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Protein

Histidinol-phosphate aminotransferase 1

Gene

hisC1

Organism
Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate.

Cofactori

Pathwayi: L-histidine biosynthesis

This protein is involved in step 7 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG), ATP phosphoribosyltransferase regulatory subunit (hisZ)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisH (hisH), Imidazole glycerol phosphate synthase subunit HisF (hisF)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase 2 (hisC2), Histidinol-phosphate aminotransferase 3 (hisC3), Histidinol-phosphate aminotransferase 1 (hisC1)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase 1 (hisD1), Histidinol dehydrogenase 2 (hisD2), Histidinol dehydrogenase 3 (hisD3)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMLOT266835:G1G20-5708-MONOMER
UniPathwayi
UPA00031;UER00012

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol-phosphate aminotransferase 1 (EC:2.6.1.9)
Alternative name(s):
Imidazole acetol-phosphate transaminase 1
Gene namesi
Name:hisC1
Ordered Locus Names:mll7105
OrganismiMesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) (Mesorhizobium loti (strain MAFF 303099))
Taxonomic identifieri266835 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesPhyllobacteriaceaeMesorhizobium
Proteomesi
  • UP000000552 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001534321 – 367Histidinol-phosphate aminotransferase 1Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229N6-(pyridoxal phosphate)lysineBy similarity1

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi266835.mll7105

Structurei

3D structure databases

ProteinModelPortaliQ987C8
SMRiQ987C8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105E45 Bacteria
COG0079 LUCA
HOGENOMiHOG000288510
KOiK00817
OMAiWRDPWPV
OrthoDBiPOG091H05S1

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_01023 HisC_aminotrans_2, 1 hit
InterProiView protein in InterPro
IPR001917 Aminotrans_II_pyridoxalP_BS
IPR004839 Aminotransferase_I/II
IPR005861 HisP_aminotrans
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
TIGRFAMsiTIGR01141 hisC, 1 hit
PROSITEiView protein in PROSITE
PS00599 AA_TRANSFER_CLASS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q987C8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSKASDMVRT EVTRPSPYNS GLTITEVMQR YAPARIAKLG SNENPLGPSP
60 70 80 90 100
TLATMLQAGA EMFRLYPDPA GRELRQAIAA KYGFGEDQII LGNGSEDLLS
110 120 130 140 150
VISRAVLRPG DSVVTLYPSF PLHEDYATLM GASVKRVTVN DDLTINADAL
160 170 180 190 200
IDAVRERPRM LLFSNPMNPV GSWLSAGDLS KVLDAVSDET LIVVDEAYAE
210 220 230 240 250
YAEGDDYASS LPDLCERDQP WIVLRTFSKA FGLAGLRIGF GIVGDPELRA
260 270 280 290 300
LLDRVRTPFN ANGMAQAAAL AALADEEHLA KVVALAKAER TQVESLLRNM
310 320 330 340 350
GFDVAPSRGN FLFFNCRQNA SAFAEGLLRE GVIVKPWKQE GFDSYVRVSI
360
GSPAENDHFM AALSQLL
Length:367
Mass (Da):39,889
Last modified:October 1, 2001 - v1
Checksum:i05E2F4E31307DB34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000012 Genomic DNA Translation: BAB53275.1
RefSeqiWP_010914582.1, NC_002678.2

Genome annotation databases

EnsemblBacteriaiBAB53275; BAB53275; BAB53275
KEGGimlo:mll7105
PATRICifig|266835.9.peg.5667

Similar proteinsi

Entry informationi

Entry nameiHIS81_RHILO
AccessioniPrimary (citable) accession number: Q987C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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