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UniProtKB - Q99467 (CD180_HUMAN)
Protein
CD180 antigen
Gene
CD180
Organism
Homo sapiens (Human)
Status
Functioni
May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells (By similarity).
By similarityGO - Biological processi
- B cell proliferation involved in immune response Source: GO_Central
- cellular response to lipopolysaccharide Source: GO_Central
- inflammatory response Source: UniProtKB-KW
- innate immune response Source: UniProtKB-KW
- positive regulation of lipopolysaccharide-mediated signaling pathway Source: MGI
Keywordsi
Molecular function | Receptor |
Biological process | Immunity, Inflammatory response, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | Q99467 |
Reactomei | R-HSA-166016, Toll Like Receptor 4 (TLR4) Cascade |
SignaLinki | Q99467 |
Names & Taxonomyi
Protein namesi | Recommended name: CD180 antigenAlternative name(s): Lymphocyte antigen 64 Radioprotective 105 kDa protein CD_antigen: CD180 |
Gene namesi | Name:CD180 Synonyms:LY64, RP105 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6726, CD180 |
MIMi | 602226, gene |
neXtProti | NX_Q99467 |
VEuPathDBi | HostDB:ENSG00000134061 |
Subcellular locationi
Plasma membrane
Cytoskeleton
- mitotic spindle Source: HPA
Extracellular region or secreted
- extracellular space Source: GO_Central
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Plasma Membrane
- plasma membrane Source: HPA
Other locations
- extracellular matrix Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 24 – 626 | ExtracellularSequence analysisAdd BLAST | 603 | |
Transmembranei | 627 – 650 | HelicalSequence analysisAdd BLAST | 24 | |
Topological domaini | 651 – 661 | CytoplasmicSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 4064 |
OpenTargetsi | ENSG00000134061 |
PharmGKBi | PA30490 |
Miscellaneous databases
Pharosi | Q99467, Tbio |
Genetic variation databases
BioMutai | CD180 |
DMDMi | 296434437 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | 1 PublicationAdd BLAST | 23 | |
ChainiPRO_0000034741 | 24 – 661 | CD180 antigenAdd BLAST | 638 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 34 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 53 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 70 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 78 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 201 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 234 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 244 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 394 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 402 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 451 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 573 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | Q99467 |
jPOSTi | Q99467 |
MassIVEi | Q99467 |
MaxQBi | Q99467 |
PaxDbi | Q99467 |
PeptideAtlasi | Q99467 |
PRIDEi | Q99467 |
ProteomicsDBi | 78284 |
PTM databases
GlyGeni | Q99467, 11 sites |
iPTMneti | Q99467 |
PhosphoSitePlusi | Q99467 |
Expressioni
Tissue specificityi
Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.
Gene expression databases
Bgeei | ENSG00000134061, Expressed in blood and 136 other tissues |
Genevisiblei | Q99467, HS |
Organism-specific databases
HPAi | ENSG00000134061, Tissue enhanced (lymphoid) |
Interactioni
Subunit structurei
M-shaped tetramer of two CD180-LY86 heterodimers.
1 PublicationBinary interactionsi
Q99467
With | #Exp. | IntAct |
---|---|---|
LY86 [O95711] | 3 | EBI-15940363,EBI-12203791 |
Protein-protein interaction databases
BioGRIDi | 110242, 1 interactor |
DIPi | DIP-59104N |
IntActi | Q99467, 1 interactor |
STRINGi | 9606.ENSP00000256447 |
Miscellaneous databases
RNActi | Q99467, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q99467 |
