Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 122 (08 May 2019)
Sequence version 1 (01 Jun 1994)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Low-density lipoprotein receptor 1

Gene

ldlr-a

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processCholesterol metabolism, Endocytosis, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Low-density lipoprotein receptor 1
Short name:
LDL receptor 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ldlr-a
Synonyms:ldlr1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-6252601 ldlr

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini22 – 836ExtracellularBy similarityAdd BLAST815
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei837 – 858HelicalSequence analysisAdd BLAST22
Topological domaini859 – 909CytoplasmicBy similarityAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Coated pit, Endosome, Golgi apparatus, LDL, Lysosome, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21By similarityAdd BLAST21
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001731522 – 909Low-density lipoprotein receptor 1Add BLAST888

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi27 ↔ 39By similarity
Disulfide bondi34 ↔ 52By similarity
Disulfide bondi46 ↔ 63By similarity
Disulfide bondi68 ↔ 82By similarity
Disulfide bondi75 ↔ 95By similarity
Disulfide bondi89 ↔ 104By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi97N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 121By similarity
Disulfide bondi116 ↔ 134By similarity
Disulfide bondi128 ↔ 143By similarity
Disulfide bondi148 ↔ 161By similarity
Disulfide bondi155 ↔ 174By similarity
Disulfide bondi168 ↔ 183By similarity
Disulfide bondi195 ↔ 207By similarity
Disulfide bondi202 ↔ 220By similarity
Disulfide bondi214 ↔ 229By similarity
Disulfide bondi234 ↔ 246By similarity
Disulfide bondi241 ↔ 259By similarity
Disulfide bondi253 ↔ 268By similarity
Glycosylationi270N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi274 ↔ 287By similarity
Disulfide bondi282 ↔ 300By similarity
Disulfide bondi294 ↔ 311By similarity
Disulfide bondi316 ↔ 327By similarity
Disulfide bondi323 ↔ 336By similarity
Disulfide bondi338 ↔ 350By similarity
Disulfide bondi356 ↔ 366By similarity
Disulfide bondi362 ↔ 375By similarity
Disulfide bondi377 ↔ 390By similarity
Glycosylationi459N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi665 ↔ 679By similarity
Disulfide bondi675 ↔ 694By similarity
Disulfide bondi696 ↔ 709By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ldlrap1.

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99087

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini25 – 65LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST41
Domaini66 – 106LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST41
Domaini107 – 145LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST39
Domaini146 – 185LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST40
Domaini193 – 231LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST39
Domaini232 – 270LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST39
Domaini272 – 311LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST40
Domaini312 – 351EGF-like 1PROSITE-ProRule annotationAdd BLAST40
Domaini352 – 391EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST40
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati395 – 436LDL-receptor class B 1Add BLAST42
Repeati437 – 483LDL-receptor class B 2Add BLAST47
Repeati484 – 526LDL-receptor class B 3Add BLAST43
Repeati527 – 570LDL-receptor class B 4Add BLAST44
Repeati571 – 613LDL-receptor class B 5Add BLAST43
Repeati614 – 656LDL-receptor class B 6Add BLAST43
Domaini661 – 710EGF-like 3PROSITE-ProRule annotationAdd BLAST50

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni717 – 813Clustered O-linked oligosaccharidesAdd BLAST97

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi871 – 876NPXY motifBy similarity6

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The NPXY motif mediates the interaction with ldlrap1.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the LDLR family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K12473

