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Entry version 132 (07 Apr 2021)
Sequence version 1 (01 Feb 1997)
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Protein

Sortilin-related receptor

Gene

SORL1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sorting receptor that directs numerous proteins to their correct location within the cell. Along with AP-1 complex, involved Golgi apparatus - endosome sorting (By similarity). Sorting receptor for APP, regulating its intracellular trafficking and processing into amyloidogenic-beta peptides. Retains APP in the trans-Golgi network, hence preventing its transit through late endosomes where amyloid beta peptides Abeta40 and Abeta42 are generated (By similarity). Sorting receptor for the BDNF receptor NTRK2/TRKB that facilitates NTRK2 trafficking between synaptic plasma membranes, postsynaptic densities and cell soma, hence positively regulates BDNF signaling by controlling the intracellular location of its receptor (By similarity). Sorting receptor for GDNF that promotes GDNF regulated, but not constitutive secretion (By similarity). Sorting receptor for ERBB2/HER2. Regulates ERBB2 subcellular distribution by promoting its recycling after internalization from endosomes back to the plasma membrane, hence stimulating phosphoinositide 3-kinase (PI3K)-dependent ERBB2 signaling (By similarity). Sorting receptor for lipoprotein lipase LPL. Promotes LPL localization to endosomes and later to the lysosomes, leading to degradation of newly synthesized LPL (By similarity). Potential sorting receptor for APOA5, inducing APOA5 internalization to early endosomes, then to late endosomes, wherefrom a portion is sent to lysosomes and degradation, another portion is sorted to the trans-Golgi network (By similarity). Sorting receptor for the insulin receptor INSR. Promotes recycling of internalized INSR via the Golgi apparatus back to the cell surface, thereby preventing lysosomal INSR catabolism, increasing INSR cell surface expression and strengthening insulin signal reception in adipose tissue (By similarity). Plays a role in renal ion homeostasis, possibly through intracellular sorting of STK39 and PPP3CB (By similarity). Stimulates, via the N-terminal ectodomain, the proliferation and migration of smooth muscle cells, possibly by increasing cell surface expression of the urokinase receptor uPAR/PLAUR, hence facilitating the proteolysis of the extracellular matrix (By similarity). May also stimulate the proliferation, adhesion and migration of monocytes/macrophages (By similarity). Metabolic regulator, which functions to maintain the adequate balance between lipid storage and oxidation in response to changing environmental conditions, such as temperature and diet (By similarity). May regulate signaling by the heterodimeric neurotrophic cytokine CLCF1-CRLF1 bound to the CNTFR receptor by promoting the endocytosis of the tripartite complex CLCF1-CRLF1-CNTFR and lysosomal degradation (By similarity). May regulate IL6 signaling (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sortilin-related receptor
Alternative name(s):
Low-density lipoprotein receptor relative with 11 ligand-binding repeats
Short name:
LDLR relative with 11 ligand-binding repeats
Short name:
LR11
SorLA-1
Sorting protein-related receptor containing LDLR class A repeats
Short name:
SorLA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SORL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Membrane, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000064332‹1 – ›1592Sortilin-related receptorAdd BLAST›1592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi65N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi275N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi523N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi581N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi725N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi778N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi975N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi985 ↔ 997PROSITE-ProRule annotation
Disulfide bondi992 ↔ 1010PROSITE-ProRule annotation
Disulfide bondi1004 ↔ 1019PROSITE-ProRule annotation
Disulfide bondi1024 ↔ 1038PROSITE-ProRule annotation
Disulfide bondi1032 ↔ 1051PROSITE-ProRule annotation
Disulfide bondi1045 ↔ 1060PROSITE-ProRule annotation
Disulfide bondi1065 ↔ 1077PROSITE-ProRule annotation
Disulfide bondi1072 ↔ 1090PROSITE-ProRule annotation
Disulfide bondi1084 ↔ 1099PROSITE-ProRule annotation
Glycosylationi1098N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1105 ↔ 1117PROSITE-ProRule annotation
Disulfide bondi1112 ↔ 1130PROSITE-ProRule annotation
Disulfide bondi1124 ↔ 1141PROSITE-ProRule annotation
Disulfide bondi1145 ↔ 1155PROSITE-ProRule annotation
Disulfide bondi1150 ↔ 1168PROSITE-ProRule annotation
Glycosylationi1152N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1162 ↔ 1177PROSITE-ProRule annotation
Disulfide bondi1182 ↔ 1196PROSITE-ProRule annotation
Disulfide bondi1190 ↔ 1209PROSITE-ProRule annotation
Disulfide bondi1203 ↔ 1222PROSITE-ProRule annotation
Disulfide bondi1232 ↔ 1244PROSITE-ProRule annotation
Disulfide bondi1239 ↔ 1257PROSITE-ProRule annotation
Disulfide bondi1251 ↔ 1266PROSITE-ProRule annotation
Disulfide bondi1275 ↔ 1288PROSITE-ProRule annotation
Disulfide bondi1283 ↔ 1301PROSITE-ProRule annotation
Disulfide bondi1295 ↔ 1310PROSITE-ProRule annotation
Disulfide bondi1326 ↔ 1338PROSITE-ProRule annotation
Disulfide bondi1333 ↔ 1351PROSITE-ProRule annotation
Disulfide bondi1345 ↔ 1360PROSITE-ProRule annotation
Glycosylationi1366N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1378 ↔ 1391PROSITE-ProRule annotation
Disulfide bondi1385 ↔ 1404PROSITE-ProRule annotation
Disulfide bondi1398 ↔ 1413PROSITE-ProRule annotation
Disulfide bondi1421 ↔ 1433PROSITE-ProRule annotation
Disulfide bondi1427 ↔ 1446PROSITE-ProRule annotation
Disulfide bondi1440 ↔ 1455PROSITE-ProRule annotation
Glycosylationi1454N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1514N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Within the Golgi apparatus, the propeptide is cleaved off by FURIN or a furin-like protease. At the cell surface, partially subjected to proteolytic shedding that releases the ectodomain in the extracellular milieu. Following shedding, may be cleaved the remaining transmembrane fragment and catalyze the release of a C-terminal fragment in the cytosol and of a soluble N-terminal beta fragment in the extracellular milieu. The C-terminal cytosolic fragment localizes to the nucleus.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q98930

