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Protein

Replicase polyprotein 1ab

Gene

rep

Organism
Feline coronavirus (strain FIPV WSU-79/1146) (FCoV)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

The replicase polyprotein of coronaviruses is a multifunctional protein: it contains the activities necessary for the transcription of negative stranded RNA, leader RNA, subgenomic mRNAs and progeny virion RNA as well as proteinases responsible for the cleavage of the polyprotein into functional products.
The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3 (By similarity).By similarity
The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).PROSITE-ProRule annotation
The helicase which contains a zinc finger structure displays RNA and DNA duplex-unwinding activities with 5' to 3' polarity. ATPase activity is strongly stimulated by poly(U), poly(dT), poly(C), poly(dA), but not by poly(G) (By similarity).By similarity
The exoribonuclease acts on both ssRNA and dsRNA in a 3' to 5' direction.By similarity
Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter.By similarity
Nsp9 is a ssRNA-binding protein.By similarity
NendoU is a Mn2+-dependent, uridylate-specific enzyme, which leaves 2'-3'-cyclic phosphates 5' to the cleaved bond.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei1117For PL1-PRO activityPROSITE-ProRule annotation1
Active sitei1268For PL1-PRO activityPROSITE-ProRule annotation1
Active sitei1599For PL2-PRO activityPROSITE-ProRule annotation1
Active sitei1752For PL2-PRO activityPROSITE-ProRule annotation1
Active sitei2944For 3CL-PRO activity1
Active sitei3047For 3CL-PRO activity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei3053Important for substrate recognition1
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi4957Zinc 1PROSITE-ProRule annotation1
Metal bindingi4960Zinc 1PROSITE-ProRule annotation1
Metal bindingi4968Zinc 2PROSITE-ProRule annotation1
Metal bindingi4971Zinc 1PROSITE-ProRule annotation1
Metal bindingi4978Zinc 1PROSITE-ProRule annotation1
Metal bindingi4981Zinc 2PROSITE-ProRule annotation1
Metal bindingi4985Zinc 2PROSITE-ProRule annotation1
Metal bindingi4991Zinc 2PROSITE-ProRule annotation1
Metal bindingi5002Zinc 3PROSITE-ProRule annotation1
Metal bindingi5007Zinc 3PROSITE-ProRule annotation1
Metal bindingi5024Zinc 3PROSITE-ProRule annotation1
Metal bindingi5027Zinc 3PROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri1188 – 1219C4-type 1PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri1678 – 1707C4-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30
Zinc fingeri3962 – 3978By similarityAdd BLAST17
Zinc fingeri4004 – 4017By similarityAdd BLAST14
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi5235 – 5242ATPBy similarity8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionEndonuclease, Exonuclease, Helicase, Hydrolase, Methyltransferase, Nuclease, Nucleotidyltransferase, Protease, RNA-binding, RNA-directed RNA polymerase, Thiol protease, Transferase
Biological processActivation of host autophagy by virus, Host-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host RLR pathway by virus, Modulation of host ubiquitin pathway by viral deubiquitinase, Modulation of host ubiquitin pathway by virus, Ubl conjugation pathway, Viral immunoevasion, Viral RNA replication
LigandATP-binding, Metal-binding, Nucleotide-binding, Zinc

