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Entry version 177 (22 Apr 2020)
Sequence version 1 (01 Nov 1995)
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Protein

Amelogenin, X isoform

Gene

AMELX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Plays a role in biomineralization. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processBiomineralization

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Amelogenin, X isoform
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AMELX
Synonyms:AMG, AMGX
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:461 AMELX

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
300391 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99217

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Amelogenesis imperfecta 1E (AI1E)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn X-linked defect of dental enamel formation. Teeth have only a thin layer of enamel with normal hardness. The thinness of the enamel makes the teeth appear small.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0375814W → S in AI1E. 1 PublicationCorresponds to variant dbSNP:rs104894738EnsemblClinVar.1
Natural variantiVAR_0005595 – 8ILFA → T in AI1E. 1 Publication4
Natural variantiVAR_03758237T → I in AI1E. 1 PublicationCorresponds to variant dbSNP:rs104894733EnsemblClinVar.1
Natural variantiVAR_03758356P → T in AI1E. 2 PublicationsCorresponds to variant dbSNP:rs104894736EnsemblClinVar.1

Keywords - Diseasei

Amelogenesis imperfecta, Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
265

MalaCards human disease database

More...
MalaCardsi
AMELX
MIMi301200 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000125363

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
100033 Hypomaturation amelogenesis imperfecta

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA24766

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q99217 Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AMELX

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1168430

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 161 PublicationAdd BLAST16
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000119917 – 191Amelogenin, X isoformAdd BLAST175

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei32PhosphoserineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by FAM20C in vitro.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q99217

PeptideAtlas

More...
PeptideAtlasi
Q99217

PRoteomics IDEntifications database

More...
PRIDEi
Q99217

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
78248 [Q99217-1]
78249 [Q99217-2]
78250 [Q99217-3]

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
Q99217-2 [Q99217-2]

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Transiently but abundantly expressed by ameloblasts during tooth development. Amelogenin is the predominant protein in developing dental enamel.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000125363 Expressed in frontal cortex and 26 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99217 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000125363 Tissue enhanced (ductus deferens, epididymis, seminal vesicle)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q99217, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370088

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99217 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99217

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the amelogenin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000009151

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_120753_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99217

KEGG Orthology (KO)

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KOi
K23443

Identification of Orthologs from Complete Genome Data

More...
OMAi
YQNMIRP

Database of Orthologous Groups

More...
OrthoDBi
1509730at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99217

TreeFam database of animal gene trees

More...
TreeFami
TF337092

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004116 Amelogenin

The PANTHER Classification System

More...
PANTHERi
PTHR46794 PTHR46794, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02948 Amelogenin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01757 AMELOGENIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00818 Amelogenin, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q99217-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGTWILFACL LGAAFAMPLP PHPGHPGYIN FSYEVLTPLK WYQSIRPPYP
60 70 80 90 100
SYGYEPMGGW LHHQIIPVLS QQHPPTHTLQ PHHHIPVVPA QQPVIPQQPM
110 120 130 140 150
MPVPGQHSMT PIQHHQPNLP PPAQQPYQPQ PVQPQPHQPM QPQPPVHPMQ
160 170 180 190
PLPPQPPLPP MFPMQPLPPM LPDLTLEAWP STDKTKREEV D
Length:191
Mass (Da):21,603
Last modified:November 1, 1995 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i322C88DA3F7155DC
GO
Isoform 2 (identifier: Q99217-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     19-34: Missing.

Show »
Length:175
Mass (Da):19,796
Checksum:i214D3018D9B50F1B
GO
Isoform 3 (identifier: Q99217-3) [UniParc]FASTAAdd to basket
Also known as: Rare

The sequence of this isoform differs from the canonical sequence as follows:
     34-34: E → ENSHSQAINVDRTAL

Show »
Length:205
Mass (Da):23,111
Checksum:i535F5454018E3D6E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti50 – 51PS → SP AA sequence (PubMed:2509010).Curated2
Sequence conflicti173D → H AA sequence (PubMed:8254123).Curated1
Sequence conflicti191D → VSIF in AAA62826 (PubMed:2004775).Curated1
Sequence conflicti191D → VSIF in CAA32613 (PubMed:2004775).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0375814W → S in AI1E. 1 PublicationCorresponds to variant dbSNP:rs104894738EnsemblClinVar.1
Natural variantiVAR_0005595 – 8ILFA → T in AI1E. 1 Publication4
Natural variantiVAR_03758237T → I in AI1E. 1 PublicationCorresponds to variant dbSNP:rs104894733EnsemblClinVar.1
Natural variantiVAR_03758356P → T in AI1E. 2 PublicationsCorresponds to variant dbSNP:rs104894736EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00022819 – 34Missing in isoform 2. CuratedAdd BLAST16
Alternative sequenceiVSP_00022934E → ENSHSQAINVDRTAL in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M86932 mRNA Translation: AAA51717.1
AF436849 mRNA Translation: AAL30432.1
AY040206 Genomic DNA Translation: AAK77213.1
AC002366 Genomic DNA Translation: AAC21581.1
BC074951 mRNA Translation: AAH74951.1
M55418 Genomic DNA Translation: AAA62826.1
X14440 Genomic DNA Translation: CAA32613.1
S67147 mRNA Translation: AAB29184.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS14144.1 [Q99217-1]
CCDS14145.1 [Q99217-3]
CCDS14146.1 [Q99217-2]

