UniProtKB - Q99467 (CD180_HUMAN)

BLAST

>sp|Q99467|CD180_HUMAN CD180 antigen OS=Homo sapiens OX=9606 GN=CD180 PE=1 SV=2
MAFDVSCFFWVVLFSAGCKVITSWDQMCIEKEANKTYNCENLGLSEIPDTLPNTTEFLEF
SFNFLPTIHNRTFSRLMNLTFLDLTRCQINWIHEDTFQSHHQLSTLVLTGNPLIFMAETS
LNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDF
QNNAIHYISREDMRSLEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFN
GLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMSVESLNLQEHRFSDISSTTFQCFTQL
QELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKLH
LGVGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECP
QLELLDLAFTRLHINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNH
FQDGTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSL
SHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLE
GSEETTCANPPSLRGVKLSDVKLSCGITAIGIFFLIVFLLLLAILLFFAVKYLLRWKYQH
I

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History
Entry version 155 (07 Nov 2018)
Sequence version 2 (18 May 2010)
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Protein

CD180 antigen

Gene

CD180

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).By similarity

GO - Biological processⁱ

B cell proliferation involved in immune response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to lipopolysaccharide
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inflammatory response Source: UniProtKB-KW
innate immune response Source: UniProtKB-KW
positive regulation of lipopolysaccharide-mediated signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 10880523

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Receptor
Biological process	Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade

Reactomeⁱ

R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: CD180 antigen Alternative name(s): Lymphocyte antigen 64 Radioprotective 105 kDa protein CD_antigen: CD180
Gene namesⁱ	Name:CD180 Synonyms:LY64, RP105
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 5

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134061.5
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6726 CD180
MIMⁱ	602226 gene
neXtProtⁱ	NX_Q99467

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	24 – 626	ExtracellularSequence analysisAdd BLAST	603
Transmembraneⁱ	627 – 650	HelicalSequence analysisAdd BLAST	24
Topological domainⁱ	651 – 661	CytoplasmicSequence analysisAdd BLAST	11

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	4064
Open Targets More...OpenTargetsⁱ	ENSG00000134061
PharmGKBⁱ	PA30490

Polymorphism and mutation databases

BioMutaⁱ	CD180
DMDMⁱ	296434437

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	1 PublicationAdd BLAST		23
ChainⁱPRO_0000034741	24 – 661	CD180 antigenAdd BLAST		638

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	34	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	53	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	70	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	78	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	201	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	234	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	244	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	394	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	402	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	451	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	573	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein

Proteomic databases

EPDⁱ	Q99467
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99467
PaxDbⁱ	Q99467
PeptideAtlas More...PeptideAtlasⁱ	Q99467
PRIDEⁱ	Q99467
ProteomicsDBⁱ	78284

PTM databases

iPTMnetⁱ	Q99467
PhosphoSitePlusⁱ	Q99467

Expressionⁱ

Tissue specificityⁱ

Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.

Gene expression databases

Bgeeⁱ	ENSG00000134061 Expressed in 107 organ(s), highest expression level in blood
CleanExⁱ	HS_CD180
Genevisibleⁱ	Q99467 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003740

HPAⁱ

HPA003740

Interactionⁱ

Subunit structureⁱ

M-shaped tetramer of two CD180-LY86 heterodimers.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
LY86	O95711	3	EBI-15940363,EBI-12203791

With

Entry

#Exp.

IntAct

Notes

LY86

O95711

EBI-15940363,EBI-12203791

Protein-protein interaction databases

BioGridⁱ	110242, 1 interactor
Database of interacting proteins More...DIPⁱ	DIP-59104N
IntActⁱ	Q99467, 1 interactor
STRINGⁱ	9606.ENSP00000256447

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	29 – 32	Combined sources	4
Turnⁱ	33 – 35	Combined sources	3
Beta strandⁱ	36 – 38	Combined sources	3
Beta strandⁱ	57 – 59	Combined sources	3
Beta strandⁱ	66 – 68	Combined sources	3
Turnⁱ	70 – 75	Combined sources	6
Beta strandⁱ	80 – 83	Combined sources	4
Turnⁱ	94 – 99	Combined sources	6
Beta strandⁱ	105 – 107	Combined sources	3
Turnⁱ	118 – 121	Combined sources	4
Beta strandⁱ	129 – 131	Combined sources	3
Helixⁱ	140 – 142	Combined sources	3
Beta strandⁱ	153 – 155	Combined sources	3
Beta strandⁱ	177 – 179	Combined sources	3
Helixⁱ	190 – 194	Combined sources	5
Turnⁱ	195 – 198	Combined sources	4
Beta strandⁱ	200 – 205	Combined sources	6
Turnⁱ	216 – 221	Combined sources	6
Beta strandⁱ	223 – 228	Combined sources	6
Helixⁱ	235 – 241	Combined sources	7
Turnⁱ	242 – 244	Combined sources	3
Beta strandⁱ	246 – 251	Combined sources	6
Turnⁱ	265 – 268	Combined sources	4
Helixⁱ	269 – 273	Combined sources	5
Beta strandⁱ	274 – 280	Combined sources	7
Beta strandⁱ	286 – 288	Combined sources	3
Turnⁱ	291 – 294	Combined sources	4
Helixⁱ	296 – 299	Combined sources	4
Beta strandⁱ	301 – 304	Combined sources	4
Beta strandⁱ	325 – 327	Combined sources	3
Helixⁱ	336 – 339	Combined sources	4
Helixⁱ	341 – 343	Combined sources	3
Beta strandⁱ	349 – 351	Combined sources	3
Turnⁱ	365 – 368	Combined sources	4
Beta strandⁱ	374 – 376	Combined sources	3
Beta strandⁱ	384 – 388	Combined sources	5
Turnⁱ	389 – 391	Combined sources	3
Beta strandⁱ	400 – 402	Combined sources	3
Beta strandⁱ	409 – 411	Combined sources	3
Turnⁱ	413 – 418	Combined sources	6
Beta strandⁱ	424 – 426	Combined sources	3
Turnⁱ	440 – 443	Combined sources	4
Beta strandⁱ	449 – 451	Combined sources	3
Turnⁱ	462 – 467	Combined sources	6
Beta strandⁱ	473 – 475	Combined sources	3
Helixⁱ	482 – 484	Combined sources	3
Helixⁱ	491 – 494	Combined sources	4
Beta strandⁱ	500 – 502	Combined sources	3
Turnⁱ	513 – 518	Combined sources	6
Beta strandⁱ	524 – 526	Combined sources	3
Helixⁱ	534 – 540	Combined sources	7
Beta strandⁱ	547 – 549	Combined sources	3
Helixⁱ	563 – 567	Combined sources	5
Beta strandⁱ	569 – 573	Combined sources	5
Helixⁱ	583 – 585	Combined sources	3
Helixⁱ	586 – 594	Combined sources	9
Beta strandⁱ	598 – 600	Combined sources	3
Beta strandⁱ	607 – 613	Combined sources	7
Turnⁱ	618 – 620	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q99467
SMRⁱ	Q99467
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	33 – 53	LRRNTAdd BLAST	21
Repeatⁱ	54 – 75	LRR 1Add BLAST	22
Repeatⁱ	78 – 99	LRR 2Add BLAST	22
Repeatⁱ	102 – 123	LRR 3Add BLAST	22
Repeatⁱ	126 – 147	LRR 4Add BLAST	22
Repeatⁱ	150 – 171	LRR 5Add BLAST	22
Repeatⁱ	174 – 195	LRR 6Add BLAST	22
Repeatⁱ	201 – 221	LRR 7Add BLAST	21
Repeatⁱ	275 – 296	LRR 8Add BLAST	22
Repeatⁱ	299 – 320	LRR 9Add BLAST	22
Repeatⁱ	322 – 343	LRR 10Add BLAST	22
Repeatⁱ	346 – 366	LRR 11Add BLAST	21
Repeatⁱ	371 – 391	LRR 12Add BLAST	21
Repeatⁱ	397 – 418	LRR 13Add BLAST	22
Repeatⁱ	421 – 442	LRR 14Add BLAST	22
Repeatⁱ	446 – 466	LRR 15Add BLAST	21
Repeatⁱ	470 – 493	LRR 16Add BLAST	24
Repeatⁱ	497 – 518	LRR 17Add BLAST	22
Repeatⁱ	521 – 544	LRR 18Add BLAST	24
Repeatⁱ	546 – 564	LRR 19Add BLAST	19
Domainⁱ	577 – 627	LRRCTAdd BLAST	51

