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Protein

Translation initiation factor 2 subunit gamma

Gene

eif2g

Organism
Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTPUniRule annotation8
Nucleotide bindingi93 – 97GTPUniRule annotation5
Nucleotide bindingi149 – 152GTPUniRule annotation4

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi3.6.5.3 6163

Names & Taxonomyi

Protein namesi
Recommended name:
Translation initiation factor 2 subunit gammaUniRule annotation
Alternative name(s):
aIF2-gammaUniRule annotation
eIF-2-gammaUniRule annotation
Gene namesi
Name:eif2gUniRule annotation
Ordered Locus Names:SSO0412
OrganismiSulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
Taxonomic identifieri273057 [NCBI]
Taxonomic lineageiArchaeaCrenarchaeotaThermoproteiSulfolobalesSulfolobaceaeSulfolobus
Proteomesi
  • UP000001974 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001374631 – 415Translation initiation factor 2 subunit gammaAdd BLAST415

Interactioni

Subunit structurei

Heterotrimer composed of an alpha, a beta and a gamma chain.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
eif2aQ97Z792EBI-9010337,EBI-9010365

Protein-protein interaction databases

DIPiDIP-29031N
IntActiQ980A5, 1 interactor
STRINGi273057.SSO0412

Structurei

Secondary structure

1415
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ980A5
SMRiQ980A5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ980A5

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 206tr-type GAdd BLAST200

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 23G1By similarity8
Regioni44 – 48G2By similarity5
Regioni93 – 96G3By similarity4
Regioni149 – 152G4By similarity4
Regioni184 – 186G5By similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiarCOG01563 Archaea
COG5257 LUCA
HOGENOMiHOG000229292
InParanoidiQ980A5
KOiK03242
OMAiCPQPQTK
OrthoDBiPOG093Z03P8

Family and domain databases

CDDicd15490 eIF2_gamma_III, 1 hit
HAMAPiMF_00119 eIF_2_gamma, 1 hit
InterProiView protein in InterPro
IPR004161 EFTu-like_2
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR000795 TF_GTP-bd_dom
IPR022424 TIF2_gsu
IPR015256 TIF2_gsu_C
IPR009000 Transl_B-barrel_sf
IPR009001 Transl_elong_EF1A/Init_IF2_C
PfamiView protein in Pfam
PF09173 eIF2_C, 1 hit
PF00009 GTP_EFTU, 1 hit
PF03144 GTP_EFTU_D2, 1 hit
PRINTSiPR00315 ELONGATNFCT
SUPFAMiSSF50447 SSF50447, 1 hit
SSF50465 SSF50465, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03680 eif2g_arch, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51722 G_TR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q980A5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAWPKVQPEV NIGVVGHVDH GKTTLVQAIT GIWTSKHSEE LKRGMTIKLG
60 70 80 90 100
YAETNIGVCE SCKKPEAYVT EPSCKSCGSD DEPKFLRRIS FIDAPGHEVL
110 120 130 140 150
MATMLSGAAL MDGAILVVAA NEPFPQPQTR EHFVALGIIG VKNLIIVQNK
160 170 180 190 200
VDVVSKEEAL SQYRQIKQFT KGTWAENVPI IPVSALHKIN IDSLIEGIEE
210 220 230 240 250
YIKTPYRDLS QKPVMLVIRS FDVNKPGTQF NELKGGVIGG SIIQGLFKVD
260 270 280 290 300
QEIKVLPGLR VEKQGKVSYE PIFTKISSIR FGDEEFKEAK PGGLVAIGTY
310 320 330 340 350
LDPSLTKADN LLGSIITLAD AEVPVLWNIR IKYNLLERVV GAKEMLKVDP
360 370 380 390 400
IRAKETLMLS VGSSTTLGIV TSVKKDEIEV ELRRPVAVWS NNIRTVISRQ
410
IAGRWRMIGW GLVEI
Length:415
Mass (Da):45,792
Last modified:October 1, 2001 - v1
Checksum:i74A1F3C850D2D3D2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE006641 Genomic DNA Translation: AAK40740.1
PIRiE90185
RefSeqiWP_009988771.1, NC_002754.1

Genome annotation databases

EnsemblBacteriaiAAK40740; AAK40740; SSO0412
GeneIDi27426710
KEGGisso:SSO0412
PATRICifig|273057.12.peg.407

Similar proteinsi

Entry informationi

Entry nameiIF2G_SULSO
AccessioniPrimary (citable) accession number: Q980A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 21, 2005
Last sequence update: October 1, 2001
Last modified: March 28, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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