Protein family/group databases

MEROPS protease database

More...
MEROPSi
C30.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Replicase polyprotein 1ab
Short name:
pp1ab
Alternative name(s):
ORF1ab polyprotein
Cleaved into the following 16 chains:
Non-structural protein 1
Short name:
nsp1
Non-structural protein 2
Short name:
nsp2
Alternative name(s):
PL1-PRO/PL2-PRO
PLP1/PLP2
Papain-like proteinases 1/2
p195
Non-structural protein 4
Short name:
nsp4
Alternative name(s):
Peptide HD2
3C-like proteinase (EC:3.4.22.-)
Short name:
3CL-PRO
Short name:
3CLp
Alternative name(s):
M-PRO
nsp5
Non-structural protein 6
Short name:
nsp6
Non-structural protein 7
Short name:
nsp7
Non-structural protein 8
Short name:
nsp8
Non-structural protein 9
Short name:
nsp9
Non-structural protein 10
Short name:
nsp10
Non-structural protein 11
Short name:
nsp11
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
Pol
Short name:
RdRp
Alternative name(s):
nsp12
Helicase (EC:3.6.4.12, EC:3.6.4.13)
Short name:
Hel
Alternative name(s):
nsp13
Exoribonuclease (EC:3.1.13.-)
Short name:
ExoN
Alternative name(s):
nsp14
Alternative name(s):
NendoU
nsp15
Alternative name(s):
nsp16
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:rep
ORF Names:1a-1b
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiFeline coronavirus (strain FIPV WSU-79/1146) (FCoV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri33734 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageNidoviralesCoronaviridaeCoronavirinaeAlphacoronavirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiFelidae (cat family) [TaxID: 9681]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000835 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome
  • UP000140386 Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Non-structural protein 7 :
  • host perinuclear region By similarity
  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Non-structural protein 8 :
  • host perinuclear region By similarity
  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Non-structural protein 9 :
  • host perinuclear region By similarity
  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Non-structural protein 10 :
  • host perinuclear region By similarity
  • Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
Helicase :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1860 – 1878HelicalSequence analysisAdd BLAST19
Transmembranei1921 – 1941HelicalSequence analysisAdd BLAST21
Transmembranei2006 – 2026HelicalSequence analysisAdd BLAST21
Transmembranei2043 – 2065HelicalSequence analysisAdd BLAST23
Transmembranei2426 – 2446HelicalSequence analysisAdd BLAST21
Transmembranei2691 – 2711HelicalSequence analysisAdd BLAST21
Transmembranei2720 – 2740HelicalSequence analysisAdd BLAST21
Transmembranei2771 – 2791HelicalSequence analysisAdd BLAST21
Transmembranei3212 – 3232HelicalSequence analysisAdd BLAST21
Transmembranei3242 – 3262HelicalSequence analysisAdd BLAST21
Transmembranei3267 – 3287HelicalSequence analysisAdd BLAST21
Transmembranei3306 – 3326HelicalSequence analysisAdd BLAST21
Transmembranei3339 – 3359HelicalSequence analysisAdd BLAST21
Transmembranei3396 – 3416HelicalSequence analysisAdd BLAST21
Transmembranei3419 – 3439HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2944H → Y or R: Complete loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi2967N → A or D: Increase of 3CL-PRO activity. 1 Publication1
Mutagenesisi2986G → A: 5% loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi2986G → D: Increase of 3CL-PRO activity. 1 Publication1
Mutagenesisi2986G → E: 50% loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi2986G → P or V: 95% loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi2986G → R, T or W: 70% loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi3041S → A: 80% loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi3041S → T: 40% loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi3047C → A or S: Complete loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi3063Y → A, F, G or T: Almost complete loss of 3CL-PRO activity. 1 Publication1
Mutagenesisi3064M → A: Increase of 3CL-PRO activity. 1 Publication1
Mutagenesisi3065H → A: Complete loss of 3CL-PRO activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002838251 – 6709Replicase polyprotein 1abAdd BLAST6709
ChainiPRO_50001402081 – 110Non-structural protein 1By similarityAdd BLAST110
ChainiPRO_5000140209111 – 879Non-structural protein 2By similarityAdd BLAST769
ChainiPRO_5000140210880 – 2413Non-structural protein 3By similarityAdd BLAST1534
ChainiPRO_50001402112414 – 2903Non-structural protein 4By similarityAdd BLAST490
ChainiPRO_50001402122904 – 32053C-like proteinaseBy similarityAdd BLAST302
ChainiPRO_50001402133206 – 3499Non-structural protein 6By similarityAdd BLAST294
ChainiPRO_50001402143500 – 3582Non-structural protein 7By similarityAdd BLAST83
ChainiPRO_50001402153583 – 3777Non-structural protein 8By similarityAdd BLAST195
ChainiPRO_50001402163778 – 3888Non-structural protein 9By similarityAdd BLAST111
ChainiPRO_50001402173889 – 4023Non-structural protein 10By similarityAdd BLAST135
ChainiPRO_50001402194024 – 4952RNA-directed RNA polymeraseBy similarityAdd BLAST929
ChainiPRO_50001402184024 – 4042Non-structural protein 11By similarityAdd BLAST19
ChainiPRO_50001402204953 – 5551HelicaseBy similarityAdd BLAST599
ChainiPRO_50001402215552 – 6070ExoribonucleaseSequence analysisAdd BLAST519
ChainiPRO_50001402226071 – 6409Uridylate-specific endoribonucleaseSequence analysisAdd BLAST339
ChainiPRO_50001402236410 – 6709Putative 2'-O-methyl transferaseSequence analysisAdd BLAST300

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Specific enzymatic cleavages in vivo by its own proteases yield mature proteins. 3CL-PRO and PL-PRO proteinases are autocatalytically processed (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei110 – 111Cleavage; by PL1-PROBy similarity2
Sitei879 – 880Cleavage; by PL1-PROBy similarity2
Sitei2413 – 2414Cleavage; by PL2-PROBy similarity2
Sitei2903 – 2904Cleavage; by 3CL-PROBy similarity2
Sitei3205 – 3206Cleavage; by 3CL-PROBy similarity2
Sitei3499 – 3500Cleavage; by 3CL-PROBy similarity2
Sitei3582 – 3583Cleavage; by 3CL-PROBy similarity2
Sitei3777 – 3778Cleavage; by 3CL-PROBy similarity2
Sitei3888 – 3889Cleavage; by 3CL-PROBy similarity2
Sitei4023 – 4024Cleavage; by 3CL-PROBy similarity2
Sitei4952 – 4953Cleavage; by 3CL-PROBy similarity2
Sitei5551 – 5552Cleavage; by 3CL-PROBy similarity2
Sitei6070 – 6071Cleavage; by 3CL-PROBy similarity2
Sitei6409 – 6410Cleavage; by 3CL-PROBy similarity2