PRoteomics IDEntifications database

More...
PRIDEi
Q98930

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, and, at lower levels, in testis and adrenal gland.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000010625

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q98930

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati43 – 54BNR 1Add BLAST12
Repeati139 – 150BNR 2Add BLAST12
Repeati348 – 359BNR 3Add BLAST12
Repeati428 – 439BNR 4Add BLAST12
Repeati469 – 480BNR 5Add BLAST12
Repeati707 – 750LDL-receptor class B 1Add BLAST44
Repeati751 – 794LDL-receptor class B 2Add BLAST44
Repeati795 – 839LDL-receptor class B 3Add BLAST45
Repeati840 – 877LDL-receptor class B 4Add BLAST38
Repeati878 – 920LDL-receptor class B 5Add BLAST43
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini933 – 979EGF-likeAdd BLAST47
Domaini983 – 1021LDL-receptor class A 1PROSITE-ProRule annotationAdd BLAST39
Domaini1022 – 1062LDL-receptor class A 2PROSITE-ProRule annotationAdd BLAST41
Domaini1063 – 1100LDL-receptor class A 3PROSITE-ProRule annotationAdd BLAST38
Domaini1103 – 1142LDL-receptor class A 4PROSITE-ProRule annotationAdd BLAST40
Domaini1144 – 1179LDL-receptor class A 5PROSITE-ProRule annotationAdd BLAST36
Domaini1180 – 1224LDL-receptor class A 6PROSITE-ProRule annotationAdd BLAST45
Domaini1230 – 1268LDL-receptor class A 7PROSITE-ProRule annotationAdd BLAST39
Domaini1273 – 1312LDL-receptor class A 8PROSITE-ProRule annotationAdd BLAST40
Domaini1324 – 1362LDL-receptor class A 9PROSITE-ProRule annotationAdd BLAST39
Domaini1376 – 1415LDL-receptor class A 10PROSITE-ProRule annotationAdd BLAST40
Domaini1419 – 1457LDL-receptor class A 11PROSITE-ProRule annotationAdd BLAST39
Domaini1463 – 1555Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini1559 – 1592Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST34

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

EGF-like domain, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1215, Eukaryota
KOG3511, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q98930

Identification of Orthologs from Complete Genome Data

More...
OMAi
IEGMAFD

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q98930

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063, FN3, 1 hit
cd00112, LDLa, 10 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.30, 1 hit
2.130.10.10, 1 hit
2.60.40.10, 1 hit
4.10.400.10, 11 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
IPR031777, Sortilin_C
IPR031778, Sortilin_N
IPR006581, VPS10
IPR015943, WD40/YVTN_repeat-like_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041, fn3, 1 hit
PF00057, Ldl_recept_a, 11 hits
PF00058, Ldl_recept_b, 1 hit
PF15902, Sortilin-Vps10, 1 hit
PF15901, Sortilin_C, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00261, LDLRECEPTOR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00192, LDLa, 11 hits
SM00135, LY, 5 hits
SM00602, VPS10, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 1 hit
SSF57424, SSF57424, 11 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01186, EGF_2, 1 hit
PS50853, FN3, 2 hits
PS01209, LDLRA_1, 11 hits
PS50068, LDLRA_2, 11 hits
PS51120, LDLRB, 5 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q98930-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GWVSLNDSHN QMVVHWAGEK SNVIVALARD SLSLLGPKNS DVYISYDYGK
60 70 80 90 100
SFKKISERFS FGDGNSSAVA IAQFYHSPAN NQRYIFVDAF VPYLWITTDF
110 120 130 140 150
CKSIQGFSIP FRAADLLLHS RNPNLVLGFD RSHPNKQLWK SDDFGQTWIM
160 170 180 190 200
IQEHVKSFSW GVEPYDKPNT VYIERHEPSG TSTVIRSTDF FQSRENKEVI
210 220 230 240 250
LEDVDDFQLR DKYLFATKAV RLLGSLQPSS VQLWVSFNRK PMRVAQFVTK
260 270 280 290 300
HPIKEYYIAD ASEDQVFVCV SHDDNRTNLY ISEAEGLKFS LSLENVLYYS
310 320 330 340 350
PGGAGSDTLV RYFANEPFAD FHRVEGVRGV YIATLLNGSF SEENMRSVIT
360 370 380 390 400
FDKGGTWEPL QPPAETRYGE KTHCELSQGC SLHLAQRLSQ LLNFQLRRMP
410 420 430 440 450
ILSKESAPGL IIATGSIGKS MAKKTNVYIS SSAGARWREA LSGPHYYTWG
460 470 480 490 500
DHGGILVAIA QGTETDQLKY STNEGETWKS FTFSEKPVFV YGLLTEPGEK
510 520 530 540 550
STIFTIFGSY KENGHSWLIL QVNTSDVLGV PCTENDYKLW SPSDERGNEC
560 570 580 590 600
LLGHKTVFKR RTPHATCFNG EDFDRPVMVS NCSCTREDFE CDFGFKLSED
610 620 630 640 650
LSLEVCVPDP EFAGKPYDPP VPCPVGSTYR RTRGYRKISG DTCMGGDIES
660 670 680 690 700
RLEGEMLPCP LAEENEFILY ATRYSIHRYD LASGLSQELP LAGLRGAVAL
710 720 730 740 750
DFDYEHNCLY WADVTLDIIQ RLCLNGSSGQ EIIISTGLET VEALAFEPLS
760 770 780 790 800
QLLYWVNAGI PKIEVANPDG DLRLTVLNSS VLERPRALAL VPREGLMFWT
810 820 830 840 850
DWGDSRPGIY RSDMDGSLAA CIVSEGVRWP NGISVDDHWI YWTEAYMDRI
860 870 880 890 900
ERVDFNGLQR SVILDSLPHP YAIAVFKNEI YWNDWSQLSI FRASKNSGSR
910 920 930 940 950
METLVGRLYG IMDMKIFYRG KTTGQNACIA HPCSLLCLPK SNNGRSCKCP
960 970 980 990 1000
EGVSSTVLPS GEVKCDCPHG YSMKNNTCVK EENTCLPNQY RCFNGNCINS
1010 1020 1030 1040 1050
IWQCDNNNDC GDMSDEKNCP TTVCDAETQF RCRESGTCIP LSYKCDLEDD
1060 1070 1080 1090 1100
CGDNSDESHC EAHQCRKDEF SCSSGMCIRL SWRCDDDNDC RDWSDEANCT
1110 1120 1130 1140 1150
MFRTCEASSF QCLNGHCIPQ RWACDGDADC QDGSDEDPTI CEKKCNGFQC
1160 1170 1180 1190 1200
PNGTCISTSK HCNGITDCAD ASDEQDCEIP LCTRYMDFVC KNRQQCLSHS
1210 1220 1230 1240 1250
MVCDGDIQCE DGSDEDANYA GCAQEPEFHR TCDQFSFQCA NGVCISLVWK
1260 1270 1280 1290 1300
CDGMDDCGDY SDEASCENPT DAPTCSRYYQ FQCGNGHCIP NQWKCDGEND
1310 1320 1330 1340 1350
CGDWSDEKEC EGSPLLPITT AVPPTCLPNH FRCGSGACIT NSWVCDGYRD
1360 1370 1380 1390 1400
CADGSDEDAC PTSHPNVTSS PPAPRGRCSR TEFECQQLHK CIPNWKRCDG
1410 1420 1430 1440 1450
RRDCQDGTDE RSCPTHSSLS CPQGYRCEDG EACLLATERC DGYLDCSDGS
1460 1470 1480 1490 1500
DERNCTDDTI VYKVQNLQWT ADFSGAITLT WARPKRMSST SCVYNVYYRM
1510 1520 1530 1540 1550
VGESIWKVLE THSNKTSSVL KVLKPDCTYQ VKVQVQCLSR VYNTNDFITL
1560 1570 1580 1590
RVPEGLPDAP FNLQLALKKE AEGVVLCSWS APVNAHGLIR EP
Length:1,592
Mass (Da):178,411
Last modified:February 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24EDAA5BA231B203
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11
Non-terminal residuei15921

