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Protein

Trafficking protein particle complex subunit 33

Gene

TRS33

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the TRAPP I, TRAPP II and TRAPP III complexes which act as guanine nucleotide exchange factors (GEF) for YPT1. TRAPP I plays a key role in the late stages of endoplasmic reticulum to Golgi traffic. TRAPP II plays a role in intra-Golgi transport. TRAPP III plays a role in autophagosome formation. Required for sporulation. Has a role late in meiosis following DNA replication.3 Publications

GO - Biological processi

Keywordsi

Biological processAutophagy, ER-Golgi transport, Transport

Enzyme and pathway databases

BioCyciYEAST:G3O-33644-MONOMER
ReactomeiR-SCE-204005 COPII-mediated vesicle transport

Names & Taxonomyi

Protein namesi
Recommended name:
Trafficking protein particle complex subunit 33
Short name:
TRAPP subunit 33
Alternative name(s):
Transport protein particle 33 kDa subunit
Gene namesi
Name:TRS33
Ordered Locus Names:YOR115C
ORF Names:O3251, YOR3251C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XV

Organism-specific databases

SGDiS000005641 TRS33

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002115892 – 268Trafficking protein particle complex subunit 33Add BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ99394
PaxDbiQ99394
PRIDEiQ99394

PTM databases

iPTMnetiQ99394

Interactioni

Subunit structurei

Part of the multisubunit TRAPP (transport protein particle) I complex composed of BET3, BET5, TRS20, TRS23, TRS31 and TRS33. Part of the multisubunit TRAPP (transport protein particle) II complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33, TRS65, TRS85, TRS120 and TRS130. Part of the multisubunit TRAPP (transport protein particle) III complex composed of BET3, BET5, TRS20, TRS23, TRS31, TRS33 and TRS85.4 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi34511, 138 interactors
ComplexPortaliCPX-1383 TRAPPIII protein complex
CPX-1939 TRAPPII protein complex
CPX-1940 TRAPPI protein complex
DIPiDIP-1712N
IntActiQ99394, 11 interactors
MINTiQ99394
STRINGi4932.YOR115C

Structurei

3D structure databases

ProteinModelPortaliQ99394
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00390000012948
HOGENOMiHOG000200502
InParanoidiQ99394
KOiK20304
OMAiYDYKPIQ
OrthoDBiEOG092C3URL

Family and domain databases

CDDicd14944 TRAPPC6A_Trs33, 1 hit
InterProiView protein in InterPro
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR007194 TRAPP_component
IPR037992 TRAPPC6/Trs33
PANTHERiPTHR12817 PTHR12817, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99394-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSTHSNNVG HPQSSPQGPL TEQQRAQQQY QIFENSLPKV SQSVYQMLLN
60 70 80 90 100
EMVPLAMGIE RQISGDVISS DSNVTSENGN INNMIKRLKI EEHHTVDIIR
110 120 130 140 150
SHNLIHELYK ADEEEKEKVL ARLRNIGFQI GLKLSELLIF SNNPNLKFKE
160 170 180 190 200
MDLLLIMKFI CRDVWKQIFG KQIDNLKTNH RGTFYLLDYD YRPIQSFSLE
210 220 230 240 250
EDAKNEELKM IEPFLEIPVG IIRGVLSSLG YSSEEVICLA SFIDRPTDRP
260
KTAFPKGVSF HVQVTMPQ
Length:268
Mass (Da):30,749
Last modified:November 1, 1996 - v1
Checksum:i2480F69D7A48D363
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90518 Genomic DNA Translation: CAA62124.1
X94335 Genomic DNA Translation: CAA64035.1
Z75023 Genomic DNA Translation: CAA99313.1
BK006948 Genomic DNA Translation: DAA10890.1
PIRiS61003
RefSeqiNP_014758.3, NM_001183534.3

Genome annotation databases

EnsemblFungiiYOR115C; YOR115C; YOR115C
GeneIDi854282
KEGGisce:YOR115C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90518 Genomic DNA Translation: CAA62124.1
X94335 Genomic DNA Translation: CAA64035.1
Z75023 Genomic DNA Translation: CAA99313.1
BK006948 Genomic DNA Translation: DAA10890.1
PIRiS61003
RefSeqiNP_014758.3, NM_001183534.3

3D structure databases

ProteinModelPortaliQ99394
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi34511, 138 interactors
ComplexPortaliCPX-1383 TRAPPIII protein complex
CPX-1939 TRAPPII protein complex
CPX-1940 TRAPPI protein complex
DIPiDIP-1712N
IntActiQ99394, 11 interactors
MINTiQ99394
STRINGi4932.YOR115C

PTM databases

iPTMnetiQ99394

Proteomic databases

MaxQBiQ99394
PaxDbiQ99394
PRIDEiQ99394

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYOR115C; YOR115C; YOR115C
GeneIDi854282
KEGGisce:YOR115C

Organism-specific databases

SGDiS000005641 TRS33

Phylogenomic databases

GeneTreeiENSGT00390000012948
HOGENOMiHOG000200502
InParanoidiQ99394
KOiK20304
OMAiYDYKPIQ
OrthoDBiEOG092C3URL

Enzyme and pathway databases

BioCyciYEAST:G3O-33644-MONOMER
ReactomeiR-SCE-204005 COPII-mediated vesicle transport

Miscellaneous databases

PROiPR:Q99394

Family and domain databases

CDDicd14944 TRAPPC6A_Trs33, 1 hit
InterProiView protein in InterPro
IPR024096 NO_sig/Golgi_transp_ligand-bd
IPR007194 TRAPP_component
IPR037992 TRAPPC6/Trs33
PANTHERiPTHR12817 PTHR12817, 1 hit
PfamiView protein in Pfam
PF04051 TRAPP, 1 hit
SUPFAMiSSF111126 SSF111126, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTRS33_YEAST
AccessioniPrimary (citable) accession number: Q99394
Secondary accession number(s): D6W2H4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 16, 2002
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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Main funding by: National Institutes of Health

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