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Entry version 158 (18 Sep 2019)
Sequence version 1 (01 May 1997)
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Protein

Translocation protein SEC62

Gene

SEC62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processProtein transport, Translocation, Transport

Protein family/group databases

Transport Classification Database

More...
TCDBi
1.A.15.1.6 the non-selective cation channel-2 (nscc2) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Translocation protein SEC62
Alternative name(s):
Translocation protein 1
Short name:
TP-1
Short name:
hTP-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SEC62
Synonyms:TLOC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11846 SEC62

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
602173 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99442

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 196CytoplasmicSequence analysisAdd BLAST196
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 234LumenalSequence analysisAdd BLAST17
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 399CytoplasmicSequence analysisAdd BLAST144

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
7095

Open Targets

More...
OpenTargetsi
ENSG00000008952

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162402849

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q99442

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SEC62

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74732781

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002066161 – 399Translocation protein SEC62Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei158PhosphothreonineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei375PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99442

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99442

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q99442

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99442

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99442

PeptideAtlas

More...
PeptideAtlasi
Q99442

PRoteomics IDEntifications database

More...
PRIDEi
Q99442

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78271

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q99442

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99442

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99442

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99442

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000008952 Expressed in 253 organ(s), highest expression level in endothelial cell

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99442 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99442 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA014059
HPA061450

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The ER translocon complex that consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63.

Interacts with SEC61B.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
112950, 39 interactors

Protein interaction database and analysis system

More...
IntActi
Q99442, 22 interactors

Molecular INTeraction database

More...
MINTi
Q99442

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000337688

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SEC62 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2927 Eukaryota
COG5232 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002757

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000016701

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99442

KEGG Orthology (KO)

More...
KOi
K12275

Identification of Orthologs from Complete Genome Data

More...
OMAi
HEYKGPR

Database of Orthologous Groups

More...
OrthoDBi
1474000at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99442

TreeFam database of animal gene trees

More...
TreeFami
TF314944

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004728 Sec62

The PANTHER Classification System

More...
PANTHERi
PTHR12443 PTHR12443, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03839 Sec62, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99442-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAERRRHKKR IQEVGEPSKE EKAVAKYLRF NCPTKSTNMM GHRVDYFIAS
60 70 80 90 100
KAVDCLLDSK WAKAKKGEEA LFTTRESVVD YCNRLLKKQF FHRALKVMKM
110 120 130 140 150
KYDKDIKKEK DKGKAESGKE EDKKSKKENI KDEKTKKEKE KKKDGEKEES
160 170 180 190 200
KKEETPGTPK KKETKKKFKL EPHDDQVFLD GNEVYVWIYD PVHFKTFVMG
210 220 230 240 250
LILVIAVIAA TLFPLWPAEM RVGVYYLSVG AGCFVASILL LAVARCILFL
260 270 280 290 300
IIWLITGGRH HFWFLPNLTA DVGFIDSFRP LYTHEYKGPK ADLKKDEKSE
310 320 330 340 350
TKKQQKSDSE EKSDSEKKED EEGKVGPGNH GTEGSGGERH SDTDSDRRED
360 370 380 390
DRSQHSSGNG NDFEMITKEE LEQQTDGDCE EDEEEENDGE TPKSSHEKS
Length:399
Mass (Da):45,862
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCACBF4F02E2D0AE5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WCJ7F8WCJ7_HUMAN
Translocation protein SEC62
SEC62
101Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WF48F8WF48_HUMAN
Translocation protein SEC62
SEC62
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WDG8F8WDG8_HUMAN
Translocation protein SEC62
SEC62
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D87127 mRNA Translation: BAA13254.1
AB024586 Genomic DNA Translation: BAB12685.1
U93239 mRNA Translation: AAB51391.1
CH471052 Genomic DNA Translation: EAW78530.1
CH471052 Genomic DNA Translation: EAW78531.1
BC012035 mRNA Translation: AAH12035.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3210.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5279

NCBI Reference Sequences

More...
RefSeqi
NP_003253.1, NM_003262.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000337002; ENSP00000337688; ENSG00000008952
ENST00000480708; ENSP00000420331; ENSG00000008952

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7095

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:7095

UCSC genome browser

More...
UCSCi
uc003fgg.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87127 mRNA Translation: BAA13254.1
AB024586 Genomic DNA Translation: BAB12685.1
U93239 mRNA Translation: AAB51391.1
CH471052 Genomic DNA Translation: EAW78530.1
CH471052 Genomic DNA Translation: EAW78531.1
BC012035 mRNA Translation: AAH12035.1
CCDSiCCDS3210.1
PIRiJC5279
RefSeqiNP_003253.1, NM_003262.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi112950, 39 interactors
IntActiQ99442, 22 interactors
MINTiQ99442
STRINGi9606.ENSP00000337688

Protein family/group databases

TCDBi1.A.15.1.6 the non-selective cation channel-2 (nscc2) family

PTM databases

iPTMnetiQ99442
PhosphoSitePlusiQ99442
SwissPalmiQ99442

Polymorphism and mutation databases

BioMutaiSEC62
DMDMi74732781

Proteomic databases

EPDiQ99442
jPOSTiQ99442
MassIVEiQ99442
MaxQBiQ99442
PaxDbiQ99442
PeptideAtlasiQ99442
PRIDEiQ99442
ProteomicsDBi78271
TopDownProteomicsiQ99442

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
7095

Genome annotation databases

EnsembliENST00000337002; ENSP00000337688; ENSG00000008952
ENST00000480708; ENSP00000420331; ENSG00000008952
GeneIDi7095
KEGGihsa:7095
UCSCiuc003fgg.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7095
DisGeNETi7095

GeneCards: human genes, protein and diseases

More...
GeneCardsi
SEC62
HGNCiHGNC:11846 SEC62
HPAiHPA014059
HPA061450
MIMi602173 gene
neXtProtiNX_Q99442
OpenTargetsiENSG00000008952
PharmGKBiPA162402849

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG2927 Eukaryota
COG5232 LUCA
GeneTreeiENSGT00390000002757
HOGENOMiHOG000016701
InParanoidiQ99442
KOiK12275
OMAiHEYKGPR
OrthoDBi1474000at2759
PhylomeDBiQ99442
TreeFamiTF314944

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
SEC62 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
SEC62

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7095
PharosiQ99442

Protein Ontology

More...
PROi
PR:Q99442

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000008952 Expressed in 253 organ(s), highest expression level in endothelial cell
ExpressionAtlasiQ99442 baseline and differential
GenevisibleiQ99442 HS

Family and domain databases

InterProiView protein in InterPro
IPR004728 Sec62
PANTHERiPTHR12443 PTHR12443, 1 hit
PfamiView protein in Pfam
PF03839 Sec62, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSEC62_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99442
Secondary accession number(s): D3DNQ0, O00682, O00729
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: May 1, 1997
Last modified: September 18, 2019
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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