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Protein

DNA-directed RNA polymerase subunit A'

Gene

rpoA1

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Zn2+By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri58 – 101C4-typeSequence analysisAdd BLAST44

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.7.6 6163

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit A' (EC:2.7.7.6)
Gene namesi
Name:rpoA1
Ordered Locus Names:SSO0225
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740081 – 880DNA-directed RNA polymerase subunit A'Add BLAST880

Proteomic databases

PRIDEiQ980R2

Interactioni

Protein-protein interaction databases

DIPiDIP-60638N
IntActiQ980R2, 1 interactor
STRINGi273057.SSO0225

Structurei

Secondary structure

1880
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ980R2
SMRiQ980R2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ980R2

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri58 – 101C4-typeSequence analysisAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiarCOG04257 Archaea
COG0086 LUCA
HOGENOMiHOG000222974
InParanoidiQ980R2
KOiK03041
OMAiAVCPPYN
OrthoDBiPOG093Z009Q

Family and domain databases

Gene3Di1.10.132.30, 1 hit
InterProiView protein in InterPro
IPR000722 RNA_pol_asu
IPR006592 RNA_pol_N
IPR007080 RNA_pol_Rpb1_1
IPR007066 RNA_pol_Rpb1_3
IPR007083 RNA_pol_Rpb1_4
IPR007081 RNA_pol_Rpb1_5
IPR012758 RNAP_A1
IPR038120 Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997 RNA_pol_Rpb1_1, 1 hit
PF00623 RNA_pol_Rpb1_2, 1 hit
PF04983 RNA_pol_Rpb1_3, 1 hit
PF05000 RNA_pol_Rpb1_4, 1 hit
PF04998 RNA_pol_Rpb1_5, 1 hit
SMARTiView protein in SMART
SM00663 RPOLA_N, 1 hit
TIGRFAMsiTIGR02390 RNA_pol_rpoA1, 1 hit

Sequencei

Sequence statusi: Complete.

Q980R2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEKNIKGIK FGILSPDEIR KMSVTAIITP DVYDEDGTPI EGSVMDPRLG
60 70 80 90 100
VIEPGQKCPT CGNTLGNCPG HFGHIELVRP VIHVGLVKHI YEFLKATCRR
110 120 130 140 150
CGRVKISEDE IEKYSRIYNA IKKRWPSAAR RLTEYVKKTA MKAQVCPHCN
160 170 180 190 200
EKQYKIKLEK PYNFYEERKE GVAKLTPSDI RERLEKIPDS DVEILGYDPT
210 220 230 240 250
TSRPEWMILT VLPVPPITIR PSIMIESGIR AEDDLTHKLV DIVRINERLK
260 270 280 290 300
ESIDAGAPQL IIEDLWDLLQ YHVATYFDNE IPGLPPSKHR SGRPLRTLAQ
310 320 330 340 350
RLKGKEGRFR GNLSGKRVDF SSRTVISPDP NISIDEVGVP EIIAKTLTVP
360 370 380 390 400
ERITPWNIEK LRQFVINGPD KWPGANYVIR PDGRRIDLRY VKDRKELAST
410 420 430 440 450
LAPGYIIERH LIDGDIVLFN RQPSLHRISM MAHRVRVLKG LTFRLNLLVC
460 470 480 490 500
PPYNADFDGD EMNLHVPQSE EAIAEAKEIM LVHKNIITPR YGGPIIGAAQ
510 520 530 540 550
DYISGAYLLT VKTTLLTKEE AQQILGVADV KIDLGEPAIL APREYYTGKQ
560 570 580 590 600
VISAFLPKDF NFHGQANVSS GPRLCKNEDC PHDSYVVIKN GILLEGVFDK
610 620 630 640 650
KAIGNQQPES ILHWLIKEYS DEYGKWLMDN LFRVFIRFVE LQGFTMRLED
660 670 680 690 700
VSLGDDVKKE IYNEIDRAKV EVDNLIQKYK NGELEPIPGR TLEESLENYI
710 720 730 740 750
LDTLDKLRST AGDIASKYLD PFNFAYVMAR TGARGSVLNI TQMAAMLGQQ
760 770 780 790 800
SVRGERIKRG YMTRTLPHFK PYDISPEARG FIYSSFRTGL KPTELFFHAA
810 820 830 840 850
GGREGLVDTA VRTSQSGYMQ RRLINALSDL RAEYDGTVRS LYGEVVQVAY
860 870 880
GDDGVFPMYS AHGKTVDVNR IFERVVGWKA
Length:880
Mass (Da):99,675
Last modified:October 1, 2001 - v1
Checksum:i5C8AE20EFC71DE25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK40566.1
PIRiG90163
RefSeqiWP_009990476.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK40566; AAK40566; SSO0225
GeneIDi27426520
KEGGisso:SSO0225
PATRICifig|273057.12.peg.221

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK40566.1
PIRiG90163
RefSeqiWP_009990476.1, NC_002754.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PMZX-ray3.40A/Q1-880[»]
3HKZX-ray3.40A/I1-880[»]
ProteinModelPortaliQ980R2
SMRiQ980R2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60638N
IntActiQ980R2, 1 interactor
STRINGi273057.SSO0225

Proteomic databases

PRIDEiQ980R2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAK40566; AAK40566; SSO0225
GeneIDi27426520
KEGGisso:SSO0225
PATRICifig|273057.12.peg.221

Phylogenomic databases

eggNOGiarCOG04257 Archaea
COG0086 LUCA
HOGENOMiHOG000222974
InParanoidiQ980R2
KOiK03041
OMAiAVCPPYN
OrthoDBiPOG093Z009Q

Enzyme and pathway databases

BRENDAi2.7.7.6 6163

Miscellaneous databases

EvolutionaryTraceiQ980R2

Family and domain databases

Gene3Di1.10.132.30, 1 hit
InterProiView protein in InterPro
IPR000722 RNA_pol_asu
IPR006592 RNA_pol_N
IPR007080 RNA_pol_Rpb1_1
IPR007066 RNA_pol_Rpb1_3
IPR007083 RNA_pol_Rpb1_4
IPR007081 RNA_pol_Rpb1_5
IPR012758 RNAP_A1
IPR038120 Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997 RNA_pol_Rpb1_1, 1 hit
PF00623 RNA_pol_Rpb1_2, 1 hit
PF04983 RNA_pol_Rpb1_3, 1 hit
PF05000 RNA_pol_Rpb1_4, 1 hit
PF04998 RNA_pol_Rpb1_5, 1 hit
SMARTiView protein in SMART
SM00663 RPOLA_N, 1 hit
TIGRFAMsiTIGR02390 RNA_pol_rpoA1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPOA1_SULSO
AccessioniPrimary (citable) accession number: Q980R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2001
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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