Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Elastin

Gene

Eln

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Major structural protein of tissues such as aorta and nuchal ligament, which must expand rapidly and recover completely. Molecular determinant of the late arterial morphogenesis, stabilizing arterial structure by regulating proliferation and organization of vascular smooth muscle (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • extracellular matrix constituent conferring elasticity Source: RGD

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Elastin
Alternative name(s):
Tropoelastin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Eln
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Rat genome database

More...
RGDi
67394 Eln

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 271 PublicationAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002116528 – 870ElastinAdd BLAST843

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei394-hydroxyprolineBy similarity1
Modified residuei754-hydroxyprolineBy similarity1
Modified residuei87HydroxyprolineBy similarity1
Modified residuei1054-hydroxyprolineBy similarity1
Modified residuei122AllysineBy similarity1
Modified residuei126AllysineBy similarity1
Modified residuei2074-hydroxyprolineBy similarity1
Modified residuei2204-hydroxyprolineBy similarity1
Modified residuei2234-hydroxyprolineBy similarity1
Modified residuei2444-hydroxyprolineBy similarity1
Modified residuei290AllysineBy similarity1
Modified residuei309AllysineBy similarity1
Modified residuei3384-hydroxyprolineBy similarity1
Modified residuei360AllysineBy similarity1
Modified residuei363AllysineBy similarity1
Modified residuei375HydroxyprolineBy similarity1
Modified residuei4024-hydroxyprolineBy similarity1
Modified residuei4084-hydroxyprolineBy similarity1
Modified residuei413HydroxyprolineBy similarity1
Modified residuei418HydroxyprolineBy similarity1
Modified residuei434AllysineBy similarity1
Modified residuei438AllysineBy similarity1
Modified residuei441AllysineBy similarity1
Modified residuei485AllysineBy similarity1
Modified residuei488AllysineBy similarity1
Modified residuei5184-hydroxyprolineBy similarity1
Modified residuei5394-hydroxyprolineBy similarity1
Modified residuei554AllysineBy similarity1
Modified residuei558AllysineBy similarity1
Modified residuei615AllysineBy similarity1
Modified residuei619AllysineBy similarity1
Modified residuei623AllysineBy similarity1
Modified residuei6374-hydroxyprolineBy similarity1
Modified residuei6464-hydroxyprolineBy similarity1
Modified residuei6624-hydroxyprolineBy similarity1
Modified residuei6704-hydroxyprolineBy similarity1
Modified residuei677AllysineBy similarity1
Modified residuei680AllysineBy similarity1
Modified residuei7154-hydroxyprolineBy similarity1
Modified residuei730AllysineBy similarity1
Modified residuei734AllysineBy similarity1
Modified residuei793AllysineBy similarity1
Modified residuei796AllysineBy similarity1
Modified residuei8424-hydroxyprolineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi860 ↔ 865By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Elastin is formed through the cross-linking of its soluble precursor tropoelastin. Cross-linking is initiated through the action of lysyl oxidase on exposed lysines to form allysine. Subsequent spontaneous condensation reactions with other allysine or unmodified lysine residues result in various bi-, tri-, and tetrafunctional cross-links. The most abundant cross-links in mature elastin fibers are lysinonorleucine, allysine aldol, desmosine, and isodesmosine.
Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates.By similarity

Keywords - PTMi

Disulfide bond, Hydroxylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99372

PRoteomics IDEntifications database

More...
PRIDEi
Q99372

PTM databases

CarbonylDB database of protein carbonylation sites

More...
CarbonylDBi
Q99372

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99372

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Down-regulated by DTR via activation of EGFR.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The polymeric elastin chains are cross-linked together into an extensible 3D network. Forms a ternary complex with BGN and MFAP2. Interacts with MFAP2 via divalent cations (calcium > magnesium > manganese) in a dose-dependent and saturating manner. Interacts with FBLN5 and FBN1. Forms a ternary complex with FBN1 and FBLN2 or FBLN5. Interacts with MFAP4 in a Ca (2+)-dependent manner; this interaction promotes ELN self-assembly.By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000030301

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99372

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi28 – 866Gly-richAdd BLAST839
Compositional biasi303 – 800Ala-richAdd BLAST498

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the elastin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IZT8 Eukaryota
ENOG4111817 LUCA

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99372

KEGG Orthology (KO)

More...
KOi
K14211

TreeFam database of animal gene trees

More...
TreeFami
TF338594

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003979 Tropoelastin

The PANTHER Classification System

More...
PANTHERi
PTHR24018 PTHR24018, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01500 TROPOELASTIN

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (8+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 8 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Experimental confirmation may be lacking for some isoforms.