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q98VG9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer (By similarity).By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

16709
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q98VG9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q98VG9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q98VG9

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1079 – 1330Peptidase C16 1PROSITE-ProRule annotationAdd BLAST252
Domaini1329 – 1500MacroPROSITE-ProRule annotationAdd BLAST172
Domaini1561 – 1814Peptidase C16 2PROSITE-ProRule annotationAdd BLAST254
Domaini2904 – 3205Peptidase C30PROSITE-ProRule annotationAdd BLAST302
Domaini4632 – 4794RdRp catalyticAdd BLAST163
Domaini4953 – 5036CV ZBDPROSITE-ProRule annotationAdd BLAST84
Domaini5200 – 5391(+)RNA virus helicase ATP-bindingAdd BLAST192
Domaini5392 – 5561(+)RNA virus helicase C-terminalAdd BLAST170

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1860 – 2065HD1By similarityAdd BLAST206
Regioni2426 – 2791HD2By similarityAdd BLAST366
Regioni3212 – 3439HD3By similarityAdd BLAST228

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The hydrophobic domains (HD) could mediate the membrane association of the replication complex and thereby alter the architecture of the host cell membrane.By similarity

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri1188 – 1219C4-type 1PROSITE-ProRule annotationAdd BLAST32
Zinc fingeri1678 – 1707C4-type 2; atypicalPROSITE-ProRule annotationAdd BLAST30
Zinc fingeri3962 – 3978By similarityAdd BLAST17
Zinc fingeri4004 – 4017By similarityAdd BLAST14

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
VOG09000000

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.150.420, 1 hit
1.10.8.370, 1 hit
2.30.30.1000, 1 hit
2.40.10.250, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR032039 A-CoV_nsp1
IPR038634 A-CoV_nsp1_sf
IPR032505 Corona_NSP4_C
IPR009461 Coronavirus_NSP16
IPR027352 CV_ZBD
IPR037227 EndoU-like
IPR002589 Macro_dom
IPR036333 NSP10_sf
IPR009466 NSP11
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR037204 NSP7_sf
IPR014829 NSP8
IPR037230 NSP8_sf
IPR014822 NSP9
IPR036499 NSP9_sf
IPR027417 P-loop_NTPase
IPR008740 Peptidase_C30
IPR013016 Peptidase_C30/C16
IPR009003 Peptidase_S1_PA
IPR009469 RNA_pol_N_coronovir
IPR018995 RNA_synth_NSP10_coronavirus
IPR029063 SAM-dependent_MTases
IPR014827 Viral_protease

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16688 CNV-Replicase_N, 1 hit
PF16348 Corona_NSP4_C, 1 hit
PF06478 Corona_RPol_N, 1 hit
PF01661 Macro, 1 hit
PF09401 NSP10, 1 hit
PF06471 NSP11, 1 hit
PF06460 NSP16, 1 hit
PF08716 nsp7, 1 hit
PF08717 nsp8, 1 hit
PF08710 nsp9, 1 hit
PF05409 Peptidase_C30, 1 hit
PF08715 Viral_protease, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00506 A1pp, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF101816 SSF101816, 1 hit
SSF140367 SSF140367, 1 hit
SSF142877 SSF142877, 1 hit
SSF143076 SSF143076, 1 hit
SSF144246 SSF144246, 2 hits
SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 1 hit
SSF53335 SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51653 CV_ZBD, 1 hit
PS51442 M_PRO, 1 hit
PS51154 MACRO, 1 hit
PS51124 PEPTIDASE_C16, 2 hits
PS51657 PSRV_HELICASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by ribosomal frameshifting. AlignAdd to basket
Isoform Replicase polyprotein 1ab (identifier: Q98VG9-1) [UniParc]FASTAAdd to basket
Also known as: pp1ab

