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Protein
Submitted name:

3-hydroxybutyryl-coA dehydrogenase

Gene

mlr6793

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32NADUniRule annotation1
Binding sitei89NADUniRule annotation1
Binding sitei94NADUniRule annotationCombined sources1
Binding sitei116NADUniRule annotation1
Sitei137Important for catalytic activityUniRule annotation1
Binding sitei140NADUniRule annotation1
Binding sitei274NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 14NADUniRule annotation6
Nucleotide bindingi12 – 13NADCombined sources2
Nucleotide bindingi32 – 33NADCombined sources2
Nucleotide bindingi86 – 89NADCombined sources4
Nucleotide bindingi114 – 116NADCombined sources3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseSAAS annotation
LigandNADUniRule annotationCombined sources, Nucleotide-bindingCombined sources

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-20508
MLOT266835:G1G20-5457-MONOMER

Names & Taxonomyi

Protein namesi
Submitted name:
3-hydroxybutyryl-coA dehydrogenaseImported
Gene namesi
Ordered Locus Names:mlr6793Imported
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))Imported
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi266835.mlr6793

Structurei

3D structure databases

ProteinModelPortaliQ988C8
SMRiQ988C8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 1813HCDH_NInterPro annotationAdd BLAST178
Domaini184 – 2823HCDHInterPro annotationAdd BLAST99

Phylogenomic databases

eggNOGiENOG4105F35 Bacteria
COG1250 LUCA
HOGENOMiHOG000141498
KOiK18612
OMAiPVLQRDH
OrthoDBiPOG091H0NDD

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR002204 3-OH-isobutyrate_DH-rel_CS
IPR022694 3-OHacyl-CoA_DH
IPR006180 3-OHacyl-CoA_DH_CS
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
PIRSFiPIRSF000105 HCDH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00895 3_HYDROXYISOBUT_DH, 1 hit
PS00067 3HCDH, 1 hit

Sequencei

Sequence statusi: Complete.

Q988C8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIRNIAIIGL GTMGPGMAAR LARGGLQVVA YDVAPAAIER ARSMLSVAET
60 70 80 90 100
VLDALGIALP SAGVGTVRFT DDIGDAVSGA DLVIENVPEN ISIKADVYRT
110 120 130 140 150
IDGLIGQDTI VASDTSGIPI TKLQAHISYP ERMVGMHWSN PPHIIPMIEV
160 170 180 190 200
IAGEKTAPQT VATIRDLIRS IGLLPVVVKK DVPGFVENRV LYALLREAVD
210 220 230 240 250
LVERGVIDPE DLDTCVSWGI GYKIAVIGPM ALLDMAGLDI YKSVSSFLNA
260 270 280 290 300
DLSNRDDVAP MVLEKTSASK FGIKSGEGMF CYTPEQTKAL QAERARKLVA

VRRILEGRE
Length:309
Mass (Da):33,061
Last modified:October 1, 2001 - v1
Checksum:i63283FA5C583AF7C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB53022.1
RefSeqiWP_010914332.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB53022; BAB53022; BAB53022
KEGGimlo:mlr6793
PATRICifig|266835.9.peg.5406

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB53022.1
RefSeqiWP_010914332.1, NC_002678.2

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4OM8X-ray1.55A/B1-309[»]
ProteinModelPortaliQ988C8
SMRiQ988C8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi266835.mlr6793

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAB53022; BAB53022; BAB53022
KEGGimlo:mlr6793
PATRICifig|266835.9.peg.5406

Phylogenomic databases

eggNOGiENOG4105F35 Bacteria
COG1250 LUCA
HOGENOMiHOG000141498
KOiK18612
OMAiPVLQRDH
OrthoDBiPOG091H0NDD

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-20508
MLOT266835:G1G20-5457-MONOMER

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR002204 3-OH-isobutyrate_DH-rel_CS
IPR022694 3-OHacyl-CoA_DH
IPR006180 3-OHacyl-CoA_DH_CS
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
PIRSFiPIRSF000105 HCDH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00895 3_HYDROXYISOBUT_DH, 1 hit
PS00067 3HCDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ988C8_RHILO
AccessioniPrimary (citable) accession number: Q988C8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2001
Last sequence update: October 1, 2001
Last modified: November 7, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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