SMRi | Q99467 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 33 – 53 | LRRNTAdd BLAST | 21 | |
Repeati | 54 – 75 | LRR 1Add BLAST | 22 | |
Repeati | 78 – 99 | LRR 2Add BLAST | 22 | |
Repeati | 102 – 123 | LRR 3Add BLAST | 22 | |
Repeati | 126 – 147 | LRR 4Add BLAST | 22 | |
Repeati | 150 – 171 | LRR 5Add BLAST | 22 | |
Repeati | 174 – 195 | LRR 6Add BLAST | 22 | |
Repeati | 201 – 221 | LRR 7Add BLAST | 21 | |
Repeati | 275 – 296 | LRR 8Add BLAST | 22 | |
Repeati | 299 – 320 | LRR 9Add BLAST | 22 | |
Repeati | 322 – 343 | LRR 10Add BLAST | 22 | |
Repeati | 346 – 366 | LRR 11Add BLAST | 21 | |
Repeati | 371 – 391 | LRR 12Add BLAST | 21 | |
Repeati | 397 – 418 | LRR 13Add BLAST | 22 | |
Repeati | 421 – 442 | LRR 14Add BLAST | 22 | |
Repeati | 446 – 466 | LRR 15Add BLAST | 21 | |
Repeati | 470 – 493 | LRR 16Add BLAST | 24 | |
Repeati | 497 – 518 | LRR 17Add BLAST | 22 | |
Repeati | 521 – 544 | LRR 18Add BLAST | 24 | |
Repeati | 546 – 564 | LRR 19Add BLAST | 19 | |
Domaini | 577 – 627 | LRRCTAdd BLAST | 51 |
Sequence similaritiesi
Belongs to the Toll-like receptor family.Curated
Keywords - Domaini
Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4641, Eukaryota |
GeneTreei | ENSGT00940000161183 |
HOGENOMi | CLU_006000_5_1_1 |
InParanoidi | Q99467 |
OMAi | MCTEKEA |
OrthoDBi | 826997at2759 |
PhylomeDBi | Q99467 |
TreeFami | TF351113 |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR041281, LRR_11 IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF00560, LRR_1, 1 hit PF18831, LRR_11, 1 hit PF13855, LRR_8, 3 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 8 hits SM00082, LRRCT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 12 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q99467-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAFDVSCFFW VVLFSAGCKV ITSWDQMCIE KEANKTYNCE NLGLSEIPDT
60 70 80 90 100
LPNTTEFLEF SFNFLPTIHN RTFSRLMNLT FLDLTRCQIN WIHEDTFQSH
110 120 130 140 150
HQLSTLVLTG NPLIFMAETS LNGPKSLKHL FLIQTGISNL EFIPVHNLEN
160 170 180 190 200
LESLYLGSNH ISSIKFPKDF PARNLKVLDF QNNAIHYISR EDMRSLEQAI
210 220 230 240 250
NLSLNFNGNN VKGIELGAFD STIFQSLNFG GTPNLSVIFN GLQNSTTQSL
260 270 280 290 300
WLGTFEDIDD EDISSAMLKG LCEMSVESLN LQEHRFSDIS STTFQCFTQL
310 320 330 340 350
QELDLTATHL KGLPSGMKGL NLLKKLVLSV NHFDQLCQIS AANFPSLTHL
360 370 380 390 400
YIRGNVKKLH LGVGCLEKLG NLQTLDLSHN DIEASDCCSL QLKNLSHLQT
410 420 430 440 450
LNLSHNEPLG LQSQAFKECP QLELLDLAFT RLHINAPQSP FQNLHFLQVL
460 470 480 490 500
NLTYCFLDTS NQHLLAGLPV LRHLNLKGNH FQDGTITKTN LLQTVGSLEV
510 520 530 540 550
LILSSCGLLS IDQQAFHSLG KMSHVDLSHN SLTCDSIDSL SHLKGIYLNL
560 570 580 590 600
AANSINIISP RLLPILSQQS TINLSHNPLD CTCSNIHFLT WYKENLHKLE
610 620 630 640 650
GSEETTCANP PSLRGVKLSD VKLSCGITAI GIFFLIVFLL LLAILLFFAV
660
KYLLRWKYQH I
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 223 | I → V in BAA12019 (PubMed:8975706).Curated | 1 | |
Sequence conflicti | 223 | I → V in BAG35994 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 223 | I → V in EAW51318 (Ref. 4) Curated | 1 | |
Sequence conflicti | 223 | I → V in AAI09070 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 223 | I → V in AAI09071 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_057298 | 20 | V → L. Corresponds to variant dbSNP:rs5744463Ensembl. | 1 | |
Natural variantiVAR_021978 | 53 | N → K. Corresponds to variant dbSNP:rs16875312Ensembl. | 1 | |
Natural variantiVAR_021979 | 99 | S → R. Corresponds to variant dbSNP:rs2230520Ensembl. | 1 | |
Natural variantiVAR_057299 | 259 | D → N. Corresponds to variant dbSNP:rs5744525Ensembl. | 1 | |
Natural variantiVAR_061859 | 356 | V → M. Corresponds to variant dbSNP:rs56752081Ensembl. | 1 | |
Natural variantiVAR_057300 | 430 | T → A. Corresponds to variant dbSNP:rs2230523EnsemblClinVar. | 1 | |
