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Protein

Nucleosome assembly protein 1-like 3

Gene

NAP1L3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • nucleosome assembly Source: ProtInc

Names & Taxonomyi

Protein namesi
Recommended name:
Nucleosome assembly protein 1-like 3
Gene namesi
Name:NAP1L3
Synonyms:BNAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000186310.9
HGNCiHGNC:7639 NAP1L3
MIMi300117 gene
neXtProtiNX_Q99457

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000186310
PharmGKBiPA31441

Polymorphism and mutation databases

BioMutaiNAP1L3
DMDMi60416442

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001856571 – 506Nucleosome assembly protein 1-like 3Add BLAST506

Proteomic databases

PaxDbiQ99457
PeptideAtlasiQ99457
PRIDEiQ99457
ProteomicsDBi78276

PTM databases

iPTMnetiQ99457
PhosphoSitePlusiQ99457

Expressioni

Gene expression databases

BgeeiENSG00000186310
CleanExiHS_NAP1L3
ExpressionAtlasiQ99457 baseline and differential
GenevisibleiQ99457 HS

Organism-specific databases

HPAiHPA026075

Interactioni

Protein-protein interaction databases

BioGridi110756, 7 interactors
IntActiQ99457, 1 interactor
MINTiQ99457
STRINGi9606.ENSP00000362171

Structurei

3D structure databases

ProteinModelPortaliQ99457
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi24 – 72Ser-richAdd BLAST49
Compositional biasi154 – 254Glu-richAdd BLAST101

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1507 Eukaryota
ENOG410XQN9 LUCA
GeneTreeiENSGT00480000042668
HOGENOMiHOG000171827
HOVERGENiHBG052653
InParanoidiQ99457
KOiK11281
OMAiNASFFNF
OrthoDBiEOG091G0B87
PhylomeDBiQ99457
TreeFamiTF314349

Family and domain databases

InterProiView protein in InterPro
IPR037231 NAP-like_sf
IPR002164 NAP_family
PANTHERiPTHR11875 PTHR11875, 1 hit
PfamiView protein in Pfam
PF00956 NAP, 1 hit
SUPFAMiSSF143113 SSF143113, 2 hits

Sequencei

Sequence statusi: Complete.

Q99457-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEADFKMVS EPVAHGVAEE EMASSTSDSG EESDSSSSSS STSDSSSSSS
60 70 80 90 100
TSGSSSGSGS SSSSSGSTSS RSRLYRKKRV PEPSRRARRA PLGTNFVDRL
110 120 130 140 150
PQAVRNRVQA LRNIQDECDK VDTLFLKAIH DLERKYAELN KPLYDRRFQI
160 170 180 190 200
INAEYEPTEE ECEWNSEDEE FSSDEEVQDN TPSEMPPLEG EEEENPKENP
210 220 230 240 250
EVKAEEKEVP KEIPEVKDEE KEVPKEIPEV KAEEKADSKD CMEATPEVKE
260 270 280 290 300
DPKEVPQVKA DDKEQPKATE AKARAAVRET HKRVPEERLQ DSVDLKRARK
310 320 330 340 350
GKPKREDPKG IPDYWLIVLK NVDKLGPMIQ KYDEPILKFL SDVSLKFSKP
360 370 380 390 400
GQPVSYTFEF HFLPNPYFRN EVLVKTYIIK AKPDHNDPFF SWGWEIEDCK
410 420 430 440 450
GCKIDWRRGK DVTVTTTQSR TTATGEIEIQ PRVVPNASFF NFFSPPEIPM
460 470 480 490 500
IGKLEPREDA ILDEDFEIGQ ILHDNVILKS IYYYTGEVNG TYYQFGKHYG

NKKYRK
Length:506
Mass (Da):57,593
Last modified:March 1, 2005 - v2
Checksum:iA63672CBC2F98A87
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290Q → R in BAA08904 (PubMed:8976385).Curated1
Sequence conflicti406W → R in BAA08904 (PubMed:8976385).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024545224P → A2 PublicationsCorresponds to variant dbSNP:rs1045686Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D50370 mRNA Translation: BAA08904.1
AK315176 mRNA Translation: BAG37617.1
AL009173 Genomic DNA No translation available.
CCDSiCCDS14465.1
RefSeqiNP_004529.2, NM_004538.5
UniGeneiHs.21365
Hs.732006

Genome annotation databases

EnsembliENST00000373079; ENSP00000362171; ENSG00000186310
GeneIDi4675
KEGGihsa:4675
UCSCiuc004efq.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiNP1L3_HUMAN
AccessioniPrimary (citable) accession number: Q99457
Secondary accession number(s): B2RCM0, O60788
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 1, 2005
Last modified: June 20, 2018
This is version 129 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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