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Protein

Translocation protein SEC62

Gene

SEC62

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.2 Publications

GO - Molecular functioni

  • signaling receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Protein family/group databases

TCDBi1.A.15.1.6 the non-selective cation channel-2 (nscc2) family

Names & Taxonomyi

Protein namesi
Recommended name:
Translocation protein SEC62
Alternative name(s):
Translocation protein 1
Short name:
TP-1
Short name:
hTP-1
Gene namesi
Name:SEC62
Synonyms:TLOC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000008952.16
HGNCiHGNC:11846 SEC62
MIMi602173 gene
neXtProtiNX_Q99442

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 196CytoplasmicSequence analysisAdd BLAST196
Transmembranei197 – 217HelicalSequence analysisAdd BLAST21
Topological domaini218 – 234LumenalSequence analysisAdd BLAST17
Transmembranei235 – 255HelicalSequence analysisAdd BLAST21
Topological domaini256 – 399CytoplasmicSequence analysisAdd BLAST144

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7095
OpenTargetsiENSG00000008952
PharmGKBiPA162402849

Polymorphism and mutation databases

BioMutaiSEC62
DMDMi74732781

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002066161 – 399Translocation protein SEC62Add BLAST399

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei158PhosphothreonineCombined sources1
Modified residuei335PhosphoserineCombined sources1
Modified residuei341PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei356PhosphoserineCombined sources1
Modified residuei375PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99442
MaxQBiQ99442
PaxDbiQ99442
PeptideAtlasiQ99442
PRIDEiQ99442
ProteomicsDBi78271
TopDownProteomicsiQ99442

PTM databases

iPTMnetiQ99442
PhosphoSitePlusiQ99442
SwissPalmiQ99442

Expressioni

Gene expression databases

BgeeiENSG00000008952 Expressed in 253 organ(s), highest expression level in endothelial cell
CleanExiHS_SEC62
ExpressionAtlasiQ99442 baseline and differential
GenevisibleiQ99442 HS

Organism-specific databases

HPAiHPA014059
HPA061450

Interactioni

Subunit structurei

The ER translocon complex that consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63. Interacts with SEC61B.By similarity

Protein-protein interaction databases

BioGridi112950, 36 interactors
CORUMiQ99442
IntActiQ99442, 16 interactors
MINTiQ99442
STRINGi9606.ENSP00000337688

Structurei

3D structure databases

ProteinModelPortaliQ99442
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SEC62 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2927 Eukaryota
COG5232 LUCA
GeneTreeiENSGT00390000002757
HOGENOMiHOG000016701
HOVERGENiHBG055550
InParanoidiQ99442
KOiK12275
OMAiFEGNEVH
OrthoDBiEOG091G0KPB
PhylomeDBiQ99442
TreeFamiTF314944

Family and domain databases

InterProiView protein in InterPro
IPR004728 Sec62
PANTHERiPTHR12443 PTHR12443, 1 hit
PfamiView protein in Pfam
PF03839 Sec62, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99442-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAERRRHKKR IQEVGEPSKE EKAVAKYLRF NCPTKSTNMM GHRVDYFIAS
60 70 80 90 100
KAVDCLLDSK WAKAKKGEEA LFTTRESVVD YCNRLLKKQF FHRALKVMKM
110 120 130 140 150
KYDKDIKKEK DKGKAESGKE EDKKSKKENI KDEKTKKEKE KKKDGEKEES
160 170 180 190 200
KKEETPGTPK KKETKKKFKL EPHDDQVFLD GNEVYVWIYD PVHFKTFVMG
210 220 230 240 250
LILVIAVIAA TLFPLWPAEM RVGVYYLSVG AGCFVASILL LAVARCILFL
260 270 280 290 300
IIWLITGGRH HFWFLPNLTA DVGFIDSFRP LYTHEYKGPK ADLKKDEKSE
310 320 330 340 350
TKKQQKSDSE EKSDSEKKED EEGKVGPGNH GTEGSGGERH SDTDSDRRED
360 370 380 390
DRSQHSSGNG NDFEMITKEE LEQQTDGDCE EDEEEENDGE TPKSSHEKS
Length:399
Mass (Da):45,862
Last modified:May 1, 1997 - v1
Checksum:iCACBF4F02E2D0AE5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WF48F8WF48_HUMAN
Translocation protein SEC62
SEC62
85Annotation score:
F8WCJ7F8WCJ7_HUMAN
Translocation protein SEC62
SEC62
101Annotation score:
F8WDG8F8WDG8_HUMAN
Translocation protein SEC62
SEC62
47Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87127 mRNA Translation: BAA13254.1
AB024586 Genomic DNA Translation: BAB12685.1
U93239 mRNA Translation: AAB51391.1
CH471052 Genomic DNA Translation: EAW78530.1
CH471052 Genomic DNA Translation: EAW78531.1
BC012035 mRNA Translation: AAH12035.1
CCDSiCCDS3210.1
PIRiJC5279
RefSeqiNP_003253.1, NM_003262.3
UniGeneiHs.744859