Natural variantiVAR_057301 | 648 | F → L. Corresponds to variant dbSNP:rs2230524Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D83597 mRNA Translation: BAA12019.1 AK313177 mRNA Translation: BAG35994.1 AC026445 Genomic DNA No translation available. CH471137 Genomic DNA Translation: EAW51318.1 BC109069 mRNA Translation: AAI09070.1 BC109070 mRNA Translation: AAI09071.1 |
CCDSi | CCDS3992.1 |
RefSeqi | NP_005573.2, NM_005582.2 |
Genome annotation databases
Ensembli | ENST00000256447.5; ENSP00000256447.4; ENSG00000134061.5 |
GeneIDi | 4064 |
KEGGi | hsa:4064 |
MANE-Selecti | ENST00000256447.5; ENSP00000256447.4; NM_005582.3; NP_005573.2 |
UCSCi | uc003juy.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D83597 mRNA Translation: BAA12019.1 AK313177 mRNA Translation: BAG35994.1 AC026445 Genomic DNA No translation available. CH471137 Genomic DNA Translation: EAW51318.1 BC109069 mRNA Translation: AAI09070.1 BC109070 mRNA Translation: AAI09071.1 |
CCDSi | CCDS3992.1 |
RefSeqi | NP_005573.2, NM_005582.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3B2D | X-ray | 2.80 | A/B | 24-626 | [»] | |
AlphaFoldDBi | Q99467 | |||||
SMRi | Q99467 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110242, 1 interactor |
DIPi | DIP-59104N |
IntActi | Q99467, 1 interactor |
STRINGi | 9606.ENSP00000256447 |
PTM databases
GlyGeni | Q99467, 11 sites |
iPTMneti | Q99467 |
PhosphoSitePlusi | Q99467 |
Genetic variation databases
BioMutai | CD180 |
DMDMi | 296434437 |
Proteomic databases
EPDi | Q99467 |
jPOSTi | Q99467 |
MassIVEi | Q99467 |
MaxQBi | Q99467 |
PaxDbi | Q99467 |
PeptideAtlasi | Q99467 |
PRIDEi | Q99467 |
ProteomicsDBi | 78284 |
Protocols and materials databases
Antibodypediai | 1122, 438 antibodies from 38 providers |
DNASUi | 4064 |
Genome annotation databases
Ensembli | ENST00000256447.5; ENSP00000256447.4; ENSG00000134061.5 |
GeneIDi | 4064 |
KEGGi | hsa:4064 |
MANE-Selecti | ENST00000256447.5; ENSP00000256447.4; NM_005582.3; NP_005573.2 |
UCSCi | uc003juy.3, human |
Organism-specific databases
CTDi | 4064 |
DisGeNETi | 4064 |
GeneCardsi | CD180 |
HGNCi | HGNC:6726, CD180 |
HPAi | ENSG00000134061, Tissue enhanced (lymphoid) |
MIMi | 602226, gene |
neXtProti | NX_Q99467 |
OpenTargetsi | ENSG00000134061 |
PharmGKBi | PA30490 |
VEuPathDBi | HostDB:ENSG00000134061 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4641, Eukaryota |
GeneTreei | ENSGT00940000161183 |
HOGENOMi | CLU_006000_5_1_1 |
InParanoidi | Q99467 |
OMAi | MCTEKEA |
OrthoDBi | 826997at2759 |
PhylomeDBi | Q99467 |
TreeFami | TF351113 |
Enzyme and pathway databases
PathwayCommonsi | Q99467 |
Reactomei | R-HSA-166016, Toll Like Receptor 4 (TLR4) Cascade |
SignaLinki | Q99467 |
Miscellaneous databases
BioGRID-ORCSi | 4064, 9 hits in 1065 CRISPR screens |
ChiTaRSi | CD180, human |
GeneWikii | CD180 |
GenomeRNAii | 4064 |
Pharosi | Q99467, Tbio |
PROi | PR:Q99467 |
RNActi | Q99467, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134061, Expressed in blood and 136 other tissues |
Genevisiblei | Q99467, HS |
Family and domain databases
Gene3Di | 3.80.10.10, 1 hit |
InterProi | View protein in InterPro IPR000483, Cys-rich_flank_reg_C IPR001611, Leu-rich_rpt IPR003591, Leu-rich_rpt_typical-subtyp IPR041281, LRR_11 IPR032675, LRR_dom_sf |
Pfami | View protein in Pfam PF00560, LRR_1, 1 hit PF18831, LRR_11, 1 hit PF13855, LRR_8, 3 hits |
SMARTi | View protein in SMART SM00369, LRR_TYP, 8 hits SM00082, LRRCT, 1 hit |
PROSITEi | View protein in PROSITE PS51450, LRR, 12 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | CD180_HUMAN | |
Accessioni | Q99467Primary (citable) accession number: Q99467 Secondary accession number(s): B2R7Z7, Q32MM5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | May 18, 2010 | |
Last modified: | May 25, 2022 | |
This is version 174 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 5
Human chromosome 5: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families