Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Orotate phosphoribosyltransferase 1

Gene

pyrE1

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).UniRule annotation

Catalytic activityi

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotation

Pathwayi: UMP biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes UMP from orotate.UniRule annotation
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Orotate phosphoribosyltransferase 2 (pyrE2), Orotate phosphoribosyltransferase 1 (pyrE1)
  2. Orotidine 5'-phosphate decarboxylase (pyrF)
This subpathway is part of the pathway UMP biosynthesis via de novo pathway, which is itself part of Pyrimidine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes UMP from orotate, the pathway UMP biosynthesis via de novo pathway and in Pyrimidine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1085-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei1095-phosphoribose 1-diphosphateUniRule annotation1
Binding sitei1125-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei1145-phosphoribose 1-diphosphate; shared with dimeric partnerUniRule annotation1
Binding sitei142OrotateUniRule annotation1
Binding sitei170OrotateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processPyrimidine biosynthesis
LigandMagnesium

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-4725-MONOMER
UniPathwayi
UPA00070;UER00119

Names & Taxonomyi

Protein namesi
Recommended name:
Orotate phosphoribosyltransferase 1UniRule annotation (EC:2.4.2.10UniRule annotation)
Short name:
OPRT 1UniRule annotation
Short name:
OPRTase 1UniRule annotation
Gene namesi
Name:pyrE1UniRule annotation
Ordered Locus Names:mll5916
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001107291 – 198Orotate phosphoribosyltransferase 1Add BLAST198

Proteomic databases

PRIDEiQ98AN7

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi266835.mll5916

Structurei

3D structure databases

ProteinModelPortaliQ98AN7
SMRiQ98AN7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni138 – 1465-phosphoribose 1-diphosphate bindingUniRule annotation9

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG41065E1 Bacteria
COG0461 LUCA
HOGENOMiHOG000037976
KOiK00762
OMAiGADPIVS
OrthoDBiPOG091H034Q

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit

Sequencei

Sequence statusi: Complete.

Q98AN7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALAKFRPV DSGQHDKDEL REIVRERSFR FGRYTLSSGI ESDIYFNMKP
60 70 80 90 100
TMMVARGAQL AALEFLKIVE QVKAEYVGGL EMGAVPVIGS MAAVSSMMNK
110 120 130 140 150
PINTIFVRKV PKAHGTRDVI EGLGPKEDLE GKVVLIVDDV ATSGKSILKA
160 170 180 190
IEEVRRVGGI VGDAACLVDR DEGATALLAQ HGVTLHSVLH ASEFVERH
Length:198
Mass (Da):21,501
Last modified:October 1, 2001 - v1
Checksum:iC51164769A4D38FC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB52285.1
RefSeqiWP_010913618.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB52285; BAB52285; BAB52285
KEGGimlo:mll5916

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB52285.1
RefSeqiWP_010913618.1, NC_002678.2

3D structure databases

ProteinModelPortaliQ98AN7
SMRiQ98AN7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mll5916

Proteomic databases

PRIDEiQ98AN7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB52285; BAB52285; BAB52285
KEGGimlo:mll5916

Phylogenomic databases

eggNOGiENOG41065E1 Bacteria
COG0461 LUCA
HOGENOMiHOG000037976
KOiK00762
OMAiGADPIVS
OrthoDBiPOG091H034Q

Enzyme and pathway databases

UniPathwayi
UPA00070;UER00119

BioCyciMLOT266835:G1G20-4725-MONOMER

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01208 PyrE, 1 hit
InterProiView protein in InterPro
IPR023031 OPRT
IPR004467 Or_phspho_trans_dom
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit
TIGRFAMsiTIGR00336 pyrE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPYRE1_RHILO
AccessioniPrimary (citable) accession number: Q98AN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 1, 2001
Last modified: October 10, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again