UniProtKB - Q98VG9 (R1AB_FIPV)
Replicase polyprotein 1ab
rep
Functioni
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal). EC:3.4.19.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 1117 | For PL1-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1268 | For PL1-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1599 | For PL2-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 1752 | For PL2-PRO activityPROSITE-ProRule annotation | 1 | |
Active sitei | 2944 | For 3CL-PRO activity | 1 | |
Active sitei | 3047 | For 3CL-PRO activity | 1 | |
Sitei | 3053 | Important for substrate recognition | 1 | |
Metal bindingi | 4957 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 4960 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 4968 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 4971 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 4978 | Zinc 1PROSITE-ProRule annotation | 1 | |
Metal bindingi | 4981 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 4985 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 4991 | Zinc 2PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5002 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5007 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5024 | Zinc 3PROSITE-ProRule annotation | 1 | |
Metal bindingi | 5027 | Zinc 3PROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1188 – 1219 | C4-type 1PROSITE-ProRule annotationAdd BLAST | 32 | |
Zinc fingeri | 1678 – 1707 | C4-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 30 | |
Zinc fingeri | 3962 – 3978 | By similarityAdd BLAST | 17 | |
Zinc fingeri | 4004 – 4017 | By similarityAdd BLAST | 14 | |
Nucleotide bindingi | 5235 – 5242 | ATPBy similarity | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type endopeptidase activity Source: InterPro
- DNA helicase activity Source: UniProtKB-EC
- endonuclease activity Source: UniProtKB-KW
- exonuclease activity Source: UniProtKB-KW
- methyltransferase activity Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- RNA helicase activity Source: UniProtKB-EC
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB-EC
- zinc ion binding Source: InterPro
GO - Biological processi
- induction by virus of host autophagy Source: UniProtKB-KW
- methylation Source: UniProtKB-KW
- modulation by virus of host protein ubiquitination Source: UniProtKB-KW
- suppression by virus of host IRF3 activity Source: UniProtKB-KW
- transcription, DNA-templated Source: InterPro
- viral genome replication Source: InterPro
- viral protein processing Source: InterPro
Keywordsi
Protein family/group databases
MEROPSi | C30.004 |
Names & Taxonomyi
Protein namesi | Recommended name: Replicase polyprotein 1abShort name: pp1ab Alternative name(s): ORF1ab polyprotein Cleaved into the following 16 chains: Alternative name(s): PL1-PRO/PL2-PRO PLP1/PLP2 Papain-like proteinases 1/2 p195 Alternative name(s): Peptide HD2 Alternative name(s): M-PRO nsp5 Alternative name(s): nsp12 Alternative name(s): nsp13 Alternative name(s): nsp14 Alternative name(s): NendoU nsp15 Alternative name(s): nsp16 |
Gene namesi | Name:rep ORF Names:1a-1b |
Organismi | Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) |
Taxonomic identifieri | 33734 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Pisoniviricetes › Nidovirales › Cornidovirineae › Coronaviridae › Orthocoronavirinae › Alphacoronavirus › Tegacovirus › |
Virus hosti | Felidae (cat family) [TaxID: 9681] |
Proteomesi |
|
Subcellular locationi
- Host membrane Curated; Multi-pass membrane protein Curated
- Host membrane Curated; Multi-pass membrane protein Curated
- Host membrane Curated; Multi-pass membrane protein Curated
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- host perinuclear region By similarity Note: nsp7, nsp8, nsp9 and nsp10 are localized in cytoplasmic foci, largely perinuclear. Late in infection, they merge into confluent complexes (By similarity).By similarity
- Host endoplasmic reticulum-Golgi intermediate compartment Curated Note: The helicase interacts with the N protein in membranous complexes and colocalizes with sites of synthesis of new viral RNA.By similarity
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1860 – 1878 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 1921 – 1941 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2006 – 2026 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2043 – 2065 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 2426 – 2446 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2691 – 2711 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2720 – 2740 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 2771 – 2791 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3212 – 3232 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3242 – 3262 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3267 – 3287 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3306 – 3326 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3339 – 3359 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3396 – 3416 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 3419 – 3439 | HelicalSequence analysisAdd BLAST | 21 |
