPLIFMAETS LNGPKSLKHL FLIQTGISNL EFIPVHNLEN 
       160        170        180        190        200
LESLYLGSNH ISSIKFPKDF PARNLKVLDF QNNAIHYISR EDMRSLEQAI 
       210        220        230        240        250
NLSLNFNGNN VKGIELGAFD STIFQSLNFG GTPNLSVIFN GLQNSTTQSL 
       260        270        280        290        300
WLGTFEDIDD EDISSAMLKG LCEMSVESLN LQEHRFSDIS STTFQCFTQL 
       310        320        330        340        350
QELDLTATHL KGLPSGMKGL NLLKKLVLSV NHFDQLCQIS AANFPSLTHL 
       360        370        380        390        400
YIRGNVKKLH LGVGCLEKLG NLQTLDLSHN DIEASDCCSL QLKNLSHLQT 
       410        420        430        440        450
LNLSHNEPLG LQSQAFKECP QLELLDLAFT RLHINAPQSP FQNLHFLQVL 
       460        470        480        490        500
NLTYCFLDTS NQHLLAGLPV LRHLNLKGNH FQDGTITKTN LLQTVGSLEV 
       510        520        530        540        550
LILSSCGLLS IDQQAFHSLG KMSHVDLSHN SLTCDSIDSL SHLKGIYLNL 
       560        570        580        590        600
AANSINIISP RLLPILSQQS TINLSHNPLD CTCSNIHFLT WYKENLHKLE 
       610        620        630        640        650
GSEETTCANP PSLRGVKLSD VKLSCGITAI GIFFLIVFLL LLAILLFFAV 
       660 
KYLLRWKYQH I
Length:661
Mass (Da):74,179
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i93DE3178594B3383
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti223I → V in BAA12019 (PubMed:8975706).Curated1
Sequence conflicti223I → V in BAG35994 (PubMed:14702039).Curated1
Sequence conflicti223I → V in EAW51318 (Ref. 4) Curated1
Sequence conflicti223I → V in AAI09070 (PubMed:15489334).Curated1
Sequence conflicti223I → V in AAI09071 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05729820V → L. Corresponds to variant dbSNP:rs5744463Ensembl.1
Natural variantiVAR_02197853N → K. Corresponds to variant dbSNP:rs16875312Ensembl.1
Natural variantiVAR_02197999S → R. Corresponds to variant dbSNP:rs2230520Ensembl.1
Natural variantiVAR_057299259D → N. Corresponds to variant dbSNP:rs5744525Ensembl.1
Natural variantiVAR_061859356V → M. Corresponds to variant dbSNP:rs56752081Ensembl.1
Natural variantiVAR_057300430T → A. Corresponds to variant dbSNP:rs2230523EnsemblClinVar.1
Natural variantiVAR_057301648F → L. Corresponds to variant dbSNP:rs2230524Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D83597 mRNA Translation: BAA12019.1
AK313177 mRNA Translation: BAG35994.1
AC026445 Genomic DNA No translation available.
CH471137 Genomic DNA Translation: EAW51318.1
BC109069 mRNA Translation: AAI09070.1
BC109070 mRNA Translation: AAI09071.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS3992.1

NCBI Reference Sequences

More...RefSeqi		NP_005573.2, NM_005582.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000256447.5; ENSP00000256447.4; ENSG00000134061.5

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4064

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:4064

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000256447.5; ENSP00000256447.4; NM_005582.3; NP_005573.2

UCSC genome browser

More...UCSCi		uc003juy.3, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83597 mRNA Translation: BAA12019.1
AK313177 mRNA Translation: BAG35994.1
AC026445 Genomic DNA No translation available.
CH471137 Genomic DNA Translation: EAW51318.1
BC109069 mRNA Translation: AAI09070.1
BC109070 mRNA Translation: AAI09071.1
CCDSiCCDS3992.1
RefSeqiNP_005573.2, NM_005582.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B2DX-ray2.80A/B24-626[»]
AlphaFoldDBiQ99467
SMRiQ99467
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi110242, 1 interactor
DIPiDIP-59104N
IntActiQ99467, 1 interactor
STRINGi9606.ENSP00000256447

PTM databases

GlyGeniQ99467, 11 sites
iPTMnetiQ99467
PhosphoSitePlusiQ99467

Genetic variation databases

BioMutaiCD180
DMDMi296434437

Proteomic databases

EPDiQ99467
jPOSTiQ99467
MassIVEiQ99467
MaxQBiQ99467
PaxDbiQ99467
PeptideAtlasiQ99467
PRIDEiQ99467
ProteomicsDBi78284

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1122, 438 antibodies from 38 providers

The DNASU plasmid repository

More...DNASUi		4064

Genome annotation databases

EnsembliENST00000256447.5; ENSP00000256447.4; ENSG00000134061.5
GeneIDi4064
KEGGihsa:4064
MANE-SelectiENST00000256447.5; ENSP00000256447.4; NM_005582.3; NP_005573.2
UCSCiuc003juy.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4064
DisGeNETi4064

GeneCards: human genes, protein and diseases

More...GeneCardsi		CD180
HGNCiHGNC:6726, CD180
HPAiENSG00000134061, Tissue enhanced (lymphoid)
MIMi602226, gene
neXtProtiNX_Q99467
OpenTargetsiENSG00000134061
PharmGKBiPA30490
VEuPathDBiHostDB:ENSG00000134061

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4641, Eukaryota
GeneTreeiENSGT00940000161183
HOGENOMiCLU_006000_5_1_1
InParanoidiQ99467
OMAiMCTEKEA
OrthoDBi826997at2759
PhylomeDBiQ99467
TreeFamiTF351113

Enzyme and pathway databases

PathwayCommonsiQ99467
ReactomeiR-HSA-166016, Toll Like Receptor 4 (TLR4) Cascade
SignaLinkiQ99467

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4064, 9 hits in 1065 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CD180, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CD180

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4064
PharosiQ99467, Tbio

Protein Ontology

More...PROi		PR:Q99467
RNActiQ99467, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000134061, Expressed in blood and 136 other tissues
GenevisibleiQ99467, HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483, Cys-rich_flank_reg_C
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR041281, LRR_11
IPR032675, LRR_dom_sf
PfamiView protein in Pfam
PF00560, LRR_1, 1 hit
PF18831, LRR_11, 1 hit
PF13855, LRR_8, 3 hits
SMARTiView protein in SMART
SM00369, LRR_TYP, 8 hits
SM00082, LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 12 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD180_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99467
Secondary accession number(s): B2R7Z7, Q32MM5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 18, 2010
Last modified: May 25, 2022
This is version 174 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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