Protein sequence database of the Protein Information Resource

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PIRi
B41816 A41816

NCBI Reference Sequences

More...
RefSeqi
NP_001133.1, NM_001142.2 [Q99217-1]
NP_872621.1, NM_182680.1 [Q99217-3]
NP_872622.1, NM_182681.1 [Q99217-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000348912; ENSP00000335312; ENSG00000125363 [Q99217-2]
ENST00000380712; ENSP00000370088; ENSG00000125363 [Q99217-3]
ENST00000380714; ENSP00000370090; ENSG00000125363 [Q99217-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
265

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:265

UCSC genome browser

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UCSCi
uc004cus.3 human [Q99217-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M86932 mRNA Translation: AAA51717.1
AF436849 mRNA Translation: AAL30432.1
AY040206 Genomic DNA Translation: AAK77213.1
AC002366 Genomic DNA Translation: AAC21581.1
BC074951 mRNA Translation: AAH74951.1
M55418 Genomic DNA Translation: AAA62826.1
X14440 Genomic DNA Translation: CAA32613.1
S67147 mRNA Translation: AAB29184.1
CCDSiCCDS14144.1 [Q99217-1]
CCDS14145.1 [Q99217-3]
CCDS14146.1 [Q99217-2]
PIRiB41816 A41816
RefSeqiNP_001133.1, NM_001142.2 [Q99217-1]
NP_872621.1, NM_182680.1 [Q99217-3]
NP_872622.1, NM_182681.1 [Q99217-2]

3D structure databases

SMRiQ99217
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ99217, 1 interactor
STRINGi9606.ENSP00000370088

Polymorphism and mutation databases

BioMutaiAMELX
DMDMi1168430

Proteomic databases

MassIVEiQ99217
PeptideAtlasiQ99217
PRIDEiQ99217
ProteomicsDBi78248 [Q99217-1]
78249 [Q99217-2]
78250 [Q99217-3]
TopDownProteomicsiQ99217-2 [Q99217-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
23742 153 antibodies

The DNASU plasmid repository

More...
DNASUi
265

Genome annotation databases

EnsembliENST00000348912; ENSP00000335312; ENSG00000125363 [Q99217-2]
ENST00000380712; ENSP00000370088; ENSG00000125363 [Q99217-3]
ENST00000380714; ENSP00000370090; ENSG00000125363 [Q99217-1]
GeneIDi265
KEGGihsa:265
UCSCiuc004cus.3 human [Q99217-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
265
DisGeNETi265

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AMELX
HGNCiHGNC:461 AMELX
HPAiENSG00000125363 Tissue enhanced (ductus deferens, epididymis, seminal vesicle)
MalaCardsiAMELX
MIMi300391 gene
301200 phenotype
neXtProtiNX_Q99217
OpenTargetsiENSG00000125363
Orphaneti100033 Hypomaturation amelogenesis imperfecta
PharmGKBiPA24766

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00390000009151
HOGENOMiCLU_120753_0_0_1
InParanoidiQ99217
KOiK23443
OMAiYQNMIRP
OrthoDBi1509730at2759
PhylomeDBiQ99217
TreeFamiTF337092

Enzyme and pathway databases

ReactomeiR-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-HSA-8957275 Post-translational protein phosphorylation

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
AMELX

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
265
PharosiQ99217 Tbio

Protein Ontology

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PROi
PR:Q99217
RNActiQ99217 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125363 Expressed in frontal cortex and 26 other tissues
GenevisibleiQ99217 HS

Family and domain databases

InterProiView protein in InterPro
IPR004116 Amelogenin
PANTHERiPTHR46794 PTHR46794, 1 hit
PfamiView protein in Pfam
PF02948 Amelogenin, 1 hit
PRINTSiPR01757 AMELOGENIN
SMARTiView protein in SMART
SM00818 Amelogenin, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAMELX_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99217
Secondary accession number(s): Q96NW6, Q9UCA7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 22, 2020
This is version 177 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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