GO - Cellular componenti
- host cell endoplasmic reticulum-Golgi intermediate compartment Source: UniProtKB-SubCell
- host cell membrane Source: UniProtKB-SubCell
- host cell perinuclear region of cytoplasm Source: UniProtKB-SubCell
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
Host cytoplasm, Host membrane, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2944 | H → Y or R: Complete loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 2967 | N → A or D: Increase of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 2986 | G → A: 5% loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 2986 | G → D: Increase of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 2986 | G → E: 50% loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 2986 | G → P or V: 95% loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 2986 | G → R, T or W: 70% loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3041 | S → A: 80% loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3041 | S → T: 40% loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3047 | C → A or S: Complete loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3063 | Y → A, F, G or T: Almost complete loss of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3064 | M → A: Increase of 3CL-PRO activity. 1 Publication | 1 | |
Mutagenesisi | 3065 | H → A: Complete loss of 3CL-PRO activity. 1 Publication | 1 |
Chemistry databases
ChEMBLi | CHEMBL4295624 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000283825 | 1 – 6709 | Replicase polyprotein 1abAdd BLAST | 6709 | |
ChainiPRO_5000140208 | 1 – 110 | Non-structural protein 1By similarityAdd BLAST | 110 | |
ChainiPRO_5000140209 | 111 – 879 | Non-structural protein 2By similarityAdd BLAST | 769 | |
ChainiPRO_5000140210 | 880 – 2413 | Non-structural protein 3By similarityAdd BLAST | 1534 | |
ChainiPRO_5000140211 | 2414 – 2903 | Non-structural protein 4By similarityAdd BLAST | 490 | |
ChainiPRO_5000140212 | 2904 – 3205 | 3C-like proteinaseBy similarityAdd BLAST | 302 | |
ChainiPRO_5000140213 | 3206 – 3499 | Non-structural protein 6By similarityAdd BLAST | 294 | |
ChainiPRO_5000140214 | 3500 – 3582 | Non-structural protein 7By similarityAdd BLAST | 83 | |
ChainiPRO_5000140215 | 3583 – 3777 | Non-structural protein 8By similarityAdd BLAST | 195 | |
ChainiPRO_5000140216 | 3778 – 3888 | Non-structural protein 9By similarityAdd BLAST | 111 | |
ChainiPRO_5000140217 | 3889 – 4023 | Non-structural protein 10By similarityAdd BLAST | 135 | |
ChainiPRO_5000140219 | 4024 – 4952 | RNA-directed RNA polymeraseBy similarityAdd BLAST | 929 | |
ChainiPRO_5000140218 | 4024 – 4042 | Non-structural protein 11By similarityAdd BLAST | 19 | |
ChainiPRO_5000140220 | 4953 – 5551 | HelicaseBy similarityAdd BLAST | 599 | |
ChainiPRO_5000140221 | 5552 – 6070 | ExoribonucleaseSequence analysisAdd BLAST | 519 | |
ChainiPRO_5000140222 | 6071 – 6409 | Uridylate-specific endoribonucleaseSequence analysisAdd BLAST | 339 | |
ChainiPRO_5000140223 | 6410 – 6709 | Putative 2'-O-methyl transferaseSequence analysisAdd BLAST | 300 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 110 – 111 | Cleavage; by PL1-PROBy similarity | 2 | |
Sitei | 879 – 880 | Cleavage; by PL1-PROBy similarity | 2 | |
Sitei | 2413 – 2414 | Cleavage; by PL2-PROBy similarity | 2 | |
Sitei | 2903 – 2904 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3205 – 3206 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3499 – 3500 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3582 – 3583 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3777 – 3778 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 3888 – 3889 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4023 – 4024 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 4952 – 4953 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 5551 – 5552 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 6070 – 6071 | Cleavage; by 3CL-PROBy similarity | 2 | |
Sitei | 6409 – 6410 | Cleavage; by 3CL-PROBy similarity | 2 |
Proteomic databases
PRIDEi | Q98VG9 |
Interactioni
Subunit structurei
3CL-PRO exists as monomer and homodimer. Eight copies of nsp7 and eight copies of nsp8 assemble to form a heterohexadecamer. Nsp9 is a dimer. Nsp10 forms a dodecamer (By similarity).
