UniProtKB - Q98982 (NK1R_LITCT)
Protein
Substance-P receptor
Gene
TACR1
Organism
Lithobates catesbeianus (American bullfrog) (Rana catesbeiana)
Status
Functioni
This is a receptor for the tachykinin neuropeptide substance P. It is probably associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
GO - Molecular functioni
- tachykinin receptor activity Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Substance-P receptorShort name: SPR Alternative name(s): NK-1 receptor Short name: NK-1R Tachykinin receptor 1 |
Gene namesi | Name:TACR1 Synonyms:TAC1R |
Organismi | Lithobates catesbeianus (American bullfrog) (Rana catesbeiana) |
Taxonomic identifieri | 8400 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Neobatrachia › Ranoidea › Ranidae › Lithobates |
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 32 | ExtracellularSequence analysisAdd BLAST | 32 | |
Transmembranei | 33 – 55 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 56 – 65 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 66 – 87 | Helical; Name=2Sequence analysisAdd BLAST | 22 | |
Topological domaini | 88 – 107 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 108 – 129 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 130 – 149 | CytoplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 150 – 170 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 171 – 196 | ExtracellularSequence analysisAdd BLAST | 26 | |
Transmembranei | 197 – 221 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 222 – 250 | CytoplasmicSequence analysisAdd BLAST | 29 | |
Transmembranei | 251 – 272 | Helical; Name=6Sequence analysisAdd BLAST | 22 | |
Topological domaini | 273 – 283 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 284 – 308 | Helical; Name=7Sequence analysisAdd BLAST | 25 | |
Topological domaini | 309 – 408 | CytoplasmicSequence analysisAdd BLAST | 100 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069889 | 1 – 408 | Substance-P receptorAdd BLAST | 408 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 9 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 14 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 19 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 106 ↔ 181 | PROSITE-ProRule annotation | ||
Lipidationi | 323 | S-palmitoyl cysteineSequence analysis | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinFamily & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixFamily and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001681, Neurokn_rcpt IPR000046, NK1_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01024, NEUROKININ1R PR00244, NEUROKININR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q98982-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNSNISAQND SALNSTIQNG TKINQFIQPP WQIALWSVAY SIIVIVSLVG
60 70 80 90 100
NIIVMWIIIA HKRMRTVTNY FLVNLAFAEA SMSAFNTVIN FTYAIHNHWY
110 120 130 140 150
YGLIYCKFHN FFPISAVFTS IYSMTAIALD RYMAIIHPLK PRLSATATKI
160 170 180 190 200
VICVIWSFSF CMAFPLGYYA DVYPMEGGDI CYLNWPDSEE NRKYEQVYQV
210 220 230 240 250
LVFCLIYILP LLVIGCAYTF IGMTLWASEI PGDSSDRYHE QVVAKRKVVK
260 270 280 290 300
MMIVVVCTFA ICWLPFHIFF LLQTLHEMTQ KFYQQFYLAI MWLAMSSTMY
310 320 330 340 350
NPIIYCCLND RFRIGFKHVF RWCPFIRAGE YEGLELKSTR YLQTQSSMYK
360 370 380 390 400
ISRIETTVSS VLNTNDEEAE ENGKSSKRLS LDLTSNGSSR SVCKTMSDSS
SFYSNNLA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67736 mRNA Translation: AAC05707.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U67736 mRNA Translation: AAC05707.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
GPCRDBi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001681, Neurokn_rcpt IPR000046, NK1_rcpt |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR01024, NEUROKININ1R PR00244, NEUROKININR |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NK1R_LITCT | |
Accessioni | Q98982Primary (citable) accession number: Q98982 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | February 1, 1997 | |
Last modified: | October 7, 2020 | |
This is version 77 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Documents
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families