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UniProtKB - Q99081 (HTF4_HUMAN)

Entry version 193 (07 Apr 2021)
Sequence version 1 (01 Oct 1996)
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Protein

Transcription factor 12

Gene

TCF12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3').

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q99081

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-525793, Myogenesis
R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-9031628, NGF-stimulated transcription

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q99081

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Transcription factor 12
Short name:
TCF-12
Alternative name(s):
Class B basic helix-loop-helix protein 20
Short name:
bHLHb20
DNA-binding protein HTF4
E-box-binding protein
Transcription factor HTF-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TCF12
Synonyms:BHLHB20, HEB, HTF4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11623, TCF12

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600480, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99081

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000140262.17

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Craniosynostosis 3 (CRS3)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_072271483L → R in CRS3. 1 PublicationCorresponds to variant dbSNP:rs36060670Ensembl.1
Natural variantiVAR_070096600L → P in CRS3. 1 Publication1
Natural variantiVAR_070097614Q → E in CRS3. 1 PublicationCorresponds to variant dbSNP:rs886037641Ensembl.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi187P → A: Decreases interaction with RUNX1T1. 1 Publication1
Mutagenesisi191P → A: Decreases interaction with RUNX1T1. 1 Publication1
Mutagenesisi192S → A: Decreases interaction with RUNX1T1. 1 Publication1

Keywords - Diseasei

Craniosynostosis, Disease variant

Organism-specific databases

DisGeNET

More...DisGeNETi		6938

MalaCards human disease database

More...MalaCardsi		TCF12
MIMi615314, phenotype

Open Targets

More...OpenTargetsi		ENSG00000140262

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		209916, Extraskeletal myxoid chondrosarcoma
35099, Isolated brachycephaly
35098, Isolated plagiocephaly

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA36381

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99081, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TCF12

Domain mapping of disease mutations (DMDM)

More...DMDMi		1708332

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001272281 – 682Transcription factor 12Add BLAST682

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei47PhosphoserineCombined sources1
Modified residuei67PhosphoserineCombined sources1
Modified residuei79PhosphoserineCombined sources1
Modified residuei98PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki110Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei116PhosphoserineCombined sources1
Cross-linki181Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei313PhosphothreonineCombined sources1
Modified residuei333PhosphoserineCombined sources1
Cross-linki519Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei540PhosphoserineCombined sources1
Cross-linki550Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei557PhosphothreonineCombined sources1
Modified residuei558PhosphoserineCombined sources1
Modified residuei559PhosphoserineCombined sources1
Cross-linki609Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki653Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99081

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99081

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99081

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99081

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99081

PeptideAtlas

More...PeptideAtlasi		Q99081

PRoteomics IDEntifications database

More...PRIDEi		Q99081

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		5790
78231 [Q99081-1]
78232 [Q99081-2]
78233 [Q99081-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99081

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99081

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000140262, Expressed in corpus callosum and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99081, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99081, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000140262, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin, E12 and ITF2 proteins.

Interacts with PTF1A.

Interacts with NEUROD2 (By similarity).

Interacts with RUNX1T1.

Interacts with AML1-MTG8/ETO (via nervy homology region 2 in oligomerized form) (PubMed:23812588).

Interacts with BHLHA9 (PubMed:25466284).

