Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ethanolamine-phosphate cytidylyltransferase

Gene

PCYT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays an important role in the biosynthesis of the phospholipid phosphatidylethanolamine. Catalyzes the formation of CDP-ethanolamine.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: phosphatidylethanolamine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes phosphatidylethanolamine from ethanolamine.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Ethanolamine kinase 1 (ETNK1), Ethanolamine kinase 2 (ETNK2), Choline/ethanolamine kinase (CHKB), Choline kinase alpha (CHKA)
  2. Ethanolamine-phosphate cytidylyltransferase (PCYT2)
  3. Choline/ethanolaminephosphotransferase 1 (CEPT1), Ethanolaminephosphotransferase 1 (SELENOI)
This subpathway is part of the pathway phosphatidylethanolamine biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes phosphatidylethanolamine from ethanolamine, the pathway phosphatidylethanolamine biosynthesis and in Phospholipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei259CTP1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi221 – 222CTP2
Nucleotide bindingi229 – 232CTP4
Nucleotide bindingi307 – 310CTP4
Nucleotide bindingi336 – 340CTP5

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • ethanolamine-phosphate cytidylyltransferase activity Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS06840-MONOMER

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1483213 Synthesis of PE

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00558;UER00742

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ethanolamine-phosphate cytidylyltransferase (EC:2.7.7.14)
Alternative name(s):
CTP:phosphoethanolamine cytidylyltransferase
Phosphorylethanolamine transferase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PCYT2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000185813.10

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8756 PCYT2

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602679 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99447

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000185813

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA33101

Chemistry databases

Drug and drug target database

More...
DrugBanki
DB00709 Lamivudine

Polymorphism and mutation databases

Domain mapping of disease mutations (DMDM)

More...
DMDMi
12585314

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002084611 – 389Ethanolamine-phosphate cytidylyltransferaseAdd BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei338PhosphoserineCombined sources1
Modified residuei341PhosphothreonineCombined sources1
Modified residuei342PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99447

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99447

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99447

PeptideAtlas

More...
PeptideAtlasi
Q99447

PRoteomics IDEntifications database

More...
PRIDEi
Q99447

ProteomicsDB human proteome resource

More...
ProteomicsDBi
78273

2D gel databases

University College Dublin 2-DE Proteome Database

More...
UCD-2DPAGEi
Q99447

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99447

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99447

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Strongest expression in liver, heart, and skeletal muscle.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000185813 Expressed in 203 organ(s), highest expression level in right testis

CleanEx database of gene expression profiles

More...
CleanExi
HS_PCYT2

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99447 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99447 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA023033
HPA023034

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111791, 20 interactors

Protein interaction database and analysis system

More...
IntActi
Q99447, 11 interactors

Molecular INTeraction database

More...
MINTi
Q99447

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000442050

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1389
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q99447

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99447

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q99447

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cytidylyltransferase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2803 Eukaryota
COG0615 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00550000075065

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000187618

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG000865

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99447

KEGG Orthology (KO)

More...
KOi
K00967

Identification of Orthologs from Complete Genome Data

More...
OMAi
CYRFVKE

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0AIL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99447

TreeFam database of animal gene trees

More...
TreeFami
TF106337

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.620, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004821 Cyt_trans-like
IPR014729 Rossmann-like_a/b/a_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01467 CTP_transf_like, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00125 cyt_tran_rel, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99447-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MIRNGRGAAG GAEQPGPGGR RAVRVWCDGC YDMVHYGHSN QLRQARAMGD
60 70 80 90 100
YLIVGVHTDE EIAKHKGPPV FTQEERYKMV QAIKWVDEVV PAAPYVTTLE
110 120 130 140 150
TLDKYNCDFC VHGNDITLTV DGRDTYEEVK QAGRYRECKR TQGVSTTDLV
160 170 180 190 200
GRMLLVTKAH HSSQEMSSEY REYADSFGKC PGGRNPWTGV SQFLQTSQKI
210 220 230 240 250
IQFASGKEPQ PGETVIYVAG AFDLFHIGHV DFLEKVHRLA ERPYIIAGLH
260 270 280 290 300
FDQEVNHYKG KNYPIMNLHE RTLSVLACRY VSEVVIGAPY AVTAELLSHF
310 320 330 340 350
KVDLVCHGKT EIIPDRDGSD PYQEPKRRGI FRQIDSGSNL TTDLIVQRII
360 370 380
TNRLEYEARN QKKEAKELAF LEAARQQAAQ PLGERDGDF
Length:389
Mass (Da):43,835
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i13FE8EAEB7FFAF7F
GO
Isoform 2 (identifier: Q99447-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-78: Missing.