This entry has 8 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99372-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGLTAAVPQ PGVLLILLLN LLHPAQPGGV PGAVPGGVPG GLPGGVPGGV
60 70 80 90 100
YYPGAGIGGG LGGGALGPGG KPPKPGAGLL GAFGAGPGGL GGAGPGAGLS
110 120 130 140 150
YASRPGGVLV PGGGAGAAAA YKAAAKAGAG LGGIGGVPGG VGVGGVPGAV
160 170 180 190 200
GVGGVPGAVG GIGGIGGLGV STGAVVPQLG AGVGAGGKPG KVPGVGLPGV
210 220 230 240 250
YPGGVLPGTG ARFPGVGVLP GVPTGTGVKA KVPGGGGGAF SGIPGVGPFG
260 270 280 290 300
GQQPGVPLGY PIKAPKLPGG YGLPYTNGKL PYGVAGAGGK AGYPTGTGVG
310 320 330 340 350
SQAAVAAAKA AKYAGAGGGG VLPGVGGGGI PGGAGAIPGI GGITGAGTPA
360 370 380 390 400
AAAAAKAAAK AAKYGAAGGL VPGGPGVRVP GAGIPGVGIP GVGGIPGVGG
410 420 430 440 450
IPGVGGIPGV GGPGIGGPGI VGGPGAVSPA AAAKAAAKAA KYGARGGVGI
460 470 480 490 500
PTYGVGAGGF PGYGVGAGAG LGGASQAAAA AAAAKAAKYG AGGAGTLGGL
510 520 530 540 550
VPGAVPGALP GAVPGALPGA VPGALPGAVP GVPGTGGVPG AGTPAAAAAA
560 570 580 590 600
AAAKAAAKAG QYGLGPGVGG VPGGVGVGGL PGGVGPGGVT GIGTGPGTGL
610 620 630 640 650
VPGDLGGAGT PAAAKSAAKA AAKAQYRAAA GLGAGVPGLG VGAGVPGFGA
660 670 680 690 700
GAGGFGAGAG VPGFGAGAVP GSLAASKAAK YGAAGGLGGP GGLGGPGGLG
710 720 730 740 750
GPGGFGGPGG LGGVPGGVAG GAPAAAAAAK AAAKAAQYGL GGAGGLGAGG
760 770 780 790 800
LGAGGLGAGG LGAGGLGAGG LGAGGVIPGA VGLGGVSPAA AAKAAKYGAA
810 820 830 840 850
GLGGVLGARP FPGGGVAARP GFGLSPIYPG GGAGGLGVGG KPPKPYGGAL
860 870
GALGYQGGGC FGKSCGRKRK
Length:870
Mass (Da):73,330
Last modified:December 6, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i75909F2432FC4054
GO
Isoform 2 (identifier: Q99372-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-313: Missing.

Show »
Length:825
Mass (Da):69,158
Checksum:iF3E089F8C8FCA22B
GO
Isoform 3 (identifier: Q99372-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-314: Missing.

Show »
Length:869
Mass (Da):73,259
Checksum:i12822008FC268B5A
GO
Isoform 4 (identifier: Q99372-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     815-829: Missing.

Show »
Length:855
Mass (Da):71,846
Checksum:i17749AE40323BAE4
GO
Isoform 5 (identifier: Q99372-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-313: Missing.
     314-314: Missing.

Show »
Length:824
Mass (Da):69,087
Checksum:i7294FCF2FCC4F4BD
GO
Isoform 6 (identifier: Q99372-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     314-314: Missing.
     815-829: Missing.

Show »
Length:854
Mass (Da):71,775
Checksum:iCB7DFD496CC4C546
GO
Isoform 7 (identifier: Q99372-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-313: Missing.
     815-829: Missing.

Show »
Length:810
Mass (Da):67,675
Checksum:iAD71B1A4B123BA30
GO
Isoform 8 (identifier: Q99372-8) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     269-313: Missing.
     314-314: Missing.
     815-829: Missing.

Show »
Length:809
Mass (Da):67,604
Checksum:i2E56BDFB6CC4118C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D4A9U4D4A9U4_RAT
Elastin
Eln
875Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JST5A0A0G2JST5_RAT
Elastin
Eln
812Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti705F → L in AAH85910 (PubMed:15489334).Curated1
Sequence conflicti713G → GPGGLGG in AAH85910 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_004244269 – 313Missing in isoform 2, isoform 5, isoform 7 and isoform 8. CuratedAdd BLAST45
Alternative sequenceiVSP_004245314Missing in isoform 3, isoform 5, isoform 6 and isoform 8. 1 Publication1
Alternative sequenceiVSP_004246815 – 829Missing in isoform 4, isoform 6, isoform 7 and isoform 8. CuratedAdd BLAST15

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC085910 mRNA Translation: AAH85910.1
M60647 mRNA Translation: AAA42269.1
M86372
, M86355, M86363, M86364, M86366, M86371 Genomic DNA Translation: AAA42271.1
M86376, M86373, M86375 Genomic DNA Translation: AAA42272.1
J04035 mRNA Translation: AAA42268.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A36106 EART

NCBI Reference Sequences

More...
RefSeqi
NP_036854.1, NM_012722.1

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Rn.54384

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
25043

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:25043

UCSC genome browser

More...
UCSCi
RGD:67394 rat [Q99372-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC085910 mRNA Translation: AAH85910.1
M60647 mRNA Translation: AAA42269.1
M86372
, M86355, M86363, M86364, M86366, M86371 Genomic DNA Translation: AAA42271.1
M86376, M86373, M86375 Genomic DNA Translation: AAA42272.1
J04035 mRNA Translation: AAA42268.1
PIRiA36106 EART
RefSeqiNP_036854.1, NM_012722.1
UniGeneiRn.54384

3D structure databases

SMRiQ99372
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000030301

PTM databases

CarbonylDBiQ99372
PhosphoSitePlusiQ99372

Proteomic databases

PaxDbiQ99372
PRIDEiQ99372

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25043
KEGGirno:25043
UCSCiRGD:67394 rat [Q99372-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
2006
RGDi67394 Eln

Phylogenomic databases

eggNOGiENOG410IZT8 Eukaryota
ENOG4111817 LUCA
InParanoidiQ99372
KOiK14211
TreeFamiTF338594

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q99372

Family and domain databases

InterProiView protein in InterPro
IPR003979 Tropoelastin
PANTHERiPTHR24018 PTHR24018, 4 hits
PRINTSiPR01500 TROPOELASTIN

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiELN_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99372
Secondary accession number(s): Q5RKH4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 6, 2005
Last modified: November 7, 2018
This is version 124 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again