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Protein

Chemotaxis response regulator protein-glutamate methylesterase

Gene

cheB

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei160UniRule annotation1
Active sitei187UniRule annotation1
Active sitei280UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-7257-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesteraseUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:mll9510
Encoded oniPlasmid pMLb0 Publication
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Plasmid pMLb

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001580181 – 339Chemotaxis response regulator protein-glutamate methylesteraseAdd BLAST339

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei534-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ98PD1

Structurei

3D structure databases

ProteinModelPortaliQ98PD1
SMRiQ98PD1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 119Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini149 – 338CheB-type methylesteraseUniRule annotationAdd BLAST190

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000151424
KOiK13491
OMAiYGMPMAV
OrthoDBiPOG091H045J

Family and domain databases

CDDicd16432 CheB_Rec, 1 hit
cd00156 REC, 1 hit
Gene3Di3.40.50.180, 1 hit
HAMAPiMF_00099 CheB_methylest, 1 hit
InterProiView protein in InterPro
IPR035909 CheB_C
IPR011006 CheY-like_superfamily
IPR008248 Sig_transdc_resp-reg_CheB
IPR000673 Sig_transdc_resp-reg_Me-estase
IPR001789 Sig_transdc_resp-reg_receiver
PfamiView protein in Pfam
PF01339 CheB_methylest, 1 hit
PF00072 Response_reg, 1 hit
PIRSFiPIRSF000876 RR_chemtxs_CheB, 1 hit
SMARTiView protein in SMART
SM00448 REC, 1 hit
SUPFAMiSSF52172 SSF52172, 1 hit
SSF52738 SSF52738, 1 hit
PROSITEiView protein in PROSITE
PS50122 CHEB, 1 hit
PS50110 RESPONSE_REGULATORY, 1 hit

Sequencei

Sequence statusi: Complete.

Q98PD1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIGVVNDMP MAVELLRRLV LSTGEHQVAW IATNGREAVE VCRRDLPDLI
60 70 80 90 100
LMDLAMPVMD GVEATRRIMA ETPCSILLVT ASIESNLADV YEAMGHGALD
110 120 130 140 150
AVDIPSVGIE GNASSQSARL LTNKIATIGK LIGDAPTKAK RRMSRAAEPT
160 170 180 190 200
PRRLIAIGAS AGGPAAVAAV LSAFPVDFGG AIVLVQHLDA QFVPGLVDWL
210 220 230 240 250
GQHTPLPIRP ARERDSPQAG TVLVASSADH LVFKSVQQLG YTPSPKDNVY
260 270 280 290 300
RPSVDVFFES AAQWWPGSVI GVLLTGMGRD GARGLRQLRD KGHLTIAQDR
310 320 330
ATSAVYGMPK AAADIGAAVD ILPLSAIGSR IIEACERST
Length:339
Mass (Da):35,890
Last modified:October 1, 2001 - v1
Checksum:i2A6BBEE29BA5D150
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP003017 Genomic DNA Translation: BAB54724.1
RefSeqiWP_010916252.1, NC_002682.1

Genome annotation databases

EnsemblBacteriaiBAB54724; BAB54724; BAB54724
KEGGimlo:mll9510

Entry informationi

Entry nameiCHEB_RHILO
AccessioniPrimary (citable) accession number: Q98PD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Plasmid, Reference proteome

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