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Entry version 93 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Alpha-glucuronidase

Gene
N/A
Organism
Hypocrea jecorina (Trichoderma reesei)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Releases 4-O-methylglucuronic acid from xylan.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Polysaccharide degradation, Xylan degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GH67, Glycoside Hydrolase Family 67

CLAE, a database of fungal genes encoding lignocellulose-active proteins

More...
CLAEi
AGU67A_TRIRE

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Alpha-glucuronidase (EC:3.2.1.139)
Alternative name(s):
Alpha-glucosiduronase
GLRI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHypocrea jecorina (Trichoderma reesei)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri51453 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaSordariomycetesHypocreomycetidaeHypocrealesHypocreaceaeTrichoderma

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001224420 – 847Alpha-glucuronidaseAdd BLAST828

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi353N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi692N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi740N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi767N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99024

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the glycosyl hydrolase 67 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
IWRAFVY

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.379.10, 1 hit
3.90.1330.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037054, A-glucoronidase_C_sf
IPR011395, Glyco_hydro_67_aGlcAse
IPR005154, Glyco_hydro_67_aGlcAse_N
IPR011099, Glyco_hydro_67_C
IPR011100, Glyco_hydro_67_cat
IPR017853, Glycoside_hydrolase_SF
IPR029018, Hex-like_dom2

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07477, Glyco_hydro_67C, 1 hit
PF07488, Glyco_hydro_67M, 1 hit
PF03648, Glyco_hydro_67N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF029900, Alpha-glucuronds, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51445, SSF51445, 1 hit
SSF55545, SSF55545, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q99024-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVIRSLLLLL LAAIVPVFAE SGIDAWLRYA RLPSSATRGH LTSFPDRIVV
60 70 80 90 100
LNASKNGPLA SASSELHKGI KGILGLDLDV SSRGGKHCST QKSIVISTLD
110 120 130 140 150
TYQSACGKLS PKLNLKEDGY WLSTKGGSVQ IIGQNERGAL YGAFQYLSYL
160 170 180 190 200
GQGDFSGKAF ASNPSAPVRW SNQWDNLNAA TAAHGSIERG YGGPSIFFEN
210 220 230 240 250
GLIKEDLSRV PLYGRLLASV GLNGIVINNV NADANLLNET NLQGLKRIAD
260 270 280 290 300
LFRPWGVNVG ISLNFASPQV LGDLSTFDPL DDSVIKWWTD KTDRIYQLVP
310 320 330 340 350
DLAGYLVKAN SEGQPGPLTY NRTLAEGANL FAKAVQPHGG IVVFRAFVYD
360 370 380 390 400
QLNETDWKAD RANAAVDFFK SLDGQFDDNV LVQIKYGPID FQVREPASPL
410 420 430 440 450
FANLPKTAVS IELEVTQEYL GQQSHLVYLP PLWQTVLGFD MRYNNRQSYV
460 470 480 490 500
RDIISGEVFG HKLGGYAGVI NVGMDDTWLG SHLAMSNMFA YGRLAWNPRA
510 520 530 540 550
DSRDIVEEWT RLTFGLDRDV VSTIADMSLK SWPAYEGYSG NLGIQTLTDI
560 570 580 590 600
LYTHYGANPA SQDNNGWGQW TRADSKTIGM DRTVSNGTGN AGQYPKEVAA
610 620 630 640 650
RFEHTQTTPD DLMLWFHHVP YTFRLHSGKS VIQHFYDAHY TGAATVQRFP
660 670 680 690 700
AAWKSLKSKI DTERYNAVLY KLQYQTGHSL VWRDAITEFY RNLSSIPDQL
710 720 730 740 750
NRVRNHPHRI EAEDMDLSGF TVVNVSPTEC ASKYKAIATN GTGTATTRLN
760 770 780 790 800
VPSGKYTVAV NYYDVINGTA SYDVLLNGKS LGKWKGDSET HLGHDFSTFL
810 820 830 840
DCHSAIRITF EGVRISRGDK LTIRGTGNAQ EQAAIDYVSI LPQGVVD
Length:847
Mass (Da):93,424
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i214AAE487382FDB4
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z68706 mRNA Translation: CAA92949.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC4836

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z68706 mRNA Translation: CAA92949.1
PIRiJC4836

3D structure databases

SMRiQ99024
ModBaseiSearch...

Protein family/group databases

CAZyiGH67, Glycoside Hydrolase Family 67
CLAEiAGU67A_TRIRE

Phylogenomic databases

OMAiIWRAFVY

Family and domain databases

Gene3Di3.30.379.10, 1 hit
3.90.1330.10, 1 hit
InterProiView protein in InterPro
IPR037054, A-glucoronidase_C_sf
IPR011395, Glyco_hydro_67_aGlcAse
IPR005154, Glyco_hydro_67_aGlcAse_N
IPR011099, Glyco_hydro_67_C
IPR011100, Glyco_hydro_67_cat
IPR017853, Glycoside_hydrolase_SF
IPR029018, Hex-like_dom2
PfamiView protein in Pfam
PF07477, Glyco_hydro_67C, 1 hit
PF07488, Glyco_hydro_67M, 1 hit
PF03648, Glyco_hydro_67N, 1 hit
PIRSFiPIRSF029900, Alpha-glucuronds, 1 hit
SUPFAMiSSF51445, SSF51445, 1 hit
SSF55545, SSF55545, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAGUA_HYPJE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99024
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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