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UniProtKB - Q98938 (IHH_CHICK)
Protein
Indian hedgehog protein
Gene
IHH
Organism
Gallus gallus (Chicken)
Status
Functioni
Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 90 | Calcium 1By similarity | 1 | |
Metal bindingi | 91 | Calcium 1By similarity | 1 | |
Metal bindingi | 91 | Calcium 2By similarity | 1 | |
Metal bindingi | 96 | Calcium 1By similarity | 1 | |
Metal bindingi | 126 | Calcium 1; via carbonyl oxygenBy similarity | 1 | |
Metal bindingi | 127 | Calcium 1By similarity | 1 | |
Metal bindingi | 127 | Calcium 2By similarity | 1 | |
Metal bindingi | 130 | Calcium 2By similarity | 1 | |
Metal bindingi | 132 | Calcium 2By similarity | 1 | |
Metal bindingi | 141 | ZincBy similarity | 1 | |
Metal bindingi | 148 | ZincBy similarity | 1 | |
Metal bindingi | 183 | ZincBy similarity | 1 | |
Sitei | 244 | Involved in cholesterol transferBy similarity | 1 | |
Sitei | 268 | Involved in auto-cleavageBy similarity | 1 | |
Sitei | 271 | Essential for auto-cleavageBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: GO_Central
- patched binding Source: GO_Central
- peptidase activity Source: UniProtKB-KW
GO - Biological processi
- bone resorption Source: Ensembl
- branching involved in blood vessel morphogenesis Source: Ensembl
- camera-type eye photoreceptor cell fate commitment Source: Ensembl
- cartilage development Source: UniProtKB
- cell-cell signaling Source: InterPro
- cell fate specification Source: GO_Central
- cell maturation Source: Ensembl
- chondroblast differentiation Source: AgBase
- chondrocyte differentiation involved in endochondral bone morphogenesis Source: Ensembl
- chondrocyte proliferation Source: AgBase
- embryonic camera-type eye morphogenesis Source: Ensembl
- embryonic digestive tract morphogenesis Source: Ensembl
- embryonic digit morphogenesis Source: AgBase
- embryonic pattern specification Source: Ensembl
- embryonic skeletal joint development Source: Ensembl
- epithelial cell-cell adhesion Source: Ensembl
- epithelial cell morphogenesis Source: Ensembl
- head morphogenesis Source: Ensembl
- heart looping Source: Ensembl
- multicellular organism growth Source: Ensembl
- negative regulation of alpha-beta T cell differentiation Source: Ensembl
- negative regulation of chondrocyte differentiation Source: AgBase
- negative regulation of chondrocyte hypertrophy Source: AgBase
- negative regulation of eye pigmentation Source: Ensembl
- negative regulation of immature T cell proliferation in thymus Source: Ensembl
- neuron development Source: Ensembl
- osteoblast differentiation Source: Ensembl
- pancreas development Source: Ensembl
- positive regulation of alkaline phosphatase activity Source: AgBase
- positive regulation of alpha-beta T cell differentiation Source: Ensembl
- positive regulation of cell morphogenesis involved in differentiation Source: AgBase
- positive regulation of collagen biosynthetic process Source: Ensembl
- positive regulation of gene expression Source: AgBase
- positive regulation of hh target transcription factor activity Source: AgBase
- positive regulation of mesenchymal cell proliferation Source: Ensembl
- positive regulation of osteoblast differentiation Source: AgBase
- positive regulation of smoothened signaling pathway Source: Ensembl
- positive regulation of T cell differentiation in thymus Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- protein autoprocessing Source: InterPro
- proteoglycan biosynthetic process Source: AgBase
- regulation of chondrocyte differentiation involved in endochondral bone morphogenesis Source: AgBase
- regulation of gene expression Source: GO_Central
- regulation of growth plate cartilage chondrocyte differentiation Source: AgBase
- regulation of growth plate cartilage chondrocyte proliferation Source: AgBase
- retinal pigment epithelium development Source: Ensembl
- smoothened signaling pathway Source: GO_Central
- smooth muscle tissue development Source: Ensembl
- somite development Source: Ensembl
- vitelline membrane formation Source: Ensembl
Keywordsi
Molecular function | Developmental protein, Hydrolase, Protease |
Ligand | Calcium, Metal-binding, Zinc |
Protein family/group databases
MEROPSi | C46.003 |
Names & Taxonomyi
Protein namesi | Recommended name: Indian hedgehog proteinShort name: IHH Cleaved into the following 2 chains: |
Gene namesi | Name:IHH |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Lipid-anchor By similarity; Extracellular side By similarity
Note: The N-terminal peptide remains associated with the cell surface.By similarity
Extracellular region or secreted
- extracellular space By similarity
Note: The C-terminal peptide diffuses from the cell.By similarity
Extracellular region or secreted
- extracellular space Source: AgBase
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- extracellular matrix Source: Ensembl
Keywords - Cellular componenti
Cell membrane, Membrane, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000013235 | 24 – 408 | Indian hedgehog proteinAdd BLAST | 385 | |
ChainiPRO_0000013236 | 24 – 198 | Indian hedgehog protein N-productAdd BLAST | 175 | |
ChainiPRO_0000013237 | 199 – 408 | Indian hedgehog protein C-productAdd BLAST | 210 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 24 | N-palmitoyl cysteineBy similarity | 1 | |
Lipidationi | 198 | Cholesterol glycine esterBy similarity | 1 |
Post-translational modificationi
The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. Both activities result in the cleavage of the full-length protein and covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-terminal fragment (N-product). The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity (By similarity).By similarity
Cholesterylation is required for N-product targeting to lipid rafts and multimerization.By similarity
N-palmitoylation is required for N-product multimerization and full activity.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 198 – 199 | Cleavage; by autolysisBy similarity | 2 |
Keywords - PTMi
Autocatalytic cleavage, Lipoprotein, PalmitateProteomic databases
PaxDbi | Q98938 |
Expressioni
Tissue specificityi
Expressed in developing midgut, lung and cartilage of developing long bones in the limb.
