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Protein

DNA-directed RNA polymerase subunit A'

Gene

rpoA1

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

Cofactori

Zn2+By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri58 – 101C4-typeSequence analysisAdd BLAST44

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi2.7.7.6 6163

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit A' (EC:2.7.7.6)
Gene namesi
Name:rpoA1
Ordered Locus Names:SSO0225
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000740081 – 880DNA-directed RNA polymerase subunit A'Add BLAST880

Proteomic databases

PRIDEiQ980R2

Interactioni

Protein-protein interaction databases

DIPiDIP-60638N
IntActiQ980R2, 1 interactor
STRINGi273057.SSO0225

Structurei

Secondary structure

1880
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi16 – 21Combined sources6
Beta strandi47 – 49Combined sources3
Beta strandi58 – 61Combined sources4
Turni84 – 86Combined sources3
Helixi87 – 93Combined sources7
Beta strandi99 – 102Combined sources4
Turni108 – 112Combined sources5
Helixi114 – 117Combined sources4
Helixi124 – 138Combined sources15
Turni143 – 145Combined sources3
Helixi177 – 184Combined sources8
Helixi189 – 196Combined sources8
Turni199 – 201Combined sources3
Turni204 – 206Combined sources3
Beta strandi207 – 211Combined sources5
Helixi217 – 219Combined sources3
Helixi234 – 253Combined sources20
Beta strandi254 – 256Combined sources3
Turni259 – 261Combined sources3
Helixi262 – 277Combined sources16
Beta strandi282 – 284Combined sources3
Helixi298 – 300Combined sources3
Helixi309 – 312Combined sources4
Beta strandi314 – 317Combined sources4
Beta strandi322 – 328Combined sources7
Beta strandi330 – 332Combined sources3
Beta strandi334 – 339Combined sources6
Helixi343 – 346Combined sources4
Beta strandi347 – 350Combined sources4
Turni355 – 357Combined sources3
Helixi358 – 367Combined sources10
Turni368 – 370Combined sources3
Beta strandi371 – 373Combined sources3
Turni394 – 396Combined sources3
Helixi397 – 400Combined sources4
Beta strandi406 – 410Combined sources5
Beta strandi416 – 420Combined sources5
Helixi427 – 429Combined sources3
Beta strandi430 – 437Combined sources8
Beta strandi439 – 445Combined sources7
Helixi447 – 449Combined sources3
Helixi450 – 453Combined sources4
Turni457 – 459Combined sources3
Beta strandi461 – 465Combined sources5
Helixi470 – 479Combined sources10
Helixi483 – 485Combined sources3
Turni489 – 492Combined sources4
Beta strandi493 – 496Combined sources4
Helixi501 – 509Combined sources9
Helixi518 – 523Combined sources6
Beta strandi541 – 543Combined sources3
Helixi548 – 552Combined sources5
Turni553 – 555Combined sources3
Beta strandi562 – 564Combined sources3
Helixi571 – 573Combined sources3
Beta strandi581 – 583Combined sources3
Beta strandi585 – 591Combined sources7
Helixi600 – 603Combined sources4
Turni607 – 609Combined sources3
Helixi611 – 617Combined sources7
Helixi623 – 630Combined sources8
Helixi632 – 639Combined sources8
Turni640 – 642Combined sources3
Turni649 – 651Combined sources3
Helixi657 – 662Combined sources6
Helixi665 – 680Combined sources16
Helixi692 – 715Combined sources24
Turni716 – 718Combined sources3
Helixi724 – 728Combined sources5
Beta strandi729 – 734Combined sources6
Helixi737 – 744Combined sources8
Beta strandi760 – 763Combined sources4
Beta strandi778 – 780Combined sources3
Turni786 – 788Combined sources3
Helixi794 – 811Combined sources18
Helixi813 – 824Combined sources12
Beta strandi841 – 843Combined sources3
Beta strandi845 – 849Combined sources5
Helixi850 – 852Combined sources3
Helixi857 – 859Combined sources3
Beta strandi860 – 864Combined sources5
Helixi867 – 874Combined sources8
Turni875 – 877Combined sources3

3D structure databases

ProteinModelPortaliQ980R2
SMRiQ980R2
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ980R2

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta' chain family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri58 – 101C4-typeSequence analysisAdd BLAST44