Genome annotation databases

EnsembliENST00000337002; ENSP00000337688; ENSG00000008952
ENST00000480708; ENSP00000420331; ENSG00000008952
GeneIDi7095
KEGGihsa:7095
UCSCiuc003fgg.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D87127 mRNA Translation: BAA13254.1
AB024586 Genomic DNA Translation: BAB12685.1
U93239 mRNA Translation: AAB51391.1
CH471052 Genomic DNA Translation: EAW78530.1
CH471052 Genomic DNA Translation: EAW78531.1
BC012035 mRNA Translation: AAH12035.1
CCDSiCCDS3210.1
PIRiJC5279
RefSeqiNP_003253.1, NM_003262.3
UniGeneiHs.744859

3D structure databases

ProteinModelPortaliQ99442
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112950, 36 interactors
CORUMiQ99442
IntActiQ99442, 16 interactors
MINTiQ99442
STRINGi9606.ENSP00000337688

Protein family/group databases

TCDBi1.A.15.1.6 the non-selective cation channel-2 (nscc2) family

PTM databases

iPTMnetiQ99442
PhosphoSitePlusiQ99442
SwissPalmiQ99442

Polymorphism and mutation databases

BioMutaiSEC62
DMDMi74732781

Proteomic databases

EPDiQ99442
MaxQBiQ99442
PaxDbiQ99442
PeptideAtlasiQ99442
PRIDEiQ99442
ProteomicsDBi78271
TopDownProteomicsiQ99442

Protocols and materials databases

DNASUi7095
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000337002; ENSP00000337688; ENSG00000008952
ENST00000480708; ENSP00000420331; ENSG00000008952
GeneIDi7095
KEGGihsa:7095
UCSCiuc003fgg.4 human

Organism-specific databases

CTDi7095
DisGeNETi7095
EuPathDBiHostDB:ENSG00000008952.16
GeneCardsiSEC62
HGNCiHGNC:11846 SEC62
HPAiHPA014059
HPA061450
MIMi602173 gene
neXtProtiNX_Q99442
OpenTargetsiENSG00000008952
PharmGKBiPA162402849
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2927 Eukaryota
COG5232 LUCA
GeneTreeiENSGT00390000002757
HOGENOMiHOG000016701
HOVERGENiHBG055550
InParanoidiQ99442
KOiK12275
OMAiFEGNEVH
OrthoDBiEOG091G0KPB
PhylomeDBiQ99442
TreeFamiTF314944

Enzyme and pathway databases

ReactomeiR-HSA-381038 XBP1(S) activates chaperone genes

Miscellaneous databases

ChiTaRSiSEC62 human
GeneWikiiSEC62
GenomeRNAii7095
PROiPR:Q99442
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000008952 Expressed in 253 organ(s), highest expression level in endothelial cell
CleanExiHS_SEC62
ExpressionAtlasiQ99442 baseline and differential
GenevisibleiQ99442 HS

Family and domain databases

InterProiView protein in InterPro
IPR004728 Sec62
PANTHERiPTHR12443 PTHR12443, 1 hit
PfamiView protein in Pfam
PF03839 Sec62, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEC62_HUMAN
AccessioniPrimary (citable) accession number: Q99442
Secondary accession number(s): D3DNQ0, O00682, O00729
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 152 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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