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Protein

Receptor-type adenylate cyclase GRESAG 4.1

Gene

GRESAG 4.1

Organism
Trypanosoma brucei brucei
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could act as a receptor for an unknown ligand.

Catalytic activityi

ATP = 3',5'-cyclic AMP + diphosphate.

Cofactori

Mg2+Note: Binds 1 Mg2+ ion per subunit.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi906MagnesiumPROSITE-ProRule annotation1
Metal bindingi949MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase, Receptor
Biological processcAMP biosynthesis
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type adenylate cyclase GRESAG 4.1 (EC:4.6.1.1)
Alternative name(s):
ATP pyrophosphate-lyase
Adenylyl cyclase
Gene namesi
Name:GRESAG 4.1
OrganismiTrypanosoma brucei brucei
Taxonomic identifieri5702 [NCBI]
Taxonomic lineageiEukaryotaEuglenozoaKinetoplastidaTrypanosomatidaeTrypanosoma

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39CytoplasmicSequence analysisAdd BLAST39
Transmembranei40 – 60HelicalSequence analysisAdd BLAST21
Topological domaini61 – 862ExtracellularSequence analysisAdd BLAST802
Transmembranei863 – 883HelicalSequence analysisAdd BLAST21
Topological domaini884 – 1242CytoplasmicSequence analysisAdd BLAST359

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001957371 – 1242Receptor-type adenylate cyclase GRESAG 4.1Add BLAST1242

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi289N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi318N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi338N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi534N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi563N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi603N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi702N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi741N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi818N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ99279

Structurei

Secondary structure

11242
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi889 – 891Combined sources3
Beta strandi900 – 907Combined sources8
Helixi910 – 916Combined sources7
Turni918 – 920Combined sources3
Helixi921 – 938Combined sources18
Beta strandi942 – 947Combined sources6
Beta strandi950 – 956Combined sources7
Helixi958 – 974Combined sources17
Helixi981 – 996Combined sources16
Helixi1009 – 1015Combined sources7
Beta strandi1021 – 1028Combined sources8
Beta strandi1039 – 1046Combined sources8
Helixi1047 – 1057Combined sources11
Beta strandi1064 – 1067Combined sources4
Helixi1068 – 1072Combined sources5
Helixi1076 – 1080Combined sources5
Beta strandi1084 – 1090Combined sources7
Beta strandi1099 – 1104Combined sources6

3D structure databases

ProteinModelPortaliQ99279
SMRiQ99279
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99279

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini901 – 1056Guanylate cyclasePROSITE-ProRule annotationAdd BLAST156

Sequence similaritiesi

Belongs to the adenylyl cyclase class-3 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di3.30.70.1230, 1 hit
InterProiView protein in InterPro
IPR001054 A/G_cyclase
IPR029787 Nucleotide_cyclase
IPR028082 Peripla_BP_I
PfamiView protein in Pfam
PF00211 Guanylate_cyc, 1 hit
SMARTiView protein in SMART
SM00044 CYCc, 1 hit
SUPFAMiSSF53822 SSF53822, 1 hit
SSF55073 SSF55073, 1 hit
PROSITEiView protein in PROSITE
PS50125 GUANYLATE_CYCLASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q99279-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHWQEGGGRG CVYTHGNCRR NLTARALQAL QHVEALTCHY CVSLLHLLPL
60 70 80 90 100
LLMWMPPVCA DDSAVTVNVL SMMYNPEYYV EKVNAINAGF DASLSAHGWK
110 120 130 140 150
TGSGATISVI RPPSYNTTAE DIFQLGVKQS EGKLLVVFGP LGTDPVVWVR
160 170 180 190 200
DKLKENDLVA IAPIAYSSEV RGWNPHLYSI SVEPNAELLA LIRYAVVYLG
210 220 230 240 250
LPRVGLMYAK GNGFDKESYE FTMRIMEIMG RKPCGVFAVE SSGGRDVLEG
260 270 280 290 300
QLNTKWGQFV ATRPQAVLLF SSLEEETTGW FVKKIAQDNR TVDMYLLAPS
310 320 330 340 350
SFQHFLIKTW SDALVSLNRT FTPGQLITTG TVPLASDNRS SMVRHFQRDM
360 370 380 390 400
DNYLDTNSDW KGFAKPEHYL KDDKLGEMMV FGWLAGEVLF EALNNAPQLT
410 420 430 440 450
NRTSFMESLY KQRRYVIDDF VVGDFGGECD EALHYRVPCV IAIKAAAWTH
460 470 480 490 500
MRVVDDSLSL KPMKKGSVTW SVSECSSANV QVSAPLIGLY VVLTDDKVAQ
510 520 530 540 550
RASMRWSLGA RSIEEADDVD KRIFFHSLKV NLKNLTQSLE QVRDTKAVAA
560 570 580 590 600
VLGVTADILS VPNMTFIGPI PLFPRLNKFW RNVIHLQPLL AHELYVLAVY
610 620 630 640 650
LSNTSSTGVK ALVRGGEASE VVDTLDKSLV TFGVSLDSSK TLGDGDPMSS
660 670 680 690 700
YLSGNGDVFC IGLTPPDVAA VARHLQTHLR ARVFVPFNDI LLFYQEFVAG
710 720 730 740 750
FNASKESIAS SEGLLFATSF PHWGKKNRKS DMVARFHRHV NESHWDPLTF
760 770 780 790 800
LGFATTRLLQ VVISNMRKVN AEPLADRIYT ESNIRVDDVG FGPFSDAECV
810 820 830 840 850
SGTSVSANEC ASNFGATNIS VWSMGACAEF KLAQDTGWDD TVYGLCYSAR
860 870 880 890 900
GSTHTVTDSW NNFWVCIRLV IIYCPWCVPT HLPAERRNNN RAPKEPTDPV
910 920 930 940 950
TLIFTDIESS TALWAAHPDL MPDAVAAHHR MVRSLIGRYK CYEVKTVGDS
960 970 980 990 1000
FMIASKSPFA AVQLAQELQL CFLHHDWGTN ALDDSYREFE EQRAEGECEY
1010 1020 1030 1040 1050
TPPTAHMDPE VYSRLWNGLR VRVGIHTGLC DIIRHDEVTK GYDYYGRTPN
1060 1070 1080 1090 1100
MAARTESVAN GGQVLMTHAA YMSLSAEDRK QIDVTALGDV ALRGVSDPVK
1110 1120 1130 1140 1150
MYQLNTVPSR NFAALRLDRE YFFDEGEDGT TTSTSDHSSS RADVSESGQI
1160 1170 1180 1190 1200
IATALQSLLS TFKTAHREKL LLPYCERWRV PLPRKAASEW DDAYCEEVVR
1210 1220 1230 1240
RIAVKVGRVA DHGADSGSES SSTQGSSSII IVPFYDMHLQ EY
Length:1,242
Mass (Da):138,158
Last modified:November 1, 1996 - v1
Checksum:i452F8B22FFC0A2E3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52119 mRNA Translation: CAA36364.1
PIRiS14201

Similar proteinsi

Entry informationi

Entry nameiCY41_TRYBB
AccessioniPrimary (citable) accession number: Q99279
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 18, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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