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Protein

Heterogeneous nuclear ribonucleoprotein A/B

Gene

Hnrnpab

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional repressor. Binds to CArG box motifs, single-stranded and double-stranded DNA, and RNA. It may be that repression by CBF-A is a result of competitive binding of CBF, a putative positive factor, and CBF-A to the same or overlapping motifs around the CArG boxes.

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • RNA binding Source: MGI

GO - Biological processi

  • epithelial to mesenchymal transition Source: HGNC
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of transcription, DNA-templated Source: HGNC
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor, RNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein A/B
Short name:
hnRNP A/B
Alternative name(s):
CArG-binding factor-A
Short name:
CBF-A
Gene namesi
Name:Hnrnpab
Synonyms:Cbf-a, Cgbfa, Hnrpab
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1330294 Hnrnpab

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000814931 – 285Heterogeneous nuclear ribonucleoprotein A/BAdd BLAST285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineBy similarity1
Cross-linki136Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki208Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei220N6-acetyllysineCombined sources1
Modified residuei247PhosphoserineBy similarity1
Modified residuei250Dimethylated arginine; alternateBy similarity1
Modified residuei250Omega-N-methylarginine; alternateCombined sources1
Modified residuei255Omega-N-methylarginineCombined sources1
Modified residuei258Omega-N-methylarginineCombined sources1
Modified residuei271N6-acetyllysineCombined sources1
Modified residuei275Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei275Dimethylated arginine; alternateBy similarity1
Modified residuei275Omega-N-methylarginine; alternateCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99020
MaxQBiQ99020
PRIDEiQ99020

PTM databases

iPTMnetiQ99020
PhosphoSitePlusiQ99020
SwissPalmiQ99020

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSMUSG00000020358
ExpressionAtlasiQ99020 baseline and differential
GenevisibleiQ99020 MM

Interactioni

Subunit structurei

Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Interacts with APOBEC1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi200358, 9 interactors
ComplexPortaliCPX-1098 C-to-U editosome complex
DIPiDIP-31415N
IntActiQ99020, 10 interactors
MINTiQ99020

Structurei

3D structure databases

ProteinModelPortaliQ99020
SMRiQ99020
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini75 – 158RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini159 – 238RRM 2PROSITE-ProRule annotationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 43Poly-Ala10
Compositional biasi246 – 277Gly-richAdd BLAST32

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00900000140835
HOGENOMiHOG000234441
HOVERGENiHBG002295
InParanoidiQ99020
KOiK13044

Family and domain databases

CDDicd12757 RRM1_hnRNPAB, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR012956 CARG-binding_factor_N
IPR034846 hnRNPAB_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF08143 CBFNT, 1 hit
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequencei

Sequence statusi: Complete.

Q99020-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDAAEEQPM ETTGATENGH EAAPEGEAPV EPSAAAAAPA ASAGSGGGTT
60 70 80 90 100
TAPSGNQNGA EGDQINASKN EEDAGKMFVG GLSWDTSKKD LKDYFTKFGE
110 120 130 140 150
VVDCTIKMDP NTGRSRGFGF ILFKDSSSVE KVLDQKEHRL DGRVIDPKKA
160 170 180 190 200
MAMKKDPVKK IFVGGLNPEA TEEKIREYFG QFGEIEAIEL PIDPKLNKRR
210 220 230 240 250
GFVFITFKEE DPVKKVLEKK FHTVSGSKCE IKVAQPKEVY QQQQYGSGGR
260 270 280
GNRNRGNRGS GGGQGSTNYG KSQRRGGHQN NYKPY
Length:285
Mass (Da):30,831
Last modified:February 1, 1995 - v1
Checksum:i7881F34131160E0C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26G → S in BAC36208 (PubMed:16141072).Curated1
Sequence conflicti41A → R in BAC36208 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D90151 mRNA Translation: BAA14181.1
L36663 mRNA Translation: AAA92146.1
AK076132 mRNA Translation: BAC36208.1
CCDSiCCDS24654.1
PIRiJQ0448
RefSeqiNP_034578.1, NM_010448.3
UniGeneiMm.256875
Mm.280842

Genome annotation databases

EnsembliENSMUST00000074669; ENSMUSP00000074238; ENSMUSG00000020358
GeneIDi15384
KEGGimmu:15384
UCSCiuc007iua.1 mouse

Similar proteinsi

Entry informationi

Entry nameiROAA_MOUSE
AccessioniPrimary (citable) accession number: Q99020
Secondary accession number(s): Q8BPE0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1995
Last sequence update: February 1, 1995
Last modified: June 20, 2018
This is version 159 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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