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Protein

V-type proton ATPase 21 kDa proteolipid subunit

Gene

ATP6V0B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei98Essential for proton translocationBy similarity1

GO - Molecular functioni

  • proton-transporting ATPase activity, rotational mechanism Source: GO_Central
  • transporter activity Source: ProtInc

GO - Biological processi

Keywordsi

Biological processHydrogen ion transport, Ion transport, Transport

Enzyme and pathway databases

BioCyciMetaCyc:ENSG00000117410-MONOMER
ReactomeiR-HSA-1222556 ROS, RNS production in phagocytes
R-HSA-77387 Insulin receptor recycling
R-HSA-917977 Transferrin endocytosis and recycling
R-HSA-983712 Ion channel transport

Names & Taxonomyi

Protein namesi
Recommended name:
V-type proton ATPase 21 kDa proteolipid subunit
Short name:
V-ATPase 21 kDa proteolipid subunit
Alternative name(s):
Vacuolar proton pump 21 kDa proteolipid subunit
hATPL
Gene namesi
Name:ATP6V0B
Synonyms:ATP6F
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117410.13
HGNCiHGNC:861 ATP6V0B
MIMi603717 gene
neXtProtiNX_Q99437

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 3LumenalSequence analysis3
Transmembranei4 – 24HelicalSequence analysisAdd BLAST21
Topological domaini25 – 51CytoplasmicSequence analysisAdd BLAST27
Transmembranei52 – 72HelicalSequence analysisAdd BLAST21
Topological domaini73 – 90LumenalSequence analysisAdd BLAST18
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Topological domaini112 – 137CytoplasmicSequence analysisAdd BLAST26
Transmembranei138 – 158HelicalSequence analysisAdd BLAST21
Topological domaini159 – 175LumenalSequence analysisAdd BLAST17
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 205CytoplasmicSequence analysis9

Keywords - Cellular componenti

Membrane, Vacuole

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000117410
PharmGKBiPA25148

Polymorphism and mutation databases

BioMutaiATP6V0B
DMDMi6136172

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000717771 – 205V-type proton ATPase 21 kDa proteolipid subunitAdd BLAST205

Proteomic databases

PaxDbiQ99437
PeptideAtlasiQ99437
PRIDEiQ99437
ProteomicsDBi78267

PTM databases

iPTMnetiQ99437
PhosphoSitePlusiQ99437

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000117410
CleanExiHS_ATP6V0B
ExpressionAtlasiQ99437 baseline and differential
GenevisibleiQ99437 HS

Organism-specific databases

HPAiHPA044281

Interactioni

Subunit structurei

Interacts with IFITM3.By similarity

Protein-protein interaction databases

BioGridi107016, 9 interactors
IntActiQ99437, 22 interactors
STRINGi9606.ENSP00000431605

Structurei

3D structure databases

ProteinModelPortaliQ99437
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0233 Eukaryota
COG0636 LUCA
GeneTreeiENSGT00550000075120
HOGENOMiHOG000056522
HOVERGENiHBG105033
InParanoidiQ99437
KOiK03661
PhylomeDBiQ99437
TreeFamiTF314946

Family and domain databases

InterProiView protein in InterPro
IPR002379 ATPase_proteolipid_c-like_dom
IPR000245 ATPase_proteolipid_csu
IPR035921 F/V-ATP_Csub_sf
PfamiView protein in Pfam
PF00137 ATP-synt_C, 2 hits
PRINTSiPR00122 VACATPASE
SUPFAMiSSF81333 SSF81333, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99437-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGLALLYSG VFVAFWACAL AVGVCYTIFD LGFRFDVAWF LTETSPFMWS
60 70 80 90 100
NLGIGLAISL SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV
110 120 130 140 150
AIYGIIMAIV ISNMAEPFSA TDPKAIGHRN YHAGYSMFGA GLTVGLSNLF
160 170 180 190 200
CGVCVGIVGS GAALADAQNP SLFVKILIVE IFGSAIGLFG VIVAILQTSR

VKMGD
Length:205
Mass (Da):21,406
Last modified:May 1, 1997 - v1
Checksum:iF17C688D068A2785
GO
Isoform 2 (identifier: Q99437-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: Missing.

Note: No experimental confirmation available. Gene prediction based on EST data.
Show »
Length:158
Mass (Da):16,206
Checksum:i93A67D6350A62D34
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035703155V → M in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs373883976Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0462881 – 47Missing in isoform 2. CuratedAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D89052 mRNA Translation: BAA13753.1
BT007151 mRNA Translation: AAP35815.1
CR456972 mRNA Translation: CAG33253.1
AL357079 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07066.1
CH471059 Genomic DNA Translation: EAX07067.1
CH471059 Genomic DNA Translation: EAX07068.1
BC000423 mRNA Translation: AAH00423.1
BC005876 mRNA Translation: AAH05876.1
CCDSiCCDS41315.1 [Q99437-2]
CCDS505.1 [Q99437-1]
RefSeqiNP_001034546.1, NM_001039457.2 [Q99437-2]
NP_004038.1, NM_004047.4 [Q99437-1]
UniGeneiHs.596514

Genome annotation databases

EnsembliENST00000236067; ENSP00000236067; ENSG00000117410 [Q99437-2]
ENST00000472174; ENSP00000431605; ENSG00000117410 [Q99437-1]
ENST00000498664; ENSP00000434094; ENSG00000117410 [Q99437-2]
GeneIDi533
KEGGihsa:533
UCSCiuc001cld.4 human [Q99437-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiVATO_HUMAN
AccessioniPrimary (citable) accession number: Q99437
Secondary accession number(s): D3DPY5, Q6IB32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: May 1, 1997
Last modified: July 18, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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