By similarityStructurei
Secondary structure
3D structure databases
SMRi | Q98VG9 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q98VG9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1079 – 1330 | Peptidase C16 1PROSITE-ProRule annotationAdd BLAST | 252 | |
Domaini | 1329 – 1500 | MacroPROSITE-ProRule annotationAdd BLAST | 172 | |
Domaini | 1561 – 1814 | Peptidase C16 2PROSITE-ProRule annotationAdd BLAST | 254 | |
Domaini | 2904 – 3205 | Peptidase C30PROSITE-ProRule annotationAdd BLAST | 302 | |
Domaini | 4632 – 4794 | RdRp catalyticAdd BLAST | 163 | |
Domaini | 4953 – 5036 | CV ZBDPROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 5200 – 5391 | (+)RNA virus helicase ATP-bindingAdd BLAST | 192 | |
Domaini | 5392 – 5561 | (+)RNA virus helicase C-terminalAdd BLAST | 170 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1860 – 2065 | HD1By similarityAdd BLAST | 206 | |
Regioni | 2426 – 2791 | HD2By similarityAdd BLAST | 366 | |
Regioni | 3212 – 3439 | HD3By similarityAdd BLAST | 228 |
Domaini
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 1188 – 1219 | C4-type 1PROSITE-ProRule annotationAdd BLAST | 32 | |
Zinc fingeri | 1678 – 1707 | C4-type 2; atypicalPROSITE-ProRule annotationAdd BLAST | 30 | |
Zinc fingeri | 3962 – 3978 | By similarityAdd BLAST | 17 | |
Zinc fingeri | 4004 – 4017 | By similarityAdd BLAST | 14 |
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helix, Zinc-fingerFamily and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.30.30.1000, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.40.220.10, 1 hit 3.40.50.11580, 1 hit 3.90.70.90, 2 hits |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR032039, A-CoV_nsp1 IPR038634, A-CoV_nsp1_sf IPR043609, CoV_NSP15_C IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043615, CoV_NSP2_N IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR027352, CV_ZBD IPR043502, DNA/RNA_pol_sf IPR041679, DNA2/NAM7-like_C IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR036333, NSP10_sf_CoV IPR009466, NSP14_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR009461, NSP16_CoV-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043503, PLpro_palm_finger_dom_CoV IPR001205, RNA-dir_pol_C IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF13087, AAA_12, 1 hit PF16688, CNV-Replicase_N, 1 hit PF06471, CoV_Methyltr_1, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 2 hits PF19211, CoV_NSP2_N, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 2 hits PF06478, CoV_RPol_N, 1 hit PF01661, Macro, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 2 hits SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 2 hits PS51657, PSRV_HELICASE, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsiribosomal frameshifting. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSSKQFKILV NEDYQVNVPS LPFRDALQEI KYCYRNGFDG YVFVPEYRRD
60 70 80 90 100
LVDCNRKDHY VIGVLGNGIS DLKPVLLTEP SVMLQGFIVR ANCNGVLEDF
110 120 130 140 150
DLKFARTGNG AIYVDQYMCG ADGKPVIEGE FKDYFGDEDV IIYEGEEYHC
160 170 180 190 200
AWLTVRDEKP LWQQTLLTIR EIQYNLDIPH KLPNCAIREV APPVKKNSKV