Sequence similaritiesⁱ

Belongs to the Toll-like receptor family.Curated

Keywords - Domainⁱ

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG4641 Eukaryota COG4886 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119006
HOGENOMⁱ	HOG000146395
HOVERGENⁱ	HBG050848
InParanoidⁱ	Q99467
KEGG Orthology (KO) More...KOⁱ	K06555
OMAⁱ	TRCQINW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G01RC
PhylomeDBⁱ	Q99467
TreeFamⁱ	TF351113

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00560 LRR_1, 1 hit PF13855 LRR_8, 3 hits
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 8 hits SM00082 LRRCT, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 12 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q99467-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAFDVSCFFW VVLFSAGCKV ITSWDQMCIE KEANKTYNCE NLGLSEIPDT 
        60         70         80         90        100
LPNTTEFLEF SFNFLPTIHN RTFSRLMNLT FLDLTRCQIN WIHEDTFQSH 
       110        120        130        140        150
HQLSTLVLTG NPLIFMAETS LNGPKSLKHL FLIQTGISNL EFIPVHNLEN 
       160        170        180        190        200
LESLYLGSNH ISSIKFPKDF PARNLKVLDF QNNAIHYISR EDMRSLEQAI 
       210        220        230        240        250
NLSLNFNGNN VKGIELGAFD STIFQSLNFG GTPNLSVIFN GLQNSTTQSL 
       260        270        280        290        300
WLGTFEDIDD EDISSAMLKG LCEMSVESLN LQEHRFSDIS STTFQCFTQL 
       310        320        330        340        350
QELDLTATHL KGLPSGMKGL NLLKKLVLSV NHFDQLCQIS AANFPSLTHL 
       360        370        380        390        400
YIRGNVKKLH LGVGCLEKLG NLQTLDLSHN DIEASDCCSL QLKNLSHLQT 
       410        420        430        440        450
LNLSHNEPLG LQSQAFKECP QLELLDLAFT RLHINAPQSP FQNLHFLQVL 
       460        470        480        490        500
NLTYCFLDTS NQHLLAGLPV LRHLNLKGNH FQDGTITKTN LLQTVGSLEV 
       510        520        530        540        550
LILSSCGLLS IDQQAFHSLG KMSHVDLSHN SLTCDSIDSL SHLKGIYLNL 
       560        570        580        590        600
AANSINIISP RLLPILSQQS TINLSHNPLD CTCSNIHFLT WYKENLHKLE 
       610        620        630        640        650
GSEETTCANP PSLRGVKLSD VKLSCGITAI GIFFLIVFLL LLAILLFFAV 
       660 
KYLLRWKYQH I

Length:661

Mass (Da):74,179

Last modified:May 18, 2010 - v2

Checksum:ⁱ93DE3178594B3383

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	223	I → V in BAA12019 (PubMed:8975706).Curated	1
Sequence conflictⁱ	223	I → V in BAG35994 (PubMed:14702039).Curated	1
Sequence conflictⁱ	223	I → V in EAW51318 (Ref. 4) Curated	1
Sequence conflictⁱ	223	I → V in AAI09070 (PubMed:15489334).Curated	1
Sequence conflictⁱ	223	I → V in AAI09071 (PubMed:15489334).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_057298	20	V → L. Corresponds to variant dbSNP:rs5744463Ensembl.	1
Natural variantⁱVAR_021978	53	N → K. Corresponds to variant dbSNP:rs16875312Ensembl.	1
Natural variantⁱVAR_021979	99	S → R. Corresponds to variant dbSNP:rs2230520Ensembl.	1
Natural variantⁱVAR_057299	259	D → N. Corresponds to variant dbSNP:rs5744525Ensembl.	1
Natural variantⁱVAR_061859	356	V → M. Corresponds to variant dbSNP:rs56752081Ensembl.	1
Natural variantⁱVAR_057300	430	T → A. Corresponds to variant dbSNP:rs2230523Ensembl.	1
Natural variantⁱVAR_057301	648	F → L. Corresponds to variant dbSNP:rs2230524Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D83597 mRNA Translation: BAA12019.1 AK313177 mRNA Translation: BAG35994.1 AC026445 Genomic DNA No translation available. CH471137 Genomic DNA Translation: EAW51318.1 BC109069 mRNA Translation: AAI09070.1 BC109070 mRNA Translation: AAI09071.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS3992.1
NCBI Reference Sequences More...RefSeqⁱ	NP_005573.2, NM_005582.2
UniGeneⁱ	Hs.87205

Genome annotation databases

Ensemblⁱ	ENST00000256447; ENSP00000256447; ENSG00000134061
GeneIDⁱ	4064
KEGGⁱ	hsa:4064
UCSC genome browser More...UCSCⁱ	uc003juy.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99467	CD180 isoform 1		PONAB		661	UniRef90_Q99467
Lymphocyte antigen 64		MACFA		661
Uncharacterized protein		COLAP		661
Uncharacterized protein		CHLSB		661
Uncharacterized protein		MANLE		661
+28

Protein	Similar proteins		Species	Score	Length	Source
Q99467	CD180 antigen	)	MOUSE		661	UniRef50_Q99467
Uncharacterized protein		COLAP		661
Uncharacterized protein		CHLSB		661
Lymphocyte antigen 64		MACMU		661
Uncharacterized protein		NOMLE		661
+158

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D83597 mRNA Translation: BAA12019.1 AK313177 mRNA Translation: BAG35994.1 AC026445 Genomic DNA No translation available. CH471137 Genomic DNA Translation: EAW51318.1 BC109069 mRNA Translation: AAI09070.1 BC109070 mRNA Translation: AAI09071.1
CCDSⁱ	CCDS3992.1
RefSeqⁱ	NP_005573.2, NM_005582.2
UniGeneⁱ	Hs.87205

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	3B2D	X-ray	2.80	A/B	24-626	[»]
ProteinModelPortalⁱ	Q99467
SMRⁱ	Q99467
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110242, 1 interactor
DIPⁱ	DIP-59104N
IntActⁱ	Q99467, 1 interactor
STRINGⁱ	9606.ENSP00000256447

PTM databases

iPTMnetⁱ	Q99467
PhosphoSitePlusⁱ	Q99467

Polymorphism and mutation databases

BioMutaⁱ	CD180
DMDMⁱ	296434437

Proteomic databases

EPDⁱ	Q99467
MaxQBⁱ	Q99467
PaxDbⁱ	Q99467
PeptideAtlasⁱ	Q99467
PRIDEⁱ	Q99467
ProteomicsDBⁱ	78284

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000256447; ENSP00000256447; ENSG00000134061
GeneIDⁱ	4064
KEGGⁱ	hsa:4064
UCSCⁱ	uc003juy.3 human

Organism-specific databases

CTDⁱ	4064
DisGeNETⁱ	4064
EuPathDBⁱ	HostDB:ENSG00000134061.5
GeneCardsⁱ	CD180
H-InvDBⁱ	HIX0032100
HGNCⁱ	HGNC:6726 CD180
HPAⁱ	HPA003740
MIMⁱ	602226 gene
neXtProtⁱ	NX_Q99467
OpenTargetsⁱ	ENSG00000134061
PharmGKBⁱ	PA30490
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG4641 Eukaryota COG4886 LUCA
GeneTreeⁱ	ENSGT00760000119006
HOGENOMⁱ	HOG000146395
HOVERGENⁱ	HBG050848
InParanoidⁱ	Q99467
KOⁱ	K06555
OMAⁱ	TRCQINW
OrthoDBⁱ	EOG091G01RC
PhylomeDBⁱ	Q99467
TreeFamⁱ	TF351113

Enzyme and pathway databases

Reactomeⁱ	R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade

Reactomeⁱ

R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade

Miscellaneous databases

ChiTaRSⁱ	CD180 human
GeneWikiⁱ	CD180
GenomeRNAiⁱ	4064
Protein Ontology More...PROⁱ	PR:Q99467
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134061 Expressed in 107 organ(s), highest expression level in blood
CleanExⁱ	HS_CD180
Genevisibleⁱ	Q99467 HS

Family and domain databases

Gene3Dⁱ	3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf
Pfamⁱ	View protein in Pfam PF00560 LRR_1, 1 hit PF13855 LRR_8, 3 hits
SMARTⁱ	View protein in SMART SM00369 LRR_TYP, 8 hits SM00082 LRRCT, 1 hit
PROSITEⁱ	View protein in PROSITE PS51450 LRR, 12 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CD180_HUMAN
Accessionⁱ	Q99467Primary (citable) accession number: Q99467 Secondary accession number(s): B2R7Z7, Q32MM5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
	Last sequence update:	May 18, 2010
	Last modified:	November 7, 2018
	This is version 155 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries

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UniRef

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Supporting data

UniProtKB - Q99467 (CD180_HUMAN)

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CD180 antigen

CD180

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