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UniProtKB - Q99385 (VCX1_YEAST)

Entry version 146 (23 Feb 2022)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Vacuolar calcium ion transporter

Gene

VCX1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.

2 Publications

Miscellaneous

Present with 7770 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Manganese, Metal-binding

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.19.2.2, the ca(2+):cation antiporter (caca) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar calcium ion transporter
Alternative name(s):
High copy number undoes manganese protein 1
Manganese resistance 1 protein
Vacuolar Ca(2+)/H(+) exchanger
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VCX1
Synonyms:HUM1, MNR1
Ordered Locus Names:YDL128W
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome IV

Organism-specific databases

Saccharomyces Genome Database

More...SGDi		S000002286, VCX1

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:YDL128W

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 30Cytoplasmic1 PublicationAdd BLAST30
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei31 – 53HelicalSequence analysisAdd BLAST23
Topological domaini54 – 59Vacuolar1 Publication6
Transmembranei60 – 82HelicalSequence analysisAdd BLAST23
Topological domaini83 – 91Cytoplasmic1 Publication9
Transmembranei92 – 114HelicalSequence analysisAdd BLAST23
Topological domaini115 – 126Vacuolar1 PublicationAdd BLAST12
Transmembranei127 – 146HelicalSequence analysisAdd BLAST20
Topological domaini147 – 160Cytoplasmic1 PublicationAdd BLAST14
Transmembranei161 – 183HelicalSequence analysisAdd BLAST23
Topological domaini184 – 203Vacuolar1 PublicationAdd BLAST20
Transmembranei204 – 226HelicalSequence analysisAdd BLAST23
Topological domaini227 – 252Cytoplasmic1 PublicationAdd BLAST26
Transmembranei253 – 275HelicalSequence analysisAdd BLAST23
Topological domaini276 – 287Vacuolar1 PublicationAdd BLAST12
Transmembranei288 – 310HelicalSequence analysisAdd BLAST23
Topological domaini311 – 319Cytoplasmic1 Publication9
Transmembranei320 – 342HelicalSequence analysisAdd BLAST23
Topological domaini343 – 348Vacuolar1 Publication6
Transmembranei349 – 371HelicalSequence analysisAdd BLAST23
Topological domaini372 – 380Cytoplasmic1 Publication9
Transmembranei381 – 398HelicalSequence analysisAdd BLAST18
Topological domaini399 – 411Vacuolar1 PublicationAdd BLAST13

Keywords - Cellular componenti

Membrane, Vacuole

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002095041 – 411Vacuolar calcium ion transporterAdd BLAST411

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1N-acetylmethionineCombined sources1
Modified residuei13PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99385

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99385

PRoteomics IDEntifications database

More...PRIDEi		Q99385

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99385

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		31935, 44 interactors

Database of interacting proteins

More...DIPi		DIP-5039N

Protein interaction database and analysis system

More...IntActi		Q99385, 1 interactor

STRING: functional protein association networks

More...STRINGi		4932.YDL128W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99385, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1411
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99385

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1397, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000016897

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_008721_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99385

Identification of Orthologs from Complete Genome Data

More...OMAi		AAVMITC

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1420.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004713, CaH_exchang
IPR004798, CAX-like
IPR004837, NaCa_Exmemb
IPR044880, NCX_ion-bd_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR31503, PTHR31503, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01699, Na_Ca_ex, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00378, cax, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q99385-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDATTPLLTV ANSHPARNPK HTAWRAAVYD LQYILKASPL NFLLVFVPLG 
        60         70         80         90        100
LIWGHFQLSH TLTFLFNFLA IIPLAAILAN ATEELADKAG NTIGGLLNAT 
       110        120        130        140        150
FGNAVELIVS IIALKKGQVR IVQASMLGSL LSNLLLVLGL CFIFGGYNRV 
       160        170        180        190        200
QQTFNQTAAQ TMSSLLAIAC ASLLIPAAFR ATLPHGKEDH FIDGKILELS 
       210        220        230        240        250
RGTSIVILIV YVLFLYFQLG SHHALFEQQE EETDEVMSTI SRNPHHSLSV 
       260        270        280        290        300
KSSLVILLGT TVIISFCADF LVGTIDNVVE STGLSKTFIG LIVIPIVGNA 
       310        320        330        340        350
AEHVTSVLVA MKDKMDLALG VAIGSSLQVA LFVTPFMVLV GWMIDVPMTL 
       360        370        380        390        400
NFSTFETATL FIAVFLSNYL ILDGESNWLE GVMSLAMYIL IAMAFFYYPD 
       410 
EKTLDSIGNS L
Length:411
Mass (Da):44,646
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A946818A02E8078
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti204S → A in manganese-resistant mutant 2. 1
Natural varianti208L → P in manganese-resistant mutant 1. 1
Natural varianti383M → I in VCX1-D1. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U18944 Genomic DNA Translation: AAC49550.1
U36603 Genomic DNA Translation: AAB60313.1
AJ001272 Genomic DNA Translation: CAA04645.1
AJ001273 Genomic DNA Translation: CAA04646.1
Z74176 Genomic DNA Translation: CAA98696.1
BK006938 Genomic DNA Translation: DAA11732.1

Protein sequence database of the Protein Information Resource

More...PIRi		S61933

NCBI Reference Sequences

More...RefSeqi		NP_010155.1, NM_001180187.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		YDL128W_mRNA; YDL128W; YDL128W

Database of genes from NCBI RefSeq genomes

More...GeneIDi		851429

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		sce:YDL128W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18944 Genomic DNA Translation: AAC49550.1
U36603 Genomic DNA Translation: AAB60313.1
AJ001272 Genomic DNA Translation: CAA04645.1
AJ001273 Genomic DNA Translation: CAA04646.1
Z74176 Genomic DNA Translation: CAA98696.1
BK006938 Genomic DNA Translation: DAA11732.1
PIRiS61933
RefSeqiNP_010155.1, NM_001180187.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4K1CX-ray2.30A/B1-411[»]
SMRiQ99385
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi31935, 44 interactors
DIPiDIP-5039N
IntActiQ99385, 1 interactor
STRINGi4932.YDL128W

Protein family/group databases

TCDBi2.A.19.2.2, the ca(2+):cation antiporter (caca) family

PTM databases

iPTMnetiQ99385

Proteomic databases

MaxQBiQ99385
PaxDbiQ99385
PRIDEiQ99385

Genome annotation databases

EnsemblFungiiYDL128W_mRNA; YDL128W; YDL128W
GeneIDi851429
KEGGisce:YDL128W

Organism-specific databases

SGDiS000002286, VCX1
VEuPathDBiFungiDB:YDL128W

Phylogenomic databases

eggNOGiKOG1397, Eukaryota
GeneTreeiENSGT00390000016897
HOGENOMiCLU_008721_4_2_1
InParanoidiQ99385
OMAiAAVMITC

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q99385
RNActiQ99385, protein

Family and domain databases

Gene3Di1.20.1420.30, 1 hit
InterProiView protein in InterPro
IPR004713, CaH_exchang
IPR004798, CAX-like
IPR004837, NaCa_Exmemb
IPR044880, NCX_ion-bd_dom_sf
PANTHERiPTHR31503, PTHR31503, 1 hit
PfamiView protein in Pfam
PF01699, Na_Ca_ex, 2 hits
TIGRFAMsiTIGR00378, cax, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVCX1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99385
Secondary accession number(s): D6VRM2, O13580, O13581
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 7, 2006
Last sequence update: November 1, 1996
Last modified: February 23, 2022
This is version 146 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome IV
    Yeast (Saccharomyces cerevisiae) chromosome IV: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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