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Entry version 88 (13 Feb 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Protein TSD2

Gene

TSD2

Organism
Ustilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Temperature-sensitive protein required for DNA synthesis. May be a transcription factor that regulates the level or influences the stability of DNA polymerases or auxiliary proteins.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 3'-5' DNA helicase activity Source: GO_Central
  • chromatin binding Source: GO_Central
  • DNA replication origin binding Source: GO_Central
  • single-stranded DNA binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell cycle, DNA replication

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TSD2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TSD2
ORF Names:UMAG_05770
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiUstilago maydis (strain 521 / FGSC 9021) (Corn smut fungus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri237631 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaUstilaginomycotinaUstilaginomycetesUstilaginalesUstilaginaceaeUstilago
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000561 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 16, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
FungiDB:UMAG_05770

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001928201 – 845Protein TSD2Add BLAST845

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q99107

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Is cell cycle-regulated; expression peaks in early S or G1 phase.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5270.UM05770P0

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CDC45 family.Curated

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99107

KEGG Orthology (KO)

More...
KOi
K06628

Identification of Orthologs from Complete Genome Data

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OMAi
FICDTHR

Database of Orthologous Groups

More...
OrthoDBi
1309031at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003874 CDC45

The PANTHER Classification System

More...
PANTHERi
PTHR10507 PTHR10507, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02724 CDC45, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q99107-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVVACPNSS LVEAQMDADR SGSCSKYDYA SAYSRLRSAA RAAGTGVSSV
60 70 80 90 100
LILSSPDVDS VCATRILTSL LLQDDIAHRI VPVEGYRTLL NTLSTVFAPH
110 120 130 140 150
DNDNASSSSS STTDVKSVVF INLGAVLSLP TTFNIPPSCT IHVIDSHRPW
160 170 180 190 200
NLENLFATSH ANDSVWCWDD GEIATKLCRQ GGERDAFEKL EFDVDSDSES
210 220 230 240 250
DSDSHSDSHS DSVSDPEDAS DSNDSGSDSA RSHDERQRDG SGGKRKRGSH
260 270 280 290 300
SPLSRRRQRH KQGQRHKPRH RSTSASATRL TNAERHRYRN ILTRYYARGE
310 320 330 340 350
SFGMSVSSML YLLCESLGRA DRESLWLAIV GLTSLYLSNN IDLETYETYS
360 370 380 390 400
AAYASEVIAI EPTSSNAPTE AWSLDLLTNA NNNAQEQAAR SATATATGAA
410 420 430 440 450
RAQNRAVRSV ISKNTKAEDA DDRSIRIVGS ELRLTLYRHW SLETAMYHTA
460 470 480 490 500
YVAAKLGIWR ERGLSKLRGL MAKMGFSLTA VRQNYTHMPL DLRRSLVRKL
510 520 530 540 550
EAIAPEYGLT QLTYRGFERS LGFRTAPLGA ADVVEGVSAL LIGAHGIKIE
560 570 580 590 600
VDTPGMVFAS SSTTPLGNSF GANLNPANPN AQTSELFATK RVWNLGTALT
610 620 630 640 650
DSITSAIGAA TGNAWSNDQT EANGGLHVDV SSTQPALAAV ASVQDVGALE
660 670 680 690 700
RAERRVATSN FYEAYRALDF SRSTSVDLLR SSVLLSEALH RKIVARGISL
710 720 730 740 750
ITNQSIRTLK NFRLAILRDG ADLELFTHVD VLARLADWLT TSLRDIIVQQ
760 770 780 790 800
QASTNAQRKK QPAASTRLPF ILAALHRAKD TFLVLGSTAS AIDGVVQHNH
810 820 830 840
FTAAFQHAAS VSRARVRHDH FRTCSIHVRT SDLAAFVENV HLKIK
Length:845
Mass (Da):92,136
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC5AF7BE60FBA5EE6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U50276 Genomic DNA Translation: AAA93459.1
CM003155 Genomic DNA Translation: KIS66988.1

NCBI Reference Sequences

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RefSeqi
XP_011391503.1, XM_011393201.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
KIS66988; KIS66988; UMAG_05770

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23565565

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
uma:UMAG_05770

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50276 Genomic DNA Translation: AAA93459.1
CM003155 Genomic DNA Translation: KIS66988.1
RefSeqiXP_011391503.1, XM_011393201.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi5270.UM05770P0

Proteomic databases

PRIDEiQ99107

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiKIS66988; KIS66988; UMAG_05770
GeneIDi23565565
KEGGiuma:UMAG_05770

Organism-specific databases

EuPathDBiFungiDB:UMAG_05770

Phylogenomic databases

InParanoidiQ99107
KOiK06628
OMAiFICDTHR
OrthoDBi1309031at2759

Family and domain databases

InterProiView protein in InterPro
IPR003874 CDC45
PANTHERiPTHR10507 PTHR10507, 1 hit
PfamiView protein in Pfam
PF02724 CDC45, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTSD2_USTMA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99107
Secondary accession number(s): A0A0D1CJA7, Q4P293
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: February 13, 2019
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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