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Protein

Keratin, type I cytoskeletal 12

Gene

KRT12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a unique role in maintaining the normal corneal epithelial function. Together with KRT3, essential for the maintenance of corneal epithelium integrity (By similarity).By similarity

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • structural molecule activity Source: ProtInc

GO - Biological processi

  • cornification Source: Reactome
  • keratinization Source: Reactome
  • visual perception Source: ProtInc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Keratin, type I cytoskeletal 12
Alternative name(s):
Cytokeratin-12
Short name:
CK-12
Keratin-12
Short name:
K12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:KRT12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000187242.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:6414 KRT12

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601687 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99456

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Intermediate filament, Keratin

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Corneal dystrophy, Meesmann (MECD)14 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal dominant corneal disease characterized by fragility of the anterior corneal epithelium. Patients are usually asymptomatic until adulthood when rupture of the corneal microcysts may cause erosions, producing clinical symptoms such as photophobia, contact lens intolerance and intermittent diminution of visual acuity. Rarely, subepithelial scarring causes irregular corneal astigmatism and permanent visual impairment. Histological examination shows a disorganized and thickened epithelium with widespread cytoplasmic vacuolation and numerous small, round, debris-laden intraepithelial cysts.
See also OMIM:122100
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013126129M → T in MECD. 2 PublicationsCorresponds to variant dbSNP:rs28936695EnsemblClinVar.1
Natural variantiVAR_072069129M → V in MECD. 1 PublicationCorresponds to variant dbSNP:rs267607387EnsemblClinVar.1
Natural variantiVAR_013127130Q → P in MECD. 1 PublicationCorresponds to variant dbSNP:rs58864803EnsemblClinVar.1
Natural variantiVAR_072070132L → P in MECD. 1 PublicationCorresponds to variant dbSNP:rs886038212EnsemblClinVar.1
Natural variantiVAR_008526135R → G in MECD. 1 PublicationCorresponds to variant dbSNP:rs58410481EnsemblClinVar.1
Natural variantiVAR_008525135R → I in MECD. 1 PublicationCorresponds to variant dbSNP:rs57218384EnsemblClinVar.1
Natural variantiVAR_031394135R → S in MECD. 1 PublicationCorresponds to variant dbSNP:rs61282718EnsemblClinVar.1
Natural variantiVAR_003834135R → T in MECD. 2 PublicationsCorresponds to variant dbSNP:rs57218384EnsemblClinVar.1
Natural variantiVAR_031395137A → P in MECD. 1 PublicationCorresponds to variant dbSNP:rs58038639EnsemblClinVar.1
Natural variantiVAR_072071140L → Q in MECD. 1 Publication1
Natural variantiVAR_008527140L → R in MECD. 1 PublicationCorresponds to variant dbSNP:rs58918655EnsemblClinVar.1
Natural variantiVAR_003835143V → L in MECD. 2 PublicationsCorresponds to variant dbSNP:rs58343600EnsemblClinVar.1
Natural variantiVAR_031396399L → LISNLEAQLL in MECD. 1
Natural variantiVAR_031397426I → S in MECD. 1 PublicationCorresponds to variant dbSNP:rs59350319EnsemblClinVar.1
Natural variantiVAR_031398429Y → C in MECD. 1 PublicationCorresponds to variant dbSNP:rs59202432EnsemblClinVar.1
Natural variantiVAR_008528429Y → D in MECD. 1 PublicationCorresponds to variant dbSNP:rs58162394EnsemblClinVar.1
Natural variantiVAR_072072430R → P in MECD. 1 PublicationCorresponds to variant dbSNP:rs62635290EnsemblClinVar.1
Natural variantiVAR_072073433L → R in MECD. 1 PublicationCorresponds to variant dbSNP:rs267607386EnsemblClinVar.1

Keywords - Diseasei

Corneal dystrophy, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
3859

MalaCards human disease database

More...
MalaCardsi
KRT12
MIMi122100 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000187242

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
98954 Meesmann corneal dystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA30201

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00400 Griseofulvin

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
KRT12

Domain mapping of disease mutations (DMDM)

More...
DMDMi
2497269

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000636441 – 494Keratin, type I cytoskeletal 12Add BLAST494

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99456

PeptideAtlas

More...
PeptideAtlasi
Q99456

PRoteomics IDEntifications database

More...
PRIDEi
Q99456

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78275

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99456

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99456

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99456

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Cornea specific.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000187242 Expressed in 22 organ(s), highest expression level in mucosa of transverse colon

CleanEx database of gene expression profiles

More...
CleanExi
HS_KRT12

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99456 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA055217
HPA055835

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotetramer of two type I and two type II keratins. Keratin-3 associates with keratin-12.