Show »
Length:311
Mass (Da):35,200
Checksum:iAE4851C05A3B403C
GO
Isoform 3 (identifier: Q99447-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     179-179: K → KPPHPIPAGDILSSEGCSQ

Note: No experimental confirmation available. Gene prediction based on cDNA data.
Show »
Length:407
Mass (Da):45,622
Checksum:i8BA20CC46F0F06C9
GO
Isoform 4 (identifier: Q99447-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Note: No experimental confirmation available.
Show »
Length:357
Mass (Da):40,520
Checksum:iF246E5C6A87F55CD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
I3L1R7I3L1R7_HUMAN
Ethanolamine-phosphate cytidylyltra...
PCYT2
367Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L3V9I3L3V9_HUMAN
Ethanolamine-phosphate cytidylyltra...
PCYT2
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1C4I3L1C4_HUMAN
Ethanolamine-phosphate cytidylyltra...
PCYT2
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3NI16I3NI16_HUMAN
Ethanolamine-phosphate cytidylyltra...
PCYT2
53Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1L9I3L1L9_HUMAN
Ethanolamine-phosphate cytidylyltra...
PCYT2
314Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L2Q1I3L2Q1_HUMAN
Ethanolamine-phosphate cytidylyltra...
PCYT2
286Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L1F9I3L1F9_HUMAN
Ethanolamine-phosphate cytidylyltra...
PCYT2
34Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
I3L102I3L102_HUMAN
Ethanolamine-phosphate cytidylyltra...
PCYT2
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti244Y → H in AAH10075 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0451311 – 78Missing in isoform 2. 1 PublicationAdd BLAST78
Alternative sequenceiVSP_0546151 – 32Missing in isoform 4. 1 PublicationAdd BLAST32
Alternative sequenceiVSP_046844179K → KPPHPIPAGDILSSEGCSQ in isoform 3. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D84307 mRNA Translation: BAA12311.1
CR456779 mRNA Translation: CAG33060.1
AK301723 mRNA Translation: BAH13541.1
AK316385 mRNA Translation: BAH14756.1
AC145207 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89705.1
BC000351 mRNA Translation: AAH00351.1
BC010075 mRNA Translation: AAH10075.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS11791.1 [Q99447-1]
CCDS54178.1 [Q99447-3]
CCDS58610.1 [Q99447-2]
CCDS62364.1 [Q99447-4]

NCBI Reference Sequences

More...
RefSeqi
NP_001171846.1, NM_001184917.2 [Q99447-3]
NP_001243364.1, NM_001256435.2 [Q99447-2]
NP_001269132.1, NM_001282203.1 [Q99447-2]
NP_001269133.1, NM_001282204.1 [Q99447-4]
NP_002852.1, NM_002861.4 [Q99447-1]
XP_016880400.1, XM_017024911.1 [Q99447-4]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.569843

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000331285; ENSP00000331719; ENSG00000185813 [Q99447-2]
ENST00000538721; ENSP00000442050; ENSG00000185813 [Q99447-3]
ENST00000538936; ENSP00000439245; ENSG00000185813 [Q99447-1]
ENST00000570388; ENSP00000458330; ENSG00000185813 [Q99447-2]
ENST00000570391; ENSP00000461190; ENSG00000185813 [Q99447-4]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5833