Database of Orthologous Groups

More...
OrthoDBi
359795at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00112 LDLa, 7 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 1 hit
4.10.400.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07645 EGF_CA, 1 hit
PF00057 Ldl_recept_a, 7 hits
PF00058 Ldl_recept_b, 5 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261 LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00192 LDLa, 7 hits
SM00135 LY, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 1 hit
SSF57424 SSF57424, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS01209 LDLRA_1, 7 hits
PS50068 LDLRA_2, 7 hits
PS51120 LDLRB, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q99087-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMKPAASFPL LLLGLCHVSA ISGIRKCDRN EFQCGDGKCI PYKWICDGSA
60 70 80 90 100
ECKDSSDESP ETCREVTCGT DQFSCGGRLN RCIPMSWKCD GQTDCENGSD
110 120 130 140 150
ENDCTHKVCA DDQFTCRSGK CISLDFVCDE DLDCDDGSDE SYCPAPTCNP
160 170 180 190 200
AMFQCKDKGI CIPKLWACDG DPDCEDGSDE EHCEGREPIK TDKPCSPLEF
210 220 230 240 250
HCGSGECIHM SWKCDGGFDC KDKSDEKDCV KPTCRPDQFQ CNTGTCIHGS
260 270 280 290 300
RQCDREYDCK DLSDEEGCVN VTKCEGPDVF KCRSGECITM DKVCNKKRDC
310 320 330 340 350
RDWSDEPLKE CGENECLRNN GGCSHICNDL KIGYECLCNE GYRLVDQKRC
360 370 380 390 400
EDINECENPN TCSQICINLV GGYKCECREG YQMDPVTASC KSIGTVAYLF
410 420 430 440 450
FTNRHEVRKM TLDRSEYTSV IPRLKNVVAL DMEIASNKIY WSDLTQRKIY
460 470 480 490 500
SASMEKADNT SHHETVISNQ IQAPDGIAVD WIHGNIYWTD SKFSTISVAN
510 520 530 540 550
TEGSKRRTPP SDDLEKPRDI VVDPSQGFMY WTDWGLPAKI EKGGLNGVDR
560 570 580 590 600
YPLVTENIEW PNGITLDLIN QRLYWVDSKL HSLSCIDVTG ENRRTVISDE
610 620 630 640 650
THLAHPFGLT IFEDLVFWTD IENEAIFSAN RLTGRNIMKV AEDLLSPEDI
660 670 680 690 700
VLYHNLRQPK AENWCEAHHL GNGGCEYLCL PAPHITARSP KFTCACPDGM
710 720 730 740 750
HLGDDMRSCV KEPVIPEASP TTTTSAPVTT TTSAPVTTTT SAPVTTTSTT
760 770 780 790 800
ARPTSRSTTL AKITSTTSTL APQRPKMAST TIAPQRPTTN SPKTTLRMIT
810 820 830 840 850
EKVPDHTTQQ PMTHSQLADN NFAKAGVVEN VRSHPTALYI VLPIVILCLV
860 870 880 890 900
AFGGFLVWKN WRLKNTNSIN FDNPVYQKTT EEDQVHICRS QDGYTYPSRQ

MVSLEDDIA
Length:909
Mass (Da):101,296
Last modified:June 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6ED41F5402A16371
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M62976 mRNA Translation: AAA49897.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A40388 QRXLL1

NCBI Reference Sequences

More...
RefSeqi
NP_001081290.1, NM_001087821.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
397757

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:397757

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M62976 mRNA Translation: AAA49897.1
PIRiA40388 QRXLL1
RefSeqiNP_001081290.1, NM_001087821.1

3D structure databases

SMRiQ99087
ModBaseiSearch...

Genome annotation databases

GeneIDi397757
KEGGixla:397757

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
397757
XenbaseiXB-GENE-6252601 ldlr

Phylogenomic databases

KOiK12473
OrthoDBi359795at2759

Family and domain databases

CDDicd00112 LDLa, 7 hits
Gene3Di2.120.10.30, 1 hit
4.10.400.10, 7 hits
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR000033 LDLR_classB_rpt
IPR002172 LDrepeatLR_classA_rpt
PfamiView protein in Pfam
PF07645 EGF_CA, 1 hit
PF00057 Ldl_recept_a, 7 hits
PF00058 Ldl_recept_b, 5 hits
PRINTSiPR00261 LDLRECEPTOR
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00192 LDLa, 7 hits
SM00135 LY, 5 hits
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57424 SSF57424, 7 hits
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 2 hits
PS01187 EGF_CA, 1 hit
PS01209 LDLRA_1, 7 hits
PS50068 LDLRA_2, 7 hits
PS51120 LDLRB, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLDLR1_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99087
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 1994
Last sequence update: June 1, 1994
Last modified: May 8, 2019
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again