By similarity4 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Q99081
With#Exp.IntAct
ARMC8 [Q8IUR7]3EBI-722877,EBI-1049469
ASCL4 [Q6XD76]3EBI-722877,EBI-10254793
BMERB1 [Q96MC5]3EBI-722877,EBI-718468
C1orf109 [Q9NX04]3EBI-722877,EBI-8643161
CDKN2C [P42773]5EBI-722877,EBI-711290
CFAP206 [Q8IYR0]3EBI-722877,EBI-749051
CRCP [O75575]3EBI-722877,EBI-2654687
EDRF1 - isoform 4 [Q3B7T1-5]3EBI-722877,EBI-10240074
FOXH1 [O75593]2EBI-722877,EBI-1759806
HEXIM2 [Q96MH2]4EBI-722877,EBI-5460660
HOPX [Q9BPY8]3EBI-722877,EBI-10295883
ID2 [Q02363]2EBI-722877,EBI-713450
ID3 [Q02535]4EBI-722877,EBI-1387094
LYSMD1 [Q96S90]3EBI-722877,EBI-10293291
MAPKBP1 [O60336]3EBI-722877,EBI-947402
MLLT6 [Q6P2C6]3EBI-722877,EBI-5773143
MORN4 [Q8NDC4]3EBI-722877,EBI-10269566
MORN4 [Q8WVZ3]3EBI-722877,EBI-10277137
NAGK [Q9UJ70]3EBI-722877,EBI-372578
NEUROG3 [Q9Y4Z2]4EBI-722877,EBI-10328570
OSGIN1 [Q9UJX0]4EBI-722877,EBI-9057006
PSMA1 [P25786]4EBI-722877,EBI-359352
QARS1 [P47897]4EBI-722877,EBI-347462
QARS1 - isoform 2 [P47897-2]3EBI-722877,EBI-10209725
RNASEL [Q1RLL8]3EBI-722877,EBI-10239181
SPG21 [Q9NZD8]4EBI-722877,EBI-742688
SRI [P30626]3EBI-722877,EBI-750459
STAT5A [P42229]3EBI-722877,EBI-749537
STK16 [O75716]3EBI-722877,EBI-749295
TAL1 [P17542]4EBI-722877,EBI-1753878
TRIM72 [Q6ZMU5]3EBI-722877,EBI-2341648
TSNAX [Q99598]3EBI-722877,EBI-742638
TWIST2 [Q8WVJ9]3EBI-722877,EBI-1797313
VPS28 [Q548N1]3EBI-722877,EBI-10243107
Isoform 3 [Q99081-3]
With#Exp.IntAct
ARL16 [Q0P5N6]3EBI-11952764,EBI-10186132
ASCL3 [Q9NQ33]3EBI-11952764,EBI-12108222
ASCL4 [Q6XD76]3EBI-11952764,EBI-10254793
CCNH [P51946]3EBI-11952764,EBI-741406
CDC20B - isoform 5 [Q86Y33-5]3EBI-11952764,EBI-11983537
CDKN2C [P42773]4EBI-11952764,EBI-711290
CKS1B [P61024]3EBI-11952764,EBI-456371
CLCNKA - isoform 3 [P51800-3]3EBI-11952764,EBI-11980535
DDX6 [P26196]3EBI-11952764,EBI-351257
EPHB6 - isoform 2 [O15197-2]3EBI-11952764,EBI-10182490
EXOC8 [Q8IYI6]3EBI-11952764,EBI-742102
FAM50B [Q9Y247]3EBI-11952764,EBI-742802
FIGLA [Q6QHK4]3EBI-11952764,EBI-11976617
GRB7 - isoform 3 [Q14451-3]3EBI-11952764,EBI-11991632
GTPBP3 [Q969Y2]3EBI-11952764,EBI-740290
HAND1 [O96004]3EBI-11952764,EBI-11320290
HAND2 - isoform 2 [P61296-2]3EBI-11952764,EBI-13086076
hCG_1987119 [A0A024R8L2]3EBI-11952764,EBI-14103818
HEXIM2 [Q96MH2]4EBI-11952764,EBI-5460660
ID1 [P41134]3EBI-11952764,EBI-1215527
ID3 [Q02535]4EBI-11952764,EBI-1387094
LNX1 [Q8TBB1]3EBI-11952764,EBI-739832
MORN4 [Q8NDC4]3EBI-11952764,EBI-10269566
MSC [O60682]3EBI-11952764,EBI-740310
MSGN1 [A6NI15]3EBI-11952764,EBI-11991020
NEK6 - isoform 4 [Q9HC98-4]3EBI-11952764,EBI-11750983
NEUROD1 [Q13562]4EBI-11952764,EBI-3908303
NEUROG1 [Q92886]3EBI-11952764,EBI-10279647
NEUROG3 [Q9Y4Z2]7EBI-11952764,EBI-10328570
NGLY1 [Q96IV0]3EBI-11952764,EBI-6165879
NHLH2 [Q02577]3EBI-11952764,EBI-5378683
PIN1 [Q13526]3EBI-11952764,EBI-714158
PRKAB2 [O43741]3EBI-11952764,EBI-1053424
RBM8A [Q9Y5S9]3EBI-11952764,EBI-447231
RUNX1T1 - isoform 4 [Q06455-4]2EBI-11952764,EBI-10224192
SH2D1B [O14796]3EBI-11952764,EBI-3923013
TBC1D21 [Q8IYX1]3EBI-11952764,EBI-12018146
TCF21 [O43680]3EBI-11952764,EBI-723267
TCF23 [Q7RTU1]3EBI-11952764,EBI-12127592
TRIM72 [Q6ZMU5]3EBI-11952764,EBI-2341648
TSNAX [Q99598]3EBI-11952764,EBI-742638
TTF2 - isoform 2 [Q9UNY4-2]3EBI-11952764,EBI-11980463
TWIST2 [Q8WVJ9]3EBI-11952764,EBI-1797313
VPS28 [Q9UK41]3EBI-11952764,EBI-727424
WTAP [Q15007]3EBI-11952764,EBI-751647
ZNF688 [A0A0S2Z6P0]3EBI-11952764,EBI-16429989