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiarCOG04257 Archaea
COG0086 LUCA
HOGENOMiHOG000222974
InParanoidiQ980R2
KOiK03041
OMAiAVCPPYN
OrthoDBiPOG093Z009Q

Family and domain databases

Gene3Di1.10.132.30, 1 hit
InterProiView protein in InterPro
IPR000722 RNA_pol_asu
IPR006592 RNA_pol_N
IPR007080 RNA_pol_Rpb1_1
IPR007066 RNA_pol_Rpb1_3
IPR007083 RNA_pol_Rpb1_4
IPR007081 RNA_pol_Rpb1_5
IPR012758 RNAP_A1
IPR038120 Rpb1_funnel_sf
PfamiView protein in Pfam
PF04997 RNA_pol_Rpb1_1, 1 hit
PF00623 RNA_pol_Rpb1_2, 1 hit
PF04983 RNA_pol_Rpb1_3, 1 hit
PF05000 RNA_pol_Rpb1_4, 1 hit
PF04998 RNA_pol_Rpb1_5, 1 hit
SMARTiView protein in SMART
SM00663 RPOLA_N, 1 hit
TIGRFAMsiTIGR02390 RNA_pol_rpoA1, 1 hit

Sequencei

Sequence statusi: Complete.

Q980R2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEKNIKGIK FGILSPDEIR KMSVTAIITP DVYDEDGTPI EGSVMDPRLG
60 70 80 90 100
VIEPGQKCPT CGNTLGNCPG HFGHIELVRP VIHVGLVKHI YEFLKATCRR
110 120 130 140 150
CGRVKISEDE IEKYSRIYNA IKKRWPSAAR RLTEYVKKTA MKAQVCPHCN
160 170 180 190 200
EKQYKIKLEK PYNFYEERKE GVAKLTPSDI RERLEKIPDS DVEILGYDPT
210 220 230 240 250
TSRPEWMILT VLPVPPITIR PSIMIESGIR AEDDLTHKLV DIVRINERLK
260 270 280 290 300
ESIDAGAPQL IIEDLWDLLQ YHVATYFDNE IPGLPPSKHR SGRPLRTLAQ
310 320 330 340 350
RLKGKEGRFR GNLSGKRVDF SSRTVISPDP NISIDEVGVP EIIAKTLTVP
360 370 380 390 400
ERITPWNIEK LRQFVINGPD KWPGANYVIR PDGRRIDLRY VKDRKELAST
410 420 430 440 450
LAPGYIIERH LIDGDIVLFN RQPSLHRISM MAHRVRVLKG LTFRLNLLVC
460 470 480 490 500
PPYNADFDGD EMNLHVPQSE EAIAEAKEIM LVHKNIITPR YGGPIIGAAQ
510 520 530 540 550
DYISGAYLLT VKTTLLTKEE AQQILGVADV KIDLGEPAIL APREYYTGKQ
560 570 580 590 600
VISAFLPKDF NFHGQANVSS GPRLCKNEDC PHDSYVVIKN GILLEGVFDK
610 620 630 640 650
KAIGNQQPES ILHWLIKEYS DEYGKWLMDN LFRVFIRFVE LQGFTMRLED
660 670 680 690 700
VSLGDDVKKE IYNEIDRAKV EVDNLIQKYK NGELEPIPGR TLEESLENYI
710 720 730 740 750
LDTLDKLRST AGDIASKYLD PFNFAYVMAR TGARGSVLNI TQMAAMLGQQ
760 770 780 790 800
SVRGERIKRG YMTRTLPHFK PYDISPEARG FIYSSFRTGL KPTELFFHAA
810 820 830 840 850
GGREGLVDTA VRTSQSGYMQ RRLINALSDL RAEYDGTVRS LYGEVVQVAY
860 870 880
GDDGVFPMYS AHGKTVDVNR IFERVVGWKA
Length:880
Mass (Da):99,675
Last modified:October 1, 2001 - v1
Checksum:i5C8AE20EFC71DE25
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK40566.1
PIRiG90163
RefSeqiWP_009990476.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK40566; AAK40566; SSO0225
GeneIDi27426520
KEGGisso:SSO0225
PATRICifig|273057.12.peg.221

Similar proteinsi

Entry informationi

Entry nameiRPOA1_SULSO
AccessioniPrimary (citable) accession number: Q980R2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2001
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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