UniProtKB - Q98UC3 (Q98UC3_CHICK)
Protein
Submitted name:
Ubiquitin fusion-degradation 1-like protein
Gene
UFD1L
Organism
Gallus gallus (Chicken)
Status
Functioni
GO - Molecular functioni
- K48-linked polyubiquitin modification-dependent protein binding Source: Ensembl
- polyubiquitin modification-dependent protein binding Source: GO_Central
GO - Biological processi
- ER-associated misfolded protein catabolic process Source: GO_Central
- negative regulation of RIG-I signaling pathway Source: Ensembl
- negative regulation of type I interferon production Source: Ensembl
- retrograde protein transport, ER to cytosol Source: Ensembl
- ubiquitin-dependent ERAD pathway Source: GO_Central
Keywordsi
Biological process | Ubl conjugation pathwayARBA annotation |
Enzyme and pathway databases
Reactomei | R-GGA-110320, Translesion Synthesis by POLH R-GGA-5689880, Ub-specific processing proteases |
Names & Taxonomyi
Protein namesi | Submitted name: Ubiquitin fusion-degradation 1-like proteinImported |
Gene namesi | Name:UFD1LImported Synonyms:Ufd1lImported |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- VCP-NPL4-UFD1 AAA ATPase complex Source: GO_Central
Other locations
- UFD1-NPL4 complex Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSGALG00000001593, Expressed in testis and 13 other tissues |
Interactioni
GO - Molecular functioni
- K48-linked polyubiquitin modification-dependent protein binding Source: Ensembl
- polyubiquitin modification-dependent protein binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000034188 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 230 – 256 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 288 – 307 | DisorderedSequence analysisAdd BLAST | 20 |
Sequence similaritiesi
Belongs to the UFD1 family.ARBA annotation
Phylogenomic databases
eggNOGi | KOG1816, Eukaryota |
GeneTreei | ENSGT00390000002408 |
OrthoDBi | 1134444at2759 |
TreeFami | TF314581 |
Family and domain databases
Gene3Di | 2.40.40.50, 1 hit |
InterProi | View protein in InterPro IPR004854, Ufd1-like IPR042299, Ufd1-like_Nn |
PANTHERi | PTHR12555, PTHR12555, 1 hit |
Pfami | View protein in Pfam PF03152, UFD1, 1 hit |
i Sequence
Sequence statusi: Complete.
Q98UC3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFSFNMFDHP IPRVFQNRFS TQYRCFSVSM LAGPNDRSDV EKGGKIIMPP
60 70 80 90 100
SALDQLSRLN ITYPMLFKLT NKNSDRMTHC GVLEFVADEG ICYLPHWMMQ
110 120 130 140 150
NLLLEEGGLV QVESVNLQVA TYSKFQPQSP DFLDITNPKA VLENALRSFA
160 170 180 190 200
CLTTGDVIAI NYNEKIYELR VMETKPDKAV SIIECDMNVD FDAPLGYKEP
210 220 230 240 250
ERSAQHEETT DVEADHSGYV SDVGFRAFSG SGNRLDGKKK GVEPSPSPIK
260 270 280 290 300
PGDIRRGIPN YDFKIGRITF IRNSRPLVKK VEEDEAGSRF IAFSGEGQSL
RKKGRKP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000505 Genomic DNA No translation available. AF228284 mRNA Translation: AAK00732.1 AF407671 mRNA Translation: AAK97650.1 |
RefSeqi | NP_989632.1, NM_204301.1 |
Genome annotation databases
Ensembli | ENSGALT00000034831; ENSGALP00000034188; ENSGALG00000001593 |
GeneIDi | 374186 |
KEGGi | gga:374186 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000505 Genomic DNA No translation available. AF228284 mRNA Translation: AAK00732.1 AF407671 mRNA Translation: AAK97650.1 |
RefSeqi | NP_989632.1, NM_204301.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000034188 |
Genome annotation databases
Ensembli | ENSGALT00000034831; ENSGALP00000034188; ENSGALG00000001593 |
GeneIDi | 374186 |
KEGGi | gga:374186 |
Organism-specific databases
CTDi | 436724 |
Phylogenomic databases
eggNOGi | KOG1816, Eukaryota |
GeneTreei | ENSGT00390000002408 |
OrthoDBi | 1134444at2759 |
TreeFami | TF314581 |
Enzyme and pathway databases
Reactomei | R-GGA-110320, Translesion Synthesis by POLH R-GGA-5689880, Ub-specific processing proteases |
Gene expression databases
Bgeei | ENSGALG00000001593, Expressed in testis and 13 other tissues |
Family and domain databases
Gene3Di | 2.40.40.50, 1 hit |
InterProi | View protein in InterPro IPR004854, Ufd1-like IPR042299, Ufd1-like_Nn |
PANTHERi | PTHR12555, PTHR12555, 1 hit |
Pfami | View protein in Pfam PF03152, UFD1, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q98UC3_CHICK | |
Accessioni | Q98UC3Primary (citable) accession number: Q98UC3 Secondary accession number(s): F1NVD8 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | June 1, 2001 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |