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Entry version 148 (10 Feb 2021)
Sequence version 1 (01 Nov 1996)
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Protein

dTTP/UTP pyrophosphatase

Gene

YOR111W

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze the modified nucleotides 5-methyl-UTP (m5UTP) and pseudo-UTP. Has weak activity with CTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219).1 Publication

Miscellaneous

Present with 1940 molecules/cell in log phase SD medium.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

a divalent metal cation1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 5.7 sec(-1) with dTTP as substrate. kcat is 2.6 sec(-1) with UTP as substrate. kcat is 1.2 sec(-1) with CTP as substrate. kcat is 2.2 sec(-1) with m5UTP as substrate. kcat is 5.3 sec(-1) with pseudo-UTP as substrate.1 Publication
  1. KM=47.4 µM for dTTP1 Publication
  2. KM=29.7 µM for UTP1 Publication
  3. KM=72.0 µM for CTP1 Publication
  4. KM=13.0 µM for m5UTP1 Publication
  5. KM=20 µM for pseudo-UTP1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei29Important for substrate specificity1 Publication1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei103Proton acceptor1 Publication1
    Sitei104Important for substrate specificity1 Publication1
    Sitei196Important for substrate specificity1 Publication1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processNucleotide metabolism

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    dTTP/UTP pyrophosphataseCurated (EC:3.6.1.91 Publication)
    Short name:
    dTTPase/UTPaseCurated
    Alternative name(s):
    Maf-like protein YOR111W
    Nucleoside triphosphate pyrophosphatase1 Publication
    Nucleotide pyrophosphatase1 Publication
    Short name:
    Nucleotide PPaseCurated
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Ordered Locus Names:YOR111W
    ORF Names:O3237, YOR3237W
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XV

    Organism-specific databases

    Saccharomyces Genome Database

    More...
    SGDi
    S000005637, YOR111W

    Eukaryotic Pathogen, Vector and Host Database Resources

    More...
    VEuPathDBi
    FungiDB:YOR111W

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi25S → A: Loss of activity. 1 Publication1
    Mutagenesisi26T → A: No change in activity. 1 Publication1
    Mutagenesisi29R → A: No change in activity. 1 Publication1
    Mutagenesisi30R → A: Loss of activity. 1 Publication1
    Mutagenesisi66Y → A: Loss of activity. 1 Publication1
    Mutagenesisi74K → A: Loss of activity. 1 Publication1
    Mutagenesisi76Q → A: No change in activity. 1 Publication1
    Mutagenesisi77N → A: No change in activity. 1 Publication1
    Mutagenesisi103D → A: Loss of activity. 1 Publication1
    Mutagenesisi104T → A: Loss of activity. 1 Publication1
    Mutagenesisi115E → A: Loss of activity. 1 Publication1
    Mutagenesisi116K → A: Loss of activity. 1 Publication1
    Mutagenesisi188E → A: Decrease in activity. 1 Publication1
    Mutagenesisi193F → A: Decrease in activity. 1 Publication1
    Mutagenesisi194K → A: No change in activity. 1 Publication1
    Mutagenesisi196Q → A or E: Loss of activity. 1 Publication1

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001230911 – 232dTTP/UTP pyrophosphataseAdd BLAST232

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q99210

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q99210

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q99210

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    The Biological General Repository for Interaction Datasets (BioGRID)

    More...
    BioGRIDi
    34507, 20 interactors

    Database of interacting proteins

    More...
    DIPi
    DIP-1305N

    Protein interaction database and analysis system

    More...
    IntActi
    Q99210, 7 interactors

    Molecular INTeraction database

    More...
    MINTi
    Q99210

    STRING: functional protein association networks

    More...
    STRINGi
    4932.YOR111W

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q99210, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q99210

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the Maf family. YhdE subfamily.1 Publication

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1509, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00940000168021

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_040416_0_2_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q99210

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    VIGCDSV

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd00555, Maf, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    3.90.950.10, 1 hit

    HAMAP database of protein families

    More...
    HAMAPi
    MF_00528, Maf, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR029001, ITPase-like_fam
    IPR003697, Maf-like