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
110057, 4 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000251643

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q99456

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99456

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 440IF rodPROSITE-ProRule annotationAdd BLAST316

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 124HeadAdd BLAST124
Regioni125 – 160Coil 1AAdd BLAST36
Regioni164 – 182Linker 1Add BLAST19
Regioni183 – 274Coil 1BAdd BLAST92
Regioni275 – 297Linker 12Add BLAST23
Regioni298 – 435Coil 2Add BLAST138
Regioni436 – 494TailAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 123Gly-richAdd BLAST96

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the intermediate filament family.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IFTF Eukaryota
ENOG410Y9IV LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000159382

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000230975

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG013015

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99456

KEGG Orthology (KO)

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KOi
K07604

Identification of Orthologs from Complete Genome Data

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OMAi
QNADHQR

Database of Orthologous Groups

More...
OrthoDBi
EOG091G087I

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99456

TreeFam database of animal gene trees

More...
TreeFami
TF332742

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I

The PANTHER Classification System

More...
PANTHERi
PTHR23239 PTHR23239, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00038 Filament, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01248 TYPE1KERATIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01391 Filament, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q99456-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLSNNTMSL SVRTPGLSRR LSSQSVIGRP RGMSASSVGS GYGGSAFGFG
60 70 80 90 100
ASCGGGFSAA SMFGSSSGFG GGSGSSMAGG LGAGYGRALG GGSFGGLGMG
110 120 130 140 150
FGGSPGGGSL GILSGNDGGL LSGSEKETMQ NLNDRLASYL DKVRALEEAN
160 170 180 190 200
TELENKIREW YETRGTGTAD ASQSDYSKYY PLIEDLRNKI ISASIGNAQL
210 220 230 240 250
LLQIDNARLA AEDFRMKYEN ELALRQGVEA DINGLRRVLD ELTLTRTDLE
260 270 280 290 300
MQIESLNEEL AYMKKNHEDE LQSFRVGGPG EVSVEMDAAP GVDLTRLLND
310 320 330 340 350
MRAQYETIAE QNRKDAEAWF IEKSGELRKE ISTNTEQLQS SKSEVTDLRR
360 370 380 390 400
AFQNLEIELQ SQLAMKKSLE DSLAEAEGDY CAQLSQVQQL ISNLEAQLLQ
410 420 430 440 450
VRADAERQNV DHQRLLNVKA RLELEIETYR RLLDGEAQGD GLEESLFVTD
460 470 480 490
SKSQAQSTDS SKDPTKTRKI KTVVQEMVNG EVVSSQVQEI EELM
Length:494
Mass (Da):53,511
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75C981380532B682
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04978315P → S2 PublicationsCorresponds to variant dbSNP:rs11650915EnsemblClinVar.1
Natural variantiVAR_00954720R → W2 PublicationsCorresponds to variant dbSNP:rs17566772Ensembl.1
Natural variantiVAR_013126129M → T in MECD. 2 PublicationsCorresponds to variant dbSNP:rs28936695EnsemblClinVar.1
Natural variantiVAR_072069129M → V in MECD. 1 PublicationCorresponds to variant dbSNP:rs267607387EnsemblClinVar.1
Natural variantiVAR_013127130Q → P in MECD. 1 PublicationCorresponds to variant dbSNP:rs58864803EnsemblClinVar.1
Natural variantiVAR_072070132L → P in MECD. 1 PublicationCorresponds to variant dbSNP:rs886038212EnsemblClinVar.1
Natural variantiVAR_008526135R → G in MECD. 1 PublicationCorresponds to variant dbSNP:rs58410481EnsemblClinVar.1
Natural variantiVAR_008525135R → I in MECD. 1 PublicationCorresponds to variant dbSNP:rs57218384EnsemblClinVar.1
Natural variantiVAR_031394135R → S in MECD. 1 PublicationCorresponds to variant dbSNP:rs61282718EnsemblClinVar.1
Natural variantiVAR_003834135R → T in MECD. 2 PublicationsCorresponds to variant dbSNP:rs57218384EnsemblClinVar.1
Natural variantiVAR_031395137A → P in MECD. 1 PublicationCorresponds to variant dbSNP:rs58038639EnsemblClinVar.1
Natural variantiVAR_072071140L → Q in MECD. 1 Publication1
Natural variantiVAR_008527140L → R in MECD. 1 PublicationCorresponds to variant dbSNP:rs58918655EnsemblClinVar.1
Natural variantiVAR_003835143V → L in MECD. 2 PublicationsCorresponds to variant dbSNP:rs58343600EnsemblClinVar.1
Natural variantiVAR_031396399L → LISNLEAQLL in MECD. 1
Natural variantiVAR_031397426I → S in MECD. 1 PublicationCorresponds to variant dbSNP:rs59350319EnsemblClinVar.1
Natural variantiVAR_031398429Y → C in MECD. 1 PublicationCorresponds to variant dbSNP:rs59202432EnsemblClinVar.1
Natural variantiVAR_008528429Y → D in MECD. 1 PublicationCorresponds to variant dbSNP:rs58162394EnsemblClinVar.1
Natural variantiVAR_072072430R → P in MECD. 1 PublicationCorresponds to variant dbSNP:rs62635290EnsemblClinVar.1
Natural variantiVAR_072073433L → R in MECD. 1 PublicationCorresponds to variant dbSNP:rs267607386EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D78367 mRNA Translation: BAA11376.1
AB007119 Genomic DNA Translation: BAA25063.1
AF137286 Genomic DNA Translation: AAF61432.1
AK313747 mRNA Translation: BAG36487.1
CH471152 Genomic DNA Translation: EAW60685.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11378.1