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Y08109 mRNA Translation: CAA69324.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08109 mRNA Translation: CAA69324.1

3D structure databases

SMRiQ98930
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010625

Proteomic databases

PaxDbiQ98930
PRIDEiQ98930

Phylogenomic databases

eggNOGiKOG1215, Eukaryota
KOG3511, Eukaryota
InParanoidiQ98930
OMAiIEGMAFD
PhylomeDBiQ98930

Family and domain databases

CDDicd00063, FN3, 1 hit
cd00112, LDLa, 10 hits
Gene3Di2.120.10.30, 1 hit
2.130.10.10, 1 hit
2.60.40.10, 1 hit
4.10.400.10, 11 hits
InterProiView protein in InterPro
IPR011042, 6-blade_b-propeller_TolB-like
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR013783, Ig-like_fold
IPR036055, LDL_receptor-like_sf
IPR023415, LDLR_class-A_CS
IPR000033, LDLR_classB_rpt
IPR002172, LDrepeatLR_classA_rpt
IPR031777, Sortilin_C
IPR031778, Sortilin_N
IPR006581, VPS10
IPR015943, WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF00041, fn3, 1 hit
PF00057, Ldl_recept_a, 11 hits
PF00058, Ldl_recept_b, 1 hit
PF15902, Sortilin-Vps10, 1 hit
PF15901, Sortilin_C, 1 hit
PRINTSiPR00261, LDLRECEPTOR
SMARTiView protein in SMART
SM00192, LDLa, 11 hits
SM00135, LY, 5 hits
SM00602, VPS10, 1 hit
SUPFAMiSSF49265, SSF49265, 1 hit
SSF57424, SSF57424, 11 hits
PROSITEiView protein in PROSITE
PS01186, EGF_2, 1 hit
PS50853, FN3, 2 hits
PS01209, LDLRA_1, 11 hits
PS50068, LDLRA_2, 11 hits
PS51120, LDLRB, 5 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSORL_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q98930
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: April 7, 2021
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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