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		112798, 113 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q99081

Database of interacting proteins

More...DIPi		DIP-29403N

Protein interaction database and analysis system

More...IntActi		Q99081, 100 interactors

Molecular INTeraction database

More...MINTi		Q99081

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000388940

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99081, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1682
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...BMRBi		Q99081

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99081

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q99081

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini577 – 630bHLHPROSITE-ProRule annotationAdd BLAST54

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni119 – 140Leucine-zipperAdd BLAST22
Regioni182 – 196Interaction with RUNX1T11 PublicationAdd BLAST15
Regioni632 – 655Class A specific domainAdd BLAST24

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi19 – 279aaTAD9

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3910, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155047

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_021099_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99081

Identification of Orthologs from Complete Genome Data

More...OMAi		RYADEDC

Database of Orthologous Groups

More...OrthoDBi		571132at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99081

TreeFam database of animal gene trees

More...TreeFami		TF321672

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		4.10.280.10, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00222

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00010, HLH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00353, HLH, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47459, SSF47459, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50888, BHLH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99081-1) [UniParc]FASTAAdd to basket
Also known as: a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNPQQQRMAA IGTDKELSDL LDFSAMFSPP VNSGKTRPTT LGSSQFSGSG 
        60         70         80         90        100
IDERGGTTSW GTSGQPSPSY DSSRGFTDSP HYSDHLNDSR LGAHEGLSPT 
       110        120        130        140        150
PFMNSNLMGK TSERGSFSLY SRDTGLPGCQ SSLLRQDLGL GSPAQLSSSG 
       160        170        180        190        200
KPGTAYYSFS ATSSRRRPLH DSAALDPLQA KKVRKVPPGL PSSVYAPSPN 
       210        220        230        240        250
SDDFNRESPS YPSPKPPTSM FASTFFMQDG THNSSDLWSS SNGMSQPGFG 
       260        270        280        290        300
GILGTSTSHM SQSSSYGNLH SHDRLSYPPH SVSPTDINTS LPPMSSFHRG 
       310        320        330        340        350
STSSSPYVAA SHTPPINGSD SILGTRGNAA GSSQTGDALG KALASIYSPD 
       360        370        380        390        400
HTSSSFPSNP STPVGSPSPL TGTSQWPRPG GQAPSSPSYE NSLHSLQSRM 
       410        420        430        440        450
EDRLDRLDDA IHVLRNHAVG PSTSLPAGHS DIHSLLGPSH NAPIGSLNSN 
       460        470        480        490        500
YGGSSLVASS RSASMVGTHR EDSVSLNGNH SVLSSTVTTS STDLNHKTQE 
       510        520        530        540        550
NYRGGLQSQS GTVVTTEIKT ENKEKDENLH EPPSSDDMKS DDESSQKDIK 
       560        570        580        590        600
VSSRGRTSST NEDEDLNPEQ KIEREKERRM ANNARERLRV RDINEAFKEL 
       610        620        630        640        650
GRMCQLHLKS EKPQTKLLIL HQAVAVILSL EQQVRERNLN PKAACLKRRE 
       660        670        680 
EEKVSAVSAE PPTTLPGTHP GLSETTNPMG HM
Length:682
Mass (Da):72,965
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9736113D9361D3F5
GO
Isoform 2 (identifier: Q99081-2) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     1-170: Missing.
     171-193: DSAALDPLQAKKVRKVPPGLPSS → MYCAYPVPGMGSNSLMYYYNGKT

Show »
Length:512
Mass (Da):55,142
Checksum:i98AF7F83F8A2AEF4
GO
Isoform 3 (identifier: Q99081-3) [UniParc]FASTAAdd to basket
Also known as: c

The sequence of this isoform differs from the canonical sequence as follows:
     396-396: L → LKNRVEQQLHEHLQDAMSFLKDVCE

Show »
Length:706
Mass (Da):75,845
Checksum:i75B7B4173C9B660D
GO
Isoform 4 (identifier: Q99081-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-39: MNPQQQRMAA...PVNSGKTRPT → MGKRYMHHPQ...VCSLALSLCK
     40-275: Missing.

Show »
Length:446
Mass (Da):48,157
Checksum:i1165CAD3B87F74DD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B4DGI9B4DGI9_HUMAN
Transcription factor 12
TCF12
666Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNQ5H0YNQ5_HUMAN
Transcription factor 12
TCF12
157Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5GY10F5GY10_HUMAN
Transcription factor 12
TCF12
536Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YNP8H0YNP8_HUMAN
Transcription factor 12
TCF12
339Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B4DZP2B4DZP2_HUMAN
Transcription factor 12
TCF12
316Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BNF4H3BNF4_HUMAN
Transcription factor 12
TCF12
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BRK2H3BRK2_HUMAN
Transcription factor 12
TCF12
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YML2H0YML2_HUMAN
Transcription factor 12
TCF12
58Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti523K → E in CAD89914 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049543300G → S. Corresponds to variant dbSNP:rs12442879EnsemblClinVar.1
Natural variantiVAR_072271483L → R in CRS3. 1 PublicationCorresponds to variant dbSNP:rs36060670Ensembl.1
Natural variantiVAR_070096600L → P in CRS3. 1 Publication1
Natural variantiVAR_070097614Q → E in CRS3. 1 PublicationCorresponds to variant dbSNP:rs886037641Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0391091 – 170Missing in isoform 2. 1 PublicationAdd BLAST170
Alternative sequenceiVSP_0574191 – 39MNPQQ…KTRPT → MGKRYMHHPQIQMISTVNLL VIHLLSHQPVCSLALSLCK in isoform 4. 1 PublicationAdd BLAST39
Alternative sequenceiVSP_05742040 – 275Missing in isoform 4. 1 PublicationAdd BLAST236
Alternative sequenceiVSP_039110171 – 193DSAAL…GLPSS → MYCAYPVPGMGSNSLMYYYN GKT in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_040024396L → LKNRVEQQLHEHLQDAMSFL KDVCE in isoform 3. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
M83233 mRNA Translation: AAB62389.1
M80627 mRNA Translation: AAA58632.1
AL831981 mRNA Translation: CAD89914.1
AK304007 mRNA Translation: BAG64923.1
BX537967 mRNA Translation: CAD97931.1
AC010999 Genomic DNA No translation available.
AC016525 Genomic DNA No translation available.
AC090511 Genomic DNA No translation available.
AC090532 Genomic DNA No translation available.
KF456057 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77512.1
BC050556 mRNA Translation: AAH50556.1
M65209 mRNA Translation: AAC37571.1
BK001049 mRNA Translation: DAA01129.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10159.1 [Q99081-1]
CCDS10160.1 [Q99081-3]
CCDS42042.1 [Q99081-2]
CCDS76761.1 [Q99081-4]

Protein sequence database of the Protein Information Resource

More...PIRi		A42121

NCBI Reference Sequences

More...RefSeqi		NP_001293149.1, NM_001306220.2 [Q99081-4]
NP_001309080.1, NM_001322151.1 [Q99081-3]
NP_001309086.1, NM_001322157.1 [Q99081-1]
NP_001309088.1, NM_001322159.1 [Q99081-3]
NP_001309091.1, NM_001322162.1 [Q99081-3]
NP_001309094.1, NM_001322165.1 [Q99081-1]
NP_003196.1, NM_003205.3 [Q99081-1]
NP_996919.1, NM_207036.1 [Q99081-3]
NP_996920.1, NM_207037.1 [Q99081-3]
NP_996921.1, NM_207038.1 [Q99081-1]
NP_996923.1, NM_207040.1 [Q99081-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000267811; ENSP00000267811; ENSG00000140262 [Q99081-1]
ENST00000333725; ENSP00000331057; ENSG00000140262 [Q99081-3]
ENST00000343827; ENSP00000342459; ENSG00000140262 [Q99081-2]
ENST00000438423; ENSP00000388940; ENSG00000140262 [Q99081-3]
ENST00000537840; ENSP00000444696; ENSG00000140262 [Q99081-4]
ENST00000557843; ENSP00000453737; ENSG00000140262 [Q99081-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		6938

