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Protein

CD180 antigen

Gene

CD180

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).By similarity

GO - Biological processi

  • B cell proliferation involved in immune response Source: GO_Central
  • cellular response to lipopolysaccharide Source: GO_Central
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • positive regulation of lipopolysaccharide-mediated signaling pathway Source: MGI

Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade

Names & Taxonomyi

Protein namesi
Recommended name:
CD180 antigen
Alternative name(s):
Lymphocyte antigen 64
Radioprotective 105 kDa protein
CD_antigen: CD180
Gene namesi
Name:CD180
Synonyms:LY64, RP105
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000134061.5
HGNCiHGNC:6726 CD180
MIMi602226 gene
neXtProtiNX_Q99467

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 626ExtracellularSequence analysisAdd BLAST603
Transmembranei627 – 650HelicalSequence analysisAdd BLAST24
Topological domaini651 – 661CytoplasmicSequence analysisAdd BLAST11

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4064
OpenTargetsiENSG00000134061
PharmGKBiPA30490

Polymorphism and mutation databases

BioMutaiCD180
DMDMi296434437

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 231 PublicationAdd BLAST23
ChainiPRO_000003474124 – 661CD180 antigenAdd BLAST638

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi53N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi78N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi234N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi394N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi451N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi573N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ99467
MaxQBiQ99467
PaxDbiQ99467
PeptideAtlasiQ99467
PRIDEiQ99467
ProteomicsDBi78284

PTM databases

iPTMnetiQ99467
PhosphoSitePlusiQ99467

Expressioni

Tissue specificityi

Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.

Gene expression databases

BgeeiENSG00000134061 Expressed in 107 organ(s), highest expression level in blood
CleanExiHS_CD180
GenevisibleiQ99467 HS

Organism-specific databases

HPAiHPA003740

Interactioni

Subunit structurei

M-shaped tetramer of two CD180-LY86 heterodimers.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
LY86O957113EBI-15940363,EBI-12203791

Protein-protein interaction databases

BioGridi110242, 1 interactor
DIPiDIP-59104N
IntActiQ99467, 1 interactor
STRINGi9606.ENSP00000256447

Structurei

Secondary structure

1661
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99467
SMRiQ99467
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 53LRRNTAdd BLAST21
Repeati54 – 75LRR 1Add BLAST22
Repeati78 – 99LRR 2Add BLAST22
Repeati102 – 123LRR 3Add BLAST22
Repeati126 – 147LRR 4Add BLAST22
Repeati150 – 171LRR 5Add BLAST22
Repeati174 – 195LRR 6Add BLAST22
Repeati201 – 221LRR 7Add BLAST21
Repeati275 – 296LRR 8Add BLAST22
Repeati299 – 320LRR 9Add BLAST22
Repeati322 – 343LRR 10Add BLAST22
Repeati346 – 366LRR 11Add BLAST21
Repeati371 – 391LRR 12Add BLAST21
Repeati397 – 418LRR 13Add BLAST22
Repeati421 – 442LRR 14Add BLAST22
Repeati446 – 466LRR 15Add BLAST21
Repeati470 – 493LRR 16Add BLAST24
Repeati497 – 518LRR 17Add BLAST22
Repeati521 – 544LRR 18Add BLAST24
Repeati546 – 564LRR 19Add BLAST19
Domaini577 – 627LRRCTAdd BLAST51

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000119006
HOGENOMiHOG000146395
HOVERGENiHBG050848
InParanoidiQ99467
KOiK06555
OMAiTRCQINW
OrthoDBiEOG091G01RC
PhylomeDBiQ99467
TreeFamiTF351113