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSSKQFKILV NEDYQVNVPS LPFRDALQEI KYCYRNGFDG YVFVPEYRRD
60 70 80 90 100
LVDCNRKDHY VIGVLGNGIS DLKPVLLTEP SVMLQGFIVR ANCNGVLEDF
110 120 130 140 150
DLKFARTGNG AIYVDQYMCG ADGKPVIEGE FKDYFGDEDV IIYEGEEYHC
160 170 180 190 200
AWLTVRDEKP LWQQTLLTIR EIQYNLDIPH KLPNCAIREV APPVKKNSKV
210 220 230 240 250
VLSEEYRKLY DIFGSPFMGN GDSLNTCFDS LHFIAATLKC PCGAESSGVG
260 270 280 290 300
DWTGFKTACC GLHGKVKGVT LGAVKPGDAI VTSMSAGKGV KFFANSVLQY
310 320 330 340 350
AGDVENVSVW KVIKTFTVNE TVCTTDFEGE LNDFIRPEST SPVSCSIKRA
360 370 380 390 400
FITGEVDDAV HDCIIAGKLD LSTNLFGSAN LLFKKMPWFV QKCGAIFADA
410 420 430 440 450
WKVVEELLCS LKLTYKQIYD VVASLCTSAF TIMDYKPVFV VSSNSVKDLV
460 470 480 490 500
DKCVKILVKA FDVFTQTITI AGVEAKCFVL GSKYLLFNNA LVKLVSVKIL
510 520 530 540 550
GKRQKGLDSA FFATNLIGAT VNVTPQRTES AYISLNKVDD VVTPGGGHIV
560 570 580 590 600
IIGDMAFYKS EEYYFMMASP DSVLVNNVFK AARVPSYNIV YDVNDDTKSK
610 620 630 640 650
MVVKIGTSFD FDGDLDAAIA KVNDLLIEFR QEKLCFRALK DGENILVEAY
660 670 680 690 700
LKKYKMPVCL KNHVGLWDII RQDSGKKGFL DTFNHLNELE DVKDIKIQTI
710 720 730 740 750
KNIICPDLLL ELDFGAIWYR CMPACSDKSI LGNVKIMLGN GVKVVCDGCH
760 770 780 790 800
SFANRLTINY NKLCDTARKD IEIGGIPFST FKTPSSSFID MKDAIYSVVE
810 820 830 840 850
YGEALSFKTA SVPVTNSGII TTDDWSDPIL LEPADYVEPK DNGDVIVIAG
860 870 880 890 900
YTFYKDEDDH FYPYGSGMVV QKMYNKMGGG DKSVSFSDNV NVREIEPVTR
910 920 930 940 950
VRLEFEFDNE VVTQVLEKVI GTKYKFIGTT WEEFEDSISE KLDKIFDTLA
960 970 980 990 1000
EQGVELEGYF IYDTCGGFDI NNPDGVMISQ YDLNTAADDK SDSDASVEDI
1010 1020 1030 1040 1050
SLISDNEDVE QIEEDNTSTD DAEDVSSVEG ETVSVVDVED FVEQVSLVEE
1060 1070 1080 1090 1100
NNVLTPAVNP DEQLSSVEKK DEVSAKNDPW AAAVDEQEAE QPKPSLTPFK
1110 1120 1130 1140 1150
TTNLNGKIIL KQQDNNCWIN ACCYQLQAFD FFNHDLWDGF KKDDVMPFVD
1160 1170 1180 1190 1200
FCYAALTLKQ GDSGDAEYLL ETMLNDYSTA KVTLSAKCGC GVKEIVLERT
1210 1220 1230 1240 1250
VFKLTPLRNE FKYGVCGDCK QINMCKFASV EGSGVFVHDR IEKQTPVSQF
1260 1270 1280 1290 1300
IVTPTMHAVY TGTTQSGHYM IEDCIHDYCV DGMGIKPRKH KFYTSTLFLN
1310 1320 1330 1340 1350
ANVMTAKSKT MVEPPVPVED KCVEDCQSPK DLILPFYKAG KVSFYQGDLD
1360 1370 1380 1390 1400
VLINFLEPDV LVNAANGDLR HVGGVARAID VFTGGKLTKR SKEYLKSSKA
1410 1420 1430 1440 1450
IAPGNAVLFE NVLEHLSVLN AVGPRNGDSR VEGKLCNVYK AIAKCDGKIL
1460 1470 1480 1490 1500
TPLISVGIFK VKLEVSLQCL LKTVTDRDLN VFVYTDQERV TIENFFNGTI
1510 1520 1530 1540 1550
PIKVTEDTVN QKRVSVALDK TYGEQLKGTV VIKDKDVTNQ LPSVSDVGEK
1560 1570 1580 1590 1600
VVKALDVDWN AYYGFPNAAA FSASSHDAYE FDVVTHNNFI VHKQTDNNCW
1610 1620 1630 1640 1650
VNAICLALQR LKPTWKFPGV KSLWDAFLTR KTAGFVHMLY HISGLTKGQP
1660 1670 1680 1690 1700
GDAELTLHKL VDLMSSDSAV TVTHTTACDK CAKVETFTGP VVAAPLLVCG
1710 1720 1730 1740 1750