    The PANTHER Classification System

    More...
    PANTHERi
    PTHR43213, PTHR43213, 1 hit

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF02545, Maf, 1 hit

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF006305, Maf, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52972, SSF52972, 1 hit

    TIGRFAMs; a protein family database

    More...
    TIGRFAMsi
    TIGR00172, maf, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q99210-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MSGNSQLPPD VIGFICSKYD IILASTSPRR YEILHDIMGI TDLKTMVSTF
    60 70 80 90 100
    EENLDKMNYS TDPIGYVCDT SWHKAQNIIE ILTDYEDENP NEIDKPKLII
    110 120 130 140 150
    CADTIIIDKS GRIYEKPKTK EVQKKFLMKF CYEDDEPVNV VTAVTLIKWY
    160 170 180 190 200
    GRENFELVPF RDETKVYFDN KIPLRILEEY VESGDGLEVG GGFKIQGQGA
    210 220 230
    ILIEKIEGDY YNVVGLPLNK TFKGLYAEAN SI
    Length:232
    Mass (Da):26,477
    Last modified:November 1, 1996 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC0A83ED2AE20BE13
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    X94335 Genomic DNA Translation: CAA64031.1
    X90518 Genomic DNA Translation: CAA62105.1
    Z75019 Genomic DNA Translation: CAA99309.1
    AY692705 Genomic DNA Translation: AAT92724.1
    BK006948 Genomic DNA Translation: DAA10886.1

    Protein sequence database of the Protein Information Resource

    More...
    PIRi
    S60984

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_014754.3, NM_001183530.3

    Genome annotation databases

    Ensembl fungal genome annotation project

    More...
    EnsemblFungii
    YOR111W_mRNA; YOR111W; YOR111W

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    854278

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    sce:YOR111W

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    X94335 Genomic DNA Translation: CAA64031.1
    X90518 Genomic DNA Translation: CAA62105.1
    Z75019 Genomic DNA Translation: CAA99309.1
    AY692705 Genomic DNA Translation: AAT92724.1
    BK006948 Genomic DNA Translation: DAA10886.1
    PIRiS60984
    RefSeqiNP_014754.3, NM_001183530.3

    3D structure databases

    SMRiQ99210
    ModBaseiSearch...

    Protein-protein interaction databases

    BioGRIDi34507, 20 interactors
    DIPiDIP-1305N
    IntActiQ99210, 7 interactors
    MINTiQ99210
    STRINGi4932.YOR111W

    Proteomic databases

    MaxQBiQ99210
    PaxDbiQ99210
    PRIDEiQ99210

    Genome annotation databases

    EnsemblFungiiYOR111W_mRNA; YOR111W; YOR111W
    GeneIDi854278
    KEGGisce:YOR111W

    Organism-specific databases

    SGDiS000005637, YOR111W
    VEuPathDBiFungiDB:YOR111W

    Phylogenomic databases

    eggNOGiKOG1509, Eukaryota
    GeneTreeiENSGT00940000168021
    HOGENOMiCLU_040416_0_2_1
    InParanoidiQ99210
    OMAiVIGCDSV

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q99210
    RNActiQ99210, protein

    Family and domain databases

    CDDicd00555, Maf, 1 hit
    Gene3Di3.90.950.10, 1 hit
    HAMAPiMF_00528, Maf, 1 hit
    InterProiView protein in InterPro
    IPR029001, ITPase-like_fam
    IPR003697, Maf-like
    PANTHERiPTHR43213, PTHR43213, 1 hit
    PfamiView protein in Pfam
    PF02545, Maf, 1 hit
    PIRSFiPIRSF006305, Maf, 1 hit
    SUPFAMiSSF52972, SSF52972, 1 hit
    TIGRFAMsiTIGR00172, maf, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNTPPA_YEAST
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99210
    Secondary accession number(s): D6W2H0
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
    Last sequence update: November 1, 1996
    Last modified: February 10, 2021
    This is version 148 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast chromosome XV
      Yeast (Saccharomyces cerevisiae) chromosome XV: entries and gene names
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