Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Due to a server migration, the UniProt 'ID mapping', 'Peptide search' and 'community bibliography submission' tools will not be available on the 19th April 2021 during the morning (EST).
Entry version 99 (02 Dec 2020)
Sequence version 3 (24 May 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Melanocyte protein PMEL

Gene

PMEL

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Might be required for polymerization of melanin onto the core structure of melanosomes with enzymatic function of tyrosinase.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

  • melanosome organization Source: GO_Central

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Melanocyte protein PMEL
Alternative name(s):
115 kDa melanosomal matrix protein
Melanocyte protein Pmel 17
Premelanosome protein
Silver locus protein homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PMEL
Synonyms:MMP115, PMEL17, SILV
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 19Sequence analysisAdd BLAST19
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002471420 – 763Melanocyte protein PMELAdd BLAST744

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi111N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi346N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi651N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi659N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylated.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q98917

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specific to pigmented epithelial cells and melanocytes. Not expressed in lens, neural retina, brain, heart, gizzard or liver.

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed during the redifferentiation of pigmented epithelial cells (PEC).

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000023540

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q98917

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini223 – 323PKDPROSITE-ProRule annotationAdd BLAST101
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati441 – 4641Add BLAST24
Repeati465 – 4882Add BLAST24
Repeati489 – 5083; approximateAdd BLAST20
Repeati509 – 5324Add BLAST24

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni441 – 5324 X 24 AA approximate tandem repeats of T-[AD]-[EG]-D-[AV]-[AV]-[AG]-[AP]-T-[AP]-[AG]-A-T-A-[AE]-[DS]-[IV]-A-[DV]-[DP]-T-A-G-AAdd BLAST92

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PMEL/NMB family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QV5K, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q98917

Database of Orthologous Groups

More...
OrthoDBi
393436at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q98917

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013783, Ig-like_fold
IPR022409, PKD/Chitinase_dom
IPR000601, PKD_dom
IPR035986, PKD_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00801, PKD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00089, PKD, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49299, SSF49299, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50093, PKD, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q98917-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLHGAIVLL AALLALVTAQ QRGGGRSRGG VKGSAWGGRP APFRSWDTAR
60 70 80 90 100
YRPWQEGTAR QNDCWRGGDV TFDISNDAPT LVGARATFSI ALRFPGTQTV
110 120 130 140 150
LPDGRVVWSQ NCTVNGTRML QGDPVYPEQL AEGSDGVFPD GQPFPRSAWG
160 170 180 190 200
KRGRFVYVWW TWGRYWQVVD GATSQLTVGT DGVALGSYTM EVVVYHYRGR
210 220 230 240 250
QRFIPIGHAS TQFSITDQVP IAVDVTQLEV AAGDGGSFVR NRPVAFNVRL
260 270 280 290 300
HDPSHYLRDA DISYSWDFGD QSGTLISRSP TVTHTYLQAG SFAARLVLQA
310 320 330 340 350
AIPLSSCGTS APPVVDPTTG PVPSLGPTAT QPVGPTGSGT ATAPSNLTGS
360 370 380 390 400
GTAAAPGTTA APRASGAPAE PTGVSVAVLS DSAATEPLPD PVLSTAVADA
410 420 430 440 450
AAGTDPTADP LPPTSVSSGG DAPGTVAPTA VEGSVAAGVG TAEDVAAATP
460 470 480 490 500
GATAADVAVD TAGATDGDAV GPTAAATAES IADPTAGATD GDAVGATAES
510 520 530 540 550
IADPTAGATD GDAVGPTAAA TAESIADPTA GATAVSSGSA TAGATAEPLL
560 570 580 590 600
LVKRQAPEAE PTGCVLYRYG TFSTELNIVQ GIESVAIVQV VPAAPEGSGN
610 620 630 640 650
SVELTVTCEG SLPEEVCTVV ADAECRTAQM QTCSAVAPAP GCQLVLRQDF
660 670 680 690 700
NQSGLYCLNV SLANGNGLAV ASTHVAVGGA SPAASGTTLT VGLLWAPLIA
710 720 730 740 750
AALGTAAYTY RRVKYSPLLP TAPTAPRPHS WLPPGATLRL LLRQAFGGAP
760
SGESSPLLRA NAV
Length:763
Mass (Da):77,038
Last modified:May 24, 2005 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA40341F69FD2C2BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti699I → M in BAA13589 (Ref. 2) Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Mutations in PMEL cause the Dominant white, Dun and Smoky plumage phenotypes in chicken. Both Dominant white and Dun inhibit the expression of black eumelanin giving rise to white plumage while Smoky gives a gray phenotype. The Dominant white phenotype is a breed characteristic of the White leghorn strain.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti34S → P in strain: Black Langshan. 1
Natural varianti35A → V in strain: Dun. 1
Natural varianti96G → S in strain: Dun. 1
Natural varianti232A → V in strain: Broiler. 1
Natural varianti280 – 283Missing in strain: Smoky. 4
Natural varianti399D → N in strain: Dun and Red jungle fowl. 1
Natural varianti495G → GPTAA in strain: Broiler. 1
Natural varianti495G → GPTAAATAESIADPTAGATD GDAVGPTAA in strain: Dun and Red jungle fowl. 1
Natural varianti505 – 506TA → IV in strain: Broiler, Dun and Red jungle fowl. 2
Natural varianti558E → K in strain: Broiler. 1
Natural varianti695 – 697Missing in strain: Black Langshan, Broiler, Dun and Red jungle fowl. 3
Natural varianti701 – 705Missing in strain: Dun. 5
Natural varianti712R → C in strain: Dun. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D88348 mRNA Translation: BAA13589.2
AY636124 Genomic DNA Translation: AAT58245.1
AY636125 Genomic DNA Translation: AAT58246.1
AY636126 Genomic DNA Translation: AAT58247.1
AY636127 Genomic DNA Translation: AAT58248.1
AY636128 Genomic DNA Translation: AAT58249.1
AY636129 Genomic DNA Translation: AAT58250.1

NCBI Reference Sequences

More...
RefSeqi
NP_990443.2, NM_205112.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
396007

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:396007

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D88348 mRNA Translation: BAA13589.2
AY636124 Genomic DNA Translation: AAT58245.1
AY636125 Genomic DNA Translation: AAT58246.1
AY636126 Genomic DNA Translation: AAT58247.1
AY636127 Genomic DNA Translation: AAT58248.1
AY636128 Genomic DNA Translation: AAT58249.1
AY636129 Genomic DNA Translation: AAT58250.1
RefSeqiNP_990443.2, NM_205112.2

3D structure databases

SMRiQ98917
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023540

Proteomic databases

PaxDbiQ98917

Genome annotation databases

GeneIDi396007
KEGGigga:396007

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6490

Phylogenomic databases

eggNOGiENOG502QV5K, Eukaryota
InParanoidiQ98917
OrthoDBi393436at2759
PhylomeDBiQ98917

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q98917

Family and domain databases

Gene3Di2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR013783, Ig-like_fold
IPR022409, PKD/Chitinase_dom
IPR000601, PKD_dom
IPR035986, PKD_dom_sf
PfamiView protein in Pfam
PF00801, PKD, 1 hit
SMARTiView protein in SMART
SM00089, PKD, 1 hit
SUPFAMiSSF49299, SSF49299, 1 hit
PROSITEiView protein in PROSITE
PS50093, PKD, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPMEL_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q98917
Secondary accession number(s): Q6DW60
, Q6DW61, Q6DW62, Q6DW63, Q6DW64, Q6DW65
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 24, 2005
Last modified: December 2, 2020
This is version 99 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again