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Protein

Receptor-type tyrosine-protein phosphatase gamma

Gene

PTPRG

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1005SubstrateBy similarity1
Active sitei1037Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei1081SubstrateBy similarity1
Sitei1328Ancestral active site1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase gamma (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase gamma
Short name:
R-PTP-gamma
Gene namesi
Name:PTPRG
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 742ExtracellularSequence analysisAdd BLAST723
Transmembranei743 – 768HelicalSequence analysisAdd BLAST26
Topological domaini769 – 1422CytoplasmicSequence analysisAdd BLAST654

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000002544320 – 1422Receptor-type tyrosine-protein phosphatase gammaAdd BLAST1403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 261By similarity
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi156N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi359N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi444N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi620N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi632N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi640N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi728N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ98936
PRIDEiQ98936

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011605

Structurei

3D structure databases

ProteinModelPortaliQ98936
SMRiQ98936
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 321Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST264
Domaini349 – 448Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST100
Domaini825 – 1096Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST272
Domaini1127 – 1387Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1037 – 1043Substrate bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
KOG0789 Eukaryota
COG3338 LUCA
COG5599 LUCA
HOGENOMiHOG000060222
HOVERGENiHBG053760
InParanoidiQ98936
PhylomeDBiQ98936

Family and domain databases

CDDicd00063 FN3, 1 hit
Gene3Di2.60.40.10, 1 hit
3.10.200.10, 1 hit
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
PF00041 fn3, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SM00060 FN3, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF49265 SSF49265, 1 hit
SSF51069 SSF51069, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS51144 ALPHA_CA_2, 1 hit
PS50853 FN3, 1 hit
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q98936-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLLQPCWW IFFLKITSSV LHDVVCFPAL TEGYVGSLHE SRHGSSVQIR
60 70 80 90 100
RRKASGDPYW GYSGTYGPEH WVTSSEKCGG SHQSPIDIVD HQAHVLYEYQ
110 120 130 140 150
ELQLDGFDNE SSNKTWMKNT GKTVAILLKD DYFVSGAGLP GRFKAEKVEF
160 170 180 190 200
HWGQSNGSAG SEHSINGKRF PVEMQIYFYN PDDFDSFGTA VLENREVGAM
210 220 230 240 250
AVFFQVSQRD NSALDPIIRG LKGVVHHEKE TFLDPFVLRD LLPTSLGSYY
260 270 280 290 300
RYTGSLTTPP CSEIVEWIIF RKPVPISYHQ LEAFYSIFTT EQQDHVKSVE
310 320 330 340 350
YLRNNFRPQQ RLNNRKVSKS AVKDAWSQDM TDILENPLGT EASKACSTPP
360 370 380 390 400
VNMKVQPVNR TALLVTWNQP ETIYHPPIMN YMISYSWTKN EDEKEKTFTK
410 420 430 440 450
DSDKDLKAII SHVSPDILYL FRVQAVCRNE MRSDFSQTML FQANTTRIFE
460 470 480 490 500
GTRIVKTGVP TASPASSADM APISSGSSTW TSSGLPFSFV SMATGMGPSS
510 520 530 540 550
SGSQATVASV VTSTLLAGLG FSGSSISSFP SSVWPTRLPT AAAPTKQAGR
560 570 580 590 600
PVVATTEPAA ASPGPERDSA LTKDGEGAEE GEKDEKSESE DGEREHEEED
610 620 630 640 650
EKEAEKKEKS RATAAAEARN STEPSVATAS PNWTAEEEGN KTVSGEEPNQ
660 670 680 690 700
NVVPKAGRPE EESFTDADTQ PQPLPSTQVP PAFTDELYLE KIPRRPETTR
710 720 730 740 750
KPLPKDNRFL EEYPSDNKFI TINPADKNSS SMATRPSPGK MEWIIPLIVV
760 770 780 790 800
SALTFVCLIL LIAVLVYWRK CFQTAHFYVE DSSSPRVVPN ESIPIIPIPD
810 820 830 840 850
DMEAIPVKQF VKHISELYSN NQHGFSEDFE EVQRCTADMN ITAEHSNHPD
860 870 880 890 900
NKHKNRYINI LAYDHSRVKL RPLPGKDSKH SDYINANYVS GYNKAKAYIA
910 920 930 940 950
TQGPLKSTFE DFWRMIWAQH TGIIVMITNL VEKGRRKCDQ YWPTENSEEY
960 970 980 990 1000
GNIIVTLKST NIHACYTVRP LHGQEHKDEK GSERKPKGRQ NERTVIQYHY
1010 1020 1030 1040 1050
TQWPDMGVPE YALPVLTFVR RSSAARTPHM GPVVVHCSAG VGRTGTYIVI
1060 1070 1080 1090 1100
DSMLQQIKDK STVNVLGFLK HIRTQRNYLV QTEEQYIFIH DALLEAILGK
1110 1120 1130 1140 1150
ETEVSANQLH SYVNSILIPG IGGKTRLEKQ FKLVTQCNAK YVECFSAQKD
1160 1170 1180 1190 1200
CNKEKNRNSS VVPSERARVG LAPLPGMKGT DYINASYIMG YYRSNENVIT
1210 1220 1230 1240 1250
QHPLPHTTKD FWRMIWDHNA QIIVMLPDNQ SLAEDEFVYW PSREESMNCE
1260 1270 1280 1290 1300
AFTVTLISKD RLCLSNEEQI IIHDFILEAT QDDYVLEVRH FQCPKWPNPD
1310 1320 1330 1340 1350
APISSTFELI NVIKEEALTR DGPTIVHDEY GAVSAGTLCA LTTLSQQLEN
1360 1370 1380 1390 1400
ENAVDVFQVA KMINLMRPGV FTDIEQYQFL YKAMLSLVST KENGNGPMTL
1410 1420
DKNGAVMASD ESDPAESMES LV
Length:1,422
Mass (Da):159,767
Last modified:February 1, 1997 - v1
Checksum:iDD484055993DA74F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38349 mRNA Translation: AAB16910.1
PIRiT42636
UniGeneiGga.2516

Similar proteinsi

Entry informationi

Entry nameiPTPRG_CHICK
AccessioniPrimary (citable) accession number: Q98936
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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