NCBI Reference Sequences

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RefSeqi
NP_000214.1, NM_000223.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.66739

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000251643; ENSP00000251643; ENSG00000187242
ENST00000572470; ENSP00000459559; ENSG00000263243
ENST00000647992; ENSP00000497200; ENSG00000187242

Database of genes from NCBI RefSeq genomes

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GeneIDi
3859

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:3859

UCSC genome browser

More...
UCSCi
uc002hvk.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Human Intermediate Filament Mutation Database
Wikipedia

Keratin-12 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78367 mRNA Translation: BAA11376.1
AB007119 Genomic DNA Translation: BAA25063.1
AF137286 Genomic DNA Translation: AAF61432.1
AK313747 mRNA Translation: BAG36487.1
CH471152 Genomic DNA Translation: EAW60685.1
CCDSiCCDS11378.1
RefSeqiNP_000214.1, NM_000223.3
UniGeneiHs.66739

3D structure databases

ProteinModelPortaliQ99456
SMRiQ99456
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110057, 4 interactors
STRINGi9606.ENSP00000251643

Chemistry databases

DrugBankiDB00400 Griseofulvin

PTM databases

iPTMnetiQ99456
PhosphoSitePlusiQ99456
SwissPalmiQ99456

Polymorphism and mutation databases

BioMutaiKRT12
DMDMi2497269

Proteomic databases

PaxDbiQ99456
PeptideAtlasiQ99456
PRIDEiQ99456
ProteomicsDBi78275

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3859
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251643; ENSP00000251643; ENSG00000187242
ENST00000572470; ENSP00000459559; ENSG00000263243
ENST00000647992; ENSP00000497200; ENSG00000187242
GeneIDi3859
KEGGihsa:3859
UCSCiuc002hvk.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3859
DisGeNETi3859
EuPathDBiHostDB:ENSG00000187242.4

GeneCards: human genes, protein and diseases

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GeneCardsi
KRT12
HGNCiHGNC:6414 KRT12
HPAiHPA055217
HPA055835
MalaCardsiKRT12
MIMi122100 phenotype
601687 gene
neXtProtiNX_Q99456
OpenTargetsiENSG00000187242
Orphaneti98954 Meesmann corneal dystrophy
PharmGKBiPA30201

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IFTF Eukaryota
ENOG410Y9IV LUCA
GeneTreeiENSGT00940000159382
HOGENOMiHOG000230975
HOVERGENiHBG013015
InParanoidiQ99456
KOiK07604
OMAiQNADHQR
OrthoDBiEOG091G087I
PhylomeDBiQ99456
TreeFamiTF332742

Enzyme and pathway databases

ReactomeiR-HSA-6805567 Keratinization
R-HSA-6809371 Formation of the cornified envelope

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
KRT12 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Keratin_12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3859

Protein Ontology

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PROi
PR:Q99456

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000187242 Expressed in 22 organ(s), highest expression level in mucosa of transverse colon
CleanExiHS_KRT12
GenevisibleiQ99456 HS

Family and domain databases

InterProiView protein in InterPro
IPR001664 IF
IPR018039 IF_conserved
IPR039008 IF_rod_dom
IPR002957 Keratin_I
PANTHERiPTHR23239 PTHR23239, 1 hit
PfamiView protein in Pfam
PF00038 Filament, 1 hit
PRINTSiPR01248 TYPE1KERATIN
SMARTiView protein in SMART
SM01391 Filament, 1 hit
PROSITEiView protein in PROSITE
PS00226 IF_ROD_1, 1 hit
PS51842 IF_ROD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiK1C12_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99456
Secondary accession number(s): B2R9E0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: December 5, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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