Gene expression databases
ExpressionAtlasi | Q98938, baseline |
Interactioni
GO - Molecular functioni
- patched binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000018493 |
Family & Domainsi
Domaini
The indian hedgehog protein N-product binds calcium and zinc ions; this stabilizes the protein fold and is essential for protein-protein interactions mediated by this domain.By similarity
Sequence similaritiesi
Belongs to the hedgehog family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG3638, Eukaryota |
GeneTreei | ENSGT00940000159207 |
InParanoidi | Q98938 |
OMAi | APAVRGC |
OrthoDBi | 1169356at2759 |
PhylomeDBi | Q98938 |
Family and domain databases
Gene3Di | 3.30.1380.10, 1 hit |
InterProi | View protein in InterPro IPR001657, Hedgehog IPR001767, Hedgehog_Hint IPR009045, Hedgehog_sig/DD-Pept_Zn-bd_sf IPR000320, Hedgehog_signalling_dom IPR003586, Hint_dom_C IPR003587, Hint_dom_N IPR036844, Hint_dom_sf IPR033385, IHH |
PANTHERi | PTHR11889:SF39, PTHR11889:SF39, 1 hit |
Pfami | View protein in Pfam PF01085, HH_signal, 1 hit PF01079, Hint, 1 hit |
PIRSFi | PIRSF009400, Peptidase_C46, 1 hit |
PRINTSi | PR00632, SONICHHOG |
SMARTi | View protein in SMART SM00305, HintC, 1 hit SM00306, HintN, 1 hit |
SUPFAMi | SSF51294, SSF51294, 1 hit SSF55166, SSF55166, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q98938-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKPARLLLLL SGCALLLAPA VRCCGPGRVV GSRRRPPRKL IPLAYKQFSP
60 70 80 90 100
NVPEKTLGAS GRYEGKIARN SERFKELTPN YNPDIIFKDE ENTGADRLMT
110 120 130 140 150
QRCKDRLNSL AISVMNQWPG VKLRVTEGWD EDGHHSEESL HYEGRAVDIT
160 170 180 190 200
TSDRDRNKYG MLARLAVEAG FDWVYYESKA HIHCSVKSEH SAAAKTGGCF
210 220 230 240 250
PGRALATLEN GARTPLWALR PGQRVLAMDG AGRPTYSDFL AFLDKEPRAL
260 270 280 290 300
TAFHVIETRQ PPRRLALTPT HLLFVADNAS APAAQFRPTF ASHVQPGHFV
310 320 330 340 350
LVAVGSGGLQ PAEVVGVRGR TDVGAYAPLT RHGTLVVDDV VASCFALVRE
360 370 380 390 400
QQLAQMAFWP LRLYHSLLGG PGVQGDGVHW YSGLLYRLGR MLLPPDSFHP
LGAPRAES
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U58511 mRNA Translation: AAC60010.1 |
RefSeqi | NP_990288.1, NM_204957.2 |
Genome annotation databases
Ensembli | ENSGALT00000018516; ENSGALP00000018493; ENSGALG00000011347 |
GeneIDi | 395801 |
KEGGi | gga:395801 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U58511 mRNA Translation: AAC60010.1 |
RefSeqi | NP_990288.1, NM_204957.2 |
3D structure databases
AlphaFoldDBi | Q98938 |
SMRi | Q98938 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000018493 |
Protein family/group databases
MEROPSi | C46.003 |
Proteomic databases
PaxDbi | Q98938 |
Genome annotation databases
Ensembli | ENSGALT00000018516; ENSGALP00000018493; ENSGALG00000011347 |
GeneIDi | 395801 |
KEGGi | gga:395801 |
Organism-specific databases
CTDi | 3549 |
Phylogenomic databases
eggNOGi | KOG3638, Eukaryota |
GeneTreei | ENSGT00940000159207 |
InParanoidi | Q98938 |
OMAi | APAVRGC |
OrthoDBi | 1169356at2759 |
PhylomeDBi | Q98938 |
Miscellaneous databases
PROi | PR:Q98938 |
Gene expression databases
ExpressionAtlasi | Q98938, baseline |
Family and domain databases
Gene3Di | 3.30.1380.10, 1 hit |
InterProi | View protein in InterPro IPR001657, Hedgehog IPR001767, Hedgehog_Hint IPR009045, Hedgehog_sig/DD-Pept_Zn-bd_sf IPR000320, Hedgehog_signalling_dom IPR003586, Hint_dom_C IPR003587, Hint_dom_N IPR036844, Hint_dom_sf IPR033385, IHH |
PANTHERi | PTHR11889:SF39, PTHR11889:SF39, 1 hit |
Pfami | View protein in Pfam PF01085, HH_signal, 1 hit PF01079, Hint, 1 hit |
PIRSFi | PIRSF009400, Peptidase_C46, 1 hit |
PRINTSi | PR00632, SONICHHOG |
SMARTi | View protein in SMART SM00305, HintC, 1 hit SM00306, HintN, 1 hit |
SUPFAMi | SSF51294, SSF51294, 1 hit SSF55166, SSF55166, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IHH_CHICK | |
Accessioni | Q98938Primary (citable) accession number: Q98938 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | February 1, 1997 | |
Last modified: | May 25, 2022 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families