Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 164 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Na(+)/H(+) antiporter

Gene

NHA1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sodium export from cell, takes up external protons in exchange for internal sodium ions.By similarity

Miscellaneous

Present with 1480 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntiport, Ion transport, Sodium transport, Transport
LigandSodium

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.36.4.1, the monovalent cation:proton antiporter-1 (cpa1) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Na(+)/H(+) antiporter
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NHA1
Ordered Locus Names:YLR138W
ORF Names:L3149, L9606.4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:YLR138W

Saccharomyces Genome Database

More...
SGDi
S000004128, NHA1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 12CytoplasmicSequence analysisAdd BLAST12
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei13 – 33HelicalSequence analysisAdd BLAST21
Topological domaini34 – 36ExtracellularSequence analysis3
Transmembranei37 – 57HelicalSequence analysisAdd BLAST21
Topological domaini58 – 70CytoplasmicSequence analysisAdd BLAST13
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Topological domaini92 – 105ExtracellularSequence analysisAdd BLAST14
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 128CytoplasmicSequence analysis2
Transmembranei129 – 149HelicalSequence analysisAdd BLAST21
Topological domaini150 – 176ExtracellularSequence analysisAdd BLAST27
Transmembranei177 – 197HelicalSequence analysisAdd BLAST21
Topological domaini198 – 203CytoplasmicSequence analysis6
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 244ExtracellularSequence analysisAdd BLAST20
Transmembranei245 – 265HelicalSequence analysisAdd BLAST21
Topological domaini266 – 294CytoplasmicSequence analysisAdd BLAST29
Transmembranei295 – 315HelicalSequence analysisAdd BLAST21
Topological domaini316 – 319ExtracellularSequence analysis4
Transmembranei320 – 340HelicalSequence analysisAdd BLAST21
Topological domaini341 – 361CytoplasmicSequence analysisAdd BLAST21
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 410ExtracellularSequence analysisAdd BLAST28
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 985CytoplasmicSequence analysisAdd BLAST554

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000524071 – 985Na(+)/H(+) antiporterAdd BLAST985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei568PhosphoserineCombined sources1
Modified residuei765PhosphothreonineCombined sources1
Modified residuei768PhosphoserineCombined sources1
Modified residuei774PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99271

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99271

PRoteomics IDEntifications database

More...
PRIDEi
Q99271

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99271

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
31407, 107 interactors

Database of interacting proteins

More...
DIPi
DIP-6364N

Protein interaction database and analysis system

More...
IntActi
Q99271, 4 interactors

Molecular INTeraction database

More...
MINTi
Q99271

STRING: functional protein association networks

More...
STRINGi
4932.YLR138W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99271, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99271

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the fungal Na(+)/H(+) exchanger family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4505, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_008635_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99271

KEGG Orthology (KO)

More...
KOi
K24160

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITRIVLC

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013928, Cation/H_antiporter_C
IPR006153, Cation/H_exchanger
IPR004712, Na+/H+_antiporter_fungi
IPR032516, Nha1

The PANTHER Classification System

More...
PANTHERi
PTHR31382:SF4, PTHR31382:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PF08619, Nha1_C, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00844, c_cpa1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q99271-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAIWEQLEVS KAHVAYACVG VFSSIFSLVS LYVKEKLYIG ESTVAGIFGL
60 70 80 90 100
IVGPVCLNWF NPLKWGNSDS ITLEITRIVL CLQIFAVAVE LPRKYMLKHW
110 120 130 140 150
VSVTMLLLPV MTAGWLIIGL FVWILIPGLN FSASLLISAC ITATDPILAQ
160 170 180 190 200
SVVSGKFAQR VPGHLRNLLS AESGCNDGMA FPFLFLSMNL ILHPGNGREI
210 220 230 240 250
VKDWICVTIL YECLFGCLLG CFIGYVGRIT IRFAEKKNII DRESFLAFYV
260 270 280 290 300
VLAFMCAGFG SILGVDDLLV SFAAGATFAW DGWFSQKTQE SNVSTVIDLL
310 320 330 340 350
LNYAYFIYFG AIIPWSQFNN GEIGTNVWRL IILSIVVIFL RRIPAVMILR
360 370 380 390 400
PLIPDIKSWR EALFVGHFGP IGVGAIFAAI LARGELESTF SDEPTPLNVV
410 420 430 440 450
PSKEESKHWQ LIACIWPITC FFIVTSIIVH GSSVAIITLG RHLNTITLTK
460 470 480 490 500
TFTTHTTNGD NGKSSWMQRL PSLDKAGRSF SLHRMDTQMT LSGDEGEAEE
510 520 530 540 550
GGGRKGLAGG EDEEGLNNDQ IGSVATSGIP ARPAGGMPRR RKLSRKEKRL
560 570 580 590 600
NRRQKLRNKG REIFSSRSKN EMYDDDELND LGRERLQKEK EARAATFALS
610 620 630 640 650
TAVNTQRNEE IGMGGDEEED EYTPEKEYSD NYNNTPSFES SERSSSLRGR
660 670 680 690 700
TYVPRNRYDG EETESEIESE DEMENESERS MASSEERRIR KMKEEEMKPG
710 720 730 740 750
TAYLDGNRMI IENKQGEILN QVDIEDRNEA RDDEVSVDST AHSSLTTTMT
760 770 780 790 800
NLSSSSGGRL KRILTPTSLG KIHSLVDKGK DKNKNSKYHA FKIDNLLIIE
810 820 830 840 850
NEDGDVIKRY KINPHKSDDD KSKNRPRNDS VVSRALTAVG LKSKANSGVP
860 870 880 890 900
PPVDEEKAIE GPSRKGPGML KKRTLTPAPP RGVQDSLDLE DEPSSEEDLG
910 920 930 940 950
DSYNMDDSED YDDNAYESET EFERQRRLNA LGEMTAPADQ DDEELPPLPV
960 970 980
EAQTGNDGPG TAEGKKKQKS AAVKSALSKT LGLNK
Length:985
Mass (Da):109,369
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAD0B86D483DCDD89
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U53881 Genomic DNA Translation: AAB82392.1
X91258 Genomic DNA Translation: CAA62653.1
Z73310 Genomic DNA Translation: CAA97709.1
Z73311 Genomic DNA Translation: CAA97711.1
BK006945 Genomic DNA Translation: DAA09449.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S59330

NCBI Reference Sequences

More...
RefSeqi
NP_013239.1, NM_001182025.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLR138W_mRNA; YLR138W; YLR138W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
850829

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR138W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U53881 Genomic DNA Translation: AAB82392.1
X91258 Genomic DNA Translation: CAA62653.1
Z73310 Genomic DNA Translation: CAA97709.1
Z73311 Genomic DNA Translation: CAA97711.1
BK006945 Genomic DNA Translation: DAA09449.1
PIRiS59330
RefSeqiNP_013239.1, NM_001182025.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6QK8X-ray2.92E/F/G/H478-485[»]
SMRiQ99271
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi31407, 107 interactors
DIPiDIP-6364N
IntActiQ99271, 4 interactors
MINTiQ99271
STRINGi4932.YLR138W

Protein family/group databases

TCDBi2.A.36.4.1, the monovalent cation:proton antiporter-1 (cpa1) family

PTM databases

iPTMnetiQ99271

Proteomic databases

MaxQBiQ99271
PaxDbiQ99271
PRIDEiQ99271

Genome annotation databases

EnsemblFungiiYLR138W_mRNA; YLR138W; YLR138W
GeneIDi850829
KEGGisce:YLR138W

Organism-specific databases

EuPathDBiFungiDB:YLR138W
SGDiS000004128, NHA1

Phylogenomic databases

eggNOGiKOG4505, Eukaryota
HOGENOMiCLU_008635_0_1_1
InParanoidiQ99271
KOiK24160
OMAiITRIVLC

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q99271
RNActiQ99271, protein

Family and domain databases

InterProiView protein in InterPro
IPR013928, Cation/H_antiporter_C
IPR006153, Cation/H_exchanger
IPR004712, Na+/H+_antiporter_fungi
IPR032516, Nha1
PANTHERiPTHR31382:SF4, PTHR31382:SF4, 1 hit
PfamiView protein in Pfam
PF00999, Na_H_Exchanger, 1 hit
PF08619, Nha1_C, 2 hits
TIGRFAMsiTIGR00844, c_cpa1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNAH1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99271
Secondary accession number(s): D6VYD3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again