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:6938

UCSC genome browser

More...UCSCi		uc002aea.4, human [Q99081-1]
uc010ugo.3, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M83233 mRNA Translation: AAB62389.1
M80627 mRNA Translation: AAA58632.1
AL831981 mRNA Translation: CAD89914.1
AK304007 mRNA Translation: BAG64923.1
BX537967 mRNA Translation: CAD97931.1
AC010999 Genomic DNA No translation available.
AC016525 Genomic DNA No translation available.
AC090511 Genomic DNA No translation available.
AC090532 Genomic DNA No translation available.
KF456057 Genomic DNA No translation available.
CH471082 Genomic DNA Translation: EAW77512.1
BC050556 mRNA Translation: AAH50556.1
M65209 mRNA Translation: AAC37571.1
BK001049 mRNA Translation: DAA01129.1
CCDSiCCDS10159.1 [Q99081-1]
CCDS10160.1 [Q99081-3]
CCDS42042.1 [Q99081-2]
CCDS76761.1 [Q99081-4]
PIRiA42121
RefSeqiNP_001293149.1, NM_001306220.2 [Q99081-4]
NP_001309080.1, NM_001322151.1 [Q99081-3]
NP_001309086.1, NM_001322157.1 [Q99081-1]
NP_001309088.1, NM_001322159.1 [Q99081-3]
NP_001309091.1, NM_001322162.1 [Q99081-3]
NP_001309094.1, NM_001322165.1 [Q99081-1]
NP_003196.1, NM_003205.3 [Q99081-1]
NP_996919.1, NM_207036.1 [Q99081-3]
NP_996920.1, NM_207037.1 [Q99081-3]
NP_996921.1, NM_207038.1 [Q99081-1]
NP_996923.1, NM_207040.1 [Q99081-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KNHNMR-B11-28[»]
4JOLX-ray2.91E/F/G/H177-200[»]
BMRBiQ99081
SMRiQ99081
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi112798, 113 interactors
CORUMiQ99081
DIPiDIP-29403N
IntActiQ99081, 100 interactors
MINTiQ99081
STRINGi9606.ENSP00000388940

PTM databases

iPTMnetiQ99081
PhosphoSitePlusiQ99081

Genetic variation databases

BioMutaiTCF12
DMDMi1708332

Proteomic databases

EPDiQ99081
jPOSTiQ99081
MassIVEiQ99081
MaxQBiQ99081
PaxDbiQ99081
PeptideAtlasiQ99081
PRIDEiQ99081
ProteomicsDBi5790
78231 [Q99081-1]
78232 [Q99081-2]
78233 [Q99081-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		913, 378 antibodies

The DNASU plasmid repository

More...DNASUi		6938

Genome annotation databases

EnsembliENST00000267811; ENSP00000267811; ENSG00000140262 [Q99081-1]
ENST00000333725; ENSP00000331057; ENSG00000140262 [Q99081-3]
ENST00000343827; ENSP00000342459; ENSG00000140262 [Q99081-2]
ENST00000438423; ENSP00000388940; ENSG00000140262 [Q99081-3]
ENST00000537840; ENSP00000444696; ENSG00000140262 [Q99081-4]
ENST00000557843; ENSP00000453737; ENSG00000140262 [Q99081-1]
GeneIDi6938
KEGGihsa:6938
UCSCiuc002aea.4, human [Q99081-1]
uc010ugo.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		6938
DisGeNETi6938

GeneCards: human genes, protein and diseases

More...GeneCardsi		TCF12
HGNCiHGNC:11623, TCF12
HPAiENSG00000140262, Tissue enhanced (lymphoid)
MalaCardsiTCF12
MIMi600480, gene
615314, phenotype
neXtProtiNX_Q99081
OpenTargetsiENSG00000140262
Orphaneti209916, Extraskeletal myxoid chondrosarcoma
35099, Isolated brachycephaly
35098, Isolated plagiocephaly
PharmGKBiPA36381
VEuPathDBiHostDB:ENSG00000140262.17

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG3910, Eukaryota
GeneTreeiENSGT00940000155047
HOGENOMiCLU_021099_2_0_1
InParanoidiQ99081
OMAiRYADEDC
OrthoDBi571132at2759
PhylomeDBiQ99081
TreeFamiTF321672

Enzyme and pathway databases

PathwayCommonsiQ99081
ReactomeiR-HSA-525793, Myogenesis
R-HSA-8939236, RUNX1 regulates transcription of genes involved in differentiation of HSCs
R-HSA-9031628, NGF-stimulated transcription
SIGNORiQ99081

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		6938, 13 hits in 1023 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TCF12, human
EvolutionaryTraceiQ99081

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		TCF12

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		6938
PharosiQ99081, Tbio

Protein Ontology

More...PROi		PR:Q99081
RNActiQ99081, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000140262, Expressed in corpus callosum and 245 other tissues
ExpressionAtlasiQ99081, baseline and differential
GenevisibleiQ99081, HS

Family and domain databases

Gene3Di4.10.280.10, 1 hit
IDEALiIID00222
InterProiView protein in InterPro
IPR011598, bHLH_dom
IPR036638, HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010, HLH, 1 hit
SMARTiView protein in SMART
SM00353, HLH, 1 hit
SUPFAMiSSF47459, SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888, BHLH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHTF4_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99081
Secondary accession number(s): B4E1W1
, Q7Z3D9, Q86TC1, Q86VM2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: April 7, 2021
This is version 193 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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