TDEICVHGVH VNVKVTSIRG TVAITSLIGP VVGDVIDATG YICYTGLNSR
1760 1770 1780 1790 1800
GHYTYYDNRN GLMVDADKAY HFEKNLLQVT TAIASNFVAN TPKKEIMPKT
1810 1820 1830 1840 1850
QAKESKAKES NTARVFSEVE ENPKNIVRKE KLLAIESGVD YTITTLGKYA
1860 1870 1880 1890 1900
DVFFMAGDKI LRFLLEVFKY LLVVFMCLRK SKMPKVKVKP PHVFRNLGAK
1910 1920 1930 1940 1950
VRTLNYVRQL NKPALWRYIK LVLLLIALYH FFYLFVSIPV VHKLACSGSV
1960 1970 1980 1990 2000
QAYSNSSFVK SEVCGNSILC KACLASYDEL ADFDHLQVSW DYKSDPLWNR
2010 2020 2030 2040 2050
VIQLSYFIFL AVFGNNYVRC LLMYFVSQYL NLWLSYFGYV KYSWFLHVVN
2060 2070 2080 2090 2100
FESISVEFVI IVVVFKAVLA LKHIFLPCNN PSCKTCSKIA RQTRIPIQVV
2110 2120 2130 2140 2150
VNGSMKTVYV HANGTGKLCK KHNFYCKNCD SYGFDHTFIC DEIVRDLSNS
2160 2170 2180 2190 2200
IKQTVYATDR SYQEVTKVEC TDGFYRFYVG EEFTAYDYDV KHKKYSSQEV
2210 2220 2230 2240 2250
LKTMFLLDDF IVYNPSGSSL ASVRNVCVYF SQLIGRPIKI VNSELLEDLS
2260 2270 2280 2290 2300
VDFKGALFNA KKNVIKNSFN VDVSECKNLE ECYKLCNLDV TFSTFEMAIN
2310 2320 2330 2340 2350
NAHRFGILIT DRSFNNFWPS KIKPGSSGVS AMDIGKCMTF DAKIVNAKVL
2360 2370 2380 2390 2400
TQRGKSVVWL SQDFSTLSST AQKVLVKTFV EEGVNFSLTF NAVGSDEDLP
2410 2420 2430 2440 2450
YERFTESVSA KSGSGFFDVL KQLKQLFWCL VLFITLYGLC SVYSVATQSY
2460 2470 2480 2490 2500
IDSAEGYDYM VIKNGVVQSF DDSINCVHNT YKGFAVWFKA KHGFVPTFDK
2510 2520 2530 2540 2550
SCPIVLGTVF DLGNMRPIPD VPAYVALVGR SLVFAINAAF GVTNVCYDHT
2560 2570 2580 2590 2600
GAAVSKNSYF DTCVFNSACT TLTGIGGTVV YCAKQGLVEG AKLYSELLPD
2610 2620 2630 2640 2650
YYYEHASGNM VKIPAIIRSF GLRFVKTQAT TYCRVGECTE SQAGFCFGGD
2660 2670 2680 2690 2700
NWFVYDKEFG DGYICGSSTL GFFKNVFALF NSNMSVVATS GAMLANIVIA
2710 2720 2730 2740 2750
CLAIAVCYGV LKFKKIFGDC TLLVVMIIVT LVVNNVSYFV TQNTFFMIVY
2760 2770 2780 2790 2800
AIIYYFTTRK LAYPGVLDAG FIIAYLNMAP WYVLVLYIMV FLYDSLPSLF
2810 2820 2830 2840 2850
KLKVTTNLFE GDKFVGSFES AAMGTFVIDM RSYETLVNST SLDRIKSYAN
2860 2870 2880 2890 2900
SFNKYKYYTG SMGEADYRMA CYAHLGKALM DYSVSRNDML YTPPTVSVNS
2910 2920 2930 2940 2950
TLQSGLRKMA QPSGVVEPCI VRVAYGNNVL NGLWLGDEVI CPRHVIASDT
2960 2970 2980 2990 3000
SRVINYENEL SSVRLHNFSI AKNNAFLGVV SAKYKGVNLV LKVNQVNPNT
3010 3020 3030 3040 3050
PEHKFKSVRP GESFNILACY EGCPGSVYGV NMRSQGTIKG SFIAGTCGSV
3060 3070 3080 3090 3100
GYVLENGTLY FVYMHHLELG NGSHVGSNLE GEMYGGYEDQ PSMQLEGTNV
3110 3120 3130 3140 3150
MSSDNVVAFL YAALINGERW FVTNTSMTLE SYNAWAKTNS FTEIVSTDAF
3160 3170 3180 3190 3200
NMLAAKTGYS VEKLLECIVR LNKGFGGRTI LSYGSLCDEF TPTEVIRQMY
3210 3220 3230 3240 3250
GVNLQSGKVK SIFYPMMTAI AILFAFWLEF FMYTPFTWIN PTFVSVVLAI
3260 3270 3280 3290 3300
TTLVSVLLVA GIKHKMLFFM SFVMPSVILA TAHNVVWDMT YYESLQVLVE
3310 3320 3330 3340 3350
NVNTTFLPVD MQGVMLALFC VVVFVICTIR FFTCKQSWFS LFATTIFVMF
3360 3370 3380 3390 3400
