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Entry version 115 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Protein DFG16

Gene

DFG16

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in invasion during filamentous growth.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • cellular response to pH Source: GO_Central
  • protein processing Source: SGD
  • pseudohyphal growth Source: SGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandZinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein DFG16
Alternative name(s):
Extracellular mutant protein 41
Zinc-regulated gene 11 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DFG16
Synonyms:ECM41, ZRG11
Ordered Locus Names:YOR030W
ORF Names:OR26.20
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

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EuPathDBi
FungiDB:YOR030W

Saccharomyces Genome Database

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SGDi
S000005556, DFG16

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1ExtracellularSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei2 – 22HelicalSequence analysisAdd BLAST21
Topological domaini23 – 167CytoplasmicSequence analysisAdd BLAST145
Transmembranei168 – 188HelicalSequence analysisAdd BLAST21
Topological domaini189 – 203ExtracellularSequence analysisAdd BLAST15
Transmembranei204 – 224HelicalSequence analysisAdd BLAST21
Topological domaini225 – 291CytoplasmicSequence analysisAdd BLAST67
Transmembranei292 – 312HelicalSequence analysisAdd BLAST21
Topological domaini313 – 321ExtracellularSequence analysis9
Transmembranei322 – 342HelicalSequence analysisAdd BLAST21
Topological domaini343 – 378CytoplasmicSequence analysisAdd BLAST36
Transmembranei379 – 399HelicalSequence analysisAdd BLAST21
Topological domaini400 – 410ExtracellularSequence analysisAdd BLAST11
Transmembranei411 – 431HelicalSequence analysisAdd BLAST21
Topological domaini432 – 619CytoplasmicSequence analysisAdd BLAST188

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000798731 – 619Protein DFG16Add BLAST619

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99234

PRoteomics IDEntifications database

More...
PRIDEi
Q99234

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99234

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Repressed by zinc.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
34432, 261 interactors

STRING: functional protein association networks

More...
STRINGi
4932.YOR030W

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99234, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi510 – 517Poly-Arg8

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RJKI, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_031414_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99234

Identification of Orthologs from Complete Genome Data

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OMAi
VEENDMH

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR014844, PalH

The PANTHER Classification System

More...
PANTHERi
PTHR35779, PTHR35779, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08733, PalH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q99234-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIIRLHFYYL LTLVYHLGLV GAYEKAARKR IQPPDLIPGP PGHKLGDERP
60 70 80 90 100
PHYDHRPPYK KHIDNIPAYN LTDLIDDKLL NKYENSCTVN VLTGGFISLA
110 120 130 140 150
SNSWHLRAYN YTLNYPSFLI RCDNGSANPN FSHVLQDFVY DINNKFNVQD
160 170 180 190 200
DSSKYIGKDP FPLGMIMITF ASGCICVATW MLFLVVLLLP SDNHNRRNKV
210 220 230 240 250
VHVYVLFSAI IRTVFLNETI AVIFDSQYHD DYQDASQFES FIVETAPYKI
260 270 280 290 300
CELVANILSD INWIYIVHYL QSNYGKPTWN WIPFKMKKGT HIIITVGCFL
310 320 330 340 350
SLADNILFAN LLWRKNLVVL KVFYKLIELL IYTIFISIIC YFTWHNFAYI
360 370 380 390 400
LLPKTAEINT DGKCKTKLRI LWENYHETIP LLAYNILIFI LFYFTTIFFA
410 420 430 440 450
AFTKHVRGWT FNFVHLLKVL ITVNVWGLIG VLEKRELHIS KKTVLGRKIN
460 470 480 490 500
NRDKFFANPT VNYYGEDLGK HLSAITLNRD LNTTKSNTTS HDSSSLVGSP
510 520 530 540 550
SPTWKSPIER IRDRRRRHKI MKSENKFGQN PSFGSKSNGK PNTKTTLSKY
560 570 580 590 600
RQLLRKPRRK TNSYEPKNGI GQNKEGSTVR PGADKHIRDS NYLATDISDN
610
ESMETELRTN HIYNYENSD
Length:619
Mass (Da):71,730
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i129097C9C9C3B817
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X87331 Genomic DNA Translation: CAA60746.1
Z74938 Genomic DNA Translation: CAA99220.1
BK006948 Genomic DNA Translation: DAA10811.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S54636

NCBI Reference Sequences

More...
RefSeqi
NP_014673.1, NM_001183449.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YOR030W_mRNA; YOR030W; YOR030W

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
854195

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YOR030W

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87331 Genomic DNA Translation: CAA60746.1
Z74938 Genomic DNA Translation: CAA99220.1
BK006948 Genomic DNA Translation: DAA10811.1
PIRiS54636
RefSeqiNP_014673.1, NM_001183449.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi34432, 261 interactors
STRINGi4932.YOR030W

PTM databases

iPTMnetiQ99234

Proteomic databases

PaxDbiQ99234
PRIDEiQ99234

Genome annotation databases

EnsemblFungiiYOR030W_mRNA; YOR030W; YOR030W
GeneIDi854195
KEGGisce:YOR030W

Organism-specific databases

EuPathDBiFungiDB:YOR030W
SGDiS000005556, DFG16

Phylogenomic databases

eggNOGiENOG502RJKI, Eukaryota
HOGENOMiCLU_031414_0_0_1
InParanoidiQ99234
OMAiVEENDMH

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q99234
RNActiQ99234, protein

Family and domain databases

InterProiView protein in InterPro
IPR014844, PalH
PANTHERiPTHR35779, PTHR35779, 1 hit
PfamiView protein in Pfam
PF08733, PalH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDFG16_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99234
Secondary accession number(s): D6W295
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast chromosome XV
    Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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