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Protein

L-lactate dehydrogenase

Gene

ldh

Organism
Mycoplasma pulmonis (strain UAB CTIP)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of lactate to pyruvate.UniRule annotation

Catalytic activityi

(S)-lactate + NAD+ = pyruvate + NADH.UniRule annotation

Enzyme regulationi

Allosterically activated by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: pyruvate fermentation to lactate

This protein is involved in step 1 of the subpathway that synthesizes (S)-lactate from pyruvate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. L-lactate dehydrogenase (ldh)
This subpathway is part of the pathway pyruvate fermentation to lactate, which is itself part of Fermentation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (S)-lactate from pyruvate, the pathway pyruvate fermentation to lactate and in Fermentation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei12NAD; via amide nitrogenUniRule annotation1
Binding sitei33NADUniRule annotation1
Binding sitei65NADUniRule annotation1
Binding sitei82SubstrateUniRule annotation1
Binding sitei88SubstrateUniRule annotation1
Binding sitei143NADUniRule annotation1
Binding sitei153Allosteric activatorUniRule annotation1
Binding sitei168Allosteric activatorUniRule annotation1
Active sitei175Proton acceptorUniRule annotation1
Binding sitei228SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi118 – 120NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAllosteric enzyme, Oxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciMPUL272635:G1GT6-770-MONOMER
UniPathwayiUPA00554; UER00611

Names & Taxonomyi

Protein namesi
Recommended name:
L-lactate dehydrogenaseUniRule annotation (EC:1.1.1.27UniRule annotation)
Short name:
L-LDHUniRule annotation
Gene namesi
Name:ldhUniRule annotation
Ordered Locus Names:MYPU_7590
OrganismiMycoplasma pulmonis (strain UAB CTIP)
Taxonomic identifieri272635 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma
Proteomesi
  • UP000000528 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001683751 – 315L-lactate dehydrogenaseAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei219PhosphotyrosineUniRule annotation1

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi272635.MYPU_7590

Structurei

3D structure databases

ProteinModelPortaliQ98PG4
SMRiQ98PG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni120 – 123Substrate bindingUniRule annotation4
Regioni148 – 151Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. LDH family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4105C80 Bacteria
COG0039 LUCA
HOGENOMiHOG000213793
KOiK00016
OMAiMDLMQTA
OrthoDBiPOG091H02EQ

Family and domain databases

Gene3Di3.90.110.10, 1 hit
HAMAPiMF_00488 Lactate_dehydrog, 1 hit
InterProiView protein in InterPro
IPR001557 L-lactate/malate_DH
IPR011304 L-lactate_DH
IPR022383 Lactate/malate_DH_C
IPR001236 Lactate/malate_DH_N
IPR015955 Lactate_DH/Glyco_Ohase_4_C
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF02866 Ldh_1_C, 1 hit
PF00056 Ldh_1_N, 1 hit
PIRSFiPIRSF000102 Lac_mal_DH, 1 hit
PRINTSiPR00086 LLDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
SSF56327 SSF56327, 1 hit
TIGRFAMsiTIGR01771 L-LDH-NAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q98PG4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKVVLIGTG NVGVTVVYTM ITKGIDAEYV LIDINTEFAK GHAMDMSDAI
60 70 80 90 100
ALNSTTGSKI RTGTYADAKG ADLLIVAAGR PQKQGETRLE MIADNSKIMK
110 120 130 140 150
DIALEIKKSG FNGFTIVISN PVDILATVFQ KVTNFPKEKV MSSGTFLDTS
160 170 180 190 200
RFRKFLSEKT GVPTNSVHGF VIGEHGDKSV VVFSRMQIGF SRLDDFLKSK
210 220 230 240 250
ALTEDDLKWI SEKTYKEAYE IINRKRSTYF GIGASVAEMA ESVLYNQRRI
260 270 280 290 300
FPIGIYLDES KPGGGIYISR PAILGENGWE EVKNYDLSPA EQKAFDESAI
310
NLKKHWDDVQ KEISF
Length:315
Mass (Da):34,925
Last modified:October 1, 2001 - v1
Checksum:i1C38941D7312EADC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL445565 Genomic DNA Translation: CAC13932.1
PIRiG90606
RefSeqiWP_010925559.1, NC_002771.1

Genome annotation databases

EnsemblBacteriaiCAC13932; CAC13932; CAC13932
KEGGimpu:MYPU_7590

Entry informationi

Entry nameiLDH_MYCPU
AccessioniPrimary (citable) accession number: Q98PG4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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