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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160SAAS annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesOrterviralesRetroviridaeOrthoretrovirinaeLentivirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Virion membrane SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei455 – 476HelicalSequence analysisAdd BLAST22

GO - Cellular componenti

Keywords - Cellular componenti

Host endosomeSAAS annotation, Membrane, Viral envelope proteinImported, Virion

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi31N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi62 ↔ 148Combined sources
Disulfide bondi69 ↔ 139Combined sources
Glycosylationi140N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi161 ↔ 190Combined sources
Disulfide bondi171 ↔ 182Combined sources
Glycosylationi173N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi177N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi184N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi205N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi219N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi232N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi238N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi239 ↔ 274Combined sources
Glycosylationi282N-linked (GlcNAc...) asparagineCombined sources1
Disulfide bondi321 ↔ 388Combined sources
Disulfide bondi328 ↔ 361Combined sources
Glycosylationi329N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi335N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi391N-linked (GlcNAc...) asparagineCombined sources1
Glycosylationi406N-linked (GlcNAc...) asparagineCombined sources1

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ993A8
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ993A8

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 454GP120InterPro annotationAdd BLAST449
Domaini473 – 587GP41InterPro annotationAdd BLAST115

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Family and domain databases

CDDicd09909 HIV-1-like_HR1-HR2, 1 hit
Gene3Di2.170.40.20, 2 hits
InterProiView protein in InterPro
IPR036377 Gp120_core_sf
IPR000328 GP41-like
IPR000777 HIV1_Gp120
PfamiView protein in Pfam
PF00516 GP120, 1 hit
PF00517 GP41, 1 hit
SUPFAMiSSF56502 SSF56502, 3 hits

Sequencei

Sequence statusi: Fragment.

Q993A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
AKAYDTEVHN VWATHACVPT DPNPQEVVLV NVTENFNMWK NDMVEQMHED
60 70 80 90 100
IISLWDQSLK PCVKLTPLCV SLKCTDLKND TNTNSSSGRM IMEKGEIKNC
110 120 130 140 150
SFNISTSIRG KVQKEYAFFY KLDIIPIDND TTSYTLTSCN TSVITQACPK
160 170 180 190 200
VSFEPIPIHY CAPAGFAILK CNNKTFNGTG PCTNVSTVQC THGIRPVVST
210 220 230 240 250
QLLLNGSLAE EEVVIRSVNF TDNAKTIIVQ LNTSVEINCT RPNNNTRKKI
260 270 280 290 300
RIQRGPGRAF VTIGKIGNMR QAHCNISRAK WNATLKQIAS KLREQFGNNK
310 320 330 340 350
TIIFKQSSGG DPEIVTHSFN CGGEFFYCNS TQLFNSTWFN STWSTEGSNN
360 370 380 390 400
TEGSDTITLP CRIKQIINMW QEVGKAMYAP PISGQIRCSS NITGLLLTRD
410 420 430 440 450
GGNSNNESEI FRPGGGDMRD NWRSELYKYK VVKIEPLGVA PTKAKRRVVQ
460 470 480 490 500
REKRAVGIGA LFLGFLGAAG STMGAASMTL TVQARQLLSG IVQQQNNLLR
510 520 530 540 550
AIEAQQHLLQ LTVWGIKQLQ ARILAVERYL KDQQLLGIWG CSGKLICTTA
560 570 580
VPWNASWSNK SLEQIWNNMT WMEWDREINN YTSLIHSL
Length:588
Mass (Da):65,643
Last modified:June 1, 2001 - v1
Checksum:i47475A5780240AE8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei588Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF321147 Genomic DNA Translation: AAK20295.1
PIRiA53591

Similar proteinsi

Entry informationi

Entry nameiQ993A8_9HIV1
AccessioniPrimary (citable) accession number: Q993A8
Entry historyiIntegrated into UniProtKB/TrEMBL: June 1, 2001
Last sequence update: June 1, 2001
Last modified: July 18, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources

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