NIVKLLGMIG EPWTDDHFLL CLVNMLTMLI SLTTKDWFVV FASYKVAYYI
3410 3420 3430 3440 3450
VVYVMQPAFV QDFGFVKCVS IIYMACGYLF CCYYGILYWV NRFTCMTCGV
3460 3470 3480 3490 3500
YQFTVSPAEL KYMTANNLSA PKTAYDAMIL SFKLMGIGGG RNIKISTVQS
3510 3520 3530 3540 3550
KLTEMKCTNV VLLGLLSKMH VESNSKEWNY CVGLHNEINL CDDPDAVLEK
3560 3570 3580 3590 3600
LLALIAFFLS KHNTCDLSDL IESYFENTTI LQSVASAYAA LPSWIAYEKA
3610 3620 3630 3640 3650
RADLEEAKKN DVSPQLLKQL TKACNIAKSE FEREASVQKK LDKMAEQAAA
3660 3670 3680 3690 3700
SMYKEARAVD RKSKIVSAMH SLLFGMLKKL DMSSVNTIIE QARNGVLPLS
3710 3720 3730 3740 3750
IIPAASATRL IVVTPNLEVL SKVRQENNVH YAGAIWSIVE VKDANGAQVH
3760 3770 3780 3790 3800
LKEVTAANEL NITWPLSITC ERTTKLQNNE ILPGKLKEKA VKASATIDGD
3810 3820 3830 3840 3850
AYGSGKALMA SEGGKSFIYA FIASDSNLKY VKWESNNDVI PIELEAPLRF
3860 3870 3880 3890 3900
YVDGVNGPEV KYLYFVKSLN TLRRGAVLGY IGATVRLQAG KPTEHPSNSG
3910 3920 3930 3940 3950
LLTLCAFAPD PAKAYVDAVK RGMQPVTNCV KMLSNGAGNG MAITNGVESN
3960 3970 3980 3990 4000
TQQDSYGGAS VCIYCRCHVE HPAIDGLCRF KGKFVQVPTG TQDPIRFCIE
4010 4020 4030 4040 4050
NEVCVVCGCW LTNGCMCDRT SIQGTTIDQS YLNECGVLVQ LDLEPCNGTD
4060 4070 4080 4090 4100
PDHVSRAFDI YNKDVACIGK FLKTNCSRFR NLDKHDAYYV VKRCTKSVMD
4110 4120 4130 4140 4150
HEQVCYNDLK DSGVVAEHDF FLYKEGRCEF GNVARKDLTK YTMMDLCYAI
4160 4170 4180 4190 4200
RNFDEKNCEV LKEILVTLGA CNESFFENKD WFDPVENEAI HEVYARLGPI
4210 4220 4230 4240 4250
VANAMLKCVA FCDAIVEKGY IGIITLDNQD LNGNFYDFGD FVKTTPGFGC
4260 4270 4280 4290 4300
ACVTSYYSYM MPLMGMTSCL ESENFVKSDI YGADYKQYDL LAYDFTDHKE
4310 4320 4330 4340 4350
KLFHKYFKHW DRTYHPNCSD CTSDECIIHC ANFNTLFSMT IPSTAFGPLV
4360 4370 4380 4390 4400
RKVHIDGVPV VVTAGYHFKQ LGIVWNLDVK LDTMKLSMTD LLRFVTDPTL
4410 4420 4430 4440 4450
LVASSPALLD QRTVCFSIAA LSTGVTYQTV KPGHFNKDFY DFITERGFFE
4460 4470 4480 4490 4500
EGSELTLKHF FFAQGGEAAM TDFNYYRYNR VTVLDICQAQ FVYKIVGKYF
4510 4520 4530 4540 4550
ECYDGGCINA REVVVTNYDK SAGYPLNKFG KARLYYETLS YEEQDALFAL
4560 4570 4580 4590 4600
TKRNVLPTMT QMNLKYAISG KARARTVGGV SLLSTMTTRQ YHQKHLKSIA
4610 4620 4630 4640 4650
ATRNATVVIG STKFYGGWDN MLKNLMRDVD NGCLMGWDYP KCDRALPNMI
4660 4670 4680 4690 4700
RMASAMILGS KHVGCCTHSD RFYRLSNELA QVLTEVVHCT GGFYFKPGGT
4710 4720 4730 4740 4750
TSGDGTTAYA NSAFNIFQAV SANVNKLLGV DSNACNNVTV KSIQRKIYDN
4760 4770 4780 4790 4800
CYRSSSIDEE FVVEYFSYLR KHFSMMILSD DGVVCYNKDY ADLGYVADIN
4810 4820 4830 4840 4850
AFKATLYYQN NVFMSTSKCW VEPDLSVGPH EFCSQHTLQI VGPDGDYYLP
4860 4870 4880 4890 4900
YPDPSRILSA GVFVDDIVKT DNVIMLERYV SLAIDAYPLT KHPKPAYQKV
4910 4920 4930 4940 4950
FYTLLDWVKH LQKNLNAGVL DSFSVTMLEE GQDKFWSEEF YASLYEKSTV
4960 4970 4980 4990 5000
LQAAGMCVVC GSQTVLRCGD CLRRPLLCTK CAYDHVMGTK HKFIMSITPY
5010 5020 5030 5040 5050
VCSFNGCNVN DVTKLFLGGL SYYCMDHKPQ LSFPLCANGN VFGLYKSSAV
5060 5070 5080 5090 5100
GSEDVEDFNK LAVSDWTNVE DYKLANNVKE SLKIFAAETV KAKEESVKSE
5110 5120 5130 5140 5150
YAYAILKEVI GPKEIVLQWE ASKTKPPLNR NSVFTCFQIS KDTKIQLGEF
5160 5170 5180 5190 5200
VFEQSEYGSD SVYYKSTSTY KLTPGMIFVL TSHNVSPLKA TILVNQEKYN
5210 5220 5230 5240 5250
TISKLYPVFN IAEAYNTLVP YYQMIGKQKF TTIQGPPGSG KSHCVIGLGL
5260 5270 5280 5290 5300
YYPQARIVYT ACSHAAVDAL CEKAAKNFNV DRCSRIIPQR IRVDCYTGFK
5310 5320 5330 5340 5350
PNNTNAQYLF CTVNALPEAS CDIVVVDEVS MCTNYDLSVI NSRLSYKHIV
5360 5370 5380 5390 5400
YVGDPQQLPA PRTLINKGVL QPQDYNVVTQ RVCTLGPDVF LHKCYRCPAE
5410 5420 5430 5440 5450
IVKTVSALVY ENKFVPVNPE SKQCFKMFVK GQVQIESNSS INNKQLEVVK
5460 5470 5480 5490 5500
AFLAHNPKWR KAVFISPYNS QNYVARRLLG LQTQTVDSAQ GSEYDYVIYT
5510 5520 5530 5540 5550
QTSDTQHATN VNRFNVAITR AKVGILCIMC DRTMYENLDF YELKDSKIGL
5560 5570 5580 5590 5600
QAKPETCGLF KDCSKSEQYI PPAYATTYMS LSDNFKTSDG LAVNIGTKDV
5610 5620 5630 5640 5650
KYANVISYMG FRFEANIPGY HTLFCTRDFA MRNVRAWLGF DVEGAHVCGD
5660 5670 5680 5690 5700
NVGTNVPLQL GFSNGVDFVV QTEGCVVTEK GNSIEVVKAR APPGEQFAHL
5710 5720 5730 5740 5750
IPLMRKGQPW HIVRRRIVQM VCDYFDGLSD ILIFVLWAGG LELTTMRYFV
5760 5770 5780 5790 5800
KIGRPQKCEC GKSATCYSSS QCVYACFKHA LGCDYLYNPY CIDIQQWGYT
5810 5820 5830 5840 5850
GSLSMNHHEV CNIHRNEHVA SGDAIMTRCL AIHDCFVKRV DWSIVYPFID
5860 5870 5880 5890 5900
NEEKINKAGR IVQSHVMKAA LKIFNPAAIH DVGNPKGIRC ATTPIPWFCY
5910 5920 5930 5940 5950
DRDPINNNVR CLEYDYMVHG QMNGLMLFWN CNVDMYPEFS IVCRFDTRTR
5960 5970 5980 5990 6000
SKLSLEGCNG GALYVNNHAF HTPAYDRRAF AKLKPMPFFY YDDSNCELVD
6010 6020 6030 6040 6050
GQPNYVPLKS NVCITKCNIG GAVCKKHAAL YRAYVEDYNM FMQAGFTIWC
6060 6070 6080 6090 6100
PQNFDTYMLW HGFVNSKALQ SLENVAFNVV KKGAFTGLKG DLPTAVIADK
6110 6120 6130 6140 6150
IMVRDGPTDK CIFTNKTSLP TNVAFELYAK RKLGLTPPLT ILRNLGVVAT
6160 6170 6180 6190 6200
YKFVLWDYEA ECPFSNFTKQ VCSYTDLDSE VVTCFDNSIA GSFERFTTTK
6210 6220 6230 6240 6250
DAVLISNNAV KGLSAIKLQY GFLNDLPVST VGNKPVTWYI YVRKNGEYVE
6260 6270 6280 6290 6300
QIDSYYTHGR TFETFKPRST MEEDFLSMDT TLFIQKYGLE DYGFEHVVFG
6310 6320 6330 6340 6350
DVSKTTIGGM HLLISQVRLA KMGLFSVQEF MTNSDSTLKS CCITYADDPS
6360 6370 6380 6390 6400
SKNVCTYMDI LLDDFVTIIK SLDLNVVSKV VDVIVDCKAW RWMLWCENSQ
6410 6420 6430 6440 6450
IKTFYPQLQS AEWNPGYSMP TLYKIQRMCL ERCNLYNYGA QVRLPDGITT
6460 6470 6480 6490 6500
NVVKYTQLCQ YLNTTTVCVP HKMRVLHLGA AGASGVAPGS TVLRRWLPDD
6510 6520 6530 6540 6550
AILVDNDLRD YVSDADFSVT GDCTSLYIED KFDLLISDLY DGSTKSIDGE
6560 6570 6580 6590 6600
NTSKDGFFTY INGFIKEKLS LGGSAAIKIT EFSWNKDLYE LIQRFEYWTV
6610 6620 6630 6640 6650
FCTSVNTSSS EGFLIGINYL GPYCDKAIVD GNIMHANYIF WRNSTIMALS
6660 6670 6680 6690 6700
HNSVLDTPKF KCRCNNALIV NLKEKELNEM VVGLLRKGKL LIRNNGKLLN