210 220 230 240 250
VLSEEYRKLY DIFGSPFMGN GDSLNTCFDS LHFIAATLKC PCGAESSGVG
260 270 280 290 300
DWTGFKTACC GLHGKVKGVT LGAVKPGDAI VTSMSAGKGV KFFANSVLQY
310 320 330 340 350
AGDVENVSVW KVIKTFTVNE TVCTTDFEGE LNDFIRPEST SPVSCSIKRA
360 370 380 390 400
FITGEVDDAV HDCIIAGKLD LSTNLFGSAN LLFKKMPWFV QKCGAIFADA
410 420 430 440 450
WKVVEELLCS LKLTYKQIYD VVASLCTSAF TIMDYKPVFV VSSNSVKDLV
460 470 480 490 500
DKCVKILVKA FDVFTQTITI AGVEAKCFVL GSKYLLFNNA LVKLVSVKIL
510 520 530 540 550
GKRQKGLDSA FFATNLIGAT VNVTPQRTES AYISLNKVDD VVTPGGGHIV
560 570 580 590 600
IIGDMAFYKS EEYYFMMASP DSVLVNNVFK AARVPSYNIV YDVNDDTKSK
610 620 630 640 650
MVVKIGTSFD FDGDLDAAIA KVNDLLIEFR QEKLCFRALK DGENILVEAY
660 670 680 690 700
LKKYKMPVCL KNHVGLWDII RQDSGKKGFL DTFNHLNELE DVKDIKIQTI
710 720 730 740 750
KNIICPDLLL ELDFGAIWYR CMPACSDKSI LGNVKIMLGN GVKVVCDGCH
760 770 780 790 800
SFANRLTINY NKLCDTARKD IEIGGIPFST FKTPSSSFID MKDAIYSVVE
810 820 830 840 850
YGEALSFKTA SVPVTNSGII TTDDWSDPIL LEPADYVEPK DNGDVIVIAG
860 870 880 890 900
YTFYKDEDDH FYPYGSGMVV QKMYNKMGGG DKSVSFSDNV NVREIEPVTR
910 920 930 940 950
VRLEFEFDNE VVTQVLEKVI GTKYKFIGTT WEEFEDSISE KLDKIFDTLA
960 970 980 990 1000
EQGVELEGYF IYDTCGGFDI NNPDGVMISQ YDLNTAADDK SDSDASVEDI
1010 1020 1030 1040 1050
SLISDNEDVE QIEEDNTSTD DAEDVSSVEG ETVSVVDVED FVEQVSLVEE
1060 1070 1080 1090 1100
NNVLTPAVNP DEQLSSVEKK DEVSAKNDPW AAAVDEQEAE QPKPSLTPFK
1110 1120 1130 1140 1150
TTNLNGKIIL KQQDNNCWIN ACCYQLQAFD FFNHDLWDGF KKDDVMPFVD
1160 1170 1180 1190 1200
FCYAALTLKQ GDSGDAEYLL ETMLNDYSTA KVTLSAKCGC GVKEIVLERT
1210 1220 1230 1240 1250
VFKLTPLRNE FKYGVCGDCK QINMCKFASV EGSGVFVHDR IEKQTPVSQF
1260 1270 1280 1290 1300
IVTPTMHAVY TGTTQSGHYM IEDCIHDYCV DGMGIKPRKH KFYTSTLFLN
1310 1320 1330 1340 1350
ANVMTAKSKT MVEPPVPVED KCVEDCQSPK DLILPFYKAG KVSFYQGDLD
1360 1370 1380 1390 1400
VLINFLEPDV LVNAANGDLR HVGGVARAID VFTGGKLTKR SKEYLKSSKA
1410 1420 1430 1440 1450
IAPGNAVLFE NVLEHLSVLN AVGPRNGDSR VEGKLCNVYK AIAKCDGKIL
1460 1470 1480 1490 1500
TPLISVGIFK VKLEVSLQCL LKTVTDRDLN VFVYTDQERV TIENFFNGTI
1510 1520 1530 1540 1550
PIKVTEDTVN QKRVSVALDK TYGEQLKGTV VIKDKDVTNQ LPSVSDVGEK
1560 1570 1580 1590 1600
VVKALDVDWN AYYGFPNAAA FSASSHDAYE FDVVTHNNFI VHKQTDNNCW
1610 1620 1630 1640 1650
VNAICLALQR LKPTWKFPGV KSLWDAFLTR KTAGFVHMLY HISGLTKGQP
1660 1670 1680 1690 1700
GDAELTLHKL VDLMSSDSAV TVTHTTACDK CAKVETFTGP VVAAPLLVCG
1710 1720 1730 1740 1750
TDEICVHGVH VNVKVTSIRG TVAITSLIGP VVGDVIDATG YICYTGLNSR
1760 1770 1780 1790 1800
GHYTYYDNRN GLMVDADKAY HFEKNLLQVT TAIASNFVAN TPKKEIMPKT
1810 1820 1830 1840 1850
QAKESKAKES NTARVFSEVE ENPKNIVRKE KLLAIESGVD YTITTLGKYA
1860 1870 1880 1890 1900
DVFFMAGDKI LRFLLEVFKY LLVVFMCLRK SKMPKVKVKP PHVFRNLGAK
1910 1920 1930 1940 1950
VRTLNYVRQL NKPALWRYIK LVLLLIALYH FFYLFVSIPV VHKLACSGSV
1960 1970 1980 1990 2000
QAYSNSSFVK SEVCGNSILC KACLASYDEL ADFDHLQVSW DYKSDPLWNR
2010 2020 2030 2040 2050
VIQLSYFIFL AVFGNNYVRC LLMYFVSQYL NLWLSYFGYV KYSWFLHVVN
2060 2070 2080 2090 2100
FESISVEFVI IVVVFKAVLA LKHIFLPCNN PSCKTCSKIA RQTRIPIQVV
2110 2120 2130 2140 2150
VNGSMKTVYV HANGTGKLCK KHNFYCKNCD SYGFDHTFIC DEIVRDLSNS