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 12 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99467-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFDVSCFFW VVLFSAGCKV ITSWDQMCIE KEANKTYNCE NLGLSEIPDT
60 70 80 90 100
LPNTTEFLEF SFNFLPTIHN RTFSRLMNLT FLDLTRCQIN WIHEDTFQSH
110 120 130 140 150
HQLSTLVLTG NPLIFMAETS LNGPKSLKHL FLIQTGISNL EFIPVHNLEN
160 170 180 190 200
LESLYLGSNH ISSIKFPKDF PARNLKVLDF QNNAIHYISR EDMRSLEQAI
210 220 230 240 250
NLSLNFNGNN VKGIELGAFD STIFQSLNFG GTPNLSVIFN GLQNSTTQSL
260 270 280 290 300
WLGTFEDIDD EDISSAMLKG LCEMSVESLN LQEHRFSDIS STTFQCFTQL
310 320 330 340 350
QELDLTATHL KGLPSGMKGL NLLKKLVLSV NHFDQLCQIS AANFPSLTHL
360 370 380 390 400
YIRGNVKKLH LGVGCLEKLG NLQTLDLSHN DIEASDCCSL QLKNLSHLQT
410 420 430 440 450
LNLSHNEPLG LQSQAFKECP QLELLDLAFT RLHINAPQSP FQNLHFLQVL
460 470 480 490 500
NLTYCFLDTS NQHLLAGLPV LRHLNLKGNH FQDGTITKTN LLQTVGSLEV
510 520 530 540 550
LILSSCGLLS IDQQAFHSLG KMSHVDLSHN SLTCDSIDSL SHLKGIYLNL
560 570 580 590 600
AANSINIISP RLLPILSQQS TINLSHNPLD CTCSNIHFLT WYKENLHKLE
610 620 630 640 650
GSEETTCANP PSLRGVKLSD VKLSCGITAI GIFFLIVFLL LLAILLFFAV
660
KYLLRWKYQH I
Length:661
Mass (Da):74,179
Last modified:May 18, 2010 - v2
Checksum:i93DE3178594B3383
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti223I → V in BAA12019 (PubMed:8975706).Curated1
Sequence conflicti223I → V in BAG35994 (PubMed:14702039).Curated1
Sequence conflicti223I → V in EAW51318 (Ref. 4) Curated1
Sequence conflicti223I → V in AAI09070 (PubMed:15489334).Curated1
Sequence conflicti223I → V in AAI09071 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05729820V → L. Corresponds to variant dbSNP:rs5744463Ensembl.1
Natural variantiVAR_02197853N → K. Corresponds to variant dbSNP:rs16875312Ensembl.1
Natural variantiVAR_02197999S → R. Corresponds to variant dbSNP:rs2230520Ensembl.1
Natural variantiVAR_057299259D → N. Corresponds to variant dbSNP:rs5744525Ensembl.1
Natural variantiVAR_061859356V → M. Corresponds to variant dbSNP:rs56752081Ensembl.1
Natural variantiVAR_057300430T → A. Corresponds to variant dbSNP:rs2230523Ensembl.1
Natural variantiVAR_057301648F → L. Corresponds to variant dbSNP:rs2230524Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83597 mRNA Translation: BAA12019.1
AK313177 mRNA Translation: BAG35994.1
AC026445 Genomic DNA No translation available.
CH471137 Genomic DNA Translation: EAW51318.1
BC109069 mRNA Translation: AAI09070.1
BC109070 mRNA Translation: AAI09071.1
CCDSiCCDS3992.1
RefSeqiNP_005573.2, NM_005582.2
UniGeneiHs.87205

Genome annotation databases

EnsembliENST00000256447; ENSP00000256447; ENSG00000134061
GeneIDi4064
KEGGihsa:4064
UCSCiuc003juy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D83597 mRNA Translation: BAA12019.1
AK313177 mRNA Translation: BAG35994.1
AC026445 Genomic DNA No translation available.
CH471137 Genomic DNA Translation: EAW51318.1
BC109069 mRNA Translation: AAI09070.1
BC109070 mRNA Translation: AAI09071.1
CCDSiCCDS3992.1
RefSeqiNP_005573.2, NM_005582.2
UniGeneiHs.87205

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3B2DX-ray2.80A/B24-626[»]
ProteinModelPortaliQ99467
SMRiQ99467
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110242, 1 interactor
DIPiDIP-59104N
IntActiQ99467, 1 interactor
STRINGi9606.ENSP00000256447

PTM databases

iPTMnetiQ99467
PhosphoSitePlusiQ99467

Polymorphism and mutation databases

BioMutaiCD180
DMDMi296434437

Proteomic databases

EPDiQ99467
MaxQBiQ99467
PaxDbiQ99467
PeptideAtlasiQ99467
PRIDEiQ99467
ProteomicsDBi78284

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000256447; ENSP00000256447; ENSG00000134061
GeneIDi4064
KEGGihsa:4064
UCSCiuc003juy.3 human

Organism-specific databases

CTDi4064
DisGeNETi4064
EuPathDBiHostDB:ENSG00000134061.5
GeneCardsiCD180
H-InvDBiHIX0032100
HGNCiHGNC:6726 CD180
HPAiHPA003740
MIMi602226 gene
neXtProtiNX_Q99467
OpenTargetsiENSG00000134061
PharmGKBiPA30490
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000119006
HOGENOMiHOG000146395
HOVERGENiHBG050848
InParanoidiQ99467
KOiK06555
OMAiTRCQINW
OrthoDBiEOG091G01RC
PhylomeDBiQ99467
TreeFamiTF351113

Enzyme and pathway databases

ReactomeiR-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade

Miscellaneous databases

ChiTaRSiCD180 human
GeneWikiiCD180
GenomeRNAii4064
PROiPR:Q99467
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000134061 Expressed in 107 organ(s), highest expression level in blood
CleanExiHS_CD180
GenevisibleiQ99467 HS

Family and domain databases

Gene3Di3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF00560 LRR_1, 1 hit
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 8 hits
SM00082 LRRCT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 12 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCD180_HUMAN
AccessioniPrimary (citable) accession number: Q99467
Secondary accession number(s): B2R7Z7, Q32MM5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: May 18, 2010
Last modified: November 7, 2018
This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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