FGNHLVNVP
Note: Produced by -1 ribosomal frameshifting at the 1a-1b genes boundary.
Length:6,709
Mass (Da):751,196
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF26AC0FFF5FE27F9
GO
Isoform Replicase polyprotein 1a (identifier: Q98VG9-2) [UniParc]FASTAAdd to basket
Also known as: pp1a, ORF1a polyprotein

The sequence of this isoform differs from the canonical sequence as follows:
     4043-6709: Missing.

Note: Produced by conventional translation.
Show »
Length:4,042
Mass (Da):449,790
Checksum:i34663B2576D09550
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAY16374 differs from that shown. Reason: Frameshift at position 4033.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1016 – 1092Missing in AAY32594 (PubMed:16033972).CuratedAdd BLAST77

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti162W → C. 1
Natural varianti177D → G. 1
Natural varianti388W → C. 1
Natural varianti808K → T. 1
Natural varianti1784A → V. 1
Natural varianti2889M → K. 1
Natural varianti3280A → V. 1
Natural varianti3992Q → R. 1
Natural varianti4304H → Q. 1
Natural varianti5846Y → H. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0328854043 – 6709Missing in isoform Replicase polyprotein 1a. CuratedAdd BLAST2667

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
DQ010921 Genomic RNA Translation: AAY32594.1
DQ010921 Genomic RNA Translation: AAY32595.1
AY994055 Genomic RNA Translation: AAY16374.1 Frameshift.
AF326575 Genomic RNA Translation: AAK09095.1

Keywords - Coding sequence diversityi

Ribosomal frameshifting

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ010921 Genomic RNA Translation: AAY32594.1
DQ010921 Genomic RNA Translation: AAY32595.1
AY994055 Genomic RNA Translation: AAY16374.1 Frameshift.
AF326575 Genomic RNA Translation: AAK09095.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3ETIX-ray2.20A/B/C/D/E/F/G/H1331-1498[»]
3EW5X-ray3.10A/B/C1331-1498[»]
3GZFX-ray2.76A/B/C/D/E2808-2902[»]
3JZTX-ray3.91A/B/C/D/E/F/G/H1331-1498[»]
3UB0X-ray2.60A/D3583-3777[»]
B/C/E/F3500-3582[»]
4ZROX-ray2.06A/B/C/D2904-3202[»]
5EU8X-ray2.45A2904-3205[»]
ProteinModelPortaliQ98VG9
SMRiQ98VG9
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiC30.004

Proteomic databases

PRIDEiQ98VG9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

OrthoDBiVOG09000000

Miscellaneous databases

EvolutionaryTraceiQ98VG9

Family and domain databases

Gene3Di1.10.150.420, 1 hit
1.10.8.370, 1 hit
2.30.30.1000, 1 hit
2.40.10.250, 1 hit
InterProiView protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR032039 A-CoV_nsp1
IPR038634 A-CoV_nsp1_sf
IPR032505 Corona_NSP4_C
IPR009461 Coronavirus_NSP16
IPR027352 CV_ZBD
IPR037227 EndoU-like
IPR002589 Macro_dom
IPR036333 NSP10_sf
IPR009466 NSP11
IPR038123 NSP4_C_sf
IPR014828 NSP7
IPR037204 NSP7_sf
IPR014829 NSP8
IPR037230 NSP8_sf
IPR014822 NSP9
IPR036499 NSP9_sf
IPR027417 P-loop_NTPase
IPR008740 Peptidase_C30
IPR013016 Peptidase_C30/C16
IPR009003 Peptidase_S1_PA
IPR009469 RNA_pol_N_coronovir
IPR018995 RNA_synth_NSP10_coronavirus
IPR029063 SAM-dependent_MTases
IPR014827 Viral_protease
PfamiView protein in Pfam
PF16688 CNV-Replicase_N, 1 hit
PF16348 Corona_NSP4_C, 1 hit
PF06478 Corona_RPol_N, 1 hit
PF01661 Macro, 1 hit
PF09401 NSP10, 1 hit
PF06471 NSP11, 1 hit
PF06460 NSP16, 1 hit
PF08716 nsp7, 1 hit
PF08717 nsp8, 1 hit
PF08710 nsp9, 1 hit
PF05409 Peptidase_C30, 1 hit
PF08715 Viral_protease, 2 hits
SMARTiView protein in SMART
SM00506 A1pp, 1 hit
SUPFAMiSSF101816 SSF101816, 1 hit
SSF140367 SSF140367, 1 hit
SSF142877 SSF142877, 1 hit
SSF143076 SSF143076, 1 hit
SSF144246 SSF144246, 2 hits
SSF50494 SSF50494, 1 hit
SSF52540 SSF52540, 1 hit
SSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51653 CV_ZBD, 1 hit
PS51442 M_PRO, 1 hit
PS51154 MACRO, 1 hit
PS51124 PEPTIDASE_C16, 2 hits
PS51657 PSRV_HELICASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiR1AB_FIPV
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q98VG9
Secondary accession number(s): Q4U5G1, Q4U5G2, Q52PA4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: April 17, 2007
Last modified: December 5, 2018
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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