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Protein

Putative neuropeptide Y receptor type 6

Gene

NPY6R

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

When expressed, is unable to bind pancreatic polypeptide (PP), neuropeptide Y (NPY), or peptide YY (PYY), suggesting that either it is functionally inactive or that it may have acquired a pancreatic polypeptide-independent function.2 Publications

Caution

Could be the product of a pseudogene. According to PubMed:8910290, PubMed:8910373 and PubMed:9013614, the human NPY6R gene is an expressed pseudogene containing a premature stop codon and encoding a non-functional truncated protein missing the last transmembrane domain. A single base pair deletion relative to the mouse ortholog, results in a truncated protein lacking the seventh transmembrane domain.Curated

GO - Molecular functioni

  • pancreatic polypeptide receptor activity Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Putative neuropeptide Y receptor type 6
Short name:
NPY6-R
Alternative name(s):
NPY Y1-like receptor
Putative pancreatic polypeptide receptor 2
Short name:
PP2
Gene namesi
Name:NPY6R
Synonyms:NPY1RL, Y2B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:7959 NPY6R
MIMi601770 gene
neXtProtiNX_Q99463

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 60Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini61 – 83CytoplasmicSequence analysisAdd BLAST23
Transmembranei84 – 104Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini105 – 111ExtracellularSequence analysis7
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 150CytoplasmicSequence analysisAdd BLAST18
Transmembranei151 – 171Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini172 – 206ExtracellularSequence analysisAdd BLAST35
Transmembranei207 – 227Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini228 – 258CytoplasmicSequence analysisAdd BLAST31
Transmembranei259 – 279Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini280 – 290ExtracellularSequence analysisAdd BLAST11

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi74762699

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003461301 – 290Putative neuropeptide Y receptor type 6Add BLAST290

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 196PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ99463
ProteomicsDBi78280

PTM databases

iPTMnetiQ99463
PhosphoSitePlusiQ99463

Expressioni

Tissue specificityi

Expressed in heart, skeletal muscle, gastrointestinal tissues, spleen, brain and adrenal glands.2 Publications

Interactioni

Protein-protein interaction databases

IntActiQ99463, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ99463
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG105676
InParanoidiQ99463
PhylomeDBiQ99463

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000986 NeuroY6_rcpt
IPR000611 NPY_rcpt
PANTHERiPTHR43916:SF9 PTHR43916:SF9, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01017 NRPEPTIDEY6R
PR01012 NRPEPTIDEYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q99463-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEVSLNHPAS NTTSTKNNNS AFFYFESCQP PSPALLLLCI AYTVVLIVGL
60 70 80 90 100
FGNLSLIIII FKKQRKAQNF TSILIANLSL SDTLVCVMCI HFTIIYTLMD
110 120 130 140 150
HWIFGDTMCR LTSYVQSVSI SVSIFSLVFT AVERYQLIVN PRGWKPSVTH
160 170 180 190 200
AYWGITLIWL FSLLLSIPFF LSYHLTDEPF RNLSLPTDLY THQVACVENW
210 220 230 240 250
PSKKDRLLFT TSLFLLQYFV PLGFILICYL KIVICLRRRN AKVDKKKENE
260 270 280 290
GRLNENKRIN TMLISIVVTF GACWLPRISS MSSLTGIMRC
Length:290
Mass (Da):33,180
Last modified:May 1, 1997 - v1
Checksum:i3ECCDD87001CA8DB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti154G → S in U59431 (PubMed:8910373).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86519 mRNA Translation: BAA13103.1
U59431 mRNA No translation available.
U67780 mRNA No translation available.
CH471062 Genomic DNA Translation: EAW62180.1
CH471062 Genomic DNA Translation: EAW62181.1
UniGeneiHs.643466

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D86519 mRNA Translation: BAA13103.1
U59431 mRNA No translation available.
U67780 mRNA No translation available.
CH471062 Genomic DNA Translation: EAW62180.1
CH471062 Genomic DNA Translation: EAW62181.1
UniGeneiHs.643466

3D structure databases

ProteinModelPortaliQ99463
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99463, 1 interactor

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ99463
PhosphoSitePlusiQ99463

Polymorphism and mutation databases

DMDMi74762699

Proteomic databases

PRIDEiQ99463
ProteomicsDBi78280

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiNPY6R
HGNCiHGNC:7959 NPY6R
MIMi601770 gene
neXtProtiNX_Q99463
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG105676
InParanoidiQ99463
PhylomeDBiQ99463

Miscellaneous databases

SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000986 NeuroY6_rcpt
IPR000611 NPY_rcpt
PANTHERiPTHR43916:SF9 PTHR43916:SF9, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01017 NRPEPTIDEY6R
PR01012 NRPEPTIDEYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPY6R_HUMAN
AccessioniPrimary (citable) accession number: Q99463
Secondary accession number(s): D3DQB4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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