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5833

UCSC genome browser

More...
UCSCi
uc002kce.4 human [Q99447-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84307 mRNA Translation: BAA12311.1
CR456779 mRNA Translation: CAG33060.1
AK301723 mRNA Translation: BAH13541.1
AK316385 mRNA Translation: BAH14756.1
AC145207 Genomic DNA No translation available.
CH471099 Genomic DNA Translation: EAW89705.1
BC000351 mRNA Translation: AAH00351.1
BC010075 mRNA Translation: AAH10075.1
CCDSiCCDS11791.1 [Q99447-1]
CCDS54178.1 [Q99447-3]
CCDS58610.1 [Q99447-2]
CCDS62364.1 [Q99447-4]
RefSeqiNP_001171846.1, NM_001184917.2 [Q99447-3]
NP_001243364.1, NM_001256435.2 [Q99447-2]
NP_001269132.1, NM_001282203.1 [Q99447-2]
NP_001269133.1, NM_001282204.1 [Q99447-4]
NP_002852.1, NM_002861.4 [Q99447-1]
XP_016880400.1, XM_017024911.1 [Q99447-4]
UniGeneiHs.569843

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ELBX-ray2.00A18-356[»]
4XSVX-ray2.70A18-356[»]
ProteinModelPortaliQ99447
SMRiQ99447
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111791, 20 interactors
IntActiQ99447, 11 interactors
MINTiQ99447
STRINGi9606.ENSP00000442050

Chemistry databases

DrugBankiDB00709 Lamivudine

PTM databases

iPTMnetiQ99447
PhosphoSitePlusiQ99447

Polymorphism and mutation databases

DMDMi12585314

2D gel databases

UCD-2DPAGEiQ99447

Proteomic databases

EPDiQ99447
MaxQBiQ99447
PaxDbiQ99447
PeptideAtlasiQ99447
PRIDEiQ99447
ProteomicsDBi78273

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5833
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331285; ENSP00000331719; ENSG00000185813 [Q99447-2]
ENST00000538721; ENSP00000442050; ENSG00000185813 [Q99447-3]
ENST00000538936; ENSP00000439245; ENSG00000185813 [Q99447-1]
ENST00000570388; ENSP00000458330; ENSG00000185813 [Q99447-2]
ENST00000570391; ENSP00000461190; ENSG00000185813 [Q99447-4]
GeneIDi5833
KEGGihsa:5833
UCSCiuc002kce.4 human [Q99447-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5833
EuPathDBiHostDB:ENSG00000185813.10

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PCYT2
HGNCiHGNC:8756 PCYT2
HPAiHPA023033
HPA023034
MIMi602679 gene
neXtProtiNX_Q99447
OpenTargetsiENSG00000185813
PharmGKBiPA33101

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2803 Eukaryota
COG0615 LUCA
GeneTreeiENSGT00550000075065
HOGENOMiHOG000187618
HOVERGENiHBG000865
InParanoidiQ99447
KOiK00967
OMAiCYRFVKE
OrthoDBiEOG091G0AIL
PhylomeDBiQ99447
TreeFamiTF106337

Enzyme and pathway databases

UniPathwayi
UPA00558;UER00742

BioCyciMetaCyc:HS06840-MONOMER
ReactomeiR-HSA-1483213 Synthesis of PE

Miscellaneous databases

EvolutionaryTraceiQ99447

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5833

Protein Ontology

More...
PROi
PR:Q99447

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000185813 Expressed in 203 organ(s), highest expression level in right testis
CleanExiHS_PCYT2
ExpressionAtlasiQ99447 baseline and differential
GenevisibleiQ99447 HS

Family and domain databases

Gene3Di3.40.50.620, 2 hits
InterProiView protein in InterPro
IPR004821 Cyt_trans-like
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF01467 CTP_transf_like, 2 hits
TIGRFAMsiTIGR00125 cyt_tran_rel, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCY2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99447
Secondary accession number(s): B7Z7A5
, B7ZAS0, F5H8B1, Q6IBM3, Q96G08
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: May 1, 1997
Last modified: December 5, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again