2160 2170 2180 2190 2200
IKQTVYATDR SYQEVTKVEC TDGFYRFYVG EEFTAYDYDV KHKKYSSQEV
2210 2220 2230 2240 2250
LKTMFLLDDF IVYNPSGSSL ASVRNVCVYF SQLIGRPIKI VNSELLEDLS
2260 2270 2280 2290 2300
VDFKGALFNA KKNVIKNSFN VDVSECKNLE ECYKLCNLDV TFSTFEMAIN
2310 2320 2330 2340 2350
NAHRFGILIT DRSFNNFWPS KIKPGSSGVS AMDIGKCMTF DAKIVNAKVL
2360 2370 2380 2390 2400
TQRGKSVVWL SQDFSTLSST AQKVLVKTFV EEGVNFSLTF NAVGSDEDLP
2410 2420 2430 2440 2450
YERFTESVSA KSGSGFFDVL KQLKQLFWCL VLFITLYGLC SVYSVATQSY
2460 2470 2480 2490 2500
IDSAEGYDYM VIKNGVVQSF DDSINCVHNT YKGFAVWFKA KHGFVPTFDK
2510 2520 2530 2540 2550
SCPIVLGTVF DLGNMRPIPD VPAYVALVGR SLVFAINAAF GVTNVCYDHT
2560 2570 2580 2590 2600
GAAVSKNSYF DTCVFNSACT TLTGIGGTVV YCAKQGLVEG AKLYSELLPD
2610 2620 2630 2640 2650
YYYEHASGNM VKIPAIIRSF GLRFVKTQAT TYCRVGECTE SQAGFCFGGD
2660 2670 2680 2690 2700
NWFVYDKEFG DGYICGSSTL GFFKNVFALF NSNMSVVATS GAMLANIVIA
2710 2720 2730 2740 2750
CLAIAVCYGV LKFKKIFGDC TLLVVMIIVT LVVNNVSYFV TQNTFFMIVY
2760 2770 2780 2790 2800
AIIYYFTTRK LAYPGVLDAG FIIAYLNMAP WYVLVLYIMV FLYDSLPSLF
2810 2820 2830 2840 2850
KLKVTTNLFE GDKFVGSFES AAMGTFVIDM RSYETLVNST SLDRIKSYAN
2860 2870 2880 2890 2900
SFNKYKYYTG SMGEADYRMA CYAHLGKALM DYSVSRNDML YTPPTVSVNS
2910 2920 2930 2940 2950
TLQSGLRKMA QPSGVVEPCI VRVAYGNNVL NGLWLGDEVI CPRHVIASDT
2960 2970 2980 2990 3000
SRVINYENEL SSVRLHNFSI AKNNAFLGVV SAKYKGVNLV LKVNQVNPNT
3010 3020 3030 3040 3050
PEHKFKSVRP GESFNILACY EGCPGSVYGV NMRSQGTIKG SFIAGTCGSV
3060 3070 3080 3090 3100
GYVLENGTLY FVYMHHLELG NGSHVGSNLE GEMYGGYEDQ PSMQLEGTNV
3110 3120 3130 3140 3150
MSSDNVVAFL YAALINGERW FVTNTSMTLE SYNAWAKTNS FTEIVSTDAF
3160 3170 3180 3190 3200
NMLAAKTGYS VEKLLECIVR LNKGFGGRTI LSYGSLCDEF TPTEVIRQMY
3210 3220 3230 3240 3250
GVNLQSGKVK SIFYPMMTAI AILFAFWLEF FMYTPFTWIN PTFVSVVLAI
3260 3270 3280 3290 3300
TTLVSVLLVA GIKHKMLFFM SFVMPSVILA TAHNVVWDMT YYESLQVLVE
3310 3320 3330 3340 3350
NVNTTFLPVD MQGVMLALFC VVVFVICTIR FFTCKQSWFS LFATTIFVMF
3360 3370 3380 3390 3400
NIVKLLGMIG EPWTDDHFLL CLVNMLTMLI SLTTKDWFVV FASYKVAYYI
3410 3420 3430 3440 3450
VVYVMQPAFV QDFGFVKCVS IIYMACGYLF CCYYGILYWV NRFTCMTCGV
3460 3470 3480 3490 3500
YQFTVSPAEL KYMTANNLSA PKTAYDAMIL SFKLMGIGGG RNIKISTVQS
3510 3520 3530 3540 3550
KLTEMKCTNV VLLGLLSKMH VESNSKEWNY CVGLHNEINL CDDPDAVLEK
3560 3570 3580 3590 3600
LLALIAFFLS KHNTCDLSDL IESYFENTTI LQSVASAYAA LPSWIAYEKA
3610 3620 3630 3640 3650
RADLEEAKKN DVSPQLLKQL TKACNIAKSE FEREASVQKK LDKMAEQAAA
3660 3670 3680 3690 3700
SMYKEARAVD RKSKIVSAMH SLLFGMLKKL DMSSVNTIIE QARNGVLPLS
3710 3720 3730 3740 3750
IIPAASATRL IVVTPNLEVL SKVRQENNVH YAGAIWSIVE VKDANGAQVH
3760 3770 3780 3790 3800
LKEVTAANEL NITWPLSITC ERTTKLQNNE ILPGKLKEKA VKASATIDGD
3810 3820 3830 3840 3850
AYGSGKALMA SEGGKSFIYA FIASDSNLKY VKWESNNDVI PIELEAPLRF
3860 3870 3880 3890 3900
YVDGVNGPEV KYLYFVKSLN TLRRGAVLGY IGATVRLQAG KPTEHPSNSG
3910 3920 3930 3940 3950
LLTLCAFAPD PAKAYVDAVK RGMQPVTNCV KMLSNGAGNG MAITNGVESN
3960 3970 3980 3990 4000
TQQDSYGGAS VCIYCRCHVE HPAIDGLCRF KGKFVQVPTG TQDPIRFCIE
4010 4020 4030 4040 4050
NEVCVVCGCW LTNGCMCDRT SIQGTTIDQS YLNECGVLVQ LDLEPCNGTD
4060 4070 4080 4090 4100
PDHVSRAFDI YNKDVACIGK FLKTNCSRFR NLDKHDAYYV VKRCTKSVMD
4110 4120 4130 4140 4150
HEQVCYNDLK DSGVVAEHDF FLYKEGRCEF GNVARKDLTK YTMMDLCYAI
4160 4170 4180 4190 4200
RNFDEKNCEV LKEILVTLGA CNESFFENKD WFDPVENEAI HEVYARLGPI
4210 4220 4230 4240 4250
VANAMLKCVA FCDAIVEKGY IGIITLDNQD LNGNFYDFGD FVKTTPGFGC
4260 4270 4280 4290 4300
ACVTSYYSYM MPLMGMTSCL ESENFVKSDI YGADYKQYDL LAYDFTDHKE
4310 4320 4330 4340 4350
KLFHKYFKHW DRTYHPNCSD CTSDECIIHC ANFNTLFSMT IPSTAFGPLV
4360 4370 4380 4390 4400
RKVHIDGVPV VVTAGYHFKQ LGIVWNLDVK LDTMKLSMTD LLRFVTDPTL
4410 4420 4430 4440 4450
LVASSPALLD QRTVCFSIAA LSTGVTYQTV KPGHFNKDFY DFITERGFFE
4460 4470 4480 4490 4500
EGSELTLKHF FFAQGGEAAM TDFNYYRYNR VTVLDICQAQ FVYKIVGKYF
4510 4520 4530 4540 4550
ECYDGGCINA REVVVTNYDK SAGYPLNKFG KARLYYETLS YEEQDALFAL
4560 4570 4580 4590 4600
TKRNVLPTMT QMNLKYAISG KARARTVGGV SLLSTMTTRQ YHQKHLKSIA
4610 4620 4630 4640 4650
ATRNATVVIG STKFYGGWDN MLKNLMRDVD NGCLMGWDYP KCDRALPNMI
4660 4670 4680 4690 4700
RMASAMILGS KHVGCCTHSD RFYRLSNELA QVLTEVVHCT GGFYFKPGGT
4710 4720 4730 4740 4750
TSGDGTTAYA NSAFNIFQAV SANVNKLLGV DSNACNNVTV KSIQRKIYDN
4760 4770 4780 4790 4800
CYRSSSIDEE FVVEYFSYLR KHFSMMILSD DGVVCYNKDY ADLGYVADIN
4810 4820 4830 4840 4850
AFKATLYYQN NVFMSTSKCW VEPDLSVGPH EFCSQHTLQI VGPDGDYYLP
4860 4870 4880 4890 4900
YPDPSRILSA GVFVDDIVKT DNVIMLERYV SLAIDAYPLT KHPKPAYQKV
4910 4920 4930 4940 4950
FYTLLDWVKH LQKNLNAGVL DSFSVTMLEE GQDKFWSEEF YASLYEKSTV
4960 4970 4980 4990 5000
LQAAGMCVVC GSQTVLRCGD CLRRPLLCTK CAYDHVMGTK HKFIMSITPY
5010 5020 5030 5040 5050
VCSFNGCNVN DVTKLFLGGL SYYCMDHKPQ LSFPLCANGN VFGLYKSSAV
5060 5070 5080 5090 5100
GSEDVEDFNK LAVSDWTNVE DYKLANNVKE SLKIFAAETV KAKEESVKSE
5110 5120 5130 5140 5150
YAYAILKEVI GPKEIVLQWE ASKTKPPLNR NSVFTCFQIS KDTKIQLGEF
5160 5170 5180 5190 5200
VFEQSEYGSD SVYYKSTSTY KLTPGMIFVL TSHNVSPLKA TILVNQEKYN
5210 5220 5230 5240 5250
TISKLYPVFN IAEAYNTLVP YYQMIGKQKF TTIQGPPGSG KSHCVIGLGL
5260 5270 5280 5290 5300
YYPQARIVYT ACSHAAVDAL CEKAAKNFNV DRCSRIIPQR IRVDCYTGFK
5310 5320 5330 5340 5350
PNNTNAQYLF CTVNALPEAS CDIVVVDEVS MCTNYDLSVI NSRLSYKHIV
5360 5370 5380 5390 5400
YVGDPQQLPA PRTLINKGVL QPQDYNVVTQ RVCTLGPDVF LHKCYRCPAE
5410 5420 5430 5440 5450
IVKTVSALVY ENKFVPVNPE SKQCFKMFVK GQVQIESNSS INNKQLEVVK
5460 5470 5480 5490 5500
AFLAHNPKWR KAVFISPYNS QNYVARRLLG LQTQTVDSAQ GSEYDYVIYT
5510 5520 5530 5540 5550
QTSDTQHATN VNRFNVAITR AKVGILCIMC DRTMYENLDF YELKDSKIGL
5560 5570 5580 5590 5600
QAKPETCGLF KDCSKSEQYI PPAYATTYMS LSDNFKTSDG LAVNIGTKDV
5610 5620 5630 5640 5650
KYANVISYMG FRFEANIPGY HTLFCTRDFA MRNVRAWLGF DVEGAHVCGD
5660 5670 5680 5690 5700
NVGTNVPLQL GFSNGVDFVV QTEGCVVTEK GNSIEVVKAR APPGEQFAHL
5710 5720 5730 5740 5750
IPLMRKGQPW HIVRRRIVQM VCDYFDGLSD ILIFVLWAGG LELTTMRYFV
5760 5770 5780 5790 5800
KIGRPQKCEC GKSATCYSSS QCVYACFKHA LGCDYLYNPY CIDIQQWGYT
5810 5820 5830 5840 5850
GSLSMNHHEV CNIHRNEHVA SGDAIMTRCL AIHDCFVKRV DWSIVYPFID
5860 5870 5880 5890 5900
NEEKINKAGR IVQSHVMKAA LKIFNPAAIH DVGNPKGIRC ATTPIPWFCY
5910 5920 5930 5940 5950
DRDPINNNVR CLEYDYMVHG QMNGLMLFWN CNVDMYPEFS IVCRFDTRTR
5960 5970 5980 5990 6000
SKLSLEGCNG GALYVNNHAF HTPAYDRRAF AKLKPMPFFY YDDSNCELVD
6010 6020 6030 6040 6050
GQPNYVPLKS NVCITKCNIG GAVCKKHAAL YRAYVEDYNM FMQAGFTIWC
6060 6070 6080 6090 6100
PQNFDTYMLW HGFVNSKALQ SLENVAFNVV KKGAFTGLKG DLPTAVIADK
6110 6120 6130 6140 6150
IMVRDGPTDK CIFTNKTSLP TNVAFELYAK RKLGLTPPLT ILRNLGVVAT
6160 6170 6180 6190 6200
YKFVLWDYEA ECPFSNFTKQ VCSYTDLDSE VVTCFDNSIA GSFERFTTTK
6210 6220 6230 6240 6250
DAVLISNNAV KGLSAIKLQY GFLNDLPVST VGNKPVTWYI YVRKNGEYVE
6260 6270 6280 6290 6300
QIDSYYTHGR TFETFKPRST MEEDFLSMDT TLFIQKYGLE DYGFEHVVFG
6310 6320 6330 6340 6350
DVSKTTIGGM HLLISQVRLA KMGLFSVQEF MTNSDSTLKS CCITYADDPS
6360 6370 6380 6390 6400
SKNVCTYMDI LLDDFVTIIK SLDLNVVSKV VDVIVDCKAW RWMLWCENSQ
6410 6420 6430 6440 6450
IKTFYPQLQS AEWNPGYSMP TLYKIQRMCL ERCNLYNYGA QVRLPDGITT
6460 6470 6480 6490 6500
NVVKYTQLCQ YLNTTTVCVP HKMRVLHLGA AGASGVAPGS TVLRRWLPDD
6510 6520 6530 6540 6550
AILVDNDLRD YVSDADFSVT GDCTSLYIED KFDLLISDLY DGSTKSIDGE
6560 6570 6580 6590 6600
NTSKDGFFTY INGFIKEKLS LGGSAAIKIT EFSWNKDLYE LIQRFEYWTV
6610 6620 6630 6640 6650
FCTSVNTSSS EGFLIGINYL GPYCDKAIVD GNIMHANYIF WRNSTIMALS
6660 6670 6680 6690 6700
HNSVLDTPKF KCRCNNALIV NLKEKELNEM VVGLLRKGKL LIRNNGKLLN
FGNHLVNVP
The sequence of this isoform differs from the canonical sequence as follows:
4043-6709: Missing.
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1016 – 1092 | Missing in AAY32594 (PubMed:16033972).CuratedAdd BLAST | 77 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural varianti | 162 | W → C. | 1 | |
Natural varianti | 177 | D → G. | 1 | |
Natural varianti | 388 | W → C. | 1 | |
Natural varianti | 808 | K → T. | 1 | |
Natural varianti | 1784 | A → V. | 1 | |
Natural varianti | 2889 | M → K. | 1 | |
Natural varianti | 3280 | A → V. | 1 | |
Natural varianti | 3992 | Q → R. | 1 | |
Natural varianti | 4304 | H → Q. | 1 | |
Natural varianti | 5846 | Y → H. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_032885 | 4043 – 6709 | Missing in isoform Replicase polyprotein 1a. CuratedAdd BLAST | 2667 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ010921 Genomic RNA Translation: AAY32594.1 DQ010921 Genomic RNA Translation: AAY32595.1 AY994055 Genomic RNA Translation: AAY16374.1 Frameshift. AF326575 Genomic RNA Translation: AAK09095.1 |
Keywords - Coding sequence diversityi
Ribosomal frameshiftingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | DQ010921 Genomic RNA Translation: AAY32594.1 DQ010921 Genomic RNA Translation: AAY32595.1 AY994055 Genomic RNA Translation: AAY16374.1 Frameshift. AF326575 Genomic RNA Translation: AAK09095.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
3ETI | X-ray | 2.20 | A/B/C/D/E/F/G/H | 1331-1498 | [»] | |
3EW5 | X-ray | 3.10 | A/B/C | 1331-1498 | [»] | |
3GZF | X-ray | 2.76 | A/B/C/D/E | 2808-2902 | [»] | |
3JZT | X-ray | 3.91 | A/B/C/D/E/F/G/H | 1331-1498 | [»] | |
3UB0 | X-ray | 2.60 | A/D | 3583-3777 | [»] | |
B/C/E/F | 3500-3582 | [»] | ||||
4ZRO | X-ray | 2.06 | A/B/C/D | 2904-3202 | [»] | |
5EU8 | X-ray | 2.45 | A | 2904-3205 | [»] | |
SMRi | Q98VG9 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Chemistry databases
ChEMBLi | CHEMBL4295624 |
Protein family/group databases
MEROPSi | C30.004 |
Proteomic databases
PRIDEi | Q98VG9 |
Miscellaneous databases
EvolutionaryTracei | Q98VG9 |
Family and domain databases
CDDi | cd18808, SF1_C_Upf1, 1 hit |
Gene3Di | 1.10.150.420, 1 hit 1.10.1840.10, 1 hit 1.10.8.370, 1 hit 2.20.25.360, 1 hit 2.30.30.1000, 1 hit 2.40.10.10, 2 hits 2.40.10.250, 1 hit 2.40.10.290, 1 hit 3.40.220.10, 1 hit 3.40.50.11580, 1 hit 3.90.70.90, 2 hits |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR032039, A-CoV_nsp1 IPR038634, A-CoV_nsp1_sf IPR043609, CoV_NSP15_C IPR043608, CoV_NSP15_M IPR043606, CoV_NSP15_N IPR043613, CoV_NSP2_C IPR043615, CoV_NSP2_N IPR043611, CoV_NSP3_C IPR043612, CoV_NSP4_N IPR043610, CoV_NSP6 IPR027352, CV_ZBD IPR043502, DNA/RNA_pol_sf IPR041679, DNA2/NAM7-like_C IPR037227, EndoU-like IPR002589, Macro_dom IPR043472, Macro_dom-like IPR036333, NSP10_sf_CoV IPR009466, NSP14_CoV IPR043174, NSP15_middle_sf IPR042515, NSP15_N_CoV IPR009461, NSP16_CoV-like IPR032505, NSP4_C_CoV IPR038123, NSP4_C_sf_CoV IPR014828, NSP7_CoV IPR037204, NSP7_sf_CoV IPR014829, NSP8_CoV-like IPR037230, NSP8_sf_CoV IPR014822, NSP9_CoV IPR036499, NSP9_sf_CoV IPR027417, P-loop_NTPase IPR013016, Peptidase_C16_CoV IPR008740, Peptidase_C30_CoV IPR043477, Peptidase_C30_dom3_CoV IPR009003, Peptidase_S1_PA IPR043504, Peptidase_S1_PA_chymotrypsin IPR043503, PLpro_palm_finger_dom_CoV IPR001205, RNA-dir_pol_C IPR009469, RNA_pol_N_coronovir IPR018995, RNA_synth_NSP10_CoV IPR029063, SAM-dependent_MTases |
Pfami | View protein in Pfam PF13087, AAA_12, 1 hit PF16688, CNV-Replicase_N, 1 hit PF06471, CoV_Methyltr_1, 1 hit PF06460, CoV_Methyltr_2, 1 hit PF09401, CoV_NSP10, 1 hit PF19215, CoV_NSP15_C, 1 hit PF19216, CoV_NSP15_M, 1 hit PF19219, CoV_NSP15_N, 1 hit PF19212, CoV_NSP2_C, 2 hits PF19211, CoV_NSP2_N, 1 hit PF19218, CoV_NSP3_C, 1 hit PF16348, CoV_NSP4_C, 1 hit PF19217, CoV_NSP4_N, 1 hit PF19213, CoV_NSP6, 1 hit PF08716, CoV_NSP7, 1 hit PF08717, CoV_NSP8, 1 hit PF08710, CoV_NSP9, 1 hit PF08715, CoV_peptidase, 2 hits PF06478, CoV_RPol_N, 1 hit PF01661, Macro, 1 hit PF05409, Peptidase_C30, 1 hit PF00680, RdRP_1, 1 hit |
SMARTi | View protein in SMART SM00506, A1pp, 1 hit |
SUPFAMi | SSF101816, SSF101816, 1 hit SSF140367, SSF140367, 1 hit SSF142877, SSF142877, 1 hit SSF143076, SSF143076, 1 hit SSF144246, SSF144246, 2 hits SSF50494, SSF50494, 1 hit SSF52540, SSF52540, 1 hit SSF52949, SSF52949, 1 hit SSF53335, SSF53335, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51653, CV_ZBD, 1 hit PS51442, M_PRO, 1 hit PS51154, MACRO, 1 hit PS51124, PEPTIDASE_C16, 2 hits PS51657, PSRV_HELICASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | R1AB_FIPV | |
Accessioni | Q98VG9Primary (citable) accession number: Q98VG9 Secondary accession number(s): Q4U5G1, Q4U5G2, Q52PA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 10, 2003 |
Last sequence update: | April 17, 2007 | |
Last modified: | December 2, 